Fatty Metabolism Pathway - Abcam

Myocardial fatty acid metabolism

Fatty acid: albumin

VLDL-TAG Fatty acid

LPL Chylomicron-TAG

Cell membrane

CD36

FATP

Acetyl CoA

Fatty acid

MLYCD

ACAC

TAG TAG

ATP AMP+PPi

FACS

Fatty acyl CoA

Acylcarnitine

Malonyl CoA Carnitine

TAG TAG

CPT1 CT

CPT2

Mitochondrial Matrix

Fatty acyl CoA

FA-

H2O ACOT2

CoA

UCP

FA-

Carnitine Acylcarnitine

Acetyl CoA

Fatty acid beta-oxidation

TCA cycle

UCP

H+

ADP

ATP

ATP5J2

FADH2 /NADH

H+ H+

H+

Cytosol

IV III II I

H+ H+

H+

AMPK

Fatty acid beta-oxidation

Acyl-CoA

Acyl-CoA

FAD

dehydrogenase

FADH2

trans-2-Enoyl-CoA

Enoyl-CoA hydratase

H2O 3-Hyroxyacyl-CoA

3-Hydroxyacyl-CoA dehydrogenase

NAD+ NADH+H+

beta-Ketoacyl-CoA

repeat

beta-Ketoacyl-CoA thiolase

CoASH Acetyl-CoA

Acyl-CoA (2 C Atoms Shorter)

Nucleus

Increase in fatty acid

Retinoic acid

RXR PPAR

PGC1 alpha PPAR RXR Response element PPAR target genes

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