Nausea and vomiting is one of the most impartment …



Comparison of dexamethasone, metoclopramide and their combination in the prevention of postoperative nausea and vomiting after laparoscopic cholecystectomy

Nesek-Adam Višnja1, MD, MS, Grizelj-Stojčić Elvira1, MD, Rašić Žarko2, MD, PhD, Čala Zoran2, MD, PhD, Mršić Viviana1, MD, Smiljanić Aleksandra1, MD

1Department of Anesthesiology, Resuscitation and Intensive Care, Sveti Duh General Hospital, Zagreb, Croatia

2University Department of Surgery, Sveti Duh General Hospital, Zagreb, Croatia

Grizelj-Stojčić Elvira – mladen.stojcic@zg.htnet.hr

Rašić Žarko - zarko.rasic@zg.htnet.hr

Zoran Čala - zoran.cala@bol-svduh.htnet.hr

Correspondence to:

Nesek-Adam Višnja, MD, MS

Žerjavićeva 12

HR-10000 Zagreb

Croatia

tihomir.adam@zg.htnet.hr

Phone: +385913712136

Abstract

Background: Postoperative nausea and vomiting (PONV) are one of the most common complaints following anesthesia and surgery. This study was designed to evaluate the efficacy of dexamethasone, metoclopramide and their combination to prevent PONV in patients undergoing laparoscopic cholecystectomy.

Methods: One-hundred and sixty ASA physical status I and II patients were included in this randomized, double blind, placebo-controlled study. Patients were randomly assigned to 4 groups (n=40 each): group 1 consisting of control patients administered 0.9% NaCl; group 2 patients received metoclopramide 10 mg just before the end of anesthesia; group 3 patients received dexamethasone 8 mg after the induction of anesthesia; and group 4 patients received dexamethasone 8 mg after the induction of anesthesia and metoclopramide 10 mg before the end of anesthesia. The incidence of PONV, mean visual analogue pain scores at rest and on movement, time to the first request for analgesia, side effects, and well-being score were recorded during the first 24 h postoperatively.

Results: Data were analyzed using one-way analysis of variance (ANOVA) and χ2 test, with p ................
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