PCB 3663C Human Genetics



[pic] BSC 1010C General Biology I

Fall, 2005 CRN’s 18054, 81055, 81094, 81095

Lecture: W F 2:00-3:20 Reed 249

Lab: M, T, W, or R 8:00 AM – 10:45 AM Griffin 209

|Faculty |Office Location |Telephone |Office Hours |

| Nora Egan Demers, PhD. |WH 218 |590-7211 |T-F 1:00 PM - 2:00 PM |

| | | |Additional office hours are available by appointment. Look|

| | | |for me in the Perch about 12:30 on Wednesdays. |

COURSE DESCRIPTION:

This course is intended for science majors. The principles of biology are studied from the molecular to the cellular level. Topics include basic biochemistry, the cell doctrine, the physical phenomena of life, elementary bioenergetics and biosynthesis, cellular and organismal reproduction and the gene concept. The curriculum is inquiry based and fully integrated with laboratory and/or field experiences that emphasizes active learning strategies.

TEXT:

Campbell NA, Reece JB. BIOLOGY . 7th ed. San Francisco: Pearson Publishing. 2005

Vodopich DS, Moore R. Biology Laboratory Manual . 7h ed. Boston: McGraw Hill Publishers. 2005

The text was chosen to provide you a good introduction to a subject rich in language and content.

GRADING POLICIES:

➢ There are four exams during this course and a comprehensive final. Exams will assess your comprehension of the material of the topics as specified.

➢ Laboratories/worksheets/problem sets will be assessed on a varying scale. All worksheets are DUE at the beginning of the following class meeting except for the formal lab reports. No late worksheets will be accepted. Grading is based on completion of the in-lab activities and the written worksheet.

| Exams I, II, III, IV, Final |500 points |

|Laboratories/Lab reports/attendance/participation |160 points |

|Poster presentations (and intermediate deadlines) |10 points |

|Total |670 points |

A. 603- 670 points. B. 536-602 points. C.469-535 points D.402-468. points F less than 401 points Note: +/- grades may be used to provide a more accurate assessment.

FACULTY COMMENTS:

The opportunity for learning in this course is a shared commitment between faculty and student. An enthusiastic learning environment enriches the gaining of knowledge. As your faculty, I will be involved with you in your learning and practice by my availability to guide and assist you in gaining the maximum value from your educational experiences. I look to you for inquiry, engagement and commitment to actively participate in the educational process.

I will be corresponding with you through your student email account. It is very important for you to have your student email activated. If you need assistance with this, please review the FGCU instructions for activating, forwarding, and getting help with your email at

COURSE POLICIES will be adhered to as follows:

• Tardiness, leaving class early or failure to come to class minimizes your opportunity to learn. If you are not in class at the time assignments are given or begin, you forfeit the opportunity to take part in that assignment or laboratory.

• All work is due on dates specified by the instructor. Work may be turned in earlier than the specified due date, but will NOT be accepted after the due date.

• Unfortunately, due to the time constraints, no make-up laboratories can be offered.

• Exams will be given on the date scheduled only.

• Unusual circumstances resulting in tardiness or class absence will be evaluated on a case-by-case basis by the instructor. The circumstances MUST be communicated to the instructor as soon as possible.

• If you experience a catastrophic event in your life that precludes you from completing course requirements, you may elect to petition for an incomplete in the course if you are in passing standing of the course to date.

• All safety guidelines set forth in student laboratory activities will be strictly adhered to.

• Faculty adhere to the FGCU policies of academic integrity provided in the Florida Gulf Coast University Student Guidebook.

• The faculty reserve the right to modify the syllabus as needed to accommodate situations that may arise during the sequence of this course.

Disability Statement: Florida Gulf Coast University, in accordance with the Americans with Disabilities Act and the university’s guiding principles, will provide classroom and academic accommodations to students with documented disabilities. If you need to request an accommodation in this class due to a disability, or you suspect that your academic performances is affected by a disability, please see me or contact the Office of Adaptive Services. The Office of Adaptive Services is located in McTarnaghan Hall, room 214. The phone number is 590-7956 or TTY 590-7930

At the completion of the course, learners should be able to meet these Student Learning Outcomes:

|Describe the scientific process. |

|Explain organic and inorganic compounds, their roles in biological systems, and their bonding properties. |

|Describe the properties of water and how they make life possible. |

|Describe how pH and buffers influence processes. |

|Identify and describe the structure and function of the 4 biological macromolecules that compose all life on the planet. |

|Describe dehydration synthesis and hydrolysis reactions and their importance in living systems. |

|Describe the role of enzymes in regulating life processes. |

|Distinguish between prokaryotes and eukaryotes. |

|Explain the interrelationship of structure and function in biological membranes. |

|Describe the major cellular organelles and their functions. |

|Explain the importance of membranes and compartmentalization of cellular functions. |

|Describe the importance of membrane proteins including serving as receptors, regulating metabolic pathways, facilitating cellular communication, and |

|establishing cellular identity. |

|Explain the basic laws of thermodynamics and their application to living organisms. |

|Explain the metabolic pathways through the study of cellular respiration (including glycolysis, krebs cycle & the electron transport chain) and photosynthesis. |

|Differentiate between somatic (mitotic) and germinal (meiotic) reproduction. |

|Explain the Central Dogma (from gene to protein) and its centrality to life. |

|Explain molecular aspects of evolution. |

|Describe basic Mendelian genetics and be able to correctly predict outcomes from monohybrid and dihybrid crosses including those involving traits that are |

|X-linked, show co-dominance, are controlled by multiple alleles, and crossing over. |

|Explain the chromosomal basis for genetics. |

|Describe how Mendelian genetics in modern genetics. |

|Describe how the genetic message can be altered through mutation and recombination. |

|Explain gene regulation through study of the lac operon, the trp operon, and metabolism. |

|Be able to explain genetic engineering including the techniques involved in electrophoresis, creating recombinant DNA, cloning, PCR, DNA sequencing, and |

|restriction mapping. |

|Explain how genetic engineering is currently being used in society and how it may be used in the future, including its role in gene therapy and development of |

|genetically engineered crops, and livestock. |

|Skills specific to the discipline -- |

|Demonstrate your knowledge of how to use scientific equipment, computer software, and microscopes. |

|Demonstrate a working knowledge of the safety features of the Biology laboratory by practicing safe science when doing laboratory science work. |

|Professional Development Skills -- that you need to develop regardless of your field of study |

|Demonstrate the ability to gather information from the library and other resources. |

|Practice solving problems, in individual and group settings, and in doing so, incorporate a diversity of values and approaches. |

|Demonstrate an ability to "learn how to learn" by interpreting and applying information from textbooks and other resources. |

|Demonstrate effective oral and written communication skills. |

|Natural Science students should realize that this course serves as a beginning point in exploration of the Sciences. The following outcomes have been developed |

|by the Natural Science faculty at FGCU to help guide your education: |

|1. All science students must demonstrate the ability to evaluate and to implement the scientific process, its application in different settings and, creative |

|alternative problem solving approaches that are explored within the context of standard scientific conventions. |

|Students must demonstrate the ability to: |

|• gather and critically evaluate information including library research skills, experimental design in laboratory or field settings, and the use of technology |

|for gathering information; |

|• analyze information; |

|• synthesize information via the formation of hypotheses, the use of numerical and statistical techniques, the use of simulation models, and the ability to apply|

|a system approach; |

|• effectively communicate in a professional setting, including technical writing, oral presentations and use of available technology; |

|• design and conduct a research investigation. |

|2. Students must demonstrate a knowledge of the interactions between science and society. |

|Students should: |

|• be aware of the ethical aspects of science; their conduct as scientists, and their conduct as citizens; |

|• develop abilities important in understanding and participating in the development and implementation of public policy; |

|• be able to solve problems in individual and group settings and to incorporate a diversity of values and approaches. |

|3. Students must demonstrate the development of a knowledge base that includes the prevailing scientific paradigms, the historical nature of these paradigms, and|

|aesthetic considerations of that knowledge. |

|• the origin of life on earth, and the mechanisms of evolution that shape that life, including an emphasis on natural selection; |

|• the origin of the earth and the processes that shape the globe, including an emphasis on plate tectonics. The origin of the universe and the mechanisms that |

|control it; |

|• the structure and organization of biotic systems from cells through the biosphere. Including and emphasis on the organization and functions of the human |

|organism. |

|Biology Specific Outcomes |

|The ability to function effectively and safely in research settings. |

|Knowledge of biological systems from the molecular, cellular, and organismic perspectives, including an historical view of their development. |

|A holistic understanding of organismal systems. |

|An understanding of ethical complexities of biological research. |

|University Student Learning Outcomes -- Upon completion of this course, students should also have gained experience and an increased proficiency in University |

|Goal #8: Technological Literacy, University Goal #7: Problem Solving, University Goal #6: Information Literacy, University Goal #4: Effective Communication. |

RESOURCES: A variety of resources are available from my home page Just click on the resources link in the header of the page. I hope you find them helpful in this class and for other purposes as well. The link that says “topics” offers an entire page of Biology resources; here is a direct URL:

General Biology I Lecture Schedule, Fall 2005

|Week |Date |Topic |Reading |Lab Activity |

|1 |Aug 24 |Course overview, Exploring Life |Ch. 1 |Measurements |

| |Aug 26 |The Chemical Context of Life |Ch. 2 | |

|2 |Aug 31 |Water and the Fitness of the Environment |Ch. 3 |pH scale |

| |Sept 2 |Carbon and the Molecular Diversity of Life |Ch. 4 | |

|3 |Sept 7 |The Structure and Function of Macromolecules |Ch. 5 |Diffusion and Osmosis |

| |Sept 9 |Exam I |Ch.s 1-5 | |

|4 |Sept 14 |A Tour of Cell |Ch. 6 |Enzymes |

| |Sept 16 |Membrane and Structure and Function |Ch. 8 | |

|5 |Sept 21 |An Introduction to Metabolism |Ch. 8 |Respiration |

| |Sept 23 |Cellular Respiration: Harvesting Chemical Energy |Ch. 9 | |

|6 |Sept 28 |Cell Respiration, continued |Ch. 9 |Photosynthesis |

| |Sept 30 |Photosynthesis |Ch. 10 | |

|7 |Oct 5 |Cell Communication |Ch. 11 |Microscopy and the Cell|

| |Oct 7 |Exam II |Ch.s 6-11 | |

|8 | | | |ODD SCHEDULE |

| |Oct 11 |The Cell Cycle- This is a TUESDAY!!! |Ch. 12 | |

|9 |Oct 12 |Meiosis and Sexual Life Cycles |Ch. 13 |Mitosis |

| |Oct 14 |Mendel and the Gene Idea |Ch. 14 | |

|10 |Oct 19 |The Chromosomal Basis of Inheritance |Ch. 15 |Meiosis |

| |Oct 21 |The Molecular Basis of Inheritance |Ch.s 16 | |

|11 |Oct 26 |From Gene to Protein |Ch.s 12-16 |Genetics problems |

| |Oct 28 |Exam III |Ch.s 17 | |

|12 |Nov 2 |The Genetics of Viruses and Bacteria |Ch.s 18 |Isolate DNA |

| |Nov 4 |The Organization and Control of Eukaryotic Genomes |Ch. 19 | |

|13 |Nov 9 |DNA Technology and Genomics |Ch. 20 |Gel electrophoresis |

| |Nov 11 |NO CLASS VETERANS DAY | | |

| |Nov 16 |The Genetic Basis of Development |Ch. 21 |Posters |

|14 |Nov 18 |Exam IV |Ch.s 17-21 | |

| |Nov 23 & 25 |Thanksgiving Holiday: No Class | |NO CLASS |

|15 |Nov 30 |Topics in Biology | |Posters |

| |Dec 1 |Review | | |

|TBA | |Final Exam |Ch.s 1-21 | |

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