Fatty Acid Metabolism

Fatty Acid Metabolism

Dr. Kevin Ahern

Fatty Acid Metabolism

? Fatty Acid Oxidation - Beta Oxidation

All Reactions Occur Between and Carbons -carbon -carbon

? Enzymes in Mitochondria and Peroxisomes

? Generates More ATP Per Carbon Than Sugars

? Proceeds 2 Carbons at a Time

Fatty Acid Metabolism

? Preparation for Oxidation

? Before Oxidation, Fatty Acids Must be Activated and Transported to the Mitochondrion.

? Activation Begins in the Cytoplasm

Long Chain Fatty Acyl-CoA Ligase

Fatty Acid

Fatty Acyl-CoA

? To Move the Acyl-CoA into the Mitochondrion, the CoA is Swapped with a Molecule of Carnitine

Four Steps in Fatty Acid Oxidation

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