Curriculum Vitae - University of Kansas Hospital

Curriculum Vitae

WEN-XING DING, PhD

Business Address Department of Pharmacology, Toxicology and Therapeutics, The University of Kansas Medical Center, Kansas City, Kansas 66160, USA Phone: 913-588-9813 Email: wxding@kumc.edu Fax: 913- 588-7501

Education Nov. 2001-2003:

Aug. 1998 - June. 2002 Ph.D.

Nov 1996- May 1997 Sep. 1992 - July 1995: Sep. 1986 - July 1992:

Post-doctoral research fellow Department of Pathology University of Pittsburgh (Mentor: Dr. Xiao-Ming Yin) Pittsburgh, PA 15261, USA (Molecular Toxicology) Department of Community, Occupational and Family Medicine (Mentor: Professor Choon-Nam Ong) National University of Singapore, Singapore China Medical Board, New York (CMB) Fellow, Department of Community, Occupational and Family Medicine National University of Singapore, Singapore M. Med (Master of Medicine on Environmental Toxicology) Shanghai Medical University, China (Mentor: Professor Huigang Zhu) B. Med. (Bachelor of Medicine on Preventive Medicine) Shanghai Medical University, China

Professional Position and Working Experience

July 2017-

Professor (with tenure), Department of Pharmacology, Toxicology and Therapeutics, The University of Kansas Medical Center, Kansas City, Kansas

July 2013-2017 July 2012July 2009-2013 July 2005-2009:

Associate Professor (with tenure), Department of Pharmacology, Toxicology and Therapeutics, The University of Kansas Medical Center, Kansas City, Kansas

Director of Histology Core, Department of Pharmacology, Toxicology and Therapeutics, The University of Kansas Medical Center, Kansas City, Kansas

Assistant Professor, Department of Pharmacology, Toxicology and Therapeutics, The University of Kansas Medical Center, Kansas City, Kansas

Research Assistant Professor Department of Pathology University of Pittsburgh Pittsburgh, PA 15261, USA

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Nov. 2003-2005: Nov. 2001-2003: Aug. 1998 to Nov 2001: Jul. 1995 to Jul. 1998:

(Projects: (1) Studies on the role of autophagy in alcohol-induced liver injury; (2) Studies on mitochondrial autophagy

Research Associate Department of Pathology University of Pittsburgh Pittsburgh, PA 15261, USA (Project: Studies on proteasome inhibitor-induced apoptosis and autophagy in cancer therapy)

Post-doctoral research fellow Department of Pathology University of Pittsburgh Pittsburgh 15261, USA (Project: Studies on death-receptor activation-induced apoptosis in hepatocytes and liver)

Ph.D. student Dept. of Community, Occupational and Family Medicine Faculty of Medicine, National University of Singapore (Project: Studies on the hepatotoxicity of cyanobacterial toxin-microcystin)

Research and Teaching Assistant Dept. of Environmental Health, School of Public Health, Shanghai Medical University, P.R. China (Project: Studies on the genotoxicity and mutagenicity of water pollutants from Changjiang River in China)

Honors and Awards:

? 1995

Science Technology Progress Awards by Shanghai Municipality, Shanghai, P.R. China

? 1996

Science Technology Progress Awards by Shanghai Municipality, Shanghai, P.R. China

? 1997 ? 2000

Research Scholarship, National University of Singapore, Singapore DSO Top-up Scholarship, National University of Singapore, Singapore

? 2003

The Pathology Post-doctoral Research Training Program (PPRTP), Department of Pathology, University of Pittsburgh

? 2003 ? 2004

? 2005 ? 2010

American Liver Foundation Postdoctoral Fellowship Third Place Award for the oral presentation at Department of Pathology Annual Research Retreat, University of Pittsburgh Liver Scholar, American Liver Foundation KUMC Faculty Travel Award

? 2011 ? 2012

? 2012

KUMC Liver Center Symposium Best Poster Award 7th International Symposium on Alcoholic Liver and Pancreatic Diseases and Cirrhosis in Beijing Travel Award Best Poster Award at 6th International Symposium on Autophagy 2012 Okinawa Japan

? 2013 ? 2014 ? 2014

AASLD President Best Poster Award (2 awards for 2 posters). KUMC Faculty Travel Award AASLD (American Association for the Study of Liver Disease) President Best Poster Award

? 2014 ? 2014

AASLD Basic Science Plenary Presentation TOP#1 Manuscript Reviewer for American Journal of Pathology

? 2015 TOP#1 Manuscript Reviewer for American Journal of Pathology

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? 2015 ? 2016 ? 2016 ? 2017 ? 2017 ? 2018

Poster presentation Award 10th International Symposium on ALPD and Cirrhosis; AASLD President Best Poster Award; University Scholarly Achievement Award (KU) AASLD President Best Poster Award; Faculty Research Investigator Award (KUMC) Fellow of AASLD

Press Release

1. Ni, H.M., Duo, K., You, M., and Ding, W.X. (2013). Critical Roles of FoxO3 in Alcohol-Induced Autophagy and Hepatotoxicity. American J of Pathology. 84(10):103511. This paper was selected as AJP Press Release.

2. Ni, H.M., McGill M., Jaeschke, H and Ding, W.X. Sequestosome 1/p62-mediated selective removal of acetaminophen protein adducts and damaged mitochondria protects against acetaminophen-induced liver injury. AASLD Annul Meeting Press Release 2014 November.

3. Ni, H.M., McGill, M.R, Chao, X., Woolbright, B., Jaeschke, H., and Ding W.X. (2016). Caspase inhibition prevents TNF--induced apoptosis and promotes necrotic cell death in mouse hepatocytes in vivo and in vitro. Am J. Pathol. PMID: 27616656. This paper was selected as AJP Press Release.

Service Activities

? Member, Cell Death Society (2002) ? Member, American Association for the Studies of Liver Disease (AASLD) (2004-) ? Member, Liver Center of KUMC (2009-) ? Member, Research Society of Alcoholism (2010-) ? Member, International Society of Biomedical Research on Alcoholism (2012-) ? Member, Cancer Center of KUMC (2013-) ? Member, American Society of Investigative Pathology (ASIP) (2013-) ? Member, Society of Toxicology (SOT) (2015-) ? Member, Society of Chinese Bioscientist in America (SCBA) (2018-)

? Program Committee Member of ASIP (2013-)

? American Society of Investigative Pathology (ASIP) program Committee: 2013-2019

? AASLD Basic Research Committee: 2017-2020. ? AASLD Research Award Committee: 2018-2021. ? AASLD Taxonomy Task Force committee: 2018 ? 2016-2020 XNDA Study Section Standing Member ? ? ? Book Editor: Cell Death In Liver Disease (2017, Springer) ? Book Editor: Molecules, Systems and Signaling in Hepatic Cell Death (2017, Springer)

? Associate Editor: Autophagy (2017-) ? Editorial Board: Hepatology (2017-) ? Editorial Board: Hepatology Communications (2018-)

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? Editorial Board: Liver Research (2017-) ? Editorial Board: Scientific Reports (2016-) ? Editorial Board: Cells (2018-) ? Editorial Board: Biological Chemistry (2015-) ? Editorial Board: American Journal of Pathology (2014-) ? Editorial Board: Experimental Biology and Medicine (2014-2016) ? Editorial Board: Autophagy (2012-2016) ? Editorial Board: Translational Surgery (2015-) ? Editor: Journal of Biological Medicine (2010-) ? Academic Editor: British Journal of Pharmaceutical Research (2013-) ? Editorial Board: Drug Metabolism & Toxicology (2011-)

Bioenergetics (2011-) ? Associate Editor: World Journal of Biological Chemistry (2009-2013) ? Foreign Members of Editorial: J Medical Postgraduates (China) (2010-2013) ?

Meeting Organizer and Moderator

? Early Morning Workshop Moderator: Autophagy session. AASLD 2013 Annual Meeting. Nov 1-5th, Washington DC, USA.

? Conference Chair. Minisymposium: Cancer Biology and Cancer Therapeutics. Experimental Biology 2009. April 18-22, 2009. New Orleans. Louisiana, USA.

? Conference Chair. Minisymposium: Cell Death: Pathways and Mechanisms" Experimental Biology Meeting, March 18-22, Boston, 2015.

? Abstract Reviewer. AASLD Annual Meeting 2014, 2015, 2016, 2017. ? Conference Chair. Symposium: Programmed non-apoptotic cell death in tissue injury. Experimental

Biology 2015. March 18-22, 2015. Boston, USA. ? Conference co-organizer: AASLD Basic Science Symposium: Autophagy in the Livers. AASLD Annual

Meeting Nov 14th, 2015. San Francisco, USA. ? Conference Chair. Symposium: Autophagy: Basic Mechanisms and Pathophysiological Roles in Diseases.

Experimental Biology 2016. April 6th, 2016. San Diego, USA. ? Abstract Reviewer. DDW (Digestive Disease Week) Annual Meeting 2015, 2016, 2017. ? Early Morning Workshop Moderator: Autophagy session. AASLD 2016 Annual Meeting. Nov 11-15th,

Boston, USA. ? Early Morning Workshop Moderator: Autophagy session. AASLD 2017 Annual Meeting. 2017 October

21, Washington DC, USA. ? AASLD 2017 Annual Meeting Moderator for "Meet the Professor Luncheon" session title "Proteostasis".

AASLD 2017 Annual Meeting. 2017 October 21, Washington DC, USA. ? AASLD 2017 Annual Meeting Parallel Session moderator for Inflammation and Innate Immunity. 2017

October 22, Washington DC, USA. ? Conference Chair. Symposium: Cellular Adaptive Response and its Role in Tissue Injury, Tumorigenesis

and Cancer Progression. Experimental Biology 2018. April 22, 2018. San Diego, USA. ? Conference Chair. 2018 AASLD Annual Meeting Basic Research Workshop. Emerging Role of Novel

Cell Death Pathways and Mediators In Liver Disease. AAASLD Annual Meeting 2018. November 11, 2018. San Francisco, USA ? Conference Chair. Gordon Research Conference 2019: Alcohol-induced Endo Organ Disease. 2019 March, Ventura, USA ?

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Book Editor: 1. Ding, W.X. and Yin, X.M. Ed. Cell Death In Liver Diseases. Springer (planned to be published in January

2017). 2. Ding, W.X. and Yin, X.M. Ed. Molecules, Systems and Signaling in Hepatic Cell Death. Springer (planned

to be published in January 2017).

Special Issue Editor:

Special Issue entitled "Autophagy in Pathobiology" for Current Pathobiology Reports 2017. Volume 5, issue 2.

? Grant Reviewer:

? Ad hoc reviewer: NIH HBPP Study Section, NIH Special Emphasis Panel ZRG1 EMNR-R(02); NIH/NIAAA Special Emphasis Panel/Scientific Review Group 2014/10 ZAA1 DD; NIH XNDA Study Section; NIH Special Emphasis Panel ZRG1 DKUS-C(04); NIH Special Emphasis Panel ZDK1 GRB-7 (O2) 1; NIH Special Emphasis Panel ZRG1 DKUS-C 82 A; AA1, ZAG1 ZIJ-P (A1) NIA review; ZCA1 PPRB-L (O1) P (NCI Program Project Review)

? 2018: NIH XNDA, University of New Mexica COBRE pilot grants; AASLD Foundation Award; Research Grant Council (Hong Kong), ZAG1 ZIJ-P (A1) NIA review; ZCA1 PPRB-L (O1) P (NCI Program Project Review); Research Grant Council (UK); Hongkong Baptist University Research Grant; Health and Medical Research Fund from The Government of the Hong Kong Special Administrative Region (HKSAR)

? 2017: NIH XNDA, Research Grant Council (Hong Kong), Universit? Bourgogne Franche-Comt? (UBFC); VA Gulf War Illness, MRC UK, KUMC Lied Grant; Health and Medical Research Fund (Hong Kong); Fonds de recherche du Qu?bec - Nature et technologies.

? 2016: NIH/NIAAA AA1 Study Section; Israel Science Foundation; Hongkong Baptist University Interdisciplinary Research Matching Scheme; Research Grant Council (Hong Kong), The Welcome Trust (UK); Universit? Bourgogne Franche-Comt? (UBFC); City University of Hong Kong; NIH XNDA.

? 2015: FWF Austrian Science Fund, Israel Science Foundation; Research Grant Council (Hong Kong), The French National Research Agency, Action Medical Research UK, NIH HBPP study section; NIH Special Emphasis Panel ZDK1 GRB-7 (O2) 1; NIH Special Emphasis Panel ZRG1 DKUS-C 82 A; NIH XNDA study section

? 2014: NIH Special Emphasis Panel ZRG1 DKUS-C(04); XNDA Study Section Ad Hoc Reviewer (October); HBPP Study Section Ad Hoc Reviewer (February); NIH Special Emphasis Panel ZRG1 EMNRR(02) April; NIH/NIAAA Special Emphasis Panel/Scientific Review Group 2014/10 ZAA1 DD (01); Israel Science Foundation; Research Grant Council (Hong Kong); COBRE Project University of Nebraska; Frontiers Clinical Pilot project; Applied Research Grant City University of Hong Kong; Lied Basic Science Grant KUMC

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