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Mayo Clinic Florida Radiation Oncology Residents Mark Waddle, M.D.Chief ResidentPGY-5 Radiation OncologyHometown -- Durham, North CarolinaUndergraduate School -- University of North Carolina (UNC) at Chapel Hill Medical School -- University of North Carolina (UNC) School of MedicineIntern Year Program -- Mayo Clinic Preliminary Internal Medicine Research/Academic Interests Informatics, Clinical oncology quality measures, Alternative payment models, Personalized cancer treatment, Quality ImprovementOutside Interests Traveling, hiking, running, food, college basketballHonors and AwardsMayo Brothers Distinguished Fellowship AwardAmerican College of Radiation Oncology (ACRO) Mevion Award for Best Abstracts, Third PrizeAmerican College of Radiation Oncology (ACRO) Resident Seed GrantAmerican College of Radiology (ACR) Capitol Hill Travel AwardAmerican College of Radiation Oncology (ACRO) Best Medical Sponsored Travel Award and Essay Competition WinnerMayo School of Continuous Professional Development Best Quality Improvement Project of 2017Florida Medical Association (FMA) Legislative Visitation AwardMayo Clinic Above and Beyond Recognition Program Award for Excellence in Patient CareDeborah C Leary Award, Honorable Mention for Most outstanding medical student research, awarded at graduationSelected Research PublicationsMa DJ, Price KA, Moore EJ, Patel SH, Hinni ML, Garcia JJ, Graner DE, Neben-Wittich M, Garces YI, Chintakuntlawar AV, Price DL, Kasperbauer JL, Janus JR, Waddle MR, Miller RC, Shiraishi S, Foster NR, Ginos B, Foote RL. A Phase II Evaluation of Aggressive Dose De-escalation for Adjuvant Chemoradiation Therapy in HPV Associated Oropharynx Squamous Cell Carcinoma. Journal of Clinical Oncology. 2019 Jun 4:JCO1900463Waddle MR, Niazi SK, Aljabri D, White L, Kaleem TA, Naessens JM, Spaulding A, Habboush JY, Rummans T, Miller RC. Cost of Acute and Follow-up Care in patients with Pre-Existing Psychiatric Diagnoses Undergoing Radiation Therapy. International Journal of Radiation Oncology, Biology, and Physics. 2019 Jul 15;104(4):748-755.Waddle MR, Kaleem TA, Stross WC, Malouff TD, White L, Zhou L, Naessens JM, Spaulding A, Aljabri D, Ma DJ, Keole S, Miller RC. Identifying and Predicting the Top Spenders in Radiation Oncology. Journal of Oncology Practice. 2019 Jun 17:JOP1800627Cantrell JN, Waddle MR, Rotman M, Peterson JL, Ruiz-Garcia H, Qui?ones-Hinojosa A, Rosenfeld SS, Brown PD, Trifiletti DM. Progress toward long-term survivors of glioblastoma. Mayo Clinic Proceedings. 2019 Jul;94(7):1278-1286.Waddle MR, Ko S, Johnson MM, Lou Y, Miller RC, Harrell AC, Trifiletti DM, Post-operative radiation therapy in locally advanced non-small cell lung cancer and the impact of sequential versus concurrent chemotherapy. Translational Lung Cancer Research. 2018;7(Suppl 2):S171-S175Waddle MR, Sio TT, Van Houten HK, Foote RL, Keole SR, Schild SE, Laack N, Daniels TB, Crown W, Shah ND, Miller RC. Photon and proton radiotherapy utilization in a population of over 100 million commercially insured patients. International Journal of Radiation Oncology, Biology, and Physics. 2017 Dec 1;99(5):1078-1082Waddle MR, Chen RC, Arastu NH, Green RL, Jackson M, Qaqish BF, Camporeale J, Collichio FA, Marks LB, Unanticipated Hospital Admissions During or Soon Following Radiotherapy: Incidence and Predictive Factors. Practical Radiation Oncology 2015;5(3):e245-253.Selected PresentationsWaddle MR. Development of an Early Stage Breast Cancer Episodic Payment in Radiation Oncology. Oral Presentation at ACRO 2019. Orlando, FL. March 2019 Waddle MR. Cost savings of aggressive dose de-escalation for adjuvant chemoradiation in HPV+ oropharynx squamous cell carcinoma versus standard of care; cost analysis of a prospective phase II study. Oral Presentation at ASTRO 2018, San Antonio, TX. October 2018.Waddle MR. Defining the Value of Care in Radiation Oncology. Invited Speaker Florida Radiological Society, July 2018. Waddle MR. Cost of Acute and Follow up Care in patients with Pre-Existing Psychiatric Diagnoses Undergoing Radiation Therapy. Late Breaking Abstract at ASTRO 2017, San Diego, CA, September 2017 Waddle MR. Lung Cancer Screening in 2017. Florida Radiological Society, Sarasota, FL. July 2017.Waddle MR. Proton Radiotherapy Utilization Patterns in the U.S. and Value of Care in Radiation Oncology. Visiting Lecturer at National Institute of Radiological Sciences National Institutes for Quantum and Radiological Science and Technology. Chiba, Japan. April 2017. Waddle MR. Quality Assessment of Timeliness of Cancer Care: A Study of Delays in Radiotherapy Start Dates. Oral Presentation at ACRO 2016, Orlando, FL. March 2016.William Stross, M.D.PGY-4 Radiation OncologyHometown – Atlantic Beach, FloridaUndergraduate School –University of South FloridaMedical School – Florida State University College of Medicine Intern Year Program – Mayo Clinic Preliminary Internal MedicineResearch/Academic Interests – Toxicity management Outside Interests -- Jacksonville Jaguars football, golfing, kayaking, fishingHonors and AwardsAlpha Omega Alpha Honor SocietyGold Humanism Honor societyMayo Fellows Association, President Mayo Clinic Jacksonville Graduate Education CommitteeMayo Clinic Alumni Association Board of DirectorsAmerican College of Radiology (ACR) Legislative Fellowship and Capitol Hill Grant RecipientFlorida Radiological Society (FRS) Legislative and Government Fellowship Grant RecipientAmerican College of Radiation Oncology (ACRO) Best Medical Sponsored Travel Award and Essay Competition WinnerSelected Research PublicationsStross W, Alsaad A, Shaprio B. A 42-Year-Old Woman with Bilateral Arm Tightness. Mayo Clinic Proceedings – Residents Corner accepted for publication, May 3, 2017. May J, Waddle M, Miller D, Stross W, Kaleem T, May B, Miller R, Strong G, Trifiletti D, Chaichana K, Reimer R, Tun H, Peterson J. Primary histiocytic sarcoma of the central nervous system: a case report with platelet derived growth factor receptor mutation and PD-L1/PD-L2 expression and literature review. Radiation Oncology. September 5, 2018.Waddle MR, Kaleem TA, Stross WC, Malouff TD, White L, Zhou L, Naessens JM, Spaulding A, Aljabri D, Ma DJ, Keole S, Miller RC. Identifying and Predicting the Top Spenders in Radiation Oncology. Journal of Oncology Practice. March 2019Malouff TD, Vallow LA, Waddle MD, Kaleem TA, Zaorsky N, Royce T, Stross WC, May B, Trifiletti DM. The Influence of Online Forums on Radiation Oncology Residency Program Selection. International Journal of Radiation Oncology Biology and Physics April 22, 2019Selected PresentationsStross W. Changing Landscapes of Radiation Oncology. Invited speaker Florida Radiological Society Annual Conference. Naples, FL. July 2019.Stross W. Mucosal Squamous Cell Carcinoma of the Head & Neck in the Immunocompromised Patient Population. Florida Radiological Society Annual Conference. July, 2018.Stross W. Utilization of Proton Beam Therapy Among Adults with Primary Brain Tumors in the United States. Particle Therapy Co-Operative Group. Cincinnati, OH. May 25, 2018.Stross W. Radiation Recall: Case study, literature review, and research preview. Florida Radiological Society Annual Conference. Sarasota, FL. July 22, 2017.Stross W. High Resolution (1mm) Magnetic Resonance Imaging (MRI) is More Sensitive Than Lower Resolution MRI for Detecting the Number of Brain Metastases in Patients Undergoing Stereotactic Radiosurgery. Radiosurgery Society Annual Meeting. San Diego, CA. March, 21,2017.Timothy Malouff, M.D. ?PGY-3 Radiation OncologyHometown – La Junta, ColoradoUndergraduate School – Creighton University, Omaha, NebraskaMedical School – Creighton University, Omaha, NebraskaIntern Year Program – Mayo Clinic Preliminary Internal MedicineResearch/Academic Interests – Medical educationOutside Interests --- Dr. Malouff enjoys spending time with his wife, son, and dog.? He is an avid theme park fan.? He is a dedicated follower of Denver sports teams, although he has adopted the Jags and Jumbo Shrimp since moving to Jacksonville.? Honors and AwardsAlpha Omega Alpha Phi Beta Kappa Selected Research PublicationsMalouff TD, Peterson JL, Mahajan A, Trifiletti DM. Carbon ion radiotherapy in the treatment of gliomas: a review. J Neurooncol. 2019 Sep 30 Epub 2019 Sept 30Kaleem T, Malouff TD, Stross WC, Waddle MR, Miller DH, Seymour AL, Zaorsky NG, Miller RC, Trifiletti DM, Vallow L. Google Search Trends in Oncology and the Impact of Celebrity Cancer Awareness. Cureus. 2019 Aug 10; 11 (8):e5360Malouff TD, Vallow LA, Waddle MR, Kaleem T, Zaorsky NG, Royce TJ, Stross WC, May B, Trifiletti DM. The Influence of Online Forums on Radiation Oncology Residency Program Selection. Int J Radiat Oncol Biol Phys. 2019 Aug 1; 104 (5):1009-1011 Epub 2019 Apr 22Waddle MR, Kaleem TA, Stross WC, Malouff TD, White L, Li Z, Naessens J, Spaulding A, Aljabri D, Ma DJ, Keole S, Miller RC. Identifying the Most Costly Patients in Radiation Oncology and Predicting the Top Spenders. J Oncol Pract. 2019 Jun 17; JOP1800627 Epub 2019 June 17Miller D, Pflederer N, Malouff T, Nguyen DR, Edney E, Silva-Lopez E, Hunter W, Nguyen C. (2017). Analysis of treatment effectiveness and complications associated with MammoSiteTM breast brachytherapy in patients treated at a single institution. Journal of Radiation Oncology, 6:353-360. doi: 10.1007/s13566-017-0320-9Malouff T, Mathy NW, Marsh S, Walters RW, Silberstein PT. (2017). Trends in the use of radiation therapy for stage IIA prostate cancer from 2004 to 2013: a retrospective analysis using the National Cancer Database. Prostate Cancer and Prostatic Diseases, 20; 334-338. doi: 10.1038/pcan.2017.15Bennion NR, Baine MJ, Malouff T, Zhen W. (2017). Osteosarcoma of the larynx: treatment outcomes and patterns of failure analysis. Rare Tumors, 9:6955, 18-22. doi: 10.4081/rt.2017.6955Malouff T, Bennion NR, Verma V, Martinez GA, Balkman N, Bhirud A, Smith T, Lin, C. (2016).? Which Prognostic Index is Most Appropriate in the Setting of Delayed Stereotactic Radiosurgery for Brain Metastases? Frontiers in Oncology, 6 (Article 248); 1-8. doi: 10.3389/fonc.2016.00248Malouff T, Verma V. (2016) Internal Mammary Node Irradiation in the Treatment of Breast Cancer. Oncology Times, 38(20); 1, 5-6. doi: 10.1097/01.COT.0000505518.30942.76Bennion NR, Malouff T, Verma V, Denniston K, Bhirud A, Zhen W, Wahl A, Lin C. (2016).? A Comparison of Clinical and Radiologic Outcomes Between Frame-based and Frameless Stereotactic Radiosurgery for Brain Metastases.? Practical Radiation Oncology, 6(6); e283-290. doi: 10.1016/j.prro.2016.05.001Selected PresentationsMalouff T. The Efficacy of a Second Course of Stereotactic Radiosurgery (SRS) in Recurrent or Progressive Brain Metastases. 58th American Society for Radiation Oncology Annual Meeting. Boston, MA. September 26, 2016. Malouff T.? Trends in the Use of Radiation Therapy for Stage IIA Prostate Cancer from 2004-2013: A Retrospective Analysis Using the National Cancer Data Base (NCDB). 58th American Society for Radiation Oncology Annual Meeting. Boston, MA. September 26, 2016.Malouff T. Comparison of External Beam Radiation Therapy (EBRT) Techniques on Survival in Stage IIA Prostate Cancer. 58th American Society for Radiation Oncology Annual Meeting. Boston, MA. September 26, 2016.Malouff T. Long-term Survival by Method of Brachytherapy in Stage IIA Prostate Cancer: A National Cancer Data Base (NCDB) Analysis. 58th American Society for Radiation Oncology Annual Meeting. Boston, MA. September 26, 2016. Malouff T. Effect of radiotherapy treatment modalities on survival in stage IIa prostate cancer: A National Cancer Data Base (NCDB) analysis.? American Society of Clinical Oncology.? June 4, 2016.? Abstract 5069. Malouff T.? Trends in the Use of Radiation Therapy for Stage IIA Prostate Cancer by Population Size.? St. Albert’s Day, Creighton University.? Omaha NE.? April 12, 2016Malouff T. Using Prognostic Indices for Brain Metastases in the Setting of Delayed Stereotactic Radiosurgery (SRS). ?American Society for Radiation Oncology Annual Meeting.? San Antonio, TX.? October 18, 2015.? International Journal of Radiation Oncology, Biology, Physics 93(3):E90.Danushka (Dee) Seneviratne, M.D., Ph.D. PGY-2 Radiation OncologyHometown –Ottawa, OntarioUndergraduate School –Queen’s University, CanadaMedical School –Virginia Commonwealth University, Richmond, VAIntern Year Program – Mayo Clinic Preliminary Internal MedicineResearch/Academic Interests –Cancer molecular signaling pathways and management of intracranial lesionsOutside Interests –Running, hiking, spending time with her husband, two cats and dog Honors and AwardsRecipient of VCU’s Susan J. Mellette Scholarship awarded for commitment to research and achievements in oncology Honors distinction for doctorate research, University of Pittsburgh, Pittsburgh, PA University of Pittsburgh-Department wide annual pathology retreat- 2nd place for poster presentation University of Pittsburgh-Department wide annual pathology retreat- 2nd place for poster presentation Robert Southam Memorial Scholarship for Writing Excellence, Queen’s University, ON, Canada Dean’s Honor List, Queen’s University, ON, Canada Kingston Frontenac County Bursary for Academic Achievement and Community Services, ON, CanadaSelected Research PublicationsSeneviratne, Danushka; Vallow, Laura; Hadley, Austin; Malouff, Timothy; Stross, William; Herchko, Steven; Trifiletti, Daniel; Peterson, Jennifer. Intracranial motion during frameless stereotactic radiosurgery; The Journal of Radiosurgery and SBRT. 7/2019, Submitted, in ReviewSeneviratne D, McLaughlin C, Todor D, Kaplan B, Fields E. The new frontier of intraoperative radiation therapy or a pricier alternative to LDR brachytherapy? Advances in Radiation Oncology. October 2017. PMID: 29556586 Seneviratne D, Ma J, Melhem M, Kwon Y, Tan X. Zarnegar, R. Genomic instability causes HGF gene activation in colon cancer cells, promoting their resistance to necroptosis. Gastroenterology, January 2015. PMID: 25244939 Boichuk S, Lee DJ, Mehalek KR, Makielski KR, Wozniak A, Seneviratne DS, Korzeniewski N, Cuevas R, Parry JA, Brown MF, Zewe J, Taguchi T, Kuan SF, Sch?ffski P, Debiec-Rychter M, Duensing A. Unbiased compound screening identifies unexpected drug sensitivities and novel treatment options for gastrointestinal stromal tumors. Cancer Research, Jan 2014. PMID:24385214 Ma J, Zou C, Guo L, Seneviratne D, Tan X, An J, Bowser R, DeFrances M, Zarnegar R. A novel Death Defying Domain in Met entraps the active site of Caspase-3 and blocks apoptosis. Hepatology. Oct 2013. PMID:24122846 Boichuk S, Parry JA, Makielski KR, Litovchick L, Baron J, Zewe J, Wozniak A, Mehalek K, Korzeniewski N, Seneviratne D, Sch?ffski P, Debiec-Rychter M, DeCaprio J, and Duensing A. The DREAM complex mediates GIST cell quiescence and is a novel therapeutic target to enhance matinib-induced apoptosis. Cancer Research, Aug 2013. PMID:23786773 Bauer S, Parry JA, Mühlenberg T, Brown MF, Seneviratne DS, Chatterjee P, Chin A, Rubin BP, Kuan SF, Fletcher JA, Duensing S, Duensing A. Pro-apoptotic activity of Bortezomib in gastrointestinal stromal tumor (GIST) cells. Cancer Research, Jan 2010. PMID:2002886Selected PresentationsSeneviratne, D, Fields, E, Impact of immune status on disease recurrence in HIV+ positive patients diagnosed with anal dysplasia, ASTRO's 59th Annual Meeting, October 2018, San Antonio, TX. Seneviratne, D, HGF gene mutation in human colorectal cancer: causes and consequences, University of Pittsburgh Annual Pathology Department Retreat, May 2012 and May 2013, Pittsburgh, PA. Seneviratne D, Parry JA, Baron JL, Duensing S, Duensing A. Imatinib mesylate leads to modulation of regulators of tumor cell quiescence in gastrointestinal stromal tumor (GIST) cells. 101st Annual Meeting of the American Association for Cancer Research, April 17-21, 2010, Washington, DC. Poster Presentation. Seneviratne D, Characterization of the DNA damage response in imatinib mesylate treated gastrointestinal stromal tumor (GIST) cells. University of Pittsburgh Cancer Institute Retreat, University of Pittsburgh, June 2009, Greensburg, PA.Parry JA, Brown MF, Seneviratne D, Duensing S, Duensing A. Imatinib mesylate modulates regulators of tumor cell quiescence in gastrointestinal stromal tumor cells. Connective Tissue Oncology Society (CTOS), 15th Annual Meeting, November 5-7, 2009, Miami, FL, oral presentationAaron Bush, M.D.PGY-1 Radiation Oncology?Hometown – Crystal River, Florida Undergraduate School – University of Florida Medical School – Georgetown University, Washington, D.C. Intern Year Program – Mayo Clinic Preliminary Internal MedicineResearch/Academic Interests – Toxicity prevention, head and neck cancer management Outside Interests – Road trips, Surfing, Football, Open water diving Honors and AwardsGeorge M. Kober research symposium – Honors recipient for oral presentationJ. Collins Foundation Scholarship for excellence in arts and academics, Georgetown University READ Poster Honoree for exemplification of outstanding patient care, Georgetown University Summa Cum Laude, University of Florida Selected PresentationsBush A, Paydar I, Aghdam N, Gramza A, Davidson B, Deeken J, Harter K. Long Term Outcomes for Re-irradiation of Recurrent Head and Neck Cancers: Mature Data from a Large Series. American Society for Radiation Oncology Annual Meeting, October 2018, San Antonio, TX. Aghdam N, Paydar I, Bush A, Gramza A, Davidson B, Deeken J, Harter K. Re-irradiation of Recurrent Head and Neck Cancers: Report of Acute and Long-Term Toxicity. American Society of Clinical Oncology Annual Meeting, June 2018, Chicago, IL. Bush A, Kim J, Clark D, Colquhoun T. Mechanisms of p-Coumaroyl Shikimate/Quinate 3’ Hydroxylase. Howard Hughes Medical Institute Conference, March 2015, Gainesville, FL. ................
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