Generic Industry Trends and Insights

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Global Generic and Biosimilars Trends and

Insights

Doug Long Vice President, Industry Relations

Association for Accessible Medicines February 13, 2018

Global generic sales continue to increase YoY, yet are decelerating in US and China

Generic Sales BNs

$120

$100

$80

$60

$40

$20

$0 USA

MAT SEPT 2012

CHINA EU5

MAT SEPT 2013

MAT SEPT 2014

MAT SEPT 2015

MAT SEPT 2016

ASIA / AUSTRALIA LATIN AMERICA JAPAN AFRICA / MIDDLE EAST

MAT SEPT 2017

ALL OTHERS

Growth

40.0% 30.0% 20.0% 10.0%

0.0% -10.0%

37.2%

11.7% 8.7%

TOTAL MARKET

Source: IQVIA MIDAS MAT Q3 2017; Rx bound; Generics include Non-original branded products and unbranded products

4.4% 1.6% -5.0%

1

Asia / Australia and EU5 dominate in generic unit volume; total generic unit volume growth is stabilizing

Generic Units BNs

25

20

15

10

5

0 USA

MAT SEPT 2012

CHINA EU5

MAT SEPT 2013

MAT SEPT 2014

MAT SEPT 2015

MAT SEPT 2016

ASIA / AUSTRALIA LATIN AMERICA JAPAN AFRICA / MIDDLE EAST

MAT SEPT 2017

ALL OTHERS

50.0% 40.0%

46.1%

Growth

30.0%

20.0% 10.0%

0.0%

10.7%

1.5%

TOTAL MARKET

Source: IQVIA MIDAS MAT Q3 2017; Rx bound; Generics include Non-original branded products and unbranded products

2.2% 2.7% 1.9%

2

Generics are taking an increased share of the value market

GENERICS MARKET SHARE (US$, Units) 2006 VS. 2016

North America: 52% North America: 16%

70% 23%

LATAM : 65% LATAM : 45%

80% 65%

Europe : 47% Europe : 26%

62% 29%

Japan: 31% Japan: 16%

40% 18%

Asia/Australasia : 74% Asia/Australasia : 31%

71% 43%

Africa/Middle East: 65% Africa/Middle East: 46%

69% 49%

Volume, Un

Value, US$

3 Source: IQVIA MIDAS MAT Q4 2016; Rx bound; Europe includes Turkey; Generics include Non-original branded products and unbranded products

Recent Headlines on Generics

The Health 202: Generic drugs had a great 2017

Washington Post January 2, 2018

2017 Was Another Record-Setting year for Generic Drugs

Kathleen "Cook" Uhl, MD February 7, 2018

4

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