Research Plan: Make the Most of Your Significance ... - I2AT
4TH OF 7 PARTS
"NIH R01 Grant Application" Mentor
An Instructional Series
Research Plan: Make the Most of Your Significance, Innovation, Approach and Overall Impact
ISBN No. 978-0-9832691-9-9
Research Plan: Make the Most of Your Significance, Innovation, Approach and Overall Impact
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Principal Investigators Association |
Research Plan: Make the Most of Your Significance, Innovation, Approach and Overall Impact
"NIH R01 Grant Application" Mentor: An Instructional Series. Research Plan: Make the Most of Your Significance, Innovation, Approach and Overall Impact (ISBN No. 978-0-9832691-9-9) is published by Research Resources, 3606 Enterprise Avenue, Suite 160, Naples, FL 34104 USA.
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Research Plan: Make the Most of Your Significance, Innovation, Approach and Overall Impact
Table of Contents
INTRODUCTION.......................................................................................... 5 Language Is Important......................................................................... 5
SPECIFIC AIMS NAIL DOWN THE STEPS................................................. 7 Overcome Specific Aims Challenges.................................................. 9 Crafting Your Specific Aims............................................................... 10 Rely on This Example......................................................................... 11
RESEARCH STRATEGY HAS 3 PARTS................................................... 15 Section 1: Significance....................................................................... 17 Section 2: Innovation.......................................................................... 26 Section 3: Approach........................................................................... 29 Preliminary Data for New Applicants................................................ 36 Progress Report for Renewal/Revision Applications...................... 41
OVERALL IMPACT BRINGS EVERYTHING TOGETHER......................... 42 Integrate Impact Throughout.............................................................. 46
COMPLETE THE INCLUSION ENROLLMENT REPORT......................... 48 CITE YOUR BIBLIOGRAPHY AND REFERENCES.................................. 53 CONCLUSION........................................................................................... 55
Color Key:
Throughout this report, we have used highlighted text to indicate the following:
-- original text by authors of this report
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-- directly quoted NIH information
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-- paraphrased NIH information
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-- directly quoted information from successful NIH grant applications
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Principal Investigators Association |
Research Plan: Make the Most of Your Significance, Innovation, Approach and Overall Impact
Introduction
Probably the most important parts of your National Institutes of Health (NIH) R01 application are those in which you describe your proposed research. In particular, these are the Specific Aims and Research Strategy sections. They address your project's Significance, Innovation and Approach, which are three of the five core grant criteria that reviewers use to score your application.
At the same time, these sections will heavily influence your application's Overall Impact score. Unfortunately, there is no template for incorporating overall impact into your application, and there is no section called "Overall Impact" -- or even an incentive to simply add a paragraph labeled as such. Instead, the NIH Office of Extramural Research has stated that you should describe "impact" clearly in the words you feel are relevant to your project.
Consequently, we will examine how you can use the Specific Aims and Research Strategy to perform double-duty:
1. Fulfill the Significance, Innovation and Approach criteria 2. Support the Overall Impact of your research
As you address each of these sections, note that NIH limits your Specific Aims to no longer than one page, and the Research Strategy cannot exceed 12 pages for an R01 application.
Language Is Important
Also keep in mind that although terms like "aims," "goals," and "objectives" may seem interchangeable, they have separate meanings within your application.
? Goals are strategic and high-level. For instance, "Our goal is to understand signal transduction in breast cancer."
? Objectives often are a restatement of your hypothesis in a way that can be falsifiable. For example, if our hypothesis is that the EGF receptor axis is key in mediating steroidal effects on proliferation, your objective would be to determine the mechanism by which that occurs.
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Research Plan: Make the Most of Your Significance, Innovation, Approach and Overall Impact
? Aims are the outlines of your tactics or tasks to be performed. For instance, "Aim 1 is to establish a culture system of primary breast epithelial cells," or "I have already accomplished this aim." If your proposed research entails a linked series of aims, one or more of which has already been achieved, you can present the sequence of aims and note for one or two inital ones, "I have already accomplished this aim."
Or think of it using this analogy: ? Goals are the view from 30,000 feet ? Objectives are the view from 10,000 feet ? Specific Aims are the view from 1,000 feet
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