Research Explorer | The University of Manchester
Full Title: Intra- and interexaminer variability in 3D fetal volume measurements during the second and third trimesters of pregnancy.Short Title: 3D fetal ultrasound reliabilityAuthors: Simcox LE1,2, Higgins LE1,2, Myers JE1,2, Johnstone ED1,2.1 Maternal and Fetal Health Research Centre, Institute of Human Development, University of Manchester. 2 St. Mary’s Hospital, Central Manchester University Hospitals NHS Foundation Trust, Manchester Academic Health Science Centre, Manchester, M13 9WL.Correspondence:Dr. Louise SimcoxClinical Research FellowMaternal and Fetal Health Research CentreUniversity of Manchester5th Floor ResearchSt. Mary’s HospitalOxford RoadManchesterM13 9WLLouise.simcox@postgrad.manchester.ac.ukTel: +44 (0) 777 607 7051Fax: +44 (0) 161 701 6971Keywords: Three-dimensional ultrasound, reliability, fractional thigh volume, total thigh volume, head volume, kidney volume, placental volume, VOCALAbstractObjective: To assess intra- and inter-examiner reliability of three dimensional fetal ultrasound measurements.Methods: Three dimensional (3D) fetal organ volumes (head, kidney, total thigh volume and fractional thigh volume (TVol)) were acquired during the second and third trimester, with the addition of placental volume in the second trimester, by 2 different experienced, blinded sonographers. 58 fetuses were examined from 21-39 weeks gestation. Intra and Inter-examiner reliability was assessed using Bland-Altman plots and their 95% limits of agreement, and intraclass correlation coefficients.Results: The most significant inter-examiner error was observed in second trimester kidney volume (95% limits of agreement ± 110%), and the best agreement was for third trimester TVol (95% limits of agreement ± 25%), and second trimester head volume (95% limits of agreement -7 to +25%). Second trimester and third trimester ICC results were all >0.75 apart from second trimester kidney volume intra (0.374) and inter-examiner (0.061) measurements, second trimester placenta inter-examiner measurements (0.390), and third trimester kidney inter-examiner measurements (0.647).Conclusions: 3D fetal ultrasound volumes of the head, kidney, total thigh and placenta have limited reproducibility and improvement in measurement techniques is needed before they can be used routinely to assess fetal growth. 3D TVol is reliably obtained in the late third trimester.IntroductionPrevious work has suggested that 3D sonography may facilitate more accurate assessment of fetal weight (either in addition to, or replacing, standard two-dimensional (2D) biometry), with measurements such as the inclusion of fractional limb volume in 2D fetal weight estimation formulas PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5ZYW5nPC9BdXRob3I+PFllYXI+MjAxMTwvWWVhcj48UmVj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ADDIN EN.CITE PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5ZYW5nPC9BdXRob3I+PFllYXI+MjAxMTwvWWVhcj48UmVj
TnVtPjE0MzwvUmVjTnVtPjxEaXNwbGF5VGV4dD4oMS0zKTwvRGlzcGxheVRleHQ+PHJlY29yZD48
cmVjLW51bWJlcj4xNDM8L3JlYy1udW1iZXI+PGZvcmVpZ24ta2V5cz48a2V5IGFwcD0iRU4iIGRi
LWlkPSIycHR6d3RyejNhNXhhaGVyNXJ0dnR0cnYwdngyOTlmYXRwenoiPjE0Mzwva2V5PjwvZm9y
ZWlnbi1rZXlzPjxyZWYtdHlwZSBuYW1lPSJKb3VybmFsIEFydGljbGUiPjE3PC9yZWYtdHlwZT48
Y29udHJpYnV0b3JzPjxhdXRob3JzPjxhdXRob3I+WWFuZywgRi48L2F1dGhvcj48YXV0aG9yPkxl
dW5nLCBLLiBZLjwvYXV0aG9yPjxhdXRob3I+SG91LCBZLiBXLjwvYXV0aG9yPjxhdXRob3I+WXVh
biwgWS48L2F1dGhvcj48YXV0aG9yPlRhbmcsIE0uIEguPC9hdXRob3I+PC9hdXRob3JzPjwvY29u
dHJpYnV0b3JzPjxhdXRoLWFkZHJlc3M+RGVwYXJ0bWVudCBvZiBPYnN0ZXRyaWNzIGFuZCBHeW5h
ZWNvbG9neSwgVW5pdmVyc2l0eSBvZiBIb25nIEtvbmcsIEhvbmcgS29uZywgQ2hpbmEuPC9hdXRo
LWFkZHJlc3M+PHRpdGxlcz48dGl0bGU+QmlydGgtd2VpZ2h0IHByZWRpY3Rpb24gdXNpbmcgdGhy
ZWUtZGltZW5zaW9uYWwgc29ub2dyYXBoaWMgZnJhY3Rpb25hbCB0aGlnaCB2b2x1bWUgYXQgdGVy
bSBpbiBhIENoaW5lc2UgcG9wdWxhdGlvbjwvdGl0bGU+PHNlY29uZGFyeS10aXRsZT5VbHRyYXNv
dW5kIE9ic3RldCBHeW5lY29sPC9zZWNvbmRhcnktdGl0bGU+PGFsdC10aXRsZT5VbHRyYXNvdW5k
IGluIG9ic3RldHJpY3MgJmFtcDsgZ3luZWNvbG9neSA6IHRoZSBvZmZpY2lhbCBqb3VybmFsIG9m
IHRoZSBJbnRlcm5hdGlvbmFsIFNvY2lldHkgb2YgVWx0cmFzb3VuZCBpbiBPYnN0ZXRyaWNzIGFu
ZCBHeW5lY29sb2d5PC9hbHQtdGl0bGU+PC90aXRsZXM+PHBlcmlvZGljYWw+PGZ1bGwtdGl0bGU+
VWx0cmFzb3VuZCBPYnN0ZXQgR3luZWNvbDwvZnVsbC10aXRsZT48YWJici0xPlVsdHJhc291bmQg
aW4gb2JzdGV0cmljcyAmYW1wOyBneW5lY29sb2d5IDogdGhlIG9mZmljaWFsIGpvdXJuYWwgb2Yg
dGhlIEludGVybmF0aW9uYWwgU29jaWV0eSBvZiBVbHRyYXNvdW5kIGluIE9ic3RldHJpY3MgYW5k
IEd5bmVjb2xvZ3k8L2FiYnItMT48L3BlcmlvZGljYWw+PGFsdC1wZXJpb2RpY2FsPjxmdWxsLXRp
dGxlPlVsdHJhc291bmQgT2JzdGV0IEd5bmVjb2w8L2Z1bGwtdGl0bGU+PGFiYnItMT5VbHRyYXNv
dW5kIGluIG9ic3RldHJpY3MgJmFtcDsgZ3luZWNvbG9neSA6IHRoZSBvZmZpY2lhbCBqb3VybmFs
IG9mIHRoZSBJbnRlcm5hdGlvbmFsIFNvY2lldHkgb2YgVWx0cmFzb3VuZCBpbiBPYnN0ZXRyaWNz
IGFuZCBHeW5lY29sb2d5PC9hYmJyLTE+PC9hbHQtcGVyaW9kaWNhbD48cGFnZXM+NDI1LTMzPC9w
YWdlcz48dm9sdW1lPjM4PC92b2x1bWU+PG51bWJlcj40PC9udW1iZXI+PGtleXdvcmRzPjxrZXl3
b3JkPkFkdWx0PC9rZXl3b3JkPjxrZXl3b3JkPkFuYWx5c2lzIG9mIFZhcmlhbmNlPC9rZXl3b3Jk
PjxrZXl3b3JkPipBc2lhbiBDb250aW5lbnRhbCBBbmNlc3RyeSBHcm91cDwva2V5d29yZD48a2V5
d29yZD4qQmlvbWV0cnk8L2tleXdvcmQ+PGtleXdvcmQ+KkJpcnRoIFdlaWdodC9waHlzaW9sb2d5
PC9rZXl3b3JkPjxrZXl3b3JkPkNyb3NzLVNlY3Rpb25hbCBTdHVkaWVzPC9rZXl3b3JkPjxrZXl3
b3JkPkZlbWFsZTwva2V5d29yZD48a2V5d29yZD4qRmV0YWwgV2VpZ2h0L3BoeXNpb2xvZ3k8L2tl
eXdvcmQ+PGtleXdvcmQ+R2VzdGF0aW9uYWwgQWdlPC9rZXl3b3JkPjxrZXl3b3JkPkh1bWFuczwv
a2V5d29yZD48a2V5d29yZD4qSW1hZ2luZywgVGhyZWUtRGltZW5zaW9uYWw8L2tleXdvcmQ+PGtl
eXdvcmQ+SW5mYW50LCBOZXdib3JuPC9rZXl3b3JkPjxrZXl3b3JkPkxpbmVhciBNb2RlbHM8L2tl
eXdvcmQ+PGtleXdvcmQ+TWFsZTwva2V5d29yZD48a2V5d29yZD5QcmVnbmFuY3k8L2tleXdvcmQ+
PGtleXdvcmQ+UHJlZ25hbmN5IFRyaW1lc3RlciwgVGhpcmQ8L2tleXdvcmQ+PGtleXdvcmQ+UHJv
c3BlY3RpdmUgU3R1ZGllczwva2V5d29yZD48a2V5d29yZD5SZXByb2R1Y2liaWxpdHkgb2YgUmVz
dWx0czwva2V5d29yZD48a2V5d29yZD5UaGlnaC9lbWJyeW9sb2d5L3VsdHJhc29ub2dyYXBoeTwv
a2V5d29yZD48a2V5d29yZD4qVWx0cmFzb25vZ3JhcGh5LCBQcmVuYXRhbDwva2V5d29yZD48L2tl
eXdvcmRzPjxkYXRlcz48eWVhcj4yMDExPC95ZWFyPjxwdWItZGF0ZXM+PGRhdGU+T2N0PC9kYXRl
PjwvcHViLWRhdGVzPjwvZGF0ZXM+PGlzYm4+MTQ2OS0wNzA1IChFbGVjdHJvbmljKSYjeEQ7MDk2
MC03NjkyIChMaW5raW5nKTwvaXNibj48YWNjZXNzaW9uLW51bT4yMTMwODgzMTwvYWNjZXNzaW9u
LW51bT48dXJscz48cmVsYXRlZC11cmxzPjx1cmw+aHR0cDovL3d3dy5uY2JpLm5sbS5uaWguZ292
L3B1Ym1lZC8yMTMwODgzMTwvdXJsPjwvcmVsYXRlZC11cmxzPjwvdXJscz48ZWxlY3Ryb25pYy1y
ZXNvdXJjZS1udW0+MTAuMTAwMi91b2cuODk0NTwvZWxlY3Ryb25pYy1yZXNvdXJjZS1udW0+PC9y
ZWNvcmQ+PC9DaXRlPjxDaXRlPjxBdXRob3I+TGVlPC9BdXRob3I+PFllYXI+MjAwOTwvWWVhcj48
UmVjTnVtPjEzPC9SZWNOdW0+PHJlY29yZD48cmVjLW51bWJlcj4xMzwvcmVjLW51bWJlcj48Zm9y
ZWlnbi1rZXlzPjxrZXkgYXBwPSJFTiIgZGItaWQ9IjJwdHp3dHJ6M2E1eGFoZXI1cnR2dHRydjB2
eDI5OWZhdHB6eiI+MTM8L2tleT48L2ZvcmVpZ24ta2V5cz48cmVmLXR5cGUgbmFtZT0iSm91cm5h
bCBBcnRpY2xlIj4xNzwvcmVmLXR5cGU+PGNvbnRyaWJ1dG9ycz48YXV0aG9ycz48YXV0aG9yPkxl
ZSwgVy48L2F1dGhvcj48YXV0aG9yPkJhbGFzdWJyYW1hbmlhbSwgTS48L2F1dGhvcj48YXV0aG9y
PkRldGVyLCBSLiBMLjwvYXV0aG9yPjxhdXRob3I+WWVvLCBMLjwvYXV0aG9yPjxhdXRob3I+SGFz
c2FuLCBTLiBTLjwvYXV0aG9yPjxhdXRob3I+R290c2NoLCBGLjwvYXV0aG9yPjxhdXRob3I+S3Vz
YW5vdmljLCBKLiBQLjwvYXV0aG9yPjxhdXRob3I+R29uY2FsdmVzLCBMLiBGLjwvYXV0aG9yPjxh
dXRob3I+Um9tZXJvLCBSLjwvYXV0aG9yPjwvYXV0aG9ycz48L2NvbnRyaWJ1dG9ycz48YXV0aC1h
ZGRyZXNzPkRpdmlzaW9uIG9mIEZldGFsIEltYWdpbmcsIERlcGFydG1lbnQgb2YgT2JzdGV0cmlj
cyBhbmQgR3luZWNvbG9neSwgT2FrbGFuZCBVbml2ZXJzaXR5IFdpbGxpYW0gQmVhdW1vbnQgU2No
b29sIG9mIE1lZGljaW5lLCBSb3lhbCBPYWssIE1JIDQ4MDczLTY3NjksIFVTQS4gd2xlZUBiZWF1
bW9udC5lZHU8L2F1dGgtYWRkcmVzcz48dGl0bGVzPjx0aXRsZT5OZXcgZmV0YWwgd2VpZ2h0IGVz
dGltYXRpb24gbW9kZWxzIHVzaW5nIGZyYWN0aW9uYWwgbGltYiB2b2x1bWU8L3RpdGxlPjxzZWNv
bmRhcnktdGl0bGU+VWx0cmFzb3VuZCBPYnN0ZXQgR3luZWNvbDwvc2Vjb25kYXJ5LXRpdGxlPjxh
bHQtdGl0bGU+VWx0cmFzb3VuZCBpbiBvYnN0ZXRyaWNzICZhbXA7IGd5bmVjb2xvZ3kgOiB0aGUg
b2ZmaWNpYWwgam91cm5hbCBvZiB0aGUgSW50ZXJuYXRpb25hbCBTb2NpZXR5IG9mIFVsdHJhc291
bmQgaW4gT2JzdGV0cmljcyBhbmQgR3luZWNvbG9neTwvYWx0LXRpdGxlPjwvdGl0bGVzPjxwZXJp
b2RpY2FsPjxmdWxsLXRpdGxlPlVsdHJhc291bmQgT2JzdGV0IEd5bmVjb2w8L2Z1bGwtdGl0bGU+
PGFiYnItMT5VbHRyYXNvdW5kIGluIG9ic3RldHJpY3MgJmFtcDsgZ3luZWNvbG9neSA6IHRoZSBv
ZmZpY2lhbCBqb3VybmFsIG9mIHRoZSBJbnRlcm5hdGlvbmFsIFNvY2lldHkgb2YgVWx0cmFzb3Vu
ZCBpbiBPYnN0ZXRyaWNzIGFuZCBHeW5lY29sb2d5PC9hYmJyLTE+PC9wZXJpb2RpY2FsPjxhbHQt
cGVyaW9kaWNhbD48ZnVsbC10aXRsZT5VbHRyYXNvdW5kIE9ic3RldCBHeW5lY29sPC9mdWxsLXRp
dGxlPjxhYmJyLTE+VWx0cmFzb3VuZCBpbiBvYnN0ZXRyaWNzICZhbXA7IGd5bmVjb2xvZ3kgOiB0
aGUgb2ZmaWNpYWwgam91cm5hbCBvZiB0aGUgSW50ZXJuYXRpb25hbCBTb2NpZXR5IG9mIFVsdHJh
c291bmQgaW4gT2JzdGV0cmljcyBhbmQgR3luZWNvbG9neTwvYWJici0xPjwvYWx0LXBlcmlvZGlj
YWw+PHBhZ2VzPjU1Ni02NTwvcGFnZXM+PHZvbHVtZT4zNDwvdm9sdW1lPjxudW1iZXI+NTwvbnVt
YmVyPjxrZXl3b3Jkcz48a2V5d29yZD5BZHVsdDwva2V5d29yZD48a2V5d29yZD5Bcm0vZW1icnlv
bG9neS8qdWx0cmFzb25vZ3JhcGh5PC9rZXl3b3JkPjxrZXl3b3JkPkJpb21ldHJ5PC9rZXl3b3Jk
PjxrZXl3b3JkPkJpcnRoIFdlaWdodDwva2V5d29yZD48a2V5d29yZD5Dcm9zcy1TZWN0aW9uYWwg
U3R1ZGllczwva2V5d29yZD48a2V5d29yZD5GZW1hbGU8L2tleXdvcmQ+PGtleXdvcmQ+KkZldGFs
IERldmVsb3BtZW50PC9rZXl3b3JkPjxrZXl3b3JkPkZldGFsIFdlaWdodC8qcGh5c2lvbG9neTwv
a2V5d29yZD48a2V5d29yZD5HZXN0YXRpb25hbCBBZ2U8L2tleXdvcmQ+PGtleXdvcmQ+SHVtYW5z
PC9rZXl3b3JkPjxrZXl3b3JkPlByZWduYW5jeTwva2V5d29yZD48a2V5d29yZD5QcmVnbmFuY3kg
VHJpbWVzdGVyLCBTZWNvbmQ8L2tleXdvcmQ+PGtleXdvcmQ+UHJlZ25hbmN5IFRyaW1lc3Rlciwg
VGhpcmQ8L2tleXdvcmQ+PGtleXdvcmQ+UHJvc3BlY3RpdmUgU3R1ZGllczwva2V5d29yZD48a2V5
d29yZD5UaGlnaC9lbWJyeW9sb2d5L3VsdHJhc29ub2dyYXBoeTwva2V5d29yZD48a2V5d29yZD5V
bHRyYXNvbm9ncmFwaHksIFByZW5hdGFsL21ldGhvZHM8L2tleXdvcmQ+PC9rZXl3b3Jkcz48ZGF0
ZXM+PHllYXI+MjAwOTwveWVhcj48cHViLWRhdGVzPjxkYXRlPk5vdjwvZGF0ZT48L3B1Yi1kYXRl
cz48L2RhdGVzPjxpc2JuPjE0NjktMDcwNSAoRWxlY3Ryb25pYykmI3hEOzA5NjAtNzY5MiAoTGlu
a2luZyk8L2lzYm4+PGFjY2Vzc2lvbi1udW0+MTk3MjUwODA8L2FjY2Vzc2lvbi1udW0+PHVybHM+
PHJlbGF0ZWQtdXJscz48dXJsPmh0dHA6Ly93d3cubmNiaS5ubG0ubmloLmdvdi9wdWJtZWQvMTk3
MjUwODA8L3VybD48L3JlbGF0ZWQtdXJscz48L3VybHM+PGN1c3RvbTI+Mjc4NDE1MjwvY3VzdG9t
Mj48ZWxlY3Ryb25pYy1yZXNvdXJjZS1udW0+MTAuMTAwMi91b2cuNzMyNzwvZWxlY3Ryb25pYy1y
ZXNvdXJjZS1udW0+PC9yZWNvcmQ+PC9DaXRlPjxDaXRlPjxBdXRob3I+TGVlPC9BdXRob3I+PFll
YXI+MjAxMzwvWWVhcj48UmVjTnVtPjIyOTwvUmVjTnVtPjxyZWNvcmQ+PHJlYy1udW1iZXI+MjI5
PC9yZWMtbnVtYmVyPjxmb3JlaWduLWtleXM+PGtleSBhcHA9IkVOIiBkYi1pZD0iMnB0end0cnoz
YTV4YWhlcjVydHZ0dHJ2MHZ4Mjk5ZmF0cHp6Ij4yMjk8L2tleT48L2ZvcmVpZ24ta2V5cz48cmVm
LXR5cGUgbmFtZT0iSm91cm5hbCBBcnRpY2xlIj4xNzwvcmVmLXR5cGU+PGNvbnRyaWJ1dG9ycz48
YXV0aG9ycz48YXV0aG9yPkxlZSwgVy48L2F1dGhvcj48YXV0aG9yPkRldGVyLCBSLjwvYXV0aG9y
PjxhdXRob3I+U2FuZ2ktSGFnaHBleWthciwgSC48L2F1dGhvcj48YXV0aG9yPlllbywgTC48L2F1
dGhvcj48YXV0aG9yPlJvbWVybywgUi48L2F1dGhvcj48L2F1dGhvcnM+PC9jb250cmlidXRvcnM+
PGF1dGgtYWRkcmVzcz5EZXBhcnRtZW50IG9mIE9ic3RldHJpY3MgYW5kIEd5bmVjb2xvZ3ksIE9h
a2xhbmQgVW5pdmVyc2l0eSBXaWxsaWFtIEJlYXVtb250IFNjaG9vbCBvZiBNZWRpY2luZSwgUm9j
aGVzdGVyLCBNSSwgVVNBLiB3ZXNsZXkubGVlQGJjbS5lZHU8L2F1dGgtYWRkcmVzcz48dGl0bGVz
Pjx0aXRsZT5Qcm9zcGVjdGl2ZSB2YWxpZGF0aW9uIG9mIGZldGFsIHdlaWdodCBlc3RpbWF0aW9u
IHVzaW5nIGZyYWN0aW9uYWwgbGltYiB2b2x1bWU8L3RpdGxlPjxzZWNvbmRhcnktdGl0bGU+VWx0
cmFzb3VuZCBPYnN0ZXQgR3luZWNvbDwvc2Vjb25kYXJ5LXRpdGxlPjxhbHQtdGl0bGU+VWx0cmFz
b3VuZCBpbiBvYnN0ZXRyaWNzICZhbXA7IGd5bmVjb2xvZ3kgOiB0aGUgb2ZmaWNpYWwgam91cm5h
bCBvZiB0aGUgSW50ZXJuYXRpb25hbCBTb2NpZXR5IG9mIFVsdHJhc291bmQgaW4gT2JzdGV0cmlj
cyBhbmQgR3luZWNvbG9neTwvYWx0LXRpdGxlPjwvdGl0bGVzPjxwZXJpb2RpY2FsPjxmdWxsLXRp
dGxlPlVsdHJhc291bmQgT2JzdGV0IEd5bmVjb2w8L2Z1bGwtdGl0bGU+PGFiYnItMT5VbHRyYXNv
dW5kIGluIG9ic3RldHJpY3MgJmFtcDsgZ3luZWNvbG9neSA6IHRoZSBvZmZpY2lhbCBqb3VybmFs
IG9mIHRoZSBJbnRlcm5hdGlvbmFsIFNvY2lldHkgb2YgVWx0cmFzb3VuZCBpbiBPYnN0ZXRyaWNz
IGFuZCBHeW5lY29sb2d5PC9hYmJyLTE+PC9wZXJpb2RpY2FsPjxhbHQtcGVyaW9kaWNhbD48ZnVs
bC10aXRsZT5VbHRyYXNvdW5kIE9ic3RldCBHeW5lY29sPC9mdWxsLXRpdGxlPjxhYmJyLTE+VWx0
cmFzb3VuZCBpbiBvYnN0ZXRyaWNzICZhbXA7IGd5bmVjb2xvZ3kgOiB0aGUgb2ZmaWNpYWwgam91
cm5hbCBvZiB0aGUgSW50ZXJuYXRpb25hbCBTb2NpZXR5IG9mIFVsdHJhc291bmQgaW4gT2JzdGV0
cmljcyBhbmQgR3luZWNvbG9neTwvYWJici0xPjwvYWx0LXBlcmlvZGljYWw+PHBhZ2VzPjE5OC0y
MDM8L3BhZ2VzPjx2b2x1bWU+NDE8L3ZvbHVtZT48bnVtYmVyPjI8L251bWJlcj48a2V5d29yZHM+
PGtleXdvcmQ+QWR1bHQ8L2tleXdvcmQ+PGtleXdvcmQ+QXJtLyplbWJyeW9sb2d5PC9rZXl3b3Jk
PjxrZXl3b3JkPkNyb3NzLVNlY3Rpb25hbCBTdHVkaWVzPC9rZXl3b3JkPjxrZXl3b3JkPkZlbWFs
ZTwva2V5d29yZD48a2V5d29yZD5GZXRhbCBXZWlnaHQvKnBoeXNpb2xvZ3k8L2tleXdvcmQ+PGtl
eXdvcmQ+R2VzdGF0aW9uYWwgQWdlPC9rZXl3b3JkPjxrZXl3b3JkPkh1bWFuczwva2V5d29yZD48
a2V5d29yZD5JbWFnaW5nLCBUaHJlZS1EaW1lbnNpb25hbDwva2V5d29yZD48a2V5d29yZD5Pcmdh
biBTaXplPC9rZXl3b3JkPjxrZXl3b3JkPlByZWduYW5jeTwva2V5d29yZD48a2V5d29yZD5QcmVn
bmFuY3kgVHJpbWVzdGVyLCBTZWNvbmQ8L2tleXdvcmQ+PGtleXdvcmQ+UHJlZ25hbmN5IFRyaW1l
c3RlciwgVGhpcmQ8L2tleXdvcmQ+PGtleXdvcmQ+UHJvc3BlY3RpdmUgU3R1ZGllczwva2V5d29y
ZD48a2V5d29yZD5UaGlnaC8qZW1icnlvbG9neTwva2V5d29yZD48a2V5d29yZD5VbHRyYXNvbm9n
cmFwaHksIFByZW5hdGFsL21ldGhvZHM8L2tleXdvcmQ+PC9rZXl3b3Jkcz48ZGF0ZXM+PHllYXI+
MjAxMzwveWVhcj48cHViLWRhdGVzPjxkYXRlPkZlYjwvZGF0ZT48L3B1Yi1kYXRlcz48L2RhdGVz
Pjxpc2JuPjE0NjktMDcwNSAoRWxlY3Ryb25pYykmI3hEOzA5NjAtNzY5MiAoTGlua2luZyk8L2lz
Ym4+PGFjY2Vzc2lvbi1udW0+MjI2MDU1MTk8L2FjY2Vzc2lvbi1udW0+PHVybHM+PHJlbGF0ZWQt
dXJscz48dXJsPmh0dHA6Ly93d3cubmNiaS5ubG0ubmloLmdvdi9wdWJtZWQvMjI2MDU1MTk8L3Vy
bD48L3JlbGF0ZWQtdXJscz48L3VybHM+PGN1c3RvbTI+MzYwMTg0NTwvY3VzdG9tMj48ZWxlY3Ry
b25pYy1yZXNvdXJjZS1udW0+MTAuMTAwMi91b2cuMTExODU8L2VsZWN0cm9uaWMtcmVzb3VyY2Ut
bnVtPjwvcmVjb3JkPjwvQ2l0ZT48L0VuZE5vdGU+
ADDIN EN.CITE.DATA (1-3). It is also proposed that the volume-rendering capabilities of 3D ultrasound will result in more accurate, precise and standardised measurements, which is particularly important in improving estimations of fetal weight in the late third trimester ADDIN EN.CITE <EndNote><Cite><Author>Platt</Author><Year>2000</Year><RecNum>137</RecNum><DisplayText>(4)</DisplayText><record><rec-number>137</rec-number><foreign-keys><key app="EN" db-id="2ptzwtrz3a5xaher5rtvttrv0vx299fatpzz">137</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>Platt, L. D.</author></authors></contributors><titles><title>Three-dimensional ultrasound, 2000</title><secondary-title>Ultrasound Obstet Gynecol</secondary-title><alt-title>Ultrasound in obstetrics & gynecology : the official journal of the International Society of Ultrasound in Obstetrics and Gynecology</alt-title></titles><periodical><full-title>Ultrasound Obstet Gynecol</full-title><abbr-1>Ultrasound in obstetrics & gynecology : the official journal of the International Society of Ultrasound in Obstetrics and Gynecology</abbr-1></periodical><alt-periodical><full-title>Ultrasound Obstet Gynecol</full-title><abbr-1>Ultrasound in obstetrics & gynecology : the official journal of the International Society of Ultrasound in Obstetrics and Gynecology</abbr-1></alt-periodical><pages>295-8</pages><volume>16</volume><number>4</number><keywords><keyword>Gynecology/*trends</keyword><keyword>Humans</keyword><keyword>Medical Laboratory Science</keyword><keyword>Obstetrics/*trends</keyword><keyword>Ultrasonography/*methods/trends</keyword><keyword>Ultrasonography, Prenatal/methods/trends</keyword></keywords><dates><year>2000</year><pub-dates><date>Sep</date></pub-dates></dates><isbn>0960-7692 (Print)
0960-7692 (Linking)</isbn><accession-num>11169302</accession-num><urls><related-urls><url>;(4). There is also the potential to use 3D ultrasound to measure fetal volumes at earlier gestations to enable calculation of ideal third trimester growth trajectories PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5MZWU8L0F1dGhvcj48WWVhcj4yMDA0PC9ZZWFyPjxSZWNO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ADDIN EN.CITE PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5MZWU8L0F1dGhvcj48WWVhcj4yMDA0PC9ZZWFyPjxSZWNO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ADDIN EN.CITE.DATA (5). This particular use of 3D ultrasound, using fractional thigh volume (TVol) in individualised growth assessment (IGA) has been prospectively evaluated in a normal pregnancy population with promising results PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5EZXRlcjwvQXV0aG9yPjxZZWFyPjIwMTQ8L1llYXI+PFJl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ADDIN EN.CITE PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5EZXRlcjwvQXV0aG9yPjxZZWFyPjIwMTQ8L1llYXI+PFJl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ADDIN EN.CITE.DATA (6, 7). Other studies, examining placental volumes in the first trimester, have demonstrated that 3D methods are superior when compared to 2D ultrasound ADDIN EN.CITE <EndNote><Cite><Author>Hata</Author><Year>2011</Year><RecNum>309</RecNum><DisplayText>(8)</DisplayText><record><rec-number>309</rec-number><foreign-keys><key app="EN" db-id="2ptzwtrz3a5xaher5rtvttrv0vx299fatpzz">309</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>Hata, T.</author><author>Tanaka, H.</author><author>Noguchi, J.</author><author>Hata, K.</author></authors></contributors><auth-address>Department of Perinatology and Gynecology, Kagawa University School of Medicine, Kagawa 761-0793, Japan. toshi28@med.kagawa-u.ac.jp</auth-address><titles><title>Three-dimensional ultrasound evaluation of the placenta</title><secondary-title>Placenta</secondary-title><alt-title>Placenta</alt-title></titles><periodical><full-title>Placenta</full-title><abbr-1>Placenta</abbr-1></periodical><alt-periodical><full-title>Placenta</full-title><abbr-1>Placenta</abbr-1></alt-periodical><pages>105-15</pages><volume>32</volume><number>2</number><keywords><keyword>Female</keyword><keyword>Fetal Growth Retardation/ultrasonography</keyword><keyword>Gestational Age</keyword><keyword>Hemangioma/ultrasonography</keyword><keyword>Humans</keyword><keyword>Hydrops Fetalis/ultrasonography</keyword><keyword>Imaging, Three-Dimensional/*methods</keyword><keyword>Placenta/blood supply/*ultrasonography</keyword><keyword>Placenta Diseases/ultrasonography</keyword><keyword>Pregnancy</keyword><keyword>Ultrasonography, Prenatal/*methods</keyword></keywords><dates><year>2011</year><pub-dates><date>Feb</date></pub-dates></dates><isbn>1532-3102 (Electronic)
0143-4004 (Linking)</isbn><accession-num>21115197</accession-num><urls><related-urls><url>;(8). This has been evaluated in an attempt to enable earlier detection of those pregnancies resulting in small for gestational age infants (SGA), early-onset intra-uterine growth restriction (IUGR) and pre-eclampsia PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5BcnR1bmMgVWxrdW1lbjwvQXV0aG9yPjxZZWFyPjIwMTQ8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ADDIN EN.CITE PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5BcnR1bmMgVWxrdW1lbjwvQXV0aG9yPjxZZWFyPjIwMTQ8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ADDIN EN.CITE.DATA (9-12).Sonographic volume calculations have now been described in a variety of fetal organs and structures PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5Sb2VsZnNlbWE8L0F1dGhvcj48WWVhcj4yMDA0PC9ZZWFy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ADDIN EN.CITE PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5Sb2VsZnNlbWE8L0F1dGhvcj48WWVhcj4yMDA0PC9ZZWFy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ADDIN EN.CITE.DATA (13-20). In the majority of cases this is achieved by manual organ segmentation, using one of two methods: the multiple parallel plane method (multiplanar) or the rotational Virtual Organ Computer-aided Analysis (VOCAL; GE Medical Systems, Zipf, Austria) PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5Jb2Fubm91PC9BdXRob3I+PFllYXI+MjAxMTwvWWVhcj48
UmVjTnVtPjEyMzwvUmVjTnVtPjxEaXNwbGF5VGV4dD4oMjEpPC9EaXNwbGF5VGV4dD48cmVjb3Jk
PjxyZWMtbnVtYmVyPjEyMzwvcmVjLW51bWJlcj48Zm9yZWlnbi1rZXlzPjxrZXkgYXBwPSJFTiIg
ZGItaWQ9IjJwdHp3dHJ6M2E1eGFoZXI1cnR2dHRydjB2eDI5OWZhdHB6eiI+MTIzPC9rZXk+PC9m
b3JlaWduLWtleXM+PHJlZi10eXBlIG5hbWU9IkpvdXJuYWwgQXJ0aWNsZSI+MTc8L3JlZi10eXBl
Pjxjb250cmlidXRvcnM+PGF1dGhvcnM+PGF1dGhvcj5Jb2Fubm91LCBDLjwvYXV0aG9yPjxhdXRo
b3I+U2FycmlzLCBJLjwvYXV0aG9yPjxhdXRob3I+U2Fsb21vbiwgTC4gSi48L2F1dGhvcj48YXV0
aG9yPlBhcGFnZW9yZ2hpb3UsIEEuIFQuPC9hdXRob3I+PC9hdXRob3JzPjwvY29udHJpYnV0b3Jz
PjxhdXRoLWFkZHJlc3M+TnVmZmllbGQgRGVwYXJ0bWVudCBvZiBPYnN0ZXRyaWNzIGFuZCBHeW5h
ZWNvbG9neSwgVW5pdmVyc2l0eSBvZiBPeGZvcmQsIE94Zm9yZCwgVUsuPC9hdXRoLWFkZHJlc3M+
PHRpdGxlcz48dGl0bGU+QSByZXZpZXcgb2YgZmV0YWwgdm9sdW1ldHJ5OiB0aGUgbmVlZCBmb3Ig
c3RhbmRhcmRpemF0aW9uIGFuZCBkZWZpbml0aW9ucyBpbiBtZWFzdXJlbWVudCBtZXRob2RvbG9n
eTwvdGl0bGU+PHNlY29uZGFyeS10aXRsZT5VbHRyYXNvdW5kIE9ic3RldCBHeW5lY29sPC9zZWNv
bmRhcnktdGl0bGU+PGFsdC10aXRsZT5VbHRyYXNvdW5kIGluIG9ic3RldHJpY3MgJmFtcDsgZ3lu
ZWNvbG9neSA6IHRoZSBvZmZpY2lhbCBqb3VybmFsIG9mIHRoZSBJbnRlcm5hdGlvbmFsIFNvY2ll
dHkgb2YgVWx0cmFzb3VuZCBpbiBPYnN0ZXRyaWNzIGFuZCBHeW5lY29sb2d5PC9hbHQtdGl0bGU+
PC90aXRsZXM+PHBlcmlvZGljYWw+PGZ1bGwtdGl0bGU+VWx0cmFzb3VuZCBPYnN0ZXQgR3luZWNv
bDwvZnVsbC10aXRsZT48YWJici0xPlVsdHJhc291bmQgaW4gb2JzdGV0cmljcyAmYW1wOyBneW5l
Y29sb2d5IDogdGhlIG9mZmljaWFsIGpvdXJuYWwgb2YgdGhlIEludGVybmF0aW9uYWwgU29jaWV0
eSBvZiBVbHRyYXNvdW5kIGluIE9ic3RldHJpY3MgYW5kIEd5bmVjb2xvZ3k8L2FiYnItMT48L3Bl
cmlvZGljYWw+PGFsdC1wZXJpb2RpY2FsPjxmdWxsLXRpdGxlPlVsdHJhc291bmQgT2JzdGV0IEd5
bmVjb2w8L2Z1bGwtdGl0bGU+PGFiYnItMT5VbHRyYXNvdW5kIGluIG9ic3RldHJpY3MgJmFtcDsg
Z3luZWNvbG9neSA6IHRoZSBvZmZpY2lhbCBqb3VybmFsIG9mIHRoZSBJbnRlcm5hdGlvbmFsIFNv
Y2lldHkgb2YgVWx0cmFzb3VuZCBpbiBPYnN0ZXRyaWNzIGFuZCBHeW5lY29sb2d5PC9hYmJyLTE+
PC9hbHQtcGVyaW9kaWNhbD48cGFnZXM+NjEzLTk8L3BhZ2VzPjx2b2x1bWU+Mzg8L3ZvbHVtZT48
bnVtYmVyPjY8L251bWJlcj48a2V5d29yZHM+PGtleXdvcmQ+QnJhaW4vKmVtYnJ5b2xvZ3k8L2tl
eXdvcmQ+PGtleXdvcmQ+RmVtYWxlPC9rZXl3b3JkPjxrZXl3b3JkPkZlbXVyLyplbWJyeW9sb2d5
L3VsdHJhc29ub2dyYXBoeTwva2V5d29yZD48a2V5d29yZD5GZXRhbCBEZXZlbG9wbWVudDwva2V5
d29yZD48a2V5d29yZD5IdW1hbnM8L2tleXdvcmQ+PGtleXdvcmQ+KkltYWdpbmcsIFRocmVlLURp
bWVuc2lvbmFsPC9rZXl3b3JkPjxrZXl3b3JkPktpZG5leS8qZW1icnlvbG9neS91bHRyYXNvbm9n
cmFwaHk8L2tleXdvcmQ+PGtleXdvcmQ+TGl2ZXIvKmVtYnJ5b2xvZ3kvdWx0cmFzb25vZ3JhcGh5
PC9rZXl3b3JkPjxrZXl3b3JkPkx1bmcvKmVtYnJ5b2xvZ3kvdWx0cmFzb25vZ3JhcGh5PC9rZXl3
b3JkPjxrZXl3b3JkPk9yZ2FuIFNpemU8L2tleXdvcmQ+PGtleXdvcmQ+UHJlZ25hbmN5PC9rZXl3
b3JkPjxrZXl3b3JkPlByZWduYW5jeSBUcmltZXN0ZXIsIEZpcnN0PC9rZXl3b3JkPjxrZXl3b3Jk
PlF1YWxpdHkgQ29udHJvbDwva2V5d29yZD48a2V5d29yZD5SZWZlcmVuY2UgU3RhbmRhcmRzPC9r
ZXl3b3JkPjxrZXl3b3JkPlJlcHJvZHVjaWJpbGl0eSBvZiBSZXN1bHRzPC9rZXl3b3JkPjxrZXl3
b3JkPlVsdHJhc29ub2dyYXBoeSwgUHJlbmF0YWwvbWV0aG9kcy8qc3RhbmRhcmRzPC9rZXl3b3Jk
Pjwva2V5d29yZHM+PGRhdGVzPjx5ZWFyPjIwMTE8L3llYXI+PHB1Yi1kYXRlcz48ZGF0ZT5EZWM8
L2RhdGU+PC9wdWItZGF0ZXM+PC9kYXRlcz48aXNibj4xNDY5LTA3MDUgKEVsZWN0cm9uaWMpJiN4
RDswOTYwLTc2OTIgKExpbmtpbmcpPC9pc2JuPjxhY2Nlc3Npb24tbnVtPjIxNjc0NjU3PC9hY2Nl
c3Npb24tbnVtPjx1cmxzPjxyZWxhdGVkLXVybHM+PHVybD5odHRwOi8vd3d3Lm5jYmkubmxtLm5p
aC5nb3YvcHVibWVkLzIxNjc0NjU3PC91cmw+PC9yZWxhdGVkLXVybHM+PC91cmxzPjxlbGVjdHJv
bmljLXJlc291cmNlLW51bT4xMC4xMDAyL3VvZy45MDc0PC9lbGVjdHJvbmljLXJlc291cmNlLW51
bT48L3JlY29yZD48L0NpdGU+PC9FbmROb3RlPgB=
ADDIN EN.CITE PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5Jb2Fubm91PC9BdXRob3I+PFllYXI+MjAxMTwvWWVhcj48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ADDIN EN.CITE.DATA (21). The VOCAL technique has the advantage of being quicker, and allowing the modification of the outline of the organ which is particularly useful for fetal organs with irregular shapes PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5Ub25uaTwvQXV0aG9yPjxZZWFyPjIwMTU8L1llYXI+PFJl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=
ADDIN EN.CITE PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5Ub25uaTwvQXV0aG9yPjxZZWFyPjIwMTU8L1llYXI+PFJl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=
ADDIN EN.CITE.DATA (17). More recently, fetal volumes have also been assessed by the extended imaging virtual organ computer-aided analysis (XI-VOCAL) technique PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5CYXJyZXRvPC9BdXRob3I+PFllYXI+MjAxNTwvWWVhcj48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ADDIN EN.CITE PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5CYXJyZXRvPC9BdXRob3I+PFllYXI+MjAxNTwvWWVhcj48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ADDIN EN.CITE.DATA (18, 22-24), with good in-vitro reproducibility in some structures ADDIN EN.CITE <EndNote><Cite><Author>Barreto</Author><Year>2015</Year><RecNum>505</RecNum><DisplayText>(18)</DisplayText><record><rec-number>505</rec-number><foreign-keys><key app="EN" db-id="2ptzwtrz3a5xaher5rtvttrv0vx299fatpzz">505</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>Barreto, E. Q.</author><author>Araujo Junior, E.</author><author>Martins, W. P.</author><author>Rolo, L. C.</author><author>Milani, H. J.</author><author>Nardozza, L. M.</author><author>Moron, A. F.</author></authors></contributors><auth-address>Department of Obstetrics, Paulista School of Medicine - Federal University of Sao Paulo (EPM-UNIFESP) , Sao Paulo - SP , Brazil and.</auth-address><titles><title>New technique for assessing fetal heart growth using three-dimensional ultrasonography: description of the technique and reference curves</title><secondary-title>J Matern Fetal Neonatal Med</secondary-title><alt-title>The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians</alt-title></titles><periodical><full-title>J Matern Fetal Neonatal Med</full-title><abbr-1>The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstet</abbr-1></periodical><pages>1087-93</pages><volume>28</volume><number>9</number><dates><year>2015</year><pub-dates><date>Jun</date></pub-dates></dates><isbn>1476-4954 (Electronic)
1476-4954 (Linking)</isbn><accession-num>25005859</accession-num><urls><related-urls><url>;(18).This technique is similar to the multiplanar method, but there is a fixed interval of slices taken through a particular object PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5Ub25uaTwvQXV0aG9yPjxZZWFyPjIwMTU8L1llYXI+PFJl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=
ADDIN EN.CITE PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5Ub25uaTwvQXV0aG9yPjxZZWFyPjIwMTU8L1llYXI+PFJl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=
ADDIN EN.CITE.DATA (17). A disadvantage of this method is that it does not take into account the up and down contours of an irregular object PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5DaGVvbmc8L0F1dGhvcj48WWVhcj4yMDA5PC9ZZWFyPjxS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ADDIN EN.CITE PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5DaGVvbmc8L0F1dGhvcj48WWVhcj4yMDA5PC9ZZWFyPjxS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ADDIN EN.CITE.DATA (24). Therefore, although this technique can be used interchangeably between some VOCAL and multiplanar techniques for regular volumes such as the fetal thigh PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5BcmF1am8gSnVuaW9yPC9BdXRob3I+PFllYXI+MjAxMTwv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ADDIN EN.CITE PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5BcmF1am8gSnVuaW9yPC9BdXRob3I+PFllYXI+MjAxMTwv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ADDIN EN.CITE.DATA (22), its results seem less valid when assessing irregular structures such as placental volumes PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5DaGVvbmc8L0F1dGhvcj48WWVhcj4yMDEwPC9ZZWFyPjxS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==
ADDIN EN.CITE PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5DaGVvbmc8L0F1dGhvcj48WWVhcj4yMDEwPC9ZZWFyPjxS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==
ADDIN EN.CITE.DATA (23). Accurate 3D volume acquisition is dependent on the quality of the 2D image and as such is very operator dependent. This increases the likelihood for random measurement error and methodological inconsistencies between studies. A recent reliability study comparing biometry and fetal weight estimation using 2D and 3D ultrasound concluded that measurements performed with 3D ultrasound were less influenced by random errors ADDIN EN.CITE <EndNote><Cite><Author>Lima</Author><Year>2012</Year><RecNum>172</RecNum><DisplayText>(25)</DisplayText><record><rec-number>172</rec-number><foreign-keys><key app="EN" db-id="2ptzwtrz3a5xaher5rtvttrv0vx299fatpzz">172</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>Lima, J. C.</author><author>Miyague, A. H.</author><author>Filho, F. M.</author><author>Nastri, C. O.</author><author>Martins, W. P.</author></authors></contributors><auth-address>Departamento de Ginecologia e Obstetricia da Faculdade de Medicina de Ribeirao Preto, Universidade de Sao Paulo (FMRP-USP), Ribeirao Preto, Brazil.</auth-address><titles><title>Biometry and fetal weight estimation by two-dimensional and three-dimensional ultrasonography: an intraobserver and interobserver reliability and agreement study</title><secondary-title>Ultrasound Obstet Gynecol</secondary-title><alt-title>Ultrasound in obstetrics & gynecology : the official journal of the International Society of Ultrasound in Obstetrics and Gynecology</alt-title></titles><periodical><full-title>Ultrasound Obstet Gynecol</full-title><abbr-1>Ultrasound in obstetrics & gynecology : the official journal of the International Society of Ultrasound in Obstetrics and Gynecology</abbr-1></periodical><alt-periodical><full-title>Ultrasound Obstet Gynecol</full-title><abbr-1>Ultrasound in obstetrics & gynecology : the official journal of the International Society of Ultrasound in Obstetrics and Gynecology</abbr-1></alt-periodical><pages>186-93</pages><volume>40</volume><number>2</number><dates><year>2012</year><pub-dates><date>Aug</date></pub-dates></dates><isbn>1469-0705 (Electronic)
0960-7692 (Linking)</isbn><accession-num>22102507</accession-num><urls><related-urls><url>;(25). However, this study was examining standard 2D measurements such as bi-parietal diameter (BPD), abdominal circumference (AC) and femur length (FL) obtained from 3D acquired data sets using a standardised multiplanar view, rather than measuring fetal volumes. Measurement reproducibility must be assessed using a robust method with a minimum of two different observers with appropriate statistical analysis PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5Jb2Fubm91PC9BdXRob3I+PFllYXI+MjAxMTwvWWVhcj48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ADDIN EN.CITE PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5Jb2Fubm91PC9BdXRob3I+PFllYXI+MjAxMTwvWWVhcj48
UmVjTnVtPjEyMzwvUmVjTnVtPjxEaXNwbGF5VGV4dD4oMjEpPC9EaXNwbGF5VGV4dD48cmVjb3Jk
PjxyZWMtbnVtYmVyPjEyMzwvcmVjLW51bWJlcj48Zm9yZWlnbi1rZXlzPjxrZXkgYXBwPSJFTiIg
ZGItaWQ9IjJwdHp3dHJ6M2E1eGFoZXI1cnR2dHRydjB2eDI5OWZhdHB6eiI+MTIzPC9rZXk+PC9m
b3JlaWduLWtleXM+PHJlZi10eXBlIG5hbWU9IkpvdXJuYWwgQXJ0aWNsZSI+MTc8L3JlZi10eXBl
Pjxjb250cmlidXRvcnM+PGF1dGhvcnM+PGF1dGhvcj5Jb2Fubm91LCBDLjwvYXV0aG9yPjxhdXRo
b3I+U2FycmlzLCBJLjwvYXV0aG9yPjxhdXRob3I+U2Fsb21vbiwgTC4gSi48L2F1dGhvcj48YXV0
aG9yPlBhcGFnZW9yZ2hpb3UsIEEuIFQuPC9hdXRob3I+PC9hdXRob3JzPjwvY29udHJpYnV0b3Jz
PjxhdXRoLWFkZHJlc3M+TnVmZmllbGQgRGVwYXJ0bWVudCBvZiBPYnN0ZXRyaWNzIGFuZCBHeW5h
ZWNvbG9neSwgVW5pdmVyc2l0eSBvZiBPeGZvcmQsIE94Zm9yZCwgVUsuPC9hdXRoLWFkZHJlc3M+
PHRpdGxlcz48dGl0bGU+QSByZXZpZXcgb2YgZmV0YWwgdm9sdW1ldHJ5OiB0aGUgbmVlZCBmb3Ig
c3RhbmRhcmRpemF0aW9uIGFuZCBkZWZpbml0aW9ucyBpbiBtZWFzdXJlbWVudCBtZXRob2RvbG9n
eTwvdGl0bGU+PHNlY29uZGFyeS10aXRsZT5VbHRyYXNvdW5kIE9ic3RldCBHeW5lY29sPC9zZWNv
bmRhcnktdGl0bGU+PGFsdC10aXRsZT5VbHRyYXNvdW5kIGluIG9ic3RldHJpY3MgJmFtcDsgZ3lu
ZWNvbG9neSA6IHRoZSBvZmZpY2lhbCBqb3VybmFsIG9mIHRoZSBJbnRlcm5hdGlvbmFsIFNvY2ll
dHkgb2YgVWx0cmFzb3VuZCBpbiBPYnN0ZXRyaWNzIGFuZCBHeW5lY29sb2d5PC9hbHQtdGl0bGU+
PC90aXRsZXM+PHBlcmlvZGljYWw+PGZ1bGwtdGl0bGU+VWx0cmFzb3VuZCBPYnN0ZXQgR3luZWNv
bDwvZnVsbC10aXRsZT48YWJici0xPlVsdHJhc291bmQgaW4gb2JzdGV0cmljcyAmYW1wOyBneW5l
Y29sb2d5IDogdGhlIG9mZmljaWFsIGpvdXJuYWwgb2YgdGhlIEludGVybmF0aW9uYWwgU29jaWV0
eSBvZiBVbHRyYXNvdW5kIGluIE9ic3RldHJpY3MgYW5kIEd5bmVjb2xvZ3k8L2FiYnItMT48L3Bl
cmlvZGljYWw+PGFsdC1wZXJpb2RpY2FsPjxmdWxsLXRpdGxlPlVsdHJhc291bmQgT2JzdGV0IEd5
bmVjb2w8L2Z1bGwtdGl0bGU+PGFiYnItMT5VbHRyYXNvdW5kIGluIG9ic3RldHJpY3MgJmFtcDsg
Z3luZWNvbG9neSA6IHRoZSBvZmZpY2lhbCBqb3VybmFsIG9mIHRoZSBJbnRlcm5hdGlvbmFsIFNv
Y2lldHkgb2YgVWx0cmFzb3VuZCBpbiBPYnN0ZXRyaWNzIGFuZCBHeW5lY29sb2d5PC9hYmJyLTE+
PC9hbHQtcGVyaW9kaWNhbD48cGFnZXM+NjEzLTk8L3BhZ2VzPjx2b2x1bWU+Mzg8L3ZvbHVtZT48
bnVtYmVyPjY8L251bWJlcj48a2V5d29yZHM+PGtleXdvcmQ+QnJhaW4vKmVtYnJ5b2xvZ3k8L2tl
eXdvcmQ+PGtleXdvcmQ+RmVtYWxlPC9rZXl3b3JkPjxrZXl3b3JkPkZlbXVyLyplbWJyeW9sb2d5
L3VsdHJhc29ub2dyYXBoeTwva2V5d29yZD48a2V5d29yZD5GZXRhbCBEZXZlbG9wbWVudDwva2V5
d29yZD48a2V5d29yZD5IdW1hbnM8L2tleXdvcmQ+PGtleXdvcmQ+KkltYWdpbmcsIFRocmVlLURp
bWVuc2lvbmFsPC9rZXl3b3JkPjxrZXl3b3JkPktpZG5leS8qZW1icnlvbG9neS91bHRyYXNvbm9n
cmFwaHk8L2tleXdvcmQ+PGtleXdvcmQ+TGl2ZXIvKmVtYnJ5b2xvZ3kvdWx0cmFzb25vZ3JhcGh5
PC9rZXl3b3JkPjxrZXl3b3JkPkx1bmcvKmVtYnJ5b2xvZ3kvdWx0cmFzb25vZ3JhcGh5PC9rZXl3
b3JkPjxrZXl3b3JkPk9yZ2FuIFNpemU8L2tleXdvcmQ+PGtleXdvcmQ+UHJlZ25hbmN5PC9rZXl3
b3JkPjxrZXl3b3JkPlByZWduYW5jeSBUcmltZXN0ZXIsIEZpcnN0PC9rZXl3b3JkPjxrZXl3b3Jk
PlF1YWxpdHkgQ29udHJvbDwva2V5d29yZD48a2V5d29yZD5SZWZlcmVuY2UgU3RhbmRhcmRzPC9r
ZXl3b3JkPjxrZXl3b3JkPlJlcHJvZHVjaWJpbGl0eSBvZiBSZXN1bHRzPC9rZXl3b3JkPjxrZXl3
b3JkPlVsdHJhc29ub2dyYXBoeSwgUHJlbmF0YWwvbWV0aG9kcy8qc3RhbmRhcmRzPC9rZXl3b3Jk
Pjwva2V5d29yZHM+PGRhdGVzPjx5ZWFyPjIwMTE8L3llYXI+PHB1Yi1kYXRlcz48ZGF0ZT5EZWM8
L2RhdGU+PC9wdWItZGF0ZXM+PC9kYXRlcz48aXNibj4xNDY5LTA3MDUgKEVsZWN0cm9uaWMpJiN4
RDswOTYwLTc2OTIgKExpbmtpbmcpPC9pc2JuPjxhY2Nlc3Npb24tbnVtPjIxNjc0NjU3PC9hY2Nl
c3Npb24tbnVtPjx1cmxzPjxyZWxhdGVkLXVybHM+PHVybD5odHRwOi8vd3d3Lm5jYmkubmxtLm5p
aC5nb3YvcHVibWVkLzIxNjc0NjU3PC91cmw+PC9yZWxhdGVkLXVybHM+PC91cmxzPjxlbGVjdHJv
bmljLXJlc291cmNlLW51bT4xMC4xMDAyL3VvZy45MDc0PC9lbGVjdHJvbmljLXJlc291cmNlLW51
bT48L3JlY29yZD48L0NpdGU+PC9FbmROb3RlPgB=
ADDIN EN.CITE.DATA (21).The aim of this study was to assess measurement reliability of 3D fetal volume measurements and placental volume measurements within and between examiners on the same occasion in the second and third trimester.Materials and MethodsStudy populationBetween January and June 2014, intra- and inter-examiner reliability of fetal and placental volume measurement was assessed in one tertiary referral unit (St Mary’s Hospital Manchester). This was part of a longitudinal prospective study of fetal and placental biometry using 2D and 3D ultrasound. Women with healthy uncomplicated pregnancies were invited to participate on the basis of strict inclusion and exclusion criteria. Exclusion criteria were; any fetus subsequently shown to have a serious congenital abnormality, pregnancies with multiple gestations, and maternal medical conditions that are known to affect growth such as maternal diabetes and chronic hypertension. Pregnancies were accurately dated using fetal crown-rump length (CRL) measurements prior to 14 weeks gestation. The study was approved by the Greater Manchester East National Research Committee (Ref 10/H1013/9), and all participants were enrolled following written informed consent. Ultrasonographic data collectionAll 3D ultrasonography was performed by two RCOG accredited sonographers (LS and LH), using a Voluson E6 (GE Healthcare) with 3D 4-8Hz curvilinear probe. 3D organ volumes (placenta, head, kidney, total thigh and TVol at 14-16 weeks, head, kidney total thigh and TVol at 20-22 weeks, 26-28 weeks and 34-36 weeks gestation) were acquired during each trimester. Intra and inter-operator reproducibility were assessed in 25 women in the second trimester and 33 women in the third trimester for the following ultrasound measures: 3D TVol, total thigh volume, head volume, kidney volume and placental volume using a VOCAL technique with manual delimitation. Excluding placental volume, which was only assessed in the second trimester, reliability was assessed at different gestational age time points in the second and third trimesters of pregnancy to evaluate previously reported increased inter-examiner percentage differences when measuring smaller fetal organ volumes ADDIN EN.CITE <EndNote><Cite><Author>Ioannou</Author><Year>2013</Year><RecNum>246</RecNum><DisplayText>(26)</DisplayText><record><rec-number>246</rec-number><foreign-keys><key app="EN" db-id="2ptzwtrz3a5xaher5rtvttrv0vx299fatpzz">246</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>Ioannou, C.</author><author>Sarris, I.</author><author>Napolitano, R.</author><author>Ohuma, E.</author><author>Javaid, M. K.</author><author>Papageorghiou, A. T.</author></authors></contributors><auth-address>Nuffield Department of Obstetrics & Gynaecology, University of Oxford, UK.</auth-address><titles><title>A longitudinal study of normal fetal femur volume</title><secondary-title>Prenat Diagn</secondary-title><alt-title>Prenatal diagnosis</alt-title></titles><periodical><full-title>Prenat Diagn</full-title><abbr-1>Prenatal diagnosis</abbr-1></periodical><alt-periodical><full-title>Prenat Diagn</full-title><abbr-1>Prenatal diagnosis</abbr-1></alt-periodical><pages>1088-94</pages><volume>33</volume><number>11</number><dates><year>2013</year><pub-dates><date>Nov</date></pub-dates></dates><isbn>1097-0223 (Electronic)
0197-3851 (Linking)</isbn><accession-num>23868615</accession-num><urls><related-urls><url>;(26). Automated volume measurements were obtained using the Voluson 4D view (GE Healthcare) tool. Each participant had a minimum of two volume calculations for each of the different measures, performed on separately acquired volumes. Examiner 1 (L.S.: 3 years of experience with 2D ultrasound and 1 year of experience with 3D ultrasound) performed growth measurements on the fetus using 2D ultrasound and acquired 3D volume datasets for later evaluation. Once all the data had been acquired, examiner 1 then left the examination room and examiner 2 (L.H.: 3 years of experience with 2D ultrasound and 1 year of experience with 3D ultrasound) entered to perform an examination to acquire the 3D volume datasets for determination of inter-examiner reliability and agreement. Afterwards, examiner 1 then re-entered the room and repeated the same examination to acquire the 3D volume datasets only for the evaluation of intra-examiner reliability and agreement. A series of three measurement sets were obtained (LS1, LH, LS2). The two examiners were not blinded to the clinical information or the name of each participant at the time of examination. However, volume measurements did not appear on the screen at the time of the ultrasound scan. The initial acquisition for examiner 1 took approximately 20 minutes; with the following further 2 examinations taking 15 minutes each, resulting in a total evaluation time of 50 minutes for each participant. Image data were archived on digital media for subsequent offline analysis and were analysed in a random order, blinded to patient identity, gestation and image pairing. Offline analysis time took approximately 2-5 minutes to estimate each fetal volume. Intra-examiner variation was assessed by comparison of LS1 and LS2 values, whilst inter-examiner reliability was assessed by comparison of LS1 and LH values ADDIN EN.CITE <EndNote><Cite><Author>Bland</Author><Year>2003</Year><RecNum>318</RecNum><DisplayText>(27)</DisplayText><record><rec-number>318</rec-number><foreign-keys><key app="EN" db-id="2ptzwtrz3a5xaher5rtvttrv0vx299fatpzz">318</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>Bland, J. M.</author><author>Altman, D. G.</author></authors></contributors><auth-address>St George's Hospital Medical School, London, UK.</auth-address><titles><title>Applying the right statistics: analyses of measurement studies</title><secondary-title>Ultrasound Obstet Gynecol</secondary-title><alt-title>Ultrasound in obstetrics & gynecology : the official journal of the International Society of Ultrasound in Obstetrics and Gynecology</alt-title></titles><periodical><full-title>Ultrasound Obstet Gynecol</full-title><abbr-1>Ultrasound in obstetrics & gynecology : the official journal of the International Society of Ultrasound in Obstetrics and Gynecology</abbr-1></periodical><alt-periodical><full-title>Ultrasound Obstet Gynecol</full-title><abbr-1>Ultrasound in obstetrics & gynecology : the official journal of the International Society of Ultrasound in Obstetrics and Gynecology</abbr-1></alt-periodical><pages>85-93</pages><volume>22</volume><number>1</number><keywords><keyword>Confidence Intervals</keyword><keyword>Data Interpretation, Statistical</keyword><keyword>Regression Analysis</keyword><keyword>*Research Design</keyword><keyword>Statistics as Topic</keyword><keyword>Statistics, Nonparametric</keyword></keywords><dates><year>2003</year><pub-dates><date>Jul</date></pub-dates></dates><isbn>0960-7692 (Print)
0960-7692 (Linking)</isbn><accession-num>12858311</accession-num><urls><related-urls><url>;(27).Each volume was only measured once and the methods of image analysis are described below.Fractional thigh volume acquisitionThis technique has previously been described by Lee et al PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5MZWU8L0F1dGhvcj48WWVhcj4yMDA5PC9ZZWFyPjxSZWNO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==
ADDIN EN.CITE PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5MZWU8L0F1dGhvcj48WWVhcj4yMDA5PC9ZZWFyPjxSZWNO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==
ADDIN EN.CITE.DATA (16). Image depth and magnification were adjusted for the volume of interest so that it filled at least two-thirds of the display screen. Each fractional thigh volume acquisition was acquired from a sagittal sweep of the entire femoral diaphysis. The volume was opened in the multiplanar mode with the sagittal view displayed in plane A, the axial view in plane B and the coronal view in plane C. Volume measurements were based on 50% of the femoral diaphysis (TVol) length. The femur diaphysis length (FDL) was measured in the sagittal plane and each volume was automatically sub-divided into 5 equidistant slices that were centred along the mid-thigh. Soft tissue borders were enhanced by the use of a colour filter (sepia) with additional gamma curve adjustments for brightness and contrast. Fractional thigh volumes were calculated after each of the 5 slices were manually traced from a transverse view of the extremity (Figure 1 – Fractional Thigh Volume).Virtual Organ Computer-aided Analysis (VOCAL, GE Healthcare)For this technique, the fetal organ of interest (thigh, kidney head or placenta) was displayed on the screen in three orthogonal planes (Figure 2 – Vocal 30 Head Volume; Figure 3 – Vocal 30 Placenta Volume; Figure 4 – Vocal 30 Thigh Volume; Figure 5 – Vocal 30 Kidney Volume). Plane A (top left image) was selected in the multiplanar display and the fetal organ outline was highlighted manually in that plane and the volume estimates were computed utilising the VOCAL program with a manual trace at 30o of rotation. The outer aspects of the different fetal organs were drawn on every image displayed sequentially in this plane. At the end of the 180o rotation, the volume was automatically calculated by the custom software PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5CZW5pbm5pPC9BdXRob3I+PFllYXI+MjAxMDwvWWVhcj48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ADDIN EN.CITE PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5CZW5pbm5pPC9BdXRob3I+PFllYXI+MjAxMDwvWWVhcj48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ADDIN EN.CITE.DATA (28). For placental volumes, the sweep angle of the ultrasound probe was adjusted to a maximum of 850 to ensure that the whole placenta could be captured in its entirety in a single 3D sweep PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5Kb25lczwvQXV0aG9yPjxZZWFyPjIwMTE8L1llYXI+PFJl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==
ADDIN EN.CITE PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5Kb25lczwvQXV0aG9yPjxZZWFyPjIwMTE8L1llYXI+PFJl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==
ADDIN EN.CITE.DATA (29). For kidney volume acquisition, a coronal section of the fetal kidney with the organ proximal to the transducer and distal to the fetal vertebral column (to avoid acoustic shadowing), was identified by 2D ultrasound and the volume box adjusted accordingly to scan the entire kidney PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5Zb3NoaXpha2k8L0F1dGhvcj48WWVhcj4yMDEzPC9ZZWFy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ADDIN EN.CITE PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5Zb3NoaXpha2k8L0F1dGhvcj48WWVhcj4yMDEzPC9ZZWFy
PjxSZWNOdW0+NTA2PC9SZWNOdW0+PERpc3BsYXlUZXh0PigxOSk8L0Rpc3BsYXlUZXh0PjxyZWNv
cmQ+PHJlYy1udW1iZXI+NTA2PC9yZWMtbnVtYmVyPjxmb3JlaWduLWtleXM+PGtleSBhcHA9IkVO
IiBkYi1pZD0iMnB0end0cnozYTV4YWhlcjVydHZ0dHJ2MHZ4Mjk5ZmF0cHp6Ij41MDY8L2tleT48
L2ZvcmVpZ24ta2V5cz48cmVmLXR5cGUgbmFtZT0iSm91cm5hbCBBcnRpY2xlIj4xNzwvcmVmLXR5
cGU+PGNvbnRyaWJ1dG9ycz48YXV0aG9ycz48YXV0aG9yPllvc2hpemFraSwgQy4gVC48L2F1dGhv
cj48YXV0aG9yPkZyYW5jaXNjbywgUi4gUC48L2F1dGhvcj48YXV0aG9yPmRlIFBpbmhvLCBKLiBD
LjwvYXV0aG9yPjxhdXRob3I+UnVhbm8sIFIuPC9hdXRob3I+PGF1dGhvcj5adWdhaWIsIE0uPC9h
dXRob3I+PC9hdXRob3JzPjwvY29udHJpYnV0b3JzPjxhdXRoLWFkZHJlc3M+RGVwYXJ0bWVudCBv
ZiBPYnN0ZXRyaWNzIGFuZCBHeW5lY29sb2d5LCBGYWN1bHR5IG9mIE1lZGljaW5lLCBVbml2ZXJz
aWRhZGUgZGUgU2FvIFBhdWxvLCAwNTQwMy05MDAgU2FvIFBhdWxvLVNQLCBCcmF6aWwuPC9hdXRo
LWFkZHJlc3M+PHRpdGxlcz48dGl0bGU+UmVuYWwgdm9sdW1lcyBtZWFzdXJlZCBieSAzLWRpbWVu
c2lvbmFsIHNvbm9ncmFwaHkgaW4gaGVhbHRoeSBmZXR1c2VzIGZyb20gMjAgdG8gNDAgd2Vla3M8
L3RpdGxlPjxzZWNvbmRhcnktdGl0bGU+SiBVbHRyYXNvdW5kIE1lZDwvc2Vjb25kYXJ5LXRpdGxl
PjxhbHQtdGl0bGU+Sm91cm5hbCBvZiB1bHRyYXNvdW5kIGluIG1lZGljaW5lIDogb2ZmaWNpYWwg
am91cm5hbCBvZiB0aGUgQW1lcmljYW4gSW5zdGl0dXRlIG9mIFVsdHJhc291bmQgaW4gTWVkaWNp
bmU8L2FsdC10aXRsZT48L3RpdGxlcz48cGVyaW9kaWNhbD48ZnVsbC10aXRsZT5KIFVsdHJhc291
bmQgTWVkPC9mdWxsLXRpdGxlPjxhYmJyLTE+Sm91cm5hbCBvZiB1bHRyYXNvdW5kIGluIG1lZGlj
aW5lIDogb2ZmaWNpYWwgam91cm5hbCBvZiB0aGUgQW1lcmljYW4gSW5zdGl0dXRlIG9mIFVsdHJh
c291bmQgaW4gTWVkaWNpbmU8L2FiYnItMT48L3BlcmlvZGljYWw+PGFsdC1wZXJpb2RpY2FsPjxm
dWxsLXRpdGxlPkogVWx0cmFzb3VuZCBNZWQ8L2Z1bGwtdGl0bGU+PGFiYnItMT5Kb3VybmFsIG9m
IHVsdHJhc291bmQgaW4gbWVkaWNpbmUgOiBvZmZpY2lhbCBqb3VybmFsIG9mIHRoZSBBbWVyaWNh
biBJbnN0aXR1dGUgb2YgVWx0cmFzb3VuZCBpbiBNZWRpY2luZTwvYWJici0xPjwvYWx0LXBlcmlv
ZGljYWw+PHBhZ2VzPjQyMS03PC9wYWdlcz48dm9sdW1lPjMyPC92b2x1bWU+PG51bWJlcj4zPC9u
dW1iZXI+PGtleXdvcmRzPjxrZXl3b3JkPkFnaW5nLypwaHlzaW9sb2d5PC9rZXl3b3JkPjxrZXl3
b3JkPipBbGdvcml0aG1zPC9rZXl3b3JkPjxrZXl3b3JkPkZlbWFsZTwva2V5d29yZD48a2V5d29y
ZD5IdW1hbnM8L2tleXdvcmQ+PGtleXdvcmQ+SW1hZ2UgRW5oYW5jZW1lbnQvbWV0aG9kczwva2V5
d29yZD48a2V5d29yZD5JbWFnZSBJbnRlcnByZXRhdGlvbiwgQ29tcHV0ZXItQXNzaXN0ZWQvKm1l
dGhvZHM8L2tleXdvcmQ+PGtleXdvcmQ+SW1hZ2luZywgVGhyZWUtRGltZW5zaW9uYWwvKm1ldGhv
ZHM8L2tleXdvcmQ+PGtleXdvcmQ+S2lkbmV5LyplbWJyeW9sb2d5L3BoeXNpb2xvZ3kvKnVsdHJh
c29ub2dyYXBoeTwva2V5d29yZD48a2V5d29yZD5NYWxlPC9rZXl3b3JkPjxrZXl3b3JkPk9yZ2Fu
IFNpemUvcGh5c2lvbG9neTwva2V5d29yZD48a2V5d29yZD5QZXJjZXB0dWFsIENsb3N1cmU8L2tl
eXdvcmQ+PGtleXdvcmQ+UmVmZXJlbmNlIFZhbHVlczwva2V5d29yZD48a2V5d29yZD5SZXByb2R1
Y2liaWxpdHkgb2YgUmVzdWx0czwva2V5d29yZD48a2V5d29yZD5TZW5zaXRpdml0eSBhbmQgU3Bl
Y2lmaWNpdHk8L2tleXdvcmQ+PGtleXdvcmQ+VWx0cmFzb25vZ3JhcGh5LCBQcmVuYXRhbC8qbWV0
aG9kczwva2V5d29yZD48L2tleXdvcmRzPjxkYXRlcz48eWVhcj4yMDEzPC95ZWFyPjxwdWItZGF0
ZXM+PGRhdGU+TWFyPC9kYXRlPjwvcHViLWRhdGVzPjwvZGF0ZXM+PGlzYm4+MTU1MC05NjEzIChF
bGVjdHJvbmljKSYjeEQ7MDI3OC00Mjk3IChMaW5raW5nKTwvaXNibj48YWNjZXNzaW9uLW51bT4y
MzQ0MzE4MjwvYWNjZXNzaW9uLW51bT48dXJscz48cmVsYXRlZC11cmxzPjx1cmw+aHR0cDovL3d3
dy5uY2JpLm5sbS5uaWguZ292L3B1Ym1lZC8yMzQ0MzE4MjwvdXJsPjwvcmVsYXRlZC11cmxzPjwv
dXJscz48L3JlY29yZD48L0NpdGU+PC9FbmROb3RlPgB=
ADDIN EN.CITE.DATA (19). Sweep angles were adjusted from 300 to 600 for fetal kidneys, and from 650 to 850 for acquisition of fetal head and thigh images depending on gestation. The justification for using 30 degrees for VOCAL rotational slices is largely based on previous literature that has revolved around the use of this method with good reliability demonstrated PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5BcmF1am8gSnVuaW9yPC9BdXRob3I+PFllYXI+MjAxNDwv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ADDIN EN.CITE PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5BcmF1am8gSnVuaW9yPC9BdXRob3I+PFllYXI+MjAxNDwv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ADDIN EN.CITE.DATA (14, 19, 28, 30, 31). This method also has the advantage of being more time efficient and applicable in all 3D ultrasound equipment, therefore increasing potential transferability into clinical practice PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5Ub25uaTwvQXV0aG9yPjxZZWFyPjIwMTU8L1llYXI+PFJl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=
ADDIN EN.CITE PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5Ub25uaTwvQXV0aG9yPjxZZWFyPjIwMTU8L1llYXI+PFJl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=
ADDIN EN.CITE.DATA (17).Statistical analysisStatistical analyses were carried out using Graphpad Prism software (San Diego, CA, Version 6.03) and Statistical Package for the Social Sciences (SPSS, version 22.0, Chicago, IL, USA). Inter-and intra-examiner agreement was assessed using Bland-Altman plots (% difference vs. average) PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5CbGFuZDwvQXV0aG9yPjxZZWFyPjE5ODY8L1llYXI+PFJl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==
ADDIN EN.CITE PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5CbGFuZDwvQXV0aG9yPjxZZWFyPjE5ODY8L1llYXI+PFJl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==
ADDIN EN.CITE.DATA (32, 33). Systematic bias was defined as the mean percentage difference between two measurements, and limits of agreement were reflected by the 95% confidence intervals (CI) of the mean percentage difference. If 0 lay within the 95% confidence intervals for the mean difference, we concluded there was no systematic bias. Inter and intra-examiner reliability was also assessed using absolute agreement two-way mixed intraclass correlation coefficients (ICCs) ADDIN EN.CITE <EndNote><Cite><Author>Kottner</Author><Year>2008</Year><RecNum>531</RecNum><DisplayText>(34)</DisplayText><record><rec-number>531</rec-number><foreign-keys><key app="EN" db-id="2ptzwtrz3a5xaher5rtvttrv0vx299fatpzz">531</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>Kottner, J.</author><author>Dassen, T.</author></authors></contributors><auth-address>Department of Nursing Science, Centre for Humanities and Health Sciences, Charite Universitatsmedizin Berlin, Chariteplatz 1, 10117 Berlin, Germany. jan.kottner@charite.de</auth-address><titles><title>Interpreting interrater reliability coefficients of the Braden scale: a discussion paper</title><secondary-title>Int J Nurs Stud</secondary-title><alt-title>International journal of nursing studies</alt-title></titles><periodical><full-title>Int J Nurs Stud</full-title><abbr-1>International journal of nursing studies</abbr-1></periodical><alt-periodical><full-title>Int J Nurs Stud</full-title><abbr-1>International journal of nursing studies</abbr-1></alt-periodical><pages>1238-46</pages><volume>45</volume><number>8</number><keywords><keyword>*Data Interpretation, Statistical</keyword><keyword>Humans</keyword><keyword>*Nursing Assessment/methods/standards</keyword><keyword>Nursing Evaluation Research/*methods</keyword><keyword>*Observer Variation</keyword><keyword>Peas</keyword><keyword>Predictive Value of Tests</keyword><keyword>Pressure Ulcer</keyword><keyword>Psychometrics</keyword><keyword>*Research Design</keyword><keyword>Risk Assessment</keyword></keywords><dates><year>2008</year><pub-dates><date>Aug</date></pub-dates></dates><isbn>0020-7489 (Print)
0020-7489 (Linking)</isbn><accession-num>17892881</accession-num><urls><related-urls><url>;(34). This correlation coefficient was interpreted as follows for fetal measurements: > 0.998, very good; 0.99-0.998, good; 0.98-0.99, moderate; 0.95-0.98 poor; less than 0.95, very poor PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5NYXJ0aW5zPC9BdXRob3I+PFllYXI+MjAxNDwvWWVhcj48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ADDIN EN.CITE PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5NYXJ0aW5zPC9BdXRob3I+PFllYXI+MjAxNDwvWWVhcj48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ADDIN EN.CITE.DATA (35).ResultsThe median (range) gestational age at ultrasound examination in the 25 pregnant women examined in the second trimester and the 33 women in the third trimester was 23 (21-23) weeks and 33 (28-39) weeks respectively. In the second trimester kidney volume measurements, nine volumes were excluded in the inter-examiner reliability analysis and four volumes were excluded in the intra-examiner reliability analysis due to sub-optimal image quality and inability to define the correct plane of measurement.Bland Altman plots of the second trimester and third trimester volume measurements are presented in Figures 6, 7 and 8, 9 respectively. Intra-examiner reliability is shown in Table 1 and inter-examiner reliability is shown in Table 2. For all measurements, intra-examiner variability was smaller than inter-examiner variability. A systematic bias was noted between the two examiners for the measurement of second trimester placental volume (as reflected by a 95% CI of a mean that does not cross 0), with one examiner systematically generating larger volumes. There was also a trend to bias in inter-examiner third trimester head volume measurements (mean bias -10.6). The measurement of random error, as reflected by the 95% limits of agreement of the mean intra and inter-examiner differences on the Bland Altman plots, was relatively large for all measurements apart from head volume and TVol measurements. Random measurement error was largest for the second trimester inter-examiner kidney volume measurements (95% limits of agreement ± 110%), and the best agreement was for third trimester intra-examiner TVol measurements (95% limits of agreement ± 10%). This random error appeared to decrease with advancing gestation when fetal volumes were larger in all fetal volume measurements apart from the head volume measurements, where it remained similar both in the second trimester and third trimester measurements. (See Tables 1 and 2)Second trimester ICC results were all >0.75 apart from kidney volume intra and inter-examiner measurements and placenta inter-examiner measurements which were 0.374, 0.061 and 0.390 respectively. Third trimester ICC results were higher for all volume measurements. The best values were observed for third trimester intra and inter-examiner TVol measurements (0.992, 95% CI 0.983-0.996 and 0.943, 95% CI 0.882-0.973).DiscussionPrevious studies of 3D ultrasound parameters have been criticised for the lack of robust methods to assess measurement variability PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5Jb2Fubm91PC9BdXRob3I+PFllYXI+MjAxMTwvWWVhcj48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ADDIN EN.CITE PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5Jb2Fubm91PC9BdXRob3I+PFllYXI+MjAxMTwvWWVhcj48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ADDIN EN.CITE.DATA (21, 33, 36). We sought to address this by performing a prospective study that examined both inter and intra-observer agreement of several different fetal volumes at varying gestational ages by two different sonographers blinded to each other’s measurements.Our findings indicate that fractional thigh volume would be the most reliable 3D measurement of fetal growth to be used either longitudinally to model individual growth trajectories or perhaps cross-sectionally as a one off measurement at 34-36 weeks to help identify those fetuses with late-onset FGR. The ability to analyse fractional thigh volume on only a limited number of ultrasound machines, and the requirement for offline image analysis would currently limit the more widespread application of this measurement. ICC values from our study in the third trimester of pregnancy are very similar to ICC values obtained in previous studies for 2D fetal measurements such as head and abdominal circumference, bi-parietal diameter and femur lengthPEVuZE5vdGU+PENpdGU+PEF1dGhvcj5QZXJuaTwvQXV0aG9yPjxZZWFyPjIwMDQ8L1llYXI+PFJl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ADDIN EN.CITE PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5QZXJuaTwvQXV0aG9yPjxZZWFyPjIwMDQ8L1llYXI+PFJl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ADDIN EN.CITE.DATA (37) (0.943-0.992). Similar measurement reliability for fractional thigh volume has been reported in studies by Lee et al and Yang et al PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5MZWU8L0F1dGhvcj48WWVhcj4yMDA5PC9ZZWFyPjxSZWNO
dW0+MTQ8L1JlY051bT48RGlzcGxheVRleHQ+KDEsIDE2KTwvRGlzcGxheVRleHQ+PHJlY29yZD48
cmVjLW51bWJlcj4xNDwvcmVjLW51bWJlcj48Zm9yZWlnbi1rZXlzPjxrZXkgYXBwPSJFTiIgZGIt
aWQ9IjJwdHp3dHJ6M2E1eGFoZXI1cnR2dHRydjB2eDI5OWZhdHB6eiI+MTQ8L2tleT48L2ZvcmVp
Z24ta2V5cz48cmVmLXR5cGUgbmFtZT0iSm91cm5hbCBBcnRpY2xlIj4xNzwvcmVmLXR5cGU+PGNv
bnRyaWJ1dG9ycz48YXV0aG9ycz48YXV0aG9yPkxlZSwgVy48L2F1dGhvcj48YXV0aG9yPkJhbGFz
dWJyYW1hbmlhbSwgTS48L2F1dGhvcj48YXV0aG9yPkRldGVyLCBSLiBMLjwvYXV0aG9yPjxhdXRo
b3I+SGFzc2FuLCBTLiBTLjwvYXV0aG9yPjxhdXRob3I+R290c2NoLCBGLjwvYXV0aG9yPjxhdXRo
b3I+S3VzYW5vdmljLCBKLiBQLjwvYXV0aG9yPjxhdXRob3I+R29uY2FsdmVzLCBMLiBGLjwvYXV0
aG9yPjxhdXRob3I+Um9tZXJvLCBSLjwvYXV0aG9yPjwvYXV0aG9ycz48L2NvbnRyaWJ1dG9ycz48
YXV0aC1hZGRyZXNzPkRpdmlzaW9uIG9mIEZldGFsIEltYWdpbmcsIERlcGFydG1lbnQgb2YgT2Jz
dGV0cmljcyBhbmQgR3luZWNvbG9neSwgV2lsbGlhbSBCZWF1bW9udCBIb3NwaXRhbCBSb3lhbCBP
YWssIE1JIDQ4MDczLTY3NjksIFVTQS4gd2xlZUBiZWF1bW9udC5lZHU8L2F1dGgtYWRkcmVzcz48
dGl0bGVzPjx0aXRsZT5GcmFjdGlvbmFsIGxpbWIgdm9sdW1lLS1hIHNvZnQgdGlzc3VlIHBhcmFt
ZXRlciBvZiBmZXRhbCBib2R5IGNvbXBvc2l0aW9uOiB2YWxpZGF0aW9uLCB0ZWNobmljYWwgY29u
c2lkZXJhdGlvbnMgYW5kIG5vcm1hbCByYW5nZXMgZHVyaW5nIHByZWduYW5jeTwvdGl0bGU+PHNl
Y29uZGFyeS10aXRsZT5VbHRyYXNvdW5kIE9ic3RldCBHeW5lY29sPC9zZWNvbmRhcnktdGl0bGU+
PGFsdC10aXRsZT5VbHRyYXNvdW5kIGluIG9ic3RldHJpY3MgJmFtcDsgZ3luZWNvbG9neSA6IHRo
ZSBvZmZpY2lhbCBqb3VybmFsIG9mIHRoZSBJbnRlcm5hdGlvbmFsIFNvY2lldHkgb2YgVWx0cmFz
b3VuZCBpbiBPYnN0ZXRyaWNzIGFuZCBHeW5lY29sb2d5PC9hbHQtdGl0bGU+PC90aXRsZXM+PHBl
cmlvZGljYWw+PGZ1bGwtdGl0bGU+VWx0cmFzb3VuZCBPYnN0ZXQgR3luZWNvbDwvZnVsbC10aXRs
ZT48YWJici0xPlVsdHJhc291bmQgaW4gb2JzdGV0cmljcyAmYW1wOyBneW5lY29sb2d5IDogdGhl
IG9mZmljaWFsIGpvdXJuYWwgb2YgdGhlIEludGVybmF0aW9uYWwgU29jaWV0eSBvZiBVbHRyYXNv
dW5kIGluIE9ic3RldHJpY3MgYW5kIEd5bmVjb2xvZ3k8L2FiYnItMT48L3BlcmlvZGljYWw+PGFs
dC1wZXJpb2RpY2FsPjxmdWxsLXRpdGxlPlVsdHJhc291bmQgT2JzdGV0IEd5bmVjb2w8L2Z1bGwt
dGl0bGU+PGFiYnItMT5VbHRyYXNvdW5kIGluIG9ic3RldHJpY3MgJmFtcDsgZ3luZWNvbG9neSA6
IHRoZSBvZmZpY2lhbCBqb3VybmFsIG9mIHRoZSBJbnRlcm5hdGlvbmFsIFNvY2lldHkgb2YgVWx0
cmFzb3VuZCBpbiBPYnN0ZXRyaWNzIGFuZCBHeW5lY29sb2d5PC9hYmJyLTE+PC9hbHQtcGVyaW9k
aWNhbD48cGFnZXM+NDI3LTQwPC9wYWdlcz48dm9sdW1lPjMzPC92b2x1bWU+PG51bWJlcj40PC9u
dW1iZXI+PGtleXdvcmRzPjxrZXl3b3JkPkFkdWx0PC9rZXl3b3JkPjxrZXl3b3JkPkFudGhyb3Bv
bWV0cnkvbWV0aG9kczwva2V5d29yZD48a2V5d29yZD5Bcm0vYW5hdG9teSAmYW1wOyBoaXN0b2xv
Z3kvZW1icnlvbG9neS8qdWx0cmFzb25vZ3JhcGh5PC9rZXl3b3JkPjxrZXl3b3JkPipCb2R5IENv
bXBvc2l0aW9uPC9rZXl3b3JkPjxrZXl3b3JkPkNyb3NzLVNlY3Rpb25hbCBTdHVkaWVzPC9rZXl3
b3JkPjxrZXl3b3JkPkZlbWFsZTwva2V5d29yZD48a2V5d29yZD4qRmV0YWwgRGV2ZWxvcG1lbnQ8
L2tleXdvcmQ+PGtleXdvcmQ+R2VzdGF0aW9uYWwgQWdlPC9rZXl3b3JkPjxrZXl3b3JkPkh1bWFu
czwva2V5d29yZD48a2V5d29yZD5JbWFnZSBJbnRlcnByZXRhdGlvbiwgQ29tcHV0ZXItQXNzaXN0
ZWQvbWV0aG9kczwva2V5d29yZD48a2V5d29yZD5NYWxlPC9rZXl3b3JkPjxrZXl3b3JkPk9ic2Vy
dmVyIFZhcmlhdGlvbjwva2V5d29yZD48a2V5d29yZD5QcmVnbmFuY3k8L2tleXdvcmQ+PGtleXdv
cmQ+UmVmZXJlbmNlIFZhbHVlczwva2V5d29yZD48a2V5d29yZD5SZXByb2R1Y2liaWxpdHkgb2Yg
UmVzdWx0czwva2V5d29yZD48a2V5d29yZD5UaGlnaC9hbmF0b215ICZhbXA7IGhpc3RvbG9neS9l
bWJyeW9sb2d5Lyp1bHRyYXNvbm9ncmFwaHk8L2tleXdvcmQ+PGtleXdvcmQ+VWx0cmFzb25vZ3Jh
cGh5LCBQcmVuYXRhbC9tZXRob2RzPC9rZXl3b3JkPjwva2V5d29yZHM+PGRhdGVzPjx5ZWFyPjIw
MDk8L3llYXI+PHB1Yi1kYXRlcz48ZGF0ZT5BcHI8L2RhdGU+PC9wdWItZGF0ZXM+PC9kYXRlcz48
aXNibj4xNDY5LTA3MDUgKEVsZWN0cm9uaWMpJiN4RDswOTYwLTc2OTIgKExpbmtpbmcpPC9pc2Ju
PjxhY2Nlc3Npb24tbnVtPjE5MjUzMzQwPC9hY2Nlc3Npb24tbnVtPjx1cmxzPjxyZWxhdGVkLXVy
bHM+PHVybD5odHRwOi8vd3d3Lm5jYmkubmxtLm5paC5nb3YvcHVibWVkLzE5MjUzMzQwPC91cmw+
PC9yZWxhdGVkLXVybHM+PC91cmxzPjxlbGVjdHJvbmljLXJlc291cmNlLW51bT4xMC4xMDAyL3Vv
Zy42MzE5PC9lbGVjdHJvbmljLXJlc291cmNlLW51bT48L3JlY29yZD48L0NpdGU+PENpdGU+PEF1
dGhvcj5ZYW5nPC9BdXRob3I+PFllYXI+MjAxMTwvWWVhcj48UmVjTnVtPjE0MzwvUmVjTnVtPjxy
ZWNvcmQ+PHJlYy1udW1iZXI+MTQzPC9yZWMtbnVtYmVyPjxmb3JlaWduLWtleXM+PGtleSBhcHA9
IkVOIiBkYi1pZD0iMnB0end0cnozYTV4YWhlcjVydHZ0dHJ2MHZ4Mjk5ZmF0cHp6Ij4xNDM8L2tl
eT48L2ZvcmVpZ24ta2V5cz48cmVmLXR5cGUgbmFtZT0iSm91cm5hbCBBcnRpY2xlIj4xNzwvcmVm
LXR5cGU+PGNvbnRyaWJ1dG9ycz48YXV0aG9ycz48YXV0aG9yPllhbmcsIEYuPC9hdXRob3I+PGF1
dGhvcj5MZXVuZywgSy4gWS48L2F1dGhvcj48YXV0aG9yPkhvdSwgWS4gVy48L2F1dGhvcj48YXV0
aG9yPll1YW4sIFkuPC9hdXRob3I+PGF1dGhvcj5UYW5nLCBNLiBILjwvYXV0aG9yPjwvYXV0aG9y
cz48L2NvbnRyaWJ1dG9ycz48YXV0aC1hZGRyZXNzPkRlcGFydG1lbnQgb2YgT2JzdGV0cmljcyBh
bmQgR3luYWVjb2xvZ3ksIFVuaXZlcnNpdHkgb2YgSG9uZyBLb25nLCBIb25nIEtvbmcsIENoaW5h
LjwvYXV0aC1hZGRyZXNzPjx0aXRsZXM+PHRpdGxlPkJpcnRoLXdlaWdodCBwcmVkaWN0aW9uIHVz
aW5nIHRocmVlLWRpbWVuc2lvbmFsIHNvbm9ncmFwaGljIGZyYWN0aW9uYWwgdGhpZ2ggdm9sdW1l
IGF0IHRlcm0gaW4gYSBDaGluZXNlIHBvcHVsYXRpb248L3RpdGxlPjxzZWNvbmRhcnktdGl0bGU+
VWx0cmFzb3VuZCBPYnN0ZXQgR3luZWNvbDwvc2Vjb25kYXJ5LXRpdGxlPjxhbHQtdGl0bGU+VWx0
cmFzb3VuZCBpbiBvYnN0ZXRyaWNzICZhbXA7IGd5bmVjb2xvZ3kgOiB0aGUgb2ZmaWNpYWwgam91
cm5hbCBvZiB0aGUgSW50ZXJuYXRpb25hbCBTb2NpZXR5IG9mIFVsdHJhc291bmQgaW4gT2JzdGV0
cmljcyBhbmQgR3luZWNvbG9neTwvYWx0LXRpdGxlPjwvdGl0bGVzPjxwZXJpb2RpY2FsPjxmdWxs
LXRpdGxlPlVsdHJhc291bmQgT2JzdGV0IEd5bmVjb2w8L2Z1bGwtdGl0bGU+PGFiYnItMT5VbHRy
YXNvdW5kIGluIG9ic3RldHJpY3MgJmFtcDsgZ3luZWNvbG9neSA6IHRoZSBvZmZpY2lhbCBqb3Vy
bmFsIG9mIHRoZSBJbnRlcm5hdGlvbmFsIFNvY2lldHkgb2YgVWx0cmFzb3VuZCBpbiBPYnN0ZXRy
aWNzIGFuZCBHeW5lY29sb2d5PC9hYmJyLTE+PC9wZXJpb2RpY2FsPjxhbHQtcGVyaW9kaWNhbD48
ZnVsbC10aXRsZT5VbHRyYXNvdW5kIE9ic3RldCBHeW5lY29sPC9mdWxsLXRpdGxlPjxhYmJyLTE+
VWx0cmFzb3VuZCBpbiBvYnN0ZXRyaWNzICZhbXA7IGd5bmVjb2xvZ3kgOiB0aGUgb2ZmaWNpYWwg
am91cm5hbCBvZiB0aGUgSW50ZXJuYXRpb25hbCBTb2NpZXR5IG9mIFVsdHJhc291bmQgaW4gT2Jz
dGV0cmljcyBhbmQgR3luZWNvbG9neTwvYWJici0xPjwvYWx0LXBlcmlvZGljYWw+PHBhZ2VzPjQy
NS0zMzwvcGFnZXM+PHZvbHVtZT4zODwvdm9sdW1lPjxudW1iZXI+NDwvbnVtYmVyPjxrZXl3b3Jk
cz48a2V5d29yZD5BZHVsdDwva2V5d29yZD48a2V5d29yZD5BbmFseXNpcyBvZiBWYXJpYW5jZTwv
a2V5d29yZD48a2V5d29yZD4qQXNpYW4gQ29udGluZW50YWwgQW5jZXN0cnkgR3JvdXA8L2tleXdv
cmQ+PGtleXdvcmQ+KkJpb21ldHJ5PC9rZXl3b3JkPjxrZXl3b3JkPipCaXJ0aCBXZWlnaHQvcGh5
c2lvbG9neTwva2V5d29yZD48a2V5d29yZD5Dcm9zcy1TZWN0aW9uYWwgU3R1ZGllczwva2V5d29y
ZD48a2V5d29yZD5GZW1hbGU8L2tleXdvcmQ+PGtleXdvcmQ+KkZldGFsIFdlaWdodC9waHlzaW9s
b2d5PC9rZXl3b3JkPjxrZXl3b3JkPkdlc3RhdGlvbmFsIEFnZTwva2V5d29yZD48a2V5d29yZD5I
dW1hbnM8L2tleXdvcmQ+PGtleXdvcmQ+KkltYWdpbmcsIFRocmVlLURpbWVuc2lvbmFsPC9rZXl3
b3JkPjxrZXl3b3JkPkluZmFudCwgTmV3Ym9ybjwva2V5d29yZD48a2V5d29yZD5MaW5lYXIgTW9k
ZWxzPC9rZXl3b3JkPjxrZXl3b3JkPk1hbGU8L2tleXdvcmQ+PGtleXdvcmQ+UHJlZ25hbmN5PC9r
ZXl3b3JkPjxrZXl3b3JkPlByZWduYW5jeSBUcmltZXN0ZXIsIFRoaXJkPC9rZXl3b3JkPjxrZXl3
b3JkPlByb3NwZWN0aXZlIFN0dWRpZXM8L2tleXdvcmQ+PGtleXdvcmQ+UmVwcm9kdWNpYmlsaXR5
IG9mIFJlc3VsdHM8L2tleXdvcmQ+PGtleXdvcmQ+VGhpZ2gvZW1icnlvbG9neS91bHRyYXNvbm9n
cmFwaHk8L2tleXdvcmQ+PGtleXdvcmQ+KlVsdHJhc29ub2dyYXBoeSwgUHJlbmF0YWw8L2tleXdv
cmQ+PC9rZXl3b3Jkcz48ZGF0ZXM+PHllYXI+MjAxMTwveWVhcj48cHViLWRhdGVzPjxkYXRlPk9j
dDwvZGF0ZT48L3B1Yi1kYXRlcz48L2RhdGVzPjxpc2JuPjE0NjktMDcwNSAoRWxlY3Ryb25pYykm
I3hEOzA5NjAtNzY5MiAoTGlua2luZyk8L2lzYm4+PGFjY2Vzc2lvbi1udW0+MjEzMDg4MzE8L2Fj
Y2Vzc2lvbi1udW0+PHVybHM+PHJlbGF0ZWQtdXJscz48dXJsPmh0dHA6Ly93d3cubmNiaS5ubG0u
bmloLmdvdi9wdWJtZWQvMjEzMDg4MzE8L3VybD48L3JlbGF0ZWQtdXJscz48L3VybHM+PGVsZWN0
cm9uaWMtcmVzb3VyY2UtbnVtPjEwLjEwMDIvdW9nLjg5NDU8L2VsZWN0cm9uaWMtcmVzb3VyY2Ut
bnVtPjwvcmVjb3JkPjwvQ2l0ZT48L0VuZE5vdGU+
ADDIN EN.CITE PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5MZWU8L0F1dGhvcj48WWVhcj4yMDA5PC9ZZWFyPjxSZWNO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ADDIN EN.CITE.DATA (1, 16). We did find higher random measurement bias in the second trimester TVol measurements (inter-examiner ± 40% and intra-examiner ± 25%). This may be because inaccuracies in calliper placement on the thigh volume image are more pronounced at smaller fetal volumes.Both Bland-Altman plots and ICC values demonstrate that both inter and intra-examiner reproducibility appeared to increase slightly with gestational age and subsequent increasing size in most fetal volumes apart from VOCAL thigh volume measurements and inter-examiner head volume measurements. This increase in measurement reliability with gestational age has been commented on in previous studies using both 3D and 2D ultrasoundPEVuZE5vdGU+PENpdGU+PEF1dGhvcj5TYXJyaXM8L0F1dGhvcj48WWVhcj4yMDEyPC9ZZWFyPjxS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ADDIN EN.CITE PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5TYXJyaXM8L0F1dGhvcj48WWVhcj4yMDEyPC9ZZWFyPjxS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ADDIN EN.CITE.DATA (26, 38), and may be attributed to better defined planes of measurements at higher gestations as fetal volumes increase in size.In this study inter-examiner reliability for placental volume at 23 weeks gestation was poor with an ICC value of 0.390 and a mean measurement bias of 44.3 with 95% limits of agreement from 2.8-85.8. Similar results have been reported by Jones et al at 12 weeks using a VOCAL 9 degree rotation step method, with an ICC of 0.590 and random measurement error of ± 37%PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5Kb25lczwvQXV0aG9yPjxZZWFyPjIwMTE8L1llYXI+PFJl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==
ADDIN EN.CITE PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5Kb25lczwvQXV0aG9yPjxZZWFyPjIwMTE8L1llYXI+PFJl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==
ADDIN EN.CITE.DATA (29). However, other studies assessing placental volume have demonstrated better inter-observer ICC values 0.85-0.90 with systematic biases close to zero and low random measurement errorsPEVuZE5vdGU+PENpdGU+PEF1dGhvcj5DaGVvbmc8L0F1dGhvcj48WWVhcj4yMDEwPC9ZZWFyPjxS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ADDIN EN.CITE PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5DaGVvbmc8L0F1dGhvcj48WWVhcj4yMDEwPC9ZZWFyPjxS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ADDIN EN.CITE.DATA (8, 23, 39). These differing results may relate to the early gestation (first or early second trimester) at which these studies were performed, as placental volumes are significantly smaller at these gestations. Other studies that have looked at 3D placental volumes after 20 weeks gestation have either not carried out reliability analysis ADDIN EN.CITE <EndNote><Cite><Author>Artunc Ulkumen</Author><Year>2014</Year><RecNum>317</RecNum><DisplayText>(10)</DisplayText><record><rec-number>317</rec-number><foreign-keys><key app="EN" db-id="2ptzwtrz3a5xaher5rtvttrv0vx299fatpzz">317</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>Artunc Ulkumen, B.</author><author>Pala, H. G.</author><author>Uyar, Y.</author><author>Koyuncu, F. M.</author><author>Bulbul Baytur, Y.</author></authors></contributors><auth-address>Perinatology Division, Obstetrics and Gynecology Department, Celal Bayar University School of Medicine , Manisa , Turkey.</auth-address><titles><title>The assessment of placental volume and mean gray value in preeclamptic placentas by using three-dimensional ultrasonography</title><secondary-title>J Matern Fetal Neonatal Med</secondary-title><alt-title>The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians</alt-title></titles><periodical><full-title>J Matern Fetal Neonatal Med</full-title><abbr-1>The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstet</abbr-1></periodical><pages>1-4</pages><dates><year>2014</year><pub-dates><date>Jul 31</date></pub-dates></dates><isbn>1476-4954 (Electronic)
1476-4954 (Linking)</isbn><accession-num>25010115</accession-num><urls><related-urls><url>;(10), only reported ICC valuesPEVuZE5vdGU+PENpdGU+PEF1dGhvcj5kZSBQYXVsYTwvQXV0aG9yPjxZZWFyPjIwMDg8L1llYXI+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ADDIN EN.CITE PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5kZSBQYXVsYTwvQXV0aG9yPjxZZWFyPjIwMDg8L1llYXI+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ADDIN EN.CITE.DATA (14) or have analysed intra-examiner reliability onlyPEVuZE5vdGU+PENpdGU+PEF1dGhvcj5SaWprZW48L0F1dGhvcj48WWVhcj4yMDEyPC9ZZWFyPjxS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==
ADDIN EN.CITE PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5SaWprZW48L0F1dGhvcj48WWVhcj4yMDEyPC9ZZWFyPjxS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==
ADDIN EN.CITE.DATA (40). Our results agree with previous work ADDIN EN.CITE <EndNote><Cite><Author>Hata</Author><Year>2011</Year><RecNum>309</RecNum><DisplayText>(8)</DisplayText><record><rec-number>309</rec-number><foreign-keys><key app="EN" db-id="2ptzwtrz3a5xaher5rtvttrv0vx299fatpzz">309</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>Hata, T.</author><author>Tanaka, H.</author><author>Noguchi, J.</author><author>Hata, K.</author></authors></contributors><auth-address>Department of Perinatology and Gynecology, Kagawa University School of Medicine, Kagawa 761-0793, Japan. toshi28@med.kagawa-u.ac.jp</auth-address><titles><title>Three-dimensional ultrasound evaluation of the placenta</title><secondary-title>Placenta</secondary-title><alt-title>Placenta</alt-title></titles><periodical><full-title>Placenta</full-title><abbr-1>Placenta</abbr-1></periodical><alt-periodical><full-title>Placenta</full-title><abbr-1>Placenta</abbr-1></alt-periodical><pages>105-15</pages><volume>32</volume><number>2</number><keywords><keyword>Female</keyword><keyword>Fetal Growth Retardation/ultrasonography</keyword><keyword>Gestational Age</keyword><keyword>Hemangioma/ultrasonography</keyword><keyword>Humans</keyword><keyword>Hydrops Fetalis/ultrasonography</keyword><keyword>Imaging, Three-Dimensional/*methods</keyword><keyword>Placenta/blood supply/*ultrasonography</keyword><keyword>Placenta Diseases/ultrasonography</keyword><keyword>Pregnancy</keyword><keyword>Ultrasonography, Prenatal/*methods</keyword></keywords><dates><year>2011</year><pub-dates><date>Feb</date></pub-dates></dates><isbn>1532-3102 (Electronic)
0143-4004 (Linking)</isbn><accession-num>21115197</accession-num><urls><related-urls><url>;(8), and likely reflect the fact the placenta is often too large >20 weeks to capture on an entire 3D sweep using the VOCAL rotational technique and therefore the chance for systematic bias and random measurement error is increased. Possible methods to improve measurement reliability would be to image placentas on the posterior uterine wall only as these are more likely to fit in a single 3D sweep PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5SaWprZW48L0F1dGhvcj48WWVhcj4yMDEyPC9ZZWFyPjxS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==
ADDIN EN.CITE PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5SaWprZW48L0F1dGhvcj48WWVhcj4yMDEyPC9ZZWFyPjxS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==
ADDIN EN.CITE.DATA (40), to use the multiplanar method for image analysis ADDIN EN.CITE <EndNote><Cite><Author>Hata</Author><Year>2011</Year><RecNum>309</RecNum><DisplayText>(8)</DisplayText><record><rec-number>309</rec-number><foreign-keys><key app="EN" db-id="2ptzwtrz3a5xaher5rtvttrv0vx299fatpzz">309</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>Hata, T.</author><author>Tanaka, H.</author><author>Noguchi, J.</author><author>Hata, K.</author></authors></contributors><auth-address>Department of Perinatology and Gynecology, Kagawa University School of Medicine, Kagawa 761-0793, Japan. toshi28@med.kagawa-u.ac.jp</auth-address><titles><title>Three-dimensional ultrasound evaluation of the placenta</title><secondary-title>Placenta</secondary-title><alt-title>Placenta</alt-title></titles><periodical><full-title>Placenta</full-title><abbr-1>Placenta</abbr-1></periodical><alt-periodical><full-title>Placenta</full-title><abbr-1>Placenta</abbr-1></alt-periodical><pages>105-15</pages><volume>32</volume><number>2</number><keywords><keyword>Female</keyword><keyword>Fetal Growth Retardation/ultrasonography</keyword><keyword>Gestational Age</keyword><keyword>Hemangioma/ultrasonography</keyword><keyword>Humans</keyword><keyword>Hydrops Fetalis/ultrasonography</keyword><keyword>Imaging, Three-Dimensional/*methods</keyword><keyword>Placenta/blood supply/*ultrasonography</keyword><keyword>Placenta Diseases/ultrasonography</keyword><keyword>Pregnancy</keyword><keyword>Ultrasonography, Prenatal/*methods</keyword></keywords><dates><year>2011</year><pub-dates><date>Feb</date></pub-dates></dates><isbn>1532-3102 (Electronic)
0143-4004 (Linking)</isbn><accession-num>21115197</accession-num><urls><related-urls><url>;(8) or to reduce the rotation angle of VOCAL to 15 or 12 degrees as this has been previously shown to reduce random measurement errorPEVuZE5vdGU+PENpdGU+PEF1dGhvcj5DaGVvbmc8L0F1dGhvcj48WWVhcj4yMDEwPC9ZZWFyPjxS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==
ADDIN EN.CITE PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5DaGVvbmc8L0F1dGhvcj48WWVhcj4yMDEwPC9ZZWFyPjxS
ZWNOdW0+MzIzPC9SZWNOdW0+PERpc3BsYXlUZXh0PigyMyk8L0Rpc3BsYXlUZXh0PjxyZWNvcmQ+
PHJlYy1udW1iZXI+MzIzPC9yZWMtbnVtYmVyPjxmb3JlaWduLWtleXM+PGtleSBhcHA9IkVOIiBk
Yi1pZD0iMnB0end0cnozYTV4YWhlcjVydHZ0dHJ2MHZ4Mjk5ZmF0cHp6Ij4zMjM8L2tleT48L2Zv
cmVpZ24ta2V5cz48cmVmLXR5cGUgbmFtZT0iSm91cm5hbCBBcnRpY2xlIj4xNzwvcmVmLXR5cGU+
PGNvbnRyaWJ1dG9ycz48YXV0aG9ycz48YXV0aG9yPkNoZW9uZywgSy4gQi48L2F1dGhvcj48YXV0
aG9yPkxldW5nLCBLLiBZLjwvYXV0aG9yPjxhdXRob3I+TGksIFQuIEsuPC9hdXRob3I+PGF1dGhv
cj5DaGFuLCBILiBZLjwvYXV0aG9yPjxhdXRob3I+TGVlLCBZLiBQLjwvYXV0aG9yPjxhdXRob3I+
VGFuZywgTS4gSC48L2F1dGhvcj48L2F1dGhvcnM+PC9jb250cmlidXRvcnM+PGF1dGgtYWRkcmVz
cz5EZXBhcnRtZW50IG9mIE9ic3RldHJpY3MgYW5kIEd5bmFlY29sb2d5LCBVbml2ZXJzaXR5IG9m
IEhvbmcgS29uZywgUXVlZW4gTWFyeSBIb3NwaXRhbCwgSG9uZyBLb25nLCBTQVIgQ2hpbmEuPC9h
dXRoLWFkZHJlc3M+PHRpdGxlcz48dGl0bGU+Q29tcGFyaXNvbiBvZiBpbnRlci0gYW5kIGludHJh
b2JzZXJ2ZXIgYWdyZWVtZW50IGFuZCByZWxpYWJpbGl0eSBiZXR3ZWVuIHRocmVlIGRpZmZlcmVu
dCB0eXBlcyBvZiBwbGFjZW50YWwgdm9sdW1lIG1lYXN1cmVtZW50IHRlY2huaXF1ZSAoWEkgVk9D
QUwsIFZPQ0FMIGFuZCBtdWx0aXBsYW5hcikgYW5kIHZhbGlkaXR5IGluIHRoZSBpbi12aXRybyBz
ZXR0aW5nPC90aXRsZT48c2Vjb25kYXJ5LXRpdGxlPlVsdHJhc291bmQgT2JzdGV0IEd5bmVjb2w8
L3NlY29uZGFyeS10aXRsZT48YWx0LXRpdGxlPlVsdHJhc291bmQgaW4gb2JzdGV0cmljcyAmYW1w
OyBneW5lY29sb2d5IDogdGhlIG9mZmljaWFsIGpvdXJuYWwgb2YgdGhlIEludGVybmF0aW9uYWwg
U29jaWV0eSBvZiBVbHRyYXNvdW5kIGluIE9ic3RldHJpY3MgYW5kIEd5bmVjb2xvZ3k8L2FsdC10
aXRsZT48L3RpdGxlcz48cGVyaW9kaWNhbD48ZnVsbC10aXRsZT5VbHRyYXNvdW5kIE9ic3RldCBH
eW5lY29sPC9mdWxsLXRpdGxlPjxhYmJyLTE+VWx0cmFzb3VuZCBpbiBvYnN0ZXRyaWNzICZhbXA7
IGd5bmVjb2xvZ3kgOiB0aGUgb2ZmaWNpYWwgam91cm5hbCBvZiB0aGUgSW50ZXJuYXRpb25hbCBT
b2NpZXR5IG9mIFVsdHJhc291bmQgaW4gT2JzdGV0cmljcyBhbmQgR3luZWNvbG9neTwvYWJici0x
PjwvcGVyaW9kaWNhbD48YWx0LXBlcmlvZGljYWw+PGZ1bGwtdGl0bGU+VWx0cmFzb3VuZCBPYnN0
ZXQgR3luZWNvbDwvZnVsbC10aXRsZT48YWJici0xPlVsdHJhc291bmQgaW4gb2JzdGV0cmljcyAm
YW1wOyBneW5lY29sb2d5IDogdGhlIG9mZmljaWFsIGpvdXJuYWwgb2YgdGhlIEludGVybmF0aW9u
YWwgU29jaWV0eSBvZiBVbHRyYXNvdW5kIGluIE9ic3RldHJpY3MgYW5kIEd5bmVjb2xvZ3k8L2Fi
YnItMT48L2FsdC1wZXJpb2RpY2FsPjxwYWdlcz4yMTAtNzwvcGFnZXM+PHZvbHVtZT4zNjwvdm9s
dW1lPjxudW1iZXI+MjwvbnVtYmVyPjxrZXl3b3Jkcz48a2V5d29yZD5GZW1hbGU8L2tleXdvcmQ+
PGtleXdvcmQ+RmV0YWwgRGV2ZWxvcG1lbnQ8L2tleXdvcmQ+PGtleXdvcmQ+R2VzdGF0aW9uYWwg
QWdlPC9rZXl3b3JkPjxrZXl3b3JkPkh1bWFuczwva2V5d29yZD48a2V5d29yZD5JbWFnZSBQcm9j
ZXNzaW5nLCBDb21wdXRlci1Bc3Npc3RlZC9pbnN0cnVtZW50YXRpb24vKm1ldGhvZHM8L2tleXdv
cmQ+PGtleXdvcmQ+SW1hZ2luZywgVGhyZWUtRGltZW5zaW9uYWwvaW5zdHJ1bWVudGF0aW9uLypt
ZXRob2RzPC9rZXl3b3JkPjxrZXl3b3JkPk9ic2VydmVyIFZhcmlhdGlvbjwva2V5d29yZD48a2V5
d29yZD5QaGFudG9tcywgSW1hZ2luZzwva2V5d29yZD48a2V5d29yZD5QbGFjZW50YS9hbmF0b215
ICZhbXA7IGhpc3RvbG9neS9waHlzaW9sb2d5Lyp1bHRyYXNvbm9ncmFwaHk8L2tleXdvcmQ+PGtl
eXdvcmQ+UHJlZ25hbmN5PC9rZXl3b3JkPjxrZXl3b3JkPlJlcHJvZHVjaWJpbGl0eSBvZiBSZXN1
bHRzPC9rZXl3b3JkPjxrZXl3b3JkPlVsdHJhc29ub2dyYXBoeSwgUHJlbmF0YWwvaW5zdHJ1bWVu
dGF0aW9uLyptZXRob2RzPC9rZXl3b3JkPjwva2V5d29yZHM+PGRhdGVzPjx5ZWFyPjIwMTA8L3ll
YXI+PHB1Yi1kYXRlcz48ZGF0ZT5BdWc8L2RhdGU+PC9wdWItZGF0ZXM+PC9kYXRlcz48aXNibj4x
NDY5LTA3MDUgKEVsZWN0cm9uaWMpJiN4RDswOTYwLTc2OTIgKExpbmtpbmcpPC9pc2JuPjxhY2Nl
c3Npb24tbnVtPjIwMjAxMTE2PC9hY2Nlc3Npb24tbnVtPjx1cmxzPjxyZWxhdGVkLXVybHM+PHVy
bD5odHRwOi8vd3d3Lm5jYmkubmxtLm5paC5nb3YvcHVibWVkLzIwMjAxMTE2PC91cmw+PC9yZWxh
dGVkLXVybHM+PC91cmxzPjxlbGVjdHJvbmljLXJlc291cmNlLW51bT4xMC4xMDAyL3VvZy43NjA5
PC9lbGVjdHJvbmljLXJlc291cmNlLW51bT48L3JlY29yZD48L0NpdGU+PC9FbmROb3RlPn==
ADDIN EN.CITE.DATA (23). This would, however, increase the time taken to perform the image analysis.There are few studies that examine fetal renal volume in the context of normal pregnancy, the focus being on ultrasound assessment of renal pelvic dilatation and parenchymal volume as prognostic indicators in congenital uropathies PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5OYW08L0F1dGhvcj48WWVhcj4yMDEyPC9ZZWFyPjxSZWNO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ADDIN EN.CITE PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5OYW08L0F1dGhvcj48WWVhcj4yMDEyPC9ZZWFyPjxSZWNO
dW0+NTM2PC9SZWNOdW0+PERpc3BsYXlUZXh0Pig0MS00Myk8L0Rpc3BsYXlUZXh0PjxyZWNvcmQ+
PHJlYy1udW1iZXI+NTM2PC9yZWMtbnVtYmVyPjxmb3JlaWduLWtleXM+PGtleSBhcHA9IkVOIiBk
Yi1pZD0iMnB0end0cnozYTV4YWhlcjVydHZ0dHJ2MHZ4Mjk5ZmF0cHp6Ij41MzY8L2tleT48L2Zv
cmVpZ24ta2V5cz48cmVmLXR5cGUgbmFtZT0iSm91cm5hbCBBcnRpY2xlIj4xNzwvcmVmLXR5cGU+
PGNvbnRyaWJ1dG9ycz48YXV0aG9ycz48YXV0aG9yPk5hbSwgSy4gSC48L2F1dGhvcj48YXV0aG9y
PkNobywgQS48L2F1dGhvcj48YXV0aG9yPkt3b24sIEouIFkuPC9hdXRob3I+PGF1dGhvcj5QYXJr
LCBZLiBXLjwvYXV0aG9yPjxhdXRob3I+S2ltLCBZLiBILjwvYXV0aG9yPjwvYXV0aG9ycz48L2Nv
bnRyaWJ1dG9ycz48YXV0aC1hZGRyZXNzPkRlcGFydG1lbnQgb2YgT2JzdGV0cmljcyBhbmQgR3lu
ZWNvbG9neSwgSW5zdGl0dXRlIG9mIFdvbWVuJmFwb3M7cyBMaWZlIE1lZGljYWwgU2NpZW5jZSwg
WW9uc2VpIFVuaXZlcnNpdHkgQ29sbGVnZSBvZiBNZWRpY2luZSxTZW91bCwgS29yZWEuPC9hdXRo
LWFkZHJlc3M+PHRpdGxlcz48dGl0bGU+RmVhc2liaWxpdHkgb2YgbWVhc3VyaW5nIDMtZGltZW5z
aW9uYWwgcmVuYWwgcGFyZW5jaHltYWwgdm9sdW1lIHRvIHByZWRpY3QgcG9zdG5hdGFsIHJlbmFs
IGZ1bmN0aW9uIGluIG5lYXItdGVybSBmZXR1c2VzIHdpdGggY29uZ2VuaXRhbCBoeWRyb25lcGhy
b3NpczogYSBwcmVsaW1pbmFyeSBzdHVkeTwvdGl0bGU+PHNlY29uZGFyeS10aXRsZT5KIFVsdHJh
c291bmQgTWVkPC9zZWNvbmRhcnktdGl0bGU+PGFsdC10aXRsZT5Kb3VybmFsIG9mIHVsdHJhc291
bmQgaW4gbWVkaWNpbmUgOiBvZmZpY2lhbCBqb3VybmFsIG9mIHRoZSBBbWVyaWNhbiBJbnN0aXR1
dGUgb2YgVWx0cmFzb3VuZCBpbiBNZWRpY2luZTwvYWx0LXRpdGxlPjwvdGl0bGVzPjxwZXJpb2Rp
Y2FsPjxmdWxsLXRpdGxlPkogVWx0cmFzb3VuZCBNZWQ8L2Z1bGwtdGl0bGU+PGFiYnItMT5Kb3Vy
bmFsIG9mIHVsdHJhc291bmQgaW4gbWVkaWNpbmUgOiBvZmZpY2lhbCBqb3VybmFsIG9mIHRoZSBB
bWVyaWNhbiBJbnN0aXR1dGUgb2YgVWx0cmFzb3VuZCBpbiBNZWRpY2luZTwvYWJici0xPjwvcGVy
aW9kaWNhbD48YWx0LXBlcmlvZGljYWw+PGZ1bGwtdGl0bGU+SiBVbHRyYXNvdW5kIE1lZDwvZnVs
bC10aXRsZT48YWJici0xPkpvdXJuYWwgb2YgdWx0cmFzb3VuZCBpbiBtZWRpY2luZSA6IG9mZmlj
aWFsIGpvdXJuYWwgb2YgdGhlIEFtZXJpY2FuIEluc3RpdHV0ZSBvZiBVbHRyYXNvdW5kIGluIE1l
ZGljaW5lPC9hYmJyLTE+PC9hbHQtcGVyaW9kaWNhbD48cGFnZXM+OTU1LTYyPC9wYWdlcz48dm9s
dW1lPjMxPC92b2x1bWU+PG51bWJlcj42PC9udW1iZXI+PGtleXdvcmRzPjxrZXl3b3JkPkh1bWFu
czwva2V5d29yZD48a2V5d29yZD5IeWRyb25lcGhyb3Npcy8qY29uZ2VuaXRhbC8qdWx0cmFzb25v
Z3JhcGh5PC9rZXl3b3JkPjxrZXl3b3JkPkltYWdpbmcsIFRocmVlLURpbWVuc2lvbmFsLyptZXRo
b2RzPC9rZXl3b3JkPjxrZXl3b3JkPktpZG5leS8qdWx0cmFzb25vZ3JhcGh5PC9rZXl3b3JkPjxr
ZXl3b3JkPk9yZ2FuIFNpemU8L2tleXdvcmQ+PGtleXdvcmQ+UHJvZ25vc2lzPC9rZXl3b3JkPjxr
ZXl3b3JkPlJlcHJvZHVjaWJpbGl0eSBvZiBSZXN1bHRzPC9rZXl3b3JkPjxrZXl3b3JkPlNlbnNp
dGl2aXR5IGFuZCBTcGVjaWZpY2l0eTwva2V5d29yZD48a2V5d29yZD5VbHRyYXNvbm9ncmFwaHks
IFByZW5hdGFsLyptZXRob2RzPC9rZXl3b3JkPjwva2V5d29yZHM+PGRhdGVzPjx5ZWFyPjIwMTI8
L3llYXI+PHB1Yi1kYXRlcz48ZGF0ZT5KdW48L2RhdGU+PC9wdWItZGF0ZXM+PC9kYXRlcz48aXNi
bj4xNTUwLTk2MTMgKEVsZWN0cm9uaWMpJiN4RDswMjc4LTQyOTcgKExpbmtpbmcpPC9pc2JuPjxh
Y2Nlc3Npb24tbnVtPjIyNjQ0NjkzPC9hY2Nlc3Npb24tbnVtPjx1cmxzPjxyZWxhdGVkLXVybHM+
PHVybD5odHRwOi8vd3d3Lm5jYmkubmxtLm5paC5nb3YvcHVibWVkLzIyNjQ0NjkzPC91cmw+PC9y
ZWxhdGVkLXVybHM+PC91cmxzPjwvcmVjb3JkPjwvQ2l0ZT48Q2l0ZT48QXV0aG9yPkR1aW48L0F1
dGhvcj48WWVhcj4yMDEzPC9ZZWFyPjxSZWNOdW0+NTM3PC9SZWNOdW0+PHJlY29yZD48cmVjLW51
bWJlcj41Mzc8L3JlYy1udW1iZXI+PGZvcmVpZ24ta2V5cz48a2V5IGFwcD0iRU4iIGRiLWlkPSIy
cHR6d3RyejNhNXhhaGVyNXJ0dnR0cnYwdngyOTlmYXRwenoiPjUzNzwva2V5PjwvZm9yZWlnbi1r
ZXlzPjxyZWYtdHlwZSBuYW1lPSJKb3VybmFsIEFydGljbGUiPjE3PC9yZWYtdHlwZT48Y29udHJp
YnV0b3JzPjxhdXRob3JzPjxhdXRob3I+RHVpbiwgTC4gSy48L2F1dGhvcj48YXV0aG9yPldpbGxl
a2VzLCBDLjwvYXV0aG9yPjxhdXRob3I+Vm9zc2VuLCBNLjwvYXV0aG9yPjxhdXRob3I+T2ZmZXJt
YW5zLCBKLjwvYXV0aG9yPjxhdXRob3I+TmlqaHVpcywgSi4gRy48L2F1dGhvcj48L2F1dGhvcnM+
PC9jb250cmlidXRvcnM+PGF1dGgtYWRkcmVzcz5EZXBhcnRtZW50IG9mIE9ic3RldHJpY3MgYW5k
IEd5bmVjb2xvZ3kgb2YgdGhlIE1hYXN0cmljaHQgVW5pdmVyc2l0eSBNZWRpY2FsIENlbnRyZSwg
NTUwMCBNQiBWZWxkaG92ZW4sIFRoZSBOZXRoZXJsYW5kcy4gTC5kdWluQG1tYy5ubDwvYXV0aC1h
ZGRyZXNzPjx0aXRsZXM+PHRpdGxlPlJlcHJvZHVjaWJpbGl0eSBvZiBmZXRhbCByZW5hbCBwZWx2
aXMgdm9sdW1lIGFzc2Vzc2VkIGJ5IHRocmVlLWRpbWVuc2lvbmFsIHVsdHJhc29ub2dyYXBoeSB3
aXRoIHR3byBkaWZmZXJlbnQgbWVhc3VyZW1lbnQgdGVjaG5pcXVlczwvdGl0bGU+PHNlY29uZGFy
eS10aXRsZT5KIENsaW4gVWx0cmFzb3VuZDwvc2Vjb25kYXJ5LXRpdGxlPjxhbHQtdGl0bGU+Sm91
cm5hbCBvZiBjbGluaWNhbCB1bHRyYXNvdW5kIDogSkNVPC9hbHQtdGl0bGU+PC90aXRsZXM+PHBl
cmlvZGljYWw+PGZ1bGwtdGl0bGU+SiBDbGluIFVsdHJhc291bmQ8L2Z1bGwtdGl0bGU+PGFiYnIt
MT5Kb3VybmFsIG9mIGNsaW5pY2FsIHVsdHJhc291bmQgOiBKQ1U8L2FiYnItMT48L3BlcmlvZGlj
YWw+PGFsdC1wZXJpb2RpY2FsPjxmdWxsLXRpdGxlPkogQ2xpbiBVbHRyYXNvdW5kPC9mdWxsLXRp
dGxlPjxhYmJyLTE+Sm91cm5hbCBvZiBjbGluaWNhbCB1bHRyYXNvdW5kIDogSkNVPC9hYmJyLTE+
PC9hbHQtcGVyaW9kaWNhbD48cGFnZXM+MjMwLTQ8L3BhZ2VzPjx2b2x1bWU+NDE8L3ZvbHVtZT48
bnVtYmVyPjQ8L251bWJlcj48a2V5d29yZHM+PGtleXdvcmQ+RmVtYWxlPC9rZXl3b3JkPjxrZXl3
b3JkPkh1bWFuczwva2V5d29yZD48a2V5d29yZD5IeWRyb25lcGhyb3Npcy91bHRyYXNvbm9ncmFw
aHk8L2tleXdvcmQ+PGtleXdvcmQ+KkltYWdlIEludGVycHJldGF0aW9uLCBDb21wdXRlci1Bc3Np
c3RlZDwva2V5d29yZD48a2V5d29yZD4qSW1hZ2luZywgVGhyZWUtRGltZW5zaW9uYWw8L2tleXdv
cmQ+PGtleXdvcmQ+S2lkbmV5IFBlbHZpcy9hbmF0b215ICZhbXA7IGhpc3RvbG9neS8qdWx0cmFz
b25vZ3JhcGh5PC9rZXl3b3JkPjxrZXl3b3JkPk1vZGVscywgU3RhdGlzdGljYWw8L2tleXdvcmQ+
PGtleXdvcmQ+T2JzZXJ2ZXIgVmFyaWF0aW9uPC9rZXl3b3JkPjxrZXl3b3JkPk9yZ2FuIFNpemU8
L2tleXdvcmQ+PGtleXdvcmQ+UHJlZ25hbmN5PC9rZXl3b3JkPjxrZXl3b3JkPlByZWduYW5jeSBU
cmltZXN0ZXIsIFNlY29uZDwva2V5d29yZD48a2V5d29yZD5QcmVnbmFuY3kgVHJpbWVzdGVyLCBU
aGlyZDwva2V5d29yZD48a2V5d29yZD5SZXByb2R1Y2liaWxpdHkgb2YgUmVzdWx0czwva2V5d29y
ZD48a2V5d29yZD5VbHRyYXNvbm9ncmFwaHksIFByZW5hdGFsLyptZXRob2RzPC9rZXl3b3JkPjwv
a2V5d29yZHM+PGRhdGVzPjx5ZWFyPjIwMTM8L3llYXI+PHB1Yi1kYXRlcz48ZGF0ZT5NYXk8L2Rh
dGU+PC9wdWItZGF0ZXM+PC9kYXRlcz48aXNibj4xMDk3LTAwOTYgKEVsZWN0cm9uaWMpJiN4RDsw
MDkxLTI3NTEgKExpbmtpbmcpPC9pc2JuPjxhY2Nlc3Npb24tbnVtPjIzMzI1NDIxPC9hY2Nlc3Np
b24tbnVtPjx1cmxzPjxyZWxhdGVkLXVybHM+PHVybD5odHRwOi8vd3d3Lm5jYmkubmxtLm5paC5n
b3YvcHVibWVkLzIzMzI1NDIxPC91cmw+PC9yZWxhdGVkLXVybHM+PC91cmxzPjxlbGVjdHJvbmlj
LXJlc291cmNlLW51bT4xMC4xMDAyL2pjdS4yMjAzOTwvZWxlY3Ryb25pYy1yZXNvdXJjZS1udW0+
PC9yZWNvcmQ+PC9DaXRlPjxDaXRlPjxBdXRob3I+RHVpbjwvQXV0aG9yPjxZZWFyPjIwMTU8L1ll
YXI+PFJlY051bT41Mzg8L1JlY051bT48cmVjb3JkPjxyZWMtbnVtYmVyPjUzODwvcmVjLW51bWJl
cj48Zm9yZWlnbi1rZXlzPjxrZXkgYXBwPSJFTiIgZGItaWQ9IjJwdHp3dHJ6M2E1eGFoZXI1cnR2
dHRydjB2eDI5OWZhdHB6eiI+NTM4PC9rZXk+PC9mb3JlaWduLWtleXM+PHJlZi10eXBlIG5hbWU9
IkpvdXJuYWwgQXJ0aWNsZSI+MTc8L3JlZi10eXBlPjxjb250cmlidXRvcnM+PGF1dGhvcnM+PGF1
dGhvcj5EdWluLCBMLiBLLjwvYXV0aG9yPjxhdXRob3I+TmlqaHVpcywgSi4gRy48L2F1dGhvcj48
YXV0aG9yPlNjaGVyam9uLCBTLiBBLjwvYXV0aG9yPjxhdXRob3I+Vm9zc2VuLCBNLjwvYXV0aG9y
PjxhdXRob3I+V2lsbGVrZXMsIEMuPC9hdXRob3I+PC9hdXRob3JzPjwvY29udHJpYnV0b3JzPjxh
dXRoLWFkZHJlc3M+YSBEZXBhcnRtZW50IG9mIE9ic3RldHJpY3MgYW5kIEd5bmVjb2xvZ3kgLCBV
bml2ZXJzaXR5IE1lZGljYWwgQ2VudGVyICwgR3JvbmluZ2VuICwgdGhlIE5ldGhlcmxhbmRzIGFu
ZC4mI3hEO2IgRGVwYXJ0bWVudCBvZiBPYnN0ZXRyaWNzIGFuZCBHeW5lY29sb2d5ICwgTWFhc3Ry
aWNodCBVbml2ZXJzaXR5IE1lZGljYWwgQ2VudGVyICwgTWFhc3RyaWNodCAsIHRoZSBOZXRoZXJs
YW5kcy48L2F1dGgtYWRkcmVzcz48dGl0bGVzPjx0aXRsZT5Db21wYXJpc29uIG9mIGNvbnZlbnRp
b25hbCB2ZXJzdXMgdGhyZWUtZGltZW5zaW9uYWwgdWx0cmFzb3VuZCBpbiBmZXRhbCByZW5hbCBw
ZWx2aXMgbWVhc3VyZW1lbnQgYW5kIHRoZWlyIHBvdGVudGlhbCBwcmVkaWN0aW9uIG9mIG5lb25h
dGFsIHVyb3BhdGhpZXM8L3RpdGxlPjxzZWNvbmRhcnktdGl0bGU+SiBNYXRlcm4gRmV0YWwgTmVv
bmF0YWwgTWVkPC9zZWNvbmRhcnktdGl0bGU+PGFsdC10aXRsZT5UaGUgam91cm5hbCBvZiBtYXRl
cm5hbC1mZXRhbCAmYW1wOyBuZW9uYXRhbCBtZWRpY2luZSA6IHRoZSBvZmZpY2lhbCBqb3VybmFs
IG9mIHRoZSBFdXJvcGVhbiBBc3NvY2lhdGlvbiBvZiBQZXJpbmF0YWwgTWVkaWNpbmUsIHRoZSBG
ZWRlcmF0aW9uIG9mIEFzaWEgYW5kIE9jZWFuaWEgUGVyaW5hdGFsIFNvY2lldGllcywgdGhlIElu
dGVybmF0aW9uYWwgU29jaWV0eSBvZiBQZXJpbmF0YWwgT2JzdGV0cmljaWFuczwvYWx0LXRpdGxl
PjwvdGl0bGVzPjxwZXJpb2RpY2FsPjxmdWxsLXRpdGxlPkogTWF0ZXJuIEZldGFsIE5lb25hdGFs
IE1lZDwvZnVsbC10aXRsZT48YWJici0xPlRoZSBqb3VybmFsIG9mIG1hdGVybmFsLWZldGFsICZh
bXA7IG5lb25hdGFsIG1lZGljaW5lIDogdGhlIG9mZmljaWFsIGpvdXJuYWwgb2YgdGhlIEV1cm9w
ZWFuIEFzc29jaWF0aW9uIG9mIFBlcmluYXRhbCBNZWRpY2luZSwgdGhlIEZlZGVyYXRpb24gb2Yg
QXNpYSBhbmQgT2NlYW5pYSBQZXJpbmF0YWwgU29jaWV0aWVzLCB0aGUgSW50ZXJuYXRpb25hbCBT
b2NpZXR5IG9mIFBlcmluYXRhbCBPYnN0ZXQ8L2FiYnItMT48L3BlcmlvZGljYWw+PHBhZ2VzPjEt
NjwvcGFnZXM+PGRhdGVzPjx5ZWFyPjIwMTU8L3llYXI+PHB1Yi1kYXRlcz48ZGF0ZT5PY3QgMjwv
ZGF0ZT48L3B1Yi1kYXRlcz48L2RhdGVzPjxpc2JuPjE0NzYtNDk1NCAoRWxlY3Ryb25pYykmI3hE
OzE0NzYtNDk1NCAoTGlua2luZyk8L2lzYm4+PGFjY2Vzc2lvbi1udW0+MjY0MzA5MDc8L2FjY2Vz
c2lvbi1udW0+PHVybHM+PHJlbGF0ZWQtdXJscz48dXJsPmh0dHA6Ly93d3cubmNiaS5ubG0ubmlo
Lmdvdi9wdWJtZWQvMjY0MzA5MDc8L3VybD48L3JlbGF0ZWQtdXJscz48L3VybHM+PGVsZWN0cm9u
aWMtcmVzb3VyY2UtbnVtPjEwLjMxMDkvMTQ3NjcwNTguMjAxNS4xMDkwOTcwPC9lbGVjdHJvbmlj
LXJlc291cmNlLW51bT48L3JlY29yZD48L0NpdGU+PC9FbmROb3RlPn==
ADDIN EN.CITE.DATA (41-43). Yu et al produced normal ranges for fetal kidney volumes at different gestations ranging from20 weeks to 40 weeks ADDIN EN.CITE <EndNote><Cite><Author>Yu</Author><Year>2000</Year><RecNum>127</RecNum><DisplayText>(44)</DisplayText><record><rec-number>127</rec-number><foreign-keys><key app="EN" db-id="2ptzwtrz3a5xaher5rtvttrv0vx299fatpzz">127</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>Yu, C.</author><author>Chang, C.</author><author>Chang, F.</author><author>Ko, H.</author><author>Chen, H.</author></authors></contributors><auth-address>Department of Obstetrics and Gynecology, National Cheng Kung University Medical College and Hospital, Tainan, Taiwan.</auth-address><titles><title>Fetal renal volume in normal gestation: a three-dimensional ultrasound study</title><secondary-title>Ultrasound Med Biol</secondary-title><alt-title>Ultrasound in medicine & biology</alt-title></titles><periodical><full-title>Ultrasound Med Biol</full-title><abbr-1>Ultrasound in medicine & biology</abbr-1></periodical><alt-periodical><full-title>Ultrasound Med Biol</full-title><abbr-1>Ultrasound in medicine & biology</abbr-1></alt-periodical><pages>1253-6</pages><volume>26</volume><number>8</number><keywords><keyword>Cross-Sectional Studies</keyword><keyword>Female</keyword><keyword>*Gestational Age</keyword><keyword>Humans</keyword><keyword>*Imaging, Three-Dimensional</keyword><keyword>Kidney/*ultrasonography</keyword><keyword>Pregnancy</keyword><keyword>Prospective Studies</keyword><keyword>Reference Values</keyword><keyword>*Ultrasonography, Prenatal</keyword></keywords><dates><year>2000</year><pub-dates><date>Oct</date></pub-dates></dates><isbn>0301-5629 (Print)
0301-5629 (Linking)</isbn><accession-num>11120361</accession-num><urls><related-urls><url>;(44), but did not perform reliability analysis. Yoshizaki et al performed reliability analysis of right and left kidney volumes in 50 fetuses using a VOCAL technique PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5Zb3NoaXpha2k8L0F1dGhvcj48WWVhcj4yMDEzPC9ZZWFy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ADDIN EN.CITE PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5Zb3NoaXpha2k8L0F1dGhvcj48WWVhcj4yMDEzPC9ZZWFy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ADDIN EN.CITE.DATA (19). They were able to demonstrate excellent intra and inter-examiner agreement using Bland-Altman analysis. However, all 3D sonographic examinations in this study for analysis were performed by the same examiner, and inter-examiner agreement was not assessed by each examiner acquiring their own individual image of the kidney volumes. Our results demonstrate poor intra and inter-observer reliability with very high random measurement error both in the second and third trimester, but worse in the second trimester. This is likely due to the difficulty in acquiring images with a clear organ border as a result of acoustic shadowing from other structures, lack of measurement technique standardisation and the relatively smaller size of the organ. Our results would suggest fetal kidney volume should not be used as a measure of fetal growth in pregnancy.Most studies looking at 3D fetal brain volume in the second and third trimesters have not assessed inter-examiner reliability. There are no studies in the literature that report reliability analysis for 3D fetal head volume measurements in pregnancy. In one study by Roelfsema et al which looked at 3D measurement of normal fetal brain volume from 18-34 weeks gestation, intra-examiner reliability was good with a coefficient of variation (CV) for 3D fetal brain volume measurement of 10.2% for repeated tests within women and 2.2% for analyses of the same recorded volume ADDIN EN.CITE <EndNote><Cite><Author>Roelfsema</Author><Year>2004</Year><RecNum>129</RecNum><DisplayText>(13)</DisplayText><record><rec-number>129</rec-number><foreign-keys><key app="EN" db-id="2ptzwtrz3a5xaher5rtvttrv0vx299fatpzz">129</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>Roelfsema, N. M.</author><author>Hop, W. C.</author><author>Boito, S. M.</author><author>Wladimiroff, J. W.</author></authors></contributors><auth-address>Department of Obstetrics and Gynecology, Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands. n.roelfsema@erasmusmc.nl</auth-address><titles><title>Three-dimensional sonographic measurement of normal fetal brain volume during the second half of pregnancy</title><secondary-title>Am J Obstet Gynecol</secondary-title><alt-title>American journal of obstetrics and gynecology</alt-title></titles><periodical><full-title>Am J Obstet Gynecol</full-title><abbr-1>American journal of obstetrics and gynecology</abbr-1></periodical><alt-periodical><full-title>Am J Obstet Gynecol</full-title><abbr-1>American journal of obstetrics and gynecology</abbr-1></alt-periodical><pages>275-80</pages><volume>190</volume><number>1</number><keywords><keyword>Adult</keyword><keyword>Brain/*embryology</keyword><keyword>Embryonic and Fetal Development</keyword><keyword>Female</keyword><keyword>Gestational Age</keyword><keyword>Humans</keyword><keyword>*Imaging, Three-Dimensional</keyword><keyword>Pregnancy</keyword><keyword>*Ultrasonography, Prenatal</keyword></keywords><dates><year>2004</year><pub-dates><date>Jan</date></pub-dates></dates><isbn>0002-9378 (Print)
0002-9378 (Linking)</isbn><accession-num>14749673</accession-num><urls><related-urls><url>;(13). Similarly in another study by Schiessl et al examining 10 images for reliability of fetal brain volumes, liver volumes and myocardial mass, CVs were 2.46 and 11.80 for intra- and inter-examiner variability of brain volume measurement respectively PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5TY2hpZXNzbDwvQXV0aG9yPjxZZWFyPjIwMTE8L1llYXI+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ADDIN EN.CITE PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5TY2hpZXNzbDwvQXV0aG9yPjxZZWFyPjIwMTE8L1llYXI+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ADDIN EN.CITE.DATA (45). In the former study, they reported a 9% failure rate to obtain a technically successful head volume measurement due to limited size of the recorded volume and position of the fetal head ADDIN EN.CITE <EndNote><Cite><Author>Roelfsema</Author><Year>2004</Year><RecNum>129</RecNum><DisplayText>(13)</DisplayText><record><rec-number>129</rec-number><foreign-keys><key app="EN" db-id="2ptzwtrz3a5xaher5rtvttrv0vx299fatpzz">129</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>Roelfsema, N. M.</author><author>Hop, W. C.</author><author>Boito, S. M.</author><author>Wladimiroff, J. W.</author></authors></contributors><auth-address>Department of Obstetrics and Gynecology, Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands. n.roelfsema@erasmusmc.nl</auth-address><titles><title>Three-dimensional sonographic measurement of normal fetal brain volume during the second half of pregnancy</title><secondary-title>Am J Obstet Gynecol</secondary-title><alt-title>American journal of obstetrics and gynecology</alt-title></titles><periodical><full-title>Am J Obstet Gynecol</full-title><abbr-1>American journal of obstetrics and gynecology</abbr-1></periodical><alt-periodical><full-title>Am J Obstet Gynecol</full-title><abbr-1>American journal of obstetrics and gynecology</abbr-1></alt-periodical><pages>275-80</pages><volume>190</volume><number>1</number><keywords><keyword>Adult</keyword><keyword>Brain/*embryology</keyword><keyword>Embryonic and Fetal Development</keyword><keyword>Female</keyword><keyword>Gestational Age</keyword><keyword>Humans</keyword><keyword>*Imaging, Three-Dimensional</keyword><keyword>Pregnancy</keyword><keyword>*Ultrasonography, Prenatal</keyword></keywords><dates><year>2004</year><pub-dates><date>Jan</date></pub-dates></dates><isbn>0002-9378 (Print)
0002-9378 (Linking)</isbn><accession-num>14749673</accession-num><urls><related-urls><url>;(13). In the second study, although image acquirement was feasible in all of the 104 fetuses examined, offline image analysis could only be performed in 66% of cases PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5TY2hpZXNzbDwvQXV0aG9yPjxZZWFyPjIwMTE8L1llYXI+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ADDIN EN.CITE PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5TY2hpZXNzbDwvQXV0aG9yPjxZZWFyPjIwMTE8L1llYXI+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ADDIN EN.CITE.DATA (45). We report similar results with excellent intra-examiner agreement, both in the second and third trimesters of pregnancy but poor inter-examiner measurement reliability with high systematic measurement bias as reflected by the Bland-Altman plots rather than the ICC values. These results reflect the increasing difficulty of being able to obtain an accurate 3D sweep of the entire fetal head as gestation advances and also the head being situated in the pelvic region where it is harder to obtain the correct image.Our reliability results for VOCAL thigh volume measurements show higher random error expressed by wide limits of agreement, especially for second trimester measurements, and more pronounced for the inter-examiner agreement in the third trimester measurements. This is in contrast to a previous study that examined VOCAL thigh volume measurements from 30-42 weeks gestation and found that the 95% limits of agreement for both inter and intra-examiner reliability was ± 7% PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5CZW5pbm5pPC9BdXRob3I+PFllYXI+MjAxMDwvWWVhcj48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ADDIN EN.CITE PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5CZW5pbm5pPC9BdXRob3I+PFllYXI+MjAxMDwvWWVhcj48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ADDIN EN.CITE.DATA (28). However, another study using a different method to measure fetal thigh volume longitudinally found similar higher random measurement error with 95% limits of agreement ± 32% for intra-examiner measurements and ± 58% for inter-examiner measurements ADDIN EN.CITE <EndNote><Cite><Author>Ioannou</Author><Year>2013</Year><RecNum>246</RecNum><DisplayText>(26)</DisplayText><record><rec-number>246</rec-number><foreign-keys><key app="EN" db-id="2ptzwtrz3a5xaher5rtvttrv0vx299fatpzz">246</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>Ioannou, C.</author><author>Sarris, I.</author><author>Napolitano, R.</author><author>Ohuma, E.</author><author>Javaid, M. K.</author><author>Papageorghiou, A. T.</author></authors></contributors><auth-address>Nuffield Department of Obstetrics & Gynaecology, University of Oxford, UK.</auth-address><titles><title>A longitudinal study of normal fetal femur volume</title><secondary-title>Prenat Diagn</secondary-title><alt-title>Prenatal diagnosis</alt-title></titles><periodical><full-title>Prenat Diagn</full-title><abbr-1>Prenatal diagnosis</abbr-1></periodical><alt-periodical><full-title>Prenat Diagn</full-title><abbr-1>Prenatal diagnosis</abbr-1></alt-periodical><pages>1088-94</pages><volume>33</volume><number>11</number><dates><year>2013</year><pub-dates><date>Nov</date></pub-dates></dates><isbn>1097-0223 (Electronic)
0197-3851 (Linking)</isbn><accession-num>23868615</accession-num><urls><related-urls><url>;(26). This wide variation in measurement repeatability may be due to the technical limitations of trying to manually trace the soft tissue borders near the ends of the bone shaft where acoustic shadowing is more pronounced. Another study by Araujo Júnior et al PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5BcmF1am8gSnVuaW9yPC9BdXRob3I+PFllYXI+MjAxMTwv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ADDIN EN.CITE PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5BcmF1am8gSnVuaW9yPC9BdXRob3I+PFllYXI+MjAxMTwv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ADDIN EN.CITE.DATA (22) has supported this theory by suggesting that planes of measurement obtained during the volume acquisition using the XI VOCAL method are much better delimitated and therefore more reproducible than the standard VOCAL technique.One of the key strengths of the study is that images were obtained in a busy clinic setting by adequately trained sonographers but non-experts in the field of 3D ultrasound and this is more representative of a real world clinical situation. A limitation of this study is measurement reliability was only assessed between two different operators. This does not accurately reflect current clinical practice whereby there are a number of different trained sonographers in most scanning departments. In conclusion, fractional thigh volume is a measurement that can be accurately and reliably measured throughout pregnancy and may be a means of monitoring and detecting fetal growth problems especially in the case of late-onset fetal growth restriction. Other fetal volumes such as placenta, head, kidney and thigh measured using a VOCAL technique showed unacceptable measurement reliability and this must be considered when interpreting studies of fetal growth. Further work could concentrate on comparing reliability of 2D biometry measures with 3D biometry measures and estimated fetal weight (EFW) calculations in the late third trimester within a busy clinic setting, with several different examiners.AcknowledgementsThe authors would like to than the women who participated in the study, and the midwives at St Mary’s Hospital, Manchester, for their participation in recruitment.Conflicts of InterestThe authors declare no conflict of interest in the work presented here.TablesTable 1: Intra-examiner Differences between 1st and 2nd Measurements made by the Same ObserverMeasurementMean Bias (cm3)SD95% Limits of AgreementICC (95% CI)Second TrimesterPlacenta-6.9116.20-38.66 - 24.840.905 (0.780-0.959)Head0.529.77-18.63 - 19.680.931 (0.848-0.969)Kidney9.8953.69-95.34 - 115.100.374 (-0.533-0.746)Thigh-6.3317.54-40.70 - 28.040.917 (0.815-0.963)TVol-1.6912.58-26.36 - 22.970.960 (0.910-0.982)Third TrimesterHead0.376.83-13.01 - 13.760.972 (0.945-0.985)Kidney-0.2238.13-74.95 - 74.520.783 (0.559-0.893)Thigh-9.6216.51-41.98 - 22.750.879 (0.685-0.946)TVol2.915.55-7.96 - 13.780.992 (0.983-0.996)ICC – Intraclass Correlation Coefficient; CI – Confidence Interval; SD – Standard DeviationTable 2: Interobserver Differences between the 1st Measurement made by 2 different ObserversMeasurementMean Bias (cm3)SD95% Limits of AgreementICC (95% CI)Second TrimesterPlacenta44.2621.172.78 - 85.750.390 (-0.189-0.758)Head8.918.30-7.35 - 25.170.874 (0.262-0.961)Kidney2.3658.57-112.40 - 117.200.061 (-1.902-0.680)Thigh11.7923.41-34.09 - 57.680.811 (0.515-0.920)TVol0.2021.49-41.93 - 42.370.867 (0.703-0.940)Third TrimesterHead-10.629.75-29.74 - 8.490.882 (0.285-0.962)Kidney-18.8157.14-130.80 - 93.190.647 (0.281-0.828)Thigh10.6123.43-35.32 - 56.530.781 (0.505-0.899)TVol3.6413.21-22.24 - 29.530.943 (0.882-0.973)ICC – Intraclass Correlation Coefficient; CI – Confidence Interval; SD – Standard DeviationFiguresFigure 1: Measurement of fractional thigh volume. By placing two electronic cursors (arrowheads, upper left window), one at each end of the femoral diaphysis, the software defines a partial volume that is based on 50% of the bone length. Five equidistant axial limb slices are used to display soft tissue borders that are traced manually for each image slice (green dots) and the TVol measurement is calculated automatically (bottom right window).Figure 2: Measurement of fetal head volume using the VOCAL technique. Manual drawing of the contour of the head was performed in plane A.Figure 3: Measurement of placental volume using the VOCAL technique. Manual drawing of the contour of the placenta was performed in plane A.Figure 4: Measurement of fetal thigh volume using the VOCAL technique. Manual drawing of the contour of the thigh was performed in plane A.Figure 5: Measurement of fetal kidney volume using the VOCAL technique. Manual drawing of the contour of the kidney was performed in plane A.Figure 6: Inter-observer reliability of second trimester volume measurements using Bland-Altman plots. The average of both observer’s readings is shown on the x-axis and the between observer difference (expressed as a percentage of the average of both readings) on the y-axis. The mean bias between observations is depicted by a solid grey line and the 95% confidence intervals of the mean are indicated by the dotted lines. Plots are presented for Kidney (A), Thigh (B), Head (C), Placenta (D), TVol (E).Figure 7: Intra-observer reliability of second trimester volume measurements using Bland-Altman plots. The average of both readings from one observer is shown on the x-axis and the between reading difference (expressed as a percentage of the average of both readings) on the y-axis. The mean bias between observations is depicted by a solid grey line and the 95% confidence intervals of the mean are indicated by the dotted lines. Plots are presented for Kidney (A), Thigh (B), Head (C), Placenta (D), TVol (E).Figure 8: Inter-observer reliability of third trimester volume measurements using Bland-Altman plots. The average of both observer’s readings is shown on the x-axis and the between observer difference (expressed as a percentage of the average of both readings) on the y-axis. The mean bias between observations is depicted by a solid grey line and the 95% confidence intervals of the mean are indicated by the dotted lines. Plots are presented for Head (A), Kidney (B), TVol (C), Thigh (D).Figure 9: Intra-observer reliability of third trimester volume measurements using Bland-Altman plots. The average of both readings from one observer is shown on the x-axis and the between reading difference (expressed as a percentage of the average of both readings) on the y-axis. The mean bias between observations is depicted by a solid grey line and the 95% confidence intervals of the mean are indicated by the dotted lines. Plots are presented for Head (A), Kidney (B), TVol (C), Thigh (D).References ADDIN EN.REFLIST 1.Yang F, Leung KY, Hou YW, Yuan Y, Tang MH. Birth-weight prediction using three-dimensional sonographic fractional thigh volume at term in a Chinese population. Ultrasound in obstetrics & gynecology : the official journal of the International Society of Ultrasound in Obstetrics and Gynecology. 2011 Oct;38(4):425-33. PubMed PMID: 21308831.2.Lee W, Balasubramaniam M, Deter RL, et al. New fetal weight estimation models using fractional limb volume. Ultrasound in obstetrics & gynecology : the official journal of the International Society of Ultrasound in Obstetrics and Gynecology. 2009 Nov;34(5):556-65. PubMed PMID: 19725080. Pubmed Central PMCID: 2784152.3.Lee W, Deter R, Sangi-Haghpeykar H, Yeo L, Romero R. Prospective validation of fetal weight estimation using fractional limb volume. Ultrasound in obstetrics & gynecology : the official journal of the International Society of Ultrasound in Obstetrics and Gynecology. 2013 Feb;41(2):198-203. PubMed PMID: 22605519. Pubmed Central PMCID: 3601845.4.Platt LD. Three-dimensional ultrasound, 2000. Ultrasound in obstetrics & gynecology : the official journal of the International Society of Ultrasound in Obstetrics and Gynecology. 2000 Sep;16(4):295-8. PubMed PMID: 11169302.5.Lee W, Deter RL, McNie B, et al. Individualized growth assessment of fetal soft tissue using fractional thigh volume. Ultrasound in obstetrics & gynecology : the official journal of the International Society of Ultrasound in Obstetrics and Gynecology. 2004 Dec;24(7):766-74. PubMed PMID: 15586365.6.Deter RL, Lee W, Sangi-Haghpeykar H, et al. Individualized fetal growth assessment: critical evaluation of key concepts in the specification of third trimester size trajectories. The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstet. 2014 Apr;27(6):543-51. PubMed PMID: 23962305.7.Deter RL, Lee W, Sangi-Haghpeykar H, et al. Personalized third-trimester fetal growth evaluation: comparisons of individualized growth assessment, percentile line and conditional probability methods. The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstet. 2016 Jan;29(2):177-85. PubMed PMID: 25491881.8.Hata T, Tanaka H, Noguchi J, Hata K. Three-dimensional ultrasound evaluation of the placenta. Placenta. 2011 Feb;32(2):105-15. PubMed PMID: 21115197.9.Artunc Ulkumen B, Pala HG, Uyar Y, Koyuncu FM, Bulbul Baytur Y. The alteration in placental volume and placental mean grey value in growth-restricted pregnancies assessed by 3D ultrasound (Growth Restriction & 3D Ultrasonography). Journal of obstetrics and gynaecology : the journal of the Institute of Obstetrics and Gynaecology. 2014 Nov 19:1-4. PubMed PMID: 25409488.10.Artunc Ulkumen B, Pala HG, Uyar Y, Koyuncu FM, Bulbul Baytur Y. The assessment of placental volume and mean gray value in preeclamptic placentas by using three-dimensional ultrasonography. The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstet. 2014 Jul 31:1-4. PubMed PMID: 25010115.11.Plasencia W, Akolekar R, Dagklis T, Veduta A, Nicolaides KH. Placental volume at 11-13 weeks' gestation in the prediction of birth weight percentile. Fetal diagnosis and therapy. 2011;30(1):23-8. PubMed PMID: 21701132.12.Hafner E, Philipp T, Schuchter K, et al. Second-trimester measurements of placental volume by three-dimensional ultrasound to predict small-for-gestational-age infants. Ultrasound in obstetrics & gynecology : the official journal of the International Society of Ultrasound in Obstetrics and Gynecology. 1998 Aug;12(2):97-102. PubMed PMID: 9744052.13.Roelfsema NM, Hop WC, Boito SM, Wladimiroff JW. Three-dimensional sonographic measurement of normal fetal brain volume during the second half of pregnancy. American journal of obstetrics and gynecology. 2004 Jan;190(1):275-80. PubMed PMID: 14749673.14.de Paula CF, Ruano R, Campos JA, Zugaib M. Placental volumes measured by 3-dimensional ultrasonography in normal pregnancies from 12 to 40 weeks' gestation. Journal of ultrasound in medicine : official journal of the American Institute of Ultrasound in Medicine. 2008 Nov;27(11):1583-90. PubMed PMID: 18946097.15.Duin LK, Willekes C, Vossen M, et al. Reproducibility of fetal renal pelvis volume measurement using three-dimensional ultrasound. Ultrasound in obstetrics & gynecology : the official journal of the International Society of Ultrasound in Obstetrics and Gynecology. 2008 Jun;31(6):657-61. PubMed PMID: 18470970.16.Lee W, Balasubramaniam M, Deter RL, et al. Fractional limb volume--a soft tissue parameter of fetal body composition: validation, technical considerations and normal ranges during pregnancy. Ultrasound in obstetrics & gynecology : the official journal of the International Society of Ultrasound in Obstetrics and Gynecology. 2009 Apr;33(4):427-40. PubMed PMID: 19253340.17.Tonni G, Martins WP, Guimaraes Filho H, Araujo Junior E. Role of 3-D ultrasound in clinical obstetric practice: evolution over 20 years. Ultrasound in medicine & biology. 2015 May;41(5):1180-211. PubMed PMID: 25748522.18.Barreto EQ, Araujo Junior E, Martins WP, et al. New technique for assessing fetal heart growth using three-dimensional ultrasonography: description of the technique and reference curves. The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstet. 2015 Jun;28(9):1087-93. PubMed PMID: 25005859.19.Yoshizaki CT, Francisco RP, de Pinho JC, Ruano R, Zugaib M. Renal volumes measured by 3-dimensional sonography in healthy fetuses from 20 to 40 weeks. Journal of ultrasound in medicine : official journal of the American Institute of Ultrasound in Medicine. 2013 Mar;32(3):421-7. PubMed PMID: 23443182.20.Araujo Junior E, Nardozza LM, Rodrigues Pires C, Filho HA, Moron AF. Comparison of two- and three-dimensional ultrasonography in lung volume measurement of normal fetuses. Journal of perinatal medicine. 2007;35(5):415-21. PubMed PMID: 17504009.21.Ioannou C, Sarris I, Salomon LJ, Papageorghiou AT. A review of fetal volumetry: the need for standardization and definitions in measurement methodology. Ultrasound in obstetrics & gynecology : the official journal of the International Society of Ultrasound in Obstetrics and Gynecology. 2011 Dec;38(6):613-9. PubMed PMID: 21674657.22.Araujo Junior E, Cavalcante RO, Nardozza LM, et al. Fetal thigh volume by 3D sonography using XI VOCAL: reproducibility and reference range for Brazilian healthy fetuses between 20 and 40 weeks. Prenatal diagnosis. 2011 Dec;31(13):1234-40. PubMed PMID: 22031336.23.Cheong KB, Leung KY, Li TK, et al. Comparison of inter- and intraobserver agreement and reliability between three different types of placental volume measurement technique (XI VOCAL, VOCAL and multiplanar) and validity in the in-vitro setting. Ultrasound in obstetrics & gynecology : the official journal of the International Society of Ultrasound in Obstetrics and Gynecology. 2010 Aug;36(2):210-7. PubMed PMID: 20201116.24.Cheong KB, Leung KY, Chan HY, et al. Comparison of inter- and intraobserver agreement between three types of fetal volume measurement technique (XI VOCAL, VOCAL and multiplanar). Ultrasound in obstetrics & gynecology : the official journal of the International Society of Ultrasound in Obstetrics and Gynecology. 2009 Mar;33(3):287-94. PubMed PMID: 19248036.25.Lima JC, Miyague AH, Filho FM, Nastri CO, Martins WP. Biometry and fetal weight estimation by two-dimensional and three-dimensional ultrasonography: an intraobserver and interobserver reliability and agreement study. Ultrasound in obstetrics & gynecology : the official journal of the International Society of Ultrasound in Obstetrics and Gynecology. 2012 Aug;40(2):186-93. PubMed PMID: 22102507.26.Ioannou C, Sarris I, Napolitano R, et al. A longitudinal study of normal fetal femur volume. Prenatal diagnosis. 2013 Nov;33(11):1088-94. PubMed PMID: 23868615.27.Bland JM, Altman DG. Applying the right statistics: analyses of measurement studies. Ultrasound in obstetrics & gynecology : the official journal of the International Society of Ultrasound in Obstetrics and Gynecology. 2003 Jul;22(1):85-93. PubMed PMID: 12858311.28.Beninni JR, Faro C, Marussi EF, Barini R, Peralta CF. Fetal thigh volumetry by three-dimensional ultrasound: comparison between multiplanar and VOCAL techniques. Ultrasound in obstetrics & gynecology : the official journal of the International Society of Ultrasound in Obstetrics and Gynecology. 2010 Apr;35(4):417-25. PubMed PMID: 20069665.29.Jones NW, Raine-Fenning NJ, Mousa HA, Bradley E, Bugg GJ. Evaluating the intra- and interobserver reliability of three-dimensional ultrasound and power Doppler angiography (3D-PDA) for assessment of placental volume and vascularity in the second trimester of pregnancy. Ultrasound in medicine & biology. 2011 Mar;37(3):376-85. PubMed PMID: 21256663.30.Araujo Junior E, Passos AP, Bruns RF, Nardozza LM, Moron AF. Reference range of fetal cisterna magna volume by three-dimensional ultrasonography using the VOCAL method. The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstet. 2014 Jul;27(10):1023-8. PubMed PMID: 24063432.31.Tedesco GD, Bussamra LC, Araujo Junior E, et al. Reference range of fetal renal volume by three-dimensional ultrasonography using the VOCAL method. Fetal diagnosis and therapy. 2009;25(4):385-91. PubMed PMID: 19786784.32.Bland JM, Altman DG. Statistical methods for assessing agreement between two methods of clinical measurement. Lancet. 1986 Feb 8;1(8476):307-10. PubMed PMID: 2868172.33.Kottner J, Audige L, Brorson S, et al. Guidelines for Reporting Reliability and Agreement Studies (GRRAS) were proposed. Journal of clinical epidemiology. 2011 Jan;64(1):96-106. PubMed PMID: 21130355.34.Kottner J, Dassen T. Interpreting interrater reliability coefficients of the Braden scale: a discussion paper. International journal of nursing studies. 2008 Aug;45(8):1238-46. PubMed PMID: 17892881.35.Martins WP, Nastri CO. Interpreting reproducibility results for ultrasound measurements. Ultrasound in obstetrics & gynecology : the official journal of the International Society of Ultrasound in Obstetrics and Gynecology. 2014 Apr;43(4):479-80. PubMed PMID: 24692222.36.Coelho Neto MA, Roncato P, Nastri CO, Martins WP. True Reproducibility of UltraSound Techniques (TRUST): systematic review of reliability studies in obstetrics and gynecology. Ultrasound in obstetrics & gynecology : the official journal of the International Society of Ultrasound in Obstetrics and Gynecology. 2015 Jul;46(1):14-20. PubMed PMID: 25175693.37.Perni SC, Chervenak FA, Kalish RB, et al. Intraobserver and interobserver reproducibility of fetal biometry. Ultrasound in obstetrics & gynecology : the official journal of the International Society of Ultrasound in Obstetrics and Gynecology. 2004 Nov;24(6):654-8. PubMed PMID: 15476300.38.Sarris I, Ioannou C, Chamberlain P, et al. Intra- and interobserver variability in fetal ultrasound measurements. Ultrasound in obstetrics & gynecology : the official journal of the International Society of Ultrasound in Obstetrics and Gynecology. 2012 Mar;39(3):266-73. PubMed PMID: 22535628.39.Hafner E, Schuchter K, van Leeuwen M, et al. Three-dimensional sonographic volumetry of the placenta and the fetus between weeks 15 and 17 of gestation. Ultrasound in obstetrics & gynecology : the official journal of the International Society of Ultrasound in Obstetrics and Gynecology. 2001 Aug;18(2):116-20. PubMed PMID: 11529989.40.Rijken MJ, Moroski WE, Kiricharoen S, et al. Effect of malaria on placental volume measured using three-dimensional ultrasound: a pilot study. Malaria journal. 2012;11:5. PubMed PMID: 22222152. Pubmed Central PMCID: 3317826.41.Nam KH, Cho A, Kwon JY, Park YW, Kim YH. Feasibility of measuring 3-dimensional renal parenchymal volume to predict postnatal renal function in near-term fetuses with congenital hydronephrosis: a preliminary study. Journal of ultrasound in medicine : official journal of the American Institute of Ultrasound in Medicine. 2012 Jun;31(6):955-62. PubMed PMID: 22644693.42.Duin LK, Willekes C, Vossen M, Offermans J, Nijhuis JG. Reproducibility of fetal renal pelvis volume assessed by three-dimensional ultrasonography with two different measurement techniques. Journal of clinical ultrasound : JCU. 2013 May;41(4):230-4. PubMed PMID: 23325421.43.Duin LK, Nijhuis JG, Scherjon SA, Vossen M, Willekes C. Comparison of conventional versus three-dimensional ultrasound in fetal renal pelvis measurement and their potential prediction of neonatal uropathies. The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstet. 2015 Oct 2:1-6. PubMed PMID: 26430907.44.Yu C, Chang C, Chang F, Ko H, Chen H. Fetal renal volume in normal gestation: a three-dimensional ultrasound study. Ultrasound in medicine & biology. 2000 Oct;26(8):1253-6. PubMed PMID: 11120361.45.Schiessl B, Fakler U, Vogt M, et al. 3-Dimensional sonographic volumetry of fetal brain, liver and myocardial mass--interdisciplinary clinical validation of the method and application in fetuses with and without structural heart disease. Zeitschrift fur Geburtshilfe und Neonatologie. 2011 Apr;215(2):60-8. PubMed PMID: 21541904. ................
................
In order to avoid copyright disputes, this page is only a partial summary.
To fulfill the demand for quickly locating and searching documents.
It is intelligent file search solution for home and business.
Related download
Related searches
- the university of scranton address
- the university of hong kong
- wharton school of the university of pennsylvania
- the university of scranton tuition
- the university of scranton
- the university of hk
- the university of scranton jobs
- the university of north texas
- the university of philosophical research
- the university of scranton players
- the university of scranton calendar
- the university of chicago jobs