Symptom Management Guidance to be used with Care …
After discontinuing a fentanyl patch, fentanyl levels fall gradually. It takes around 20 (range 13-27) hours for the plasma-fentanyl concentration to decrease by 50% (4-14). Patients who experience serious adverse effects should have patches removed immediately and should be monitored for at least 24 hours after the patch is removed (4-12). ................
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