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Standard Operating ProcedureArsenic pentafluorideThis is an SOP template and is not complete until: 1) lab specific information is entered into the box below 2) lab specific protocol/procedure is added to the protocol/procedure section and 3) SOP has been signed and dated by the PI and relevant lab personnel. Print a copy and insert into your Laboratory Safety Manual and Chemical Hygiene Plan. Refer to instructions for assistance.School / Department:Click here to enter text.SOP Preparation Date:Click here to enter a date.SOP Approval Date:Click here to enter a date.Principal Investigator:Click here to enter text.Lab Manager Name:Click here to enter text.Laboratory Phone:Click here to enter text.Office Phone:Click here to enter text.Emergency Contact:Click here to enter text.Contact Phone:Click here to enter text.Laboratory locations covered by this SOP (building / room number):Click here to enter text.PurposeArsenic pentafluoride is colorless gas that is extremely toxic and corrosive. It is also a potential carcinogen. Highly toxic, may be fatal if inhaled, swallowed or absorbed through skin. Use extreme caution when handling. Physical & Chemical Properties/Definition of Chemical GroupCAS#: 7784-36-3 Class: Very toxic, Carcinogen, CorrosiveMolecular Formula: AsF5Form (physical state): gasColor: ColorlessBoiling point: 53 ?CPotential Hazards/ToxicityArsenic pentafluoride is extremely toxic and corrosive. It is also a potential carcinogen. May cause severe irritation and burns to the eyes, mucous membranes and skin. Inhalation may cause dangerous retention of body fluid in the lungs (pulmonary edema), respiratory damage, and systemic toxicity. Long-term exposure to inorganic arsenic compounds can increase the risks of developing cancer. Decomposes to hydrofluoric acid and arsenic on contact with moisture. Has the following permissible exposure limit data: 5 ?g/m3 action level, 10 ?g/m3 TWA (as As), 2.5 mg/m3 TWA as F.Personal Protective Equipment (PPE)Respirator ProtectionUse a full-face respirator with multi-purpose combination (US) respirator cartridges as a backup to engineering controls. If the respirator is the sole means of protection, use a full-face supplied air respirator.Respirators should be used only under any of the following circumstances:As a last line of defense (i.e., after engineering and administrative controls have been exhausted).When Permissible Exposure Limit (PEL) has exceeded or when there is a possibility that PEL will be exceeded. Regulations require the use of a respirator.An employer requires the use of a respirator. There is potential for harmful exposure due to an atmospheric contaminant (in the absence of PEL)As PPE in the event of a chemical spill clean-up processLab personnel intending to use/wear a respirator mask must be trained and fit-tested by EH&S. This is a regulatory requirement. Hand ProtectionRubber protective gloves.NOTE: Consult with your preferred glove manufacturer to ensure that the gloves you plan on using are compatible with Arsenic pentafluoride.Refer to glove selection chart from the links below: OR ProtectionANSI approved, tight-fitting safety glasses/goggles. Face shield recommended.Skin and Body ProtectionFlame resistant lab coat, long pants, and closed-toe shoes.Hygiene MeasuresAvoid contact with skin, eyes and clothing. Wash hands before breaks and immediately after handling the product.Engineering ControlsChemical fume hood. Adequate exhaust ventilation.First Aid ProceduresIf inhaledRemove immediately to fresh air. If not breathing, give artificial respiration. If breathing is difficult, provide oxygen. Seek medical aid immediately.In case of skin contactRemove contaminated clothing as rapidly as possible. Flush affected skin with plenty of water and mild soap. Seek immediate medical attention. In case of eye contactPersons with potential exposure to Arsenic pentafluoride should not wear contact lenses. Flush eyes with plenty of water for at least 30 minutes lifting lower and upper eyelids. Seek medical aid. Continue rinsing during transport to hospital.If swallowedDo not induce vomiting. Never give anything by mouth to an unconscious person. Rinse mouth with water. Seek medical aid immediately.Special Handling and Storage RequirementsPrecautions for safe handling: Avoid contact with skin, eyes, and clothing. Avoid inhalation and ingestion. Use only with adequate ventilation. Conditions for safe storage: Store in cool, dry, well-ventilated area of non-combustible construction. Cylinders should be stored upright and firmly secured to prevent falling.Leak/Spill and Accident ProcedureChemical Leak/Spill Dial 911 and (480) 965-1823If a chemical leak is detected, turn off all sources of ignition and all personnel should evacuate and contact EH&S. If possible without risk, stop flow of gas leak. Dial 911 and EH&S at (480) 965-1823 for assistance. Help contaminated or injured persons. Avoid breathing vapors. Prevent others from entering contaminated area (e.g., use caution tape, barriers, etc.). Large (>1 L) – Dial 911 and EH&S at (480) 965-1823 for assistance. Chemical Spill on Body or Clothes – Remove clothing and rinse body thoroughly in emergency shower for at least 15 minutes. Seek medical attention. Notify supervisor and EH&S at x59797 immediately. Chemical Splash Into Eyes – Immediately rinse eyeball and inner surface of eyelid with water from the emergency eyewash station for 15 minutes by forcibly holding the eye open. Seek medical attention. Notify supervisor and EH&S at x59797 immediately.Medical Emergency Dial 911 Life Threatening emergency, After Hours, Weekends and Holidays – Dial 911 or go to the nearest emergency room.) Note: All Serious injuries must be reported to EH&S within 8 hours. Non-Life Threatening Emergency – Go to the Occupational Health Facility (OHF). After hours go to the nearest emergency room. Note: All serious injuries must be reported to EH&S within 8 hours. Needle stick/puncture exposure (as applicable to chemical handling procedure) – Wash the affected area with antiseptic soap and warm water for 15 minutes. For mucous membrane exposure, flush the affected area for 15 minutes using an eyewash station. Page the needle stick nurse \ and then enter your extension. After hours go to the nearest emergency room. Note: All needle stick/puncture exposures must be reported to EH&S within 8 hours. Decontamination/Waste Disposal ProcedureWearing proper PPE, decontaminate equipment and bench tops using soap and water. Dispose of the used chemical and contaminated disposables as hazardous waste following the guidelines below.General hazardous waste disposal guidelines:Label wasteAttach a completed ASU Hazardous Waste tag to all waste containers as soon as the first drop of waste is added to the container.Store wasteStore hazardous waste in closed containers, in secondary containment and in a designated storage location.Double-bag dry waste using sealable transparent bags.Waste must be under the control of the person generating and disposing of it.Dispose of wasteDispose of regularly generated chemical waste within 90 days.Use EHS Assistant online hazardous waste pick-up request system.Contact ASU EH&S at (480) 965-1823 with questions.Protocol / ProcedureLaboratory-specific proceduresAdd your lab’s specific procedures in this section.Click here to enter text.IMPORTANT NOTE: Any deviation from this SOP requires advance PI approval.Documentation of TrainingPrior to conducting any work with this material, Principal Investigator or designee must provide to his/her laboratory personnel specific to the hazards involved in working with this substance, work area decontamination, and emergency procedures.The Principal Investigator must provide his/her laboratory personnel with a copy of this SOP and a copy of the MSDS provided by the manufacturer.The Principal Investigator must ensure that his/her laboratory personnel have attended appropriate/required laboratory safety training or refresher training within the last one year.I have read and understand the content of this SOP.Employee NameASU Affiliate No.SignatureDateClick here to enter text.Click here to enter text.Click here to enter a date.Click here to enter text.Click here to enter text.Click here to enter a date.Click here to enter text.Click here to enter text.Click here to enter a date.Click here to enter text.Click here to enter text.Click here to enter a date.Click here to enter text.Click here to enter text.Click here to enter a date.Click here to enter text.Click here to enter text.Click here to enter a date.Click here to enter text.Click here to enter text.Click here to enter a date. ................
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