SF424(R&R) Biographical Sketch Format Page

[Pages:5]BIOGRAPHICAL SKETCH

Provide the following information for the Senior/key personnel and other significant contributors. Follow this format for each person. DO NOT EXCEED FOUR PAGES.

NAME

Yiling Fu

POSITION TITLE

Scientist III-PT

eRA COMMONS USER NAME (credential, e.g., agency login)

YILINGFU

EDUCATION/TRAINING (Begin with baccalaureate or other initial professional education, such as nursing, include postdoctoral training and residency training if applicable.)

INSTITUTION AND LOCATION

DEGREE (if applicable)

MM/YY

FIELD OF STUDY

Shandong University, School of Medicine, China

Ph.D.

09/02-06/07 Endocrinology

Shandong University, School of Medicine, China

M.D.

09/96-07/01 Medicine

A. Positions and Honors

Positions and Employment 08/2007-10/2008 Medical Residency, Internal Medicine, Qilu Hospital of Shandong University, China 10/2008-06/2011 Postdoctoral Research Fellow, Department of Physiology & Biophysics, University of

Mississippi Medical Center, Jackson, MS 07/2011-07/2013 Instructor, Department of Physiology & Biophysics, University of Mississippi Medical Center,

Jackson, MS 07/2013-05/2018 Research Scientist, Veterans Medical Research Foundation/UCSD, San Diego, CA 06/2018-present Scientist III-PT

Other Experience 06/2006-05/2007 Exchange Student, Westmead Hospital, Sydney, Australia

Honors

06/2006-05/2007 Shandong University Predoctoral Fellowship Grant, Jinan, China

04/2013

Amgen Postdoctoral Excellence in Research Award Finalist. The American Physiological

Society Renal Section, Experimental Biology 2013, Boston, MA

B. Selected Peer-reviewed Publications

1. Fu Y, Yi S, Wu J, Jimenez E, Simond D, Hawthorne WJ, O'Connell PJ. In vitro suppression of xenoimmune-mediated macrophage activation by human CD4+CD25+ regulatory T cells. Transplantation, 86:865-74 (2008) PMID: 18813112

2. Fu Y, Lu X, Yi S, Wu J, O'Hara JM, Hawthorne WJ, Hucker K, O'Connell PJ . Selective rejection of porcine islet xenografts by macrophages. Xenotransplantation, 15:307-12 (2008) PMID: 19134160

3. Lin P, Chen L, Li D, Liu J, Yang N, Sun Y, Xu Y, Fu Y, Hou X. Adiponectin reduces glucotoxicity-induced apoptosis of INS-1 rat insulin-secreting cells on a microfluidic chip. Tohoku J Exp Med, 217:59-65 (2009) PMID: 19155609

4. Fu Y, Zhang R, Lu D, Liu H, Chandrashekar K, Juncos LA, Liu R. NOX2 is the primary source of angiotensin II induced superoxide in the macula densa. Am J Physiol Regul Integr Comp Physiol, 298:R707-12 (2010) PMID: 20053956

5. Lu D, Fu Y, Lopez-Ruiz A, Zhang R, Juncos R, Liu H, Manning RD Jr, Juncos LA, Liu R. Salt-sensitive splice variant of nNOS expressed in the macula densa cells. Am J Physiol Renal Physiol, 298:F1465-71 (2010) PMID: 20335319

6. Zhu X, Manning RD Jr, Lu D, Gomez-Sanchez CE, Fu Y, Juncos LA, Liu R. Aldosterone stimulates superoxide production in the macula densa cells. Am J Physiol Renal Physiol, 301:F529-35 (2011) PMID: 21270097

7. Fu Y, Hall JE, Lu D, Lin L, Manning RD Jr, Gomez-Sanchez CE, Juncos LA, Liu R. Aldosterone blunts tubuloglomerular feedback by activating macula densa mineralocorticoid receptors. Hypertension, 59:599606 (2012) PMID: 22311906

8. Lu Y, Fu Y, Ge Y, Juncos LA, Reckelhoff JF, Liu R. The vasodilatory effect of testosterone on renal afferent arterioles. Gend Med, 9:103-11 (2012) PMID: 22445695

9. Fu Y, Lu Y, Liu EY, Zhu X, Mahajan GJ, Lu D, Roman RJ, Liu R. Testosterone enhances tubuloglomerular feedback by increasing superoxide production in the macula densa. Am J Physiol Regul Integr Comp Physiol, 304:R726-33 (2013) PMID: 23467324

10. Masuda T, Fu Y, Eguchi A, Czogalla J, Rose MA, Kuczkowski A, Gerasimova M, Feldstein AE, Scadeng M, Vallon V. Dipeptidyl peptidase IV inhibitor lowers PPAR agonist-induced body weight gain by affecting food intake, fat mass, and beige/brown fat but not fluid retention. Am J Physiol Endocrinol Metab, 306(4):E388-98 (2014) PMID: 24347054

11. Fu Y, Vallon V. Mineralocorticoid-induced sodium appetite and renal salt retention: evidence for common signaling and effector mechanisms. Nephron Physiol. 128(1-2):8-16 (2014) PMID: 25376899

12. Fu Y, Gerasimova M, Batz F, Kuczkowski A, Alam Y, Sanders PW, Ronzaud C, Hummler E, Vallon V. PPAR Agonist-Induced Fluid Retention Depends on ENaC Expression in Connecting Tubules. Nephron Physiol, 129(1):68-74 (2015) PMID: 25531136

13. Lu Y, Zhang R, Ge Y, Carlstr?m M, Wang S, Fu Y, Cheng L, Wei J, Roman RJ, Wang L, Gao X, Liu R. Identification and function of A3 receptor in afferent arteriole. Am J Physiol Renal Physiol, 1;308(9):F10205 (2015) PMID: 25608966

14. Lu Y, Wei J, Stec DE, Roman RJ, Ge Y, Cheng L, Liu EY, Zhang J, Hansen PB, Fan F, Juncos LA, Wang L, Pollock J, Huang PL, Fu Y, Wang S, Liu R. Macula Densa Nitric Oxide Synthase 1 Protects against Salt-Sensitive Hypertension. J Am Soc Nephrol, 27(8):2346-56 (2016) PMID: 26647426

15. Song J, Wang L, Fan F, Wei J, Zhang J, Lu Y, Fu Y, Wang S, Juncos LA, Liu R. Role of the Primary Cilia on the Macula Densa and Thick Ascending Limbs in Regulation of Sodium Excretion and Hemodynamics. Hypertension, 70(2):324-333 (2017) PMID: 28607127

16. Fu Y, Breljak D, Onishi A, Batz F, Patel R, Huang W, Song P, Freeman B, Mayoux E, Koepsell H, Anzai N, Nigam SK, Sabolic I, Vallon V. Organic anion transporter OAT3 enhances the glucosuric effect of the SGLT2 inhibitor empagliflozin. Am J Physiol Renal Physiol. 315(2):F386-F394 (2018) PMID: 29412698

17. Novikov A, Fu Y, Huang W, Freeman B, Patel R, van Ginkel C, Koepsell H, Busslinger M, Onishi A, Nespoux J, Vallon V. SGLT2 inhibition and renal urate excretion: role of luminal glucose, GLUT9, and URAT1. Am J Physiol Renal Physiol. 316(1):F173-F185 (2019) PMID: 30427222 (co-first author)

Presentations at national and international meetings

1. Fu Y, Zhang R, Lu D, Liu H, Chandrashekar K, Juncos LA, Liu R. Sources of Ang II Induced Superoxide in a Macula Densa Cell Line. High Blood Pressure Research Conference 2009. Chicago, IL (oral presentation)

2. Lu D, Fu Y, Lopez-Ruiz A, Zhang R, Juncos R, Liu H, Manning RD, Jr, Juncos LA, Liu R. Salt sensitive splice variant of nNOS expressed in the macula densa cells. High Blood Pressure Research Conference 2009. Chicago, IL (oral presentation)

3. Zhang R, Lu D, Fu Y, Juncos L, Liu R. NOX2 is the primary source of superoxide in the macula densa in angiotension II induced hypertension. Experimental Biology 2009. New Orleans, LA (poster presentation)

4. Fu Y, Zhang R, Stec DE, Lu D, Juncos LA, Liu R. GTP-ase Rac facilitate superoxide production by the macula densa induced by membrane depolarization. Amercian Socienty of Nephrology Kidney Week 2009. San Diego, CA (oral presentation)

5. Fu Y, Roman RJ, Lu D, Zhu X, Liu R. High salt intake-induced TGF suppression is partially mediated by primary cilia on the macula densa. High Blood Pressure Research Conference 2010. Washington, DC (poster presentation)

6. Fu Y, Hall JE, Lin L, Gomez-Sanchez CE, Juncos LA, Liu R. Aldosterone blunts tubuloglomerular feedback by activating mineralocorticoid receptors on the macula densa. High Blood Pressure Research Conference 2010. Washington, DC (poster presentation)

7. Liu H, Lu D, Fu Y, Zhu X, Juncos LA, Liu R. Shear stress induced nitric oxide (NO) production in macula densa cells is mediated by the primary cilia. Experimental Biology 2010, Anaheim, CA (poster presentation)

8. Fu Y, Reckelhoff JF, Lu D, Juncos LA, Liu R. Testosterone (TST) has a biphasic effect on tubuloglomerular feedback (TGF). Experimental Biology 2011. Washington, DC (poster presentation)

9. Fu Y, Lu D, Juncos LA, Liu R. Increases in pH suppress tubuloglomerular feedback by enhancing activities of nNOS and nNOS in the macula densa. High Blood Pressure Research Conference 2011. Orlando, FL (poster presentation)

10. Fu Y, Lu Y, Ge Y, Juncos LA, Liu R. Activation of Na+/H+ exchanger (NHE) in the macula densa (MD) enhances tubuloglomerular feedback (TGF) in spontaneously hypertensive rats (SHR). Experimental Biology 2012. San Diego, CA (oral presentation)

11. Lu Y, Stec DE, Cheng L, Ge Y, Fu Y, Wei J, Pollock JS, Juncos LA, Liu R. Deletion of Nos1 In The Macula Densa Induces Salt-sensitive Hypertension. High Blood Pressure Research Conference 2012. Washington, DC (oral presentation)

12. Lu Y, Chandrashekar KB, Ge Y, Fu Y, Wei J, Kampen RL, Arany I, Juncos LA, Roman RJ, Liu R. Deletion of NOS1 in the macula densa exacerbates ischemia-induced acute kidney injury. Amercian Socienty of Nephrology Kidney Week 2012. San Diego, CA (poster presentation)

13. Lu Y, Stec D, Cheng L, Ge Y, Fu Y, Huang PL, Wei J, Pollock JS, Juncos LA, Liu R: Deletion of NOS1 in the macula densa induces salt-sensitive hypertension. Amercian Socienty of Nephrology Kidney Week 2012. San Diego, CA. (oral presentation)

14. Fu Y, Lu Y, Juncos LA, Ge Y, Pollock JS, Wei J, Roman RJ, Cheng L, Liu R. Macula Densa (MD) NOS1 Protects Against Acute Kidney Injury (AKI) Mediated by Primary Cilia. Experimental Biology 2013. Boston, MA (oral presentation)

15. Fu Y, Masuda T, Eguchi A, Czogalla J, Rose MA, Kuczkowski A, Gerasimova M, Feldstein AE, Scadeng M, Vallon V. Dipeptidyl peptidase-4 (DPP-4) inhibitor lowers PPAR agonist-induced body weight gain by affecting food intake, fat mass and beige/brown fat but not fluid retention. Experimental Biology 2014. San Diego, CA (poster presentation)

16. Fu Y, Gerasimova M, Mayoux E, Masuda T, Vallon V. SGLT2 inhibitor empagliflozin increases renal NHE3 phosphorylation in diabetic Akita mice: possible implications for the prevention of glomerular hyperfiltration. American Diabetes Association 74th Scientific Session, 2014. San Francisco, CA (poster presentation)

17. Fu Y, Gerasimova M, Batz F, Kuczkowski A, Alam Y, Hummler E, Vallon V. A role for ENaC in connecting tubules in PPAR agonist-induced fluid retention. Amercian Socienty of Nephrology Kidney Week 2014. Philadelphia, PA (poster presentation)

18. Fu Y, Gerasimova M, Masuda T, Alam Y, Batz F, Vallon V. The natriuretic effect of the glucagon-like peptide 1 receptor agonist, exendin-4, is independent of eNOS and phosphorylation of NKCC2 and NCC, and absent in STZ-diabetic mice. Amercian Socienty of Nephrology Kidney Week 2014. Philadelphia, PA (poster presentation)

19. Fu Y, Batz F, Onishi A, Novikov A, Song P, Vallon V. Characterization of aged mice lacking SGLT2. Amercian Socienty of Nephrology Kidney Week 2015. San Diego, CA (poster presentation)

20. Fu Y, Onishi A, Song P, Batz F, Mayoux E, Vallon V. Renal secretion of the SGLT2 inhibitor empagliflozin and rightward shift in its glucosuric response curve in mice lacking OAT3. Amercian Socienty of Nephrology Kidney Week 2015. San Diego, CA (poster presentation)

21. Fu Y, Song P, Onishi A, Batz F, Soleimani M, Busslinger M and Vallon V. The diuretic and natriuretic effect of the GLP-1 receptor agonist, exendin-4 is independent of tubular NHE3. Amercian Socienty of Nephrology Kidney Week 2015. San Diego, CA (poster presentation)

22. Onishi A, Fu Y, Song P, Busslinger M, Soleimani M, Rubera I, Tauc M, Vallon V. A role of Na+/H+ exchanger 3 in renal sodium and acid-base handling in the early proximal tubule and further downstream segments. Amercian Socienty of Nephrology Kidney Week 2015. San Diego, CA (poster presentation)

23. Song P, Fu Y, Onishi A, Qiu H, Koepsell H, Vallon V. Knockout of Na-glucose transporter SGLT1 does not affect hyperglycemia but attenuates diabetes-induced hyperfiltration. Experimental Biology 2016. San Diego, CA

24. Song P, Fu Y, Qiu H, Drucker DJ, Onishi A, Vallon V, Renal effects of glucagon-like peptide-1 receptor knockout in Akita-diabetic mice. Experimental Biology 2016. San Diego, CA

25. Onishi A, Fu Y, Song P, Busslinger M, Soleimani M, Vallon V, Renal tubule-specific knockdown of Na+/H+ exchanger 3 attenuates diabetic kidney growth independent of acid-base balance and GFR. Experimental Biology 2016. San Diego, CA

26. Fu Y, Qiu H, Kelada J, Novikov A, Khang S, Honndorf S, and Vallon V, Renal hemodynamics and tubular function are preserved when hydroxyethyl starch is dosed to acutely restore blood pressure after blood loss in rats. Experimental Biology 2016. San Diego, CA

27. Fu Y, Breljak D, Onishi A, Batz F, Patel R, Huang W, Song P, Mayoux E, Koepsell E, Anzai N, Nigam SK, Sabolic I, and Vallon V. The organic anion transporter OAT3 sensitizes the kidney to the glucosuric effect of the SGLT2 inhibitor empagliflozin. American Diabetes Association 77th Scientific Session, 2017. San Diego, CA

28. Onishi A, Fu Y, Huang W, Masip MC, Song P, Patel R, Busslinger M, Soleimani M, and Vallon V. Effect of renal tubule-specific knockdown of Na+/H+ exchanger NHE3 in Akita diabetic mice. American Diabetes Association 77th Scientific Session, 2017. San Diego, CA

C. Research Support (Secured)

American Heart Association GSA Postdoctoral Fellowship (11POST7750023), 07/2011-06/2013 Title: Renal NO bioavailability and hypertension

 ................
................

In order to avoid copyright disputes, this page is only a partial summary.

Google Online Preview   Download