Single Patient IND - Dana–Farber/Harvard Cancer Center
Bevacizumb (Avastin)
FDA Approved
Risks Associated with Bevacizumab
Frequent (Between a 10-50% chance that this will happen)
• High blood pressure
• Stomach cramps, pain in the abdomen due to cramping
• Inflammation of the nasal passageway due to allergies. This generally causes a stuffy or runny nose and sneezing.
• Loss of appetite and weight loss
• Feeling weak and having no energy
• Shortness of breath
• Tearing
• Headache
• Feeling sick to the stomach, vomiting
• Infection of the lung
• Excess protein in the urine. This may cause fluid retention.
• Chills and shivering
• Sores in the mouth and esophagus, which may be painful and cause difficulty swallowing.
• Low number of platelets, which may cause bleeding and bruising. Bleeding may be serious or life threatening and may required a blood transfusion.
• Loss of function of the ovaries that can lead to menopause
Occasional (Between a 1-10% chance that this will happen)
• Allergic reaction that may include a rash, hives, fever, difficulty breathing, and low blood pressure. Although usually reversible with treatment, it can be severe or life threatening.
• Hairloss
• Build up of fluid in the abdomen, which causes bloating and discomfort. This could require that the fluid be removed by a procedure called paracentesis
• Blood clots can form leading to swelling in the arms and legs. These clots can travel to the lungs causing shortness of breath or to the brain causing a stroke. This may be serious or life threatening.
• Bowel perforation (a hole in the intestines) that could result in a serious, life-threatening infection and may require surgery
• Heart problems (including shortness of breath, congestive heart failure, lower leg swelling, decreased heart function) often reversible, but may be permanent.
• Confusion
• Dehydration. If severe it may require medication, IV fluids and possibly hospitalization.
• Bloody nose
• An abnormal connection between two different organs. This side effect may lead to life-threatening complications including serious infections, bleeding or dysfunction of the organs.
• Low levels of potassium in the blood, which can cause an abnormal heart rate. This could cause an irregular heartbeat, which can be serious and life threatening
• Bleeding internally which may require hospitalization and surgery
• Rash flaking or sloughing of skin
• Stunted growth
• A rare reversible risk of confusion, visual loss, seizures and coma that can happen in association with very high blood pressure.
• Slow or poor healing of surgical wounds
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DANA-FARBER / HARVARD CANCER CENTER
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