Disease - CDNA National Guidelines for Public Health Units
ListeriosisCDNA National Guidelines for Public Health UnitsRevision historyVersionDateRevised byChanges1.0September 2015Developed by the Listeriosis SoNG working group1.1June 2018Case definition working groupIncorporated the updated case definition (1 Jan 2017) to the SoNGThe Series of National Guidelines (‘the Guidelines’) have been developed by the Communicable Diseases Network Australia (CDNA) and noted by the Australian Health Protection Principal Committee (AHPPC). Their purpose is to provide nationally consistent guidance to public health units (PHUs) in responding to a notifiable disease event.These guidelines capture the knowledge of experienced professionals and provide guidance on best practice based upon the best available evidence at the time of completion.Readers should not rely solely on the information contained within these guidelines. Guideline information is not intended to be a substitute for advice from other relevant sources including, but not limited to, the advice from a health professional. Clinical judgment and discretion may be required in the interpretation and application of these guidelines.The membership of CDNA and AHPPC, and the Commonwealth of Australia as represented by the Department of Health (‘Health’), do not warrant or represent that the information contained in the Guidelines is accurate, current or complete. CDNA, AHPPC and Health do not accept any legal liability or responsibility for any loss, damages, costs or expenses incurred by the use of, or reliance on, or interpretation of, the information contained in the guidelines.Endorsed by CDNA: November 2015Endorsed by AHPPC: April 2016Released by Health: 06 May 2016Contents TOC \o "1-3" \h \z \u 1. Summary PAGEREF _Toc517183886 \h 3Public health priority PAGEREF _Toc517183887 \h 3Case management PAGEREF _Toc517183888 \h 3Contact management PAGEREF _Toc517183889 \h 32. The disease PAGEREF _Toc517183890 \h 3Infectious agent PAGEREF _Toc517183891 \h 3Source of human infections PAGEREF _Toc517183892 \h 4Mode of acquisition PAGEREF _Toc517183893 \h 4Incubation period PAGEREF _Toc517183894 \h 4Infectious period PAGEREF _Toc517183895 \h 4Clinical presentation and outcome PAGEREF _Toc517183896 \h 4Persons at increased risk of disease PAGEREF _Toc517183897 \h 5Disease occurrence and public health significance PAGEREF _Toc517183898 \h 53. Routine prevention activities PAGEREF _Toc517183899 \h 6Reducing contamination of food products PAGEREF _Toc517183900 \h 64. Surveillance objectives PAGEREF _Toc517183901 \h 75. Data management PAGEREF _Toc517183902 \h 76. Communications PAGEREF _Toc517183903 \h 8Immediately post-notification PAGEREF _Toc517183904 \h 8OzFoodNet central routine PAGEREF _Toc517183905 \h 8Laboratory reporting PAGEREF _Toc517183906 \h 8MJOI under consideration or declared PAGEREF _Toc517183907 \h 8Suspect food under investigation PAGEREF _Toc517183908 \h 8International considerations PAGEREF _Toc517183909 \h 87. Case definition PAGEREF _Toc517183910 \h 8Reporting PAGEREF _Toc517183911 \h 8Confirmed case PAGEREF _Toc517183912 \h 9Laboratory definitive evidence PAGEREF _Toc517183913 \h 98. Laboratory testing PAGEREF _Toc517183914 \h 109. Case management PAGEREF _Toc517183915 \h 11Response times PAGEREF _Toc517183916 \h 11Response procedure PAGEREF _Toc517183917 \h 1110. Environmental and Food evaluation PAGEREF _Toc517183918 \h 1211. Contact management PAGEREF _Toc517183919 \h 12Identification of contacts PAGEREF _Toc517183920 \h 12Contact definition PAGEREF _Toc517183921 \h 12Prophylaxis PAGEREF _Toc517183922 \h 12Education PAGEREF _Toc517183923 \h 13Isolation and restriction PAGEREF _Toc517183924 \h 1312. Special situations PAGEREF _Toc517183925 \h 13Vulnerable infant populations PAGEREF _Toc517183926 \h 14Cases among travellers on aeroplanes PAGEREF _Toc517183927 \h 1413. References and additional sources of information PAGEREF _Toc517183928 \h 1414. Appendices PAGEREF _Toc517183929 \h 1615. Jurisdiction specific issues PAGEREF _Toc517183930 \h 16Appendix 1: Listeriosis factsheets PAGEREF _Toc517183931 \h 17Appendix 2: Listeriosis Case Investigation Checklist PAGEREF _Toc517183932 \h 18Appendix 3: Listeriosis Disease Investigation form PAGEREF _Toc517183933 \h 19LISTERIOSISCDNA National Guidelines for Public Health Units1. SummaryPublic health priorityHigh in view of potential severity and potential to mitigate ongoing exposure.Case managementrespond to notifications of confirmed cases as per local protocols within 1 working dayenter confirmed cases in jurisdictional Notifiable Diseases Database within 1 working dayadvise jurisdictional OzFoodNet epidemiologist of case within 1 working day of notification receiptprovide data to National Enhanced Listeriosis Surveillance Scheme (NELSS) within 1 week of initial notification and update case details within 1 working day of new data receipt.Contact managementCounsel and disseminate information to those exposed to a suspected common food source.2. The diseaseInfectious agentHuman listeriosis is caused by a single species of Listeria, L. monocytogenes, which can be further characterised.Source of human infectionsL. monocytogenes survives and multiplies in many non-human niches. Humans are an ‘accidental’ host, usually becoming infected following the consumption of contaminated food, or in the case of a fetus or newborn, vertically from their pregnant mother.The sources of food contamination are many and varied as L. monocytogenes is widespread in the environment. For example, L. monocytogenes may be isolated from soil, surface water, decomposing organic matter, spoiled silage, sewage, commercial food-manufacturing environments, raw foods including vegetables, meats and dairy products and is carried in the gastrointestinal tract of many animals.Although asymptomatic vaginal and faecal carriage has been reported ADDIN EN.CITE <EndNote><Cite><Author>Lamont</Author><Year>2011</Year><RecNum>4102</RecNum><DisplayText>(1)</DisplayText><record><rec-number>4102</rec-number><foreign-keys><key app="EN" db-id="vf2eve221fwdtme9pxspr9f9zz5ravx0zwar">4102</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>Lamont, R. F.</author><author>Sobel, J.</author><author>Mazaki-Tovi, S.</author><author>Kusanovic, J. P.</author><author>Vaisbuch, E.</author><author>Kim, S. K.</author><author>Uldbjerg, N.</author><author>Romero, R.</author></authors></contributors><auth-address>Perinatology Research Branch, NICHD/NIH/DHHS, Wayne State University/Hutzel Women's Hospital, 3990 John R, Detroit, MI 48201, USA. rlamont@med.wayne.edu</auth-address><titles><title>Listeriosis in human pregnancy: a systematic review</title><secondary-title>J Perinat Med</secondary-title><alt-title>Journal of perinatal medicine</alt-title></titles><pages>227-36</pages><volume>39</volume><number>3</number><edition>2011/04/27</edition><dates><year>2011</year><pub-dates><date>May</date></pub-dates></dates><isbn>1619-3997 (Electronic)
0300-5577 (Linking)</isbn><accession-num>21517700</accession-num><work-type>Research Support, N.I.H., Intramural
Review</work-type><urls><related-urls><url>;(1) it is not considered a common source of infection in humans.Mode of acquisitionNearly all cases of human listeriosis result from the consumption of L.?monocytogenes contaminated food ADDIN EN.CITE <EndNote><Cite><Author>World Health Organization</Author><Year>2004</Year><RecNum>7631</RecNum><DisplayText>(2)</DisplayText><record><rec-number>7631</rec-number><foreign-keys><key app="EN" db-id="vf2eve221fwdtme9pxspr9f9zz5ravx0zwar">7631</key></foreign-keys><ref-type name="Serial">57</ref-type><contributors><authors><author>World Health Organization,</author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Risk assessment of </style><style face="italic" font="default" size="100%">Listeria monocytogenes</style><style face="normal" font="default" size="100%"> in ready-to-eat foods. Technical report</style></title><tertiary-title>Microbiological Risk Assessment Series</tertiary-title></titles><volume>5</volume><dates><year>2004</year></dates><pub-location>Geneva</pub-location><publisher>World Health Organization</publisher><urls></urls></record></Cite></EndNote>(2) and vertical transmission during gestation, or uncommonly, birth or shortly after birth ADDIN EN.CITE <EndNote><Cite><Author>Lamont</Author><Year>2011</Year><RecNum>4102</RecNum><DisplayText>(1)</DisplayText><record><rec-number>4102</rec-number><foreign-keys><key app="EN" db-id="vf2eve221fwdtme9pxspr9f9zz5ravx0zwar">4102</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>Lamont, R. F.</author><author>Sobel, J.</author><author>Mazaki-Tovi, S.</author><author>Kusanovic, J. P.</author><author>Vaisbuch, E.</author><author>Kim, S. K.</author><author>Uldbjerg, N.</author><author>Romero, R.</author></authors></contributors><auth-address>Perinatology Research Branch, NICHD/NIH/DHHS, Wayne State University/Hutzel Women's Hospital, 3990 John R, Detroit, MI 48201, USA. rlamont@med.wayne.edu</auth-address><titles><title>Listeriosis in human pregnancy: a systematic review</title><secondary-title>J Perinat Med</secondary-title><alt-title>Journal of perinatal medicine</alt-title></titles><pages>227-36</pages><volume>39</volume><number>3</number><edition>2011/04/27</edition><dates><year>2011</year><pub-dates><date>May</date></pub-dates></dates><isbn>1619-3997 (Electronic)
0300-5577 (Linking)</isbn><accession-num>21517700</accession-num><work-type>Research Support, N.I.H., Intramural
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ADDIN EN.CITE.DATA (3-5).Unusual modes of transmission include: nosocomial transmission in the newborn period ADDIN EN.CITE <EndNote><Cite><Author>Lamont</Author><Year>2011</Year><RecNum>4102</RecNum><DisplayText>(1)</DisplayText><record><rec-number>4102</rec-number><foreign-keys><key app="EN" db-id="vf2eve221fwdtme9pxspr9f9zz5ravx0zwar">4102</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>Lamont, R. F.</author><author>Sobel, J.</author><author>Mazaki-Tovi, S.</author><author>Kusanovic, J. P.</author><author>Vaisbuch, E.</author><author>Kim, S. K.</author><author>Uldbjerg, N.</author><author>Romero, R.</author></authors></contributors><auth-address>Perinatology Research Branch, NICHD/NIH/DHHS, Wayne State University/Hutzel Women's Hospital, 3990 John R, Detroit, MI 48201, USA. rlamont@med.wayne.edu</auth-address><titles><title>Listeriosis in human pregnancy: a systematic review</title><secondary-title>J Perinat Med</secondary-title><alt-title>Journal of perinatal medicine</alt-title></titles><pages>227-36</pages><volume>39</volume><number>3</number><edition>2011/04/27</edition><dates><year>2011</year><pub-dates><date>May</date></pub-dates></dates><isbn>1619-3997 (Electronic)
0300-5577 (Linking)</isbn><accession-num>21517700</accession-num><work-type>Research Support, N.I.H., Intramural
Review</work-type><urls><related-urls><url>;(1); zoonotic transmission ADDIN EN.CITE <EndNote><Cite><Author>Oevermann</Author><Year>2010</Year><RecNum>146</RecNum><DisplayText>(6)</DisplayText><record><rec-number>146</rec-number><foreign-keys><key app="EN" db-id="t0erfewpvsr2d6eexw8xxpfla50vzpe5stfx">146</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>Oevermann, A.</author><author>Zurbriggen, A.</author><author>Vandevelde, M.</author></authors></contributors><auth-address>Neurocenter, Department of Clinical Research and Veterinary Public Health, Vetsuisse Faculty, University of Bern, 3001 Bern, Switzerland.</auth-address><titles><title>Rhombencephalitis Caused by Listeria monocytogenes in Humans and Ruminants: A Zoonosis on the Rise?</title><secondary-title>Interdiscip Perspect Infect Dis</secondary-title><alt-title>Interdisciplinary perspectives on infectious diseases</alt-title></titles><periodical><full-title>Interdiscip Perspect Infect Dis</full-title><abbr-1>Interdisciplinary perspectives on infectious diseases</abbr-1></periodical><alt-periodical><full-title>Interdiscip Perspect Infect Dis</full-title><abbr-1>Interdisciplinary perspectives on infectious diseases</abbr-1></alt-periodical><pages>632513</pages><volume>2010</volume><edition>2010/03/06</edition><dates><year>2010</year></dates><isbn>1687-7098 (Electronic)
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ADDIN EN.CITE.DATA (7).The outcome of exposure is highly dependent on the immune status of the host and the dose of organisms ingested ADDIN EN.CITE <EndNote><Cite><Author>Lamont</Author><Year>2011</Year><RecNum>4102</RecNum><DisplayText>(1)</DisplayText><record><rec-number>4102</rec-number><foreign-keys><key app="EN" db-id="vf2eve221fwdtme9pxspr9f9zz5ravx0zwar">4102</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>Lamont, R. F.</author><author>Sobel, J.</author><author>Mazaki-Tovi, S.</author><author>Kusanovic, J. P.</author><author>Vaisbuch, E.</author><author>Kim, S. K.</author><author>Uldbjerg, N.</author><author>Romero, R.</author></authors></contributors><auth-address>Perinatology Research Branch, NICHD/NIH/DHHS, Wayne State University/Hutzel Women's Hospital, 3990 John R, Detroit, MI 48201, USA. rlamont@med.wayne.edu</auth-address><titles><title>Listeriosis in human pregnancy: a systematic review</title><secondary-title>J Perinat Med</secondary-title><alt-title>Journal of perinatal medicine</alt-title></titles><pages>227-36</pages><volume>39</volume><number>3</number><edition>2011/04/27</edition><dates><year>2011</year><pub-dates><date>May</date></pub-dates></dates><isbn>1619-3997 (Electronic)
0300-5577 (Linking)</isbn><accession-num>21517700</accession-num><work-type>Research Support, N.I.H., Intramural
Review</work-type><urls><related-urls><url>;(1).Incubation periodThe incubation period can be up to 70 days after exposure ADDIN EN.CITE <EndNote><Cite><Year>2015</Year><RecNum>143</RecNum><DisplayText>(8)</DisplayText><record><rec-number>143</rec-number><foreign-keys><key app="EN" db-id="t0erfewpvsr2d6eexw8xxpfla50vzpe5stfx">143</key></foreign-keys><ref-type name="Edited Book">28</ref-type><contributors><authors><author>Heymann, D.L.</author></authors></contributors><titles><title>Control of Communicable Diseases Manual</title></titles><edition>20th</edition><dates><year>2015</year></dates><pub-location>Washington</pub-location><publisher>American Public Health Association</publisher><urls></urls></record></Cite></EndNote>(8) and can vary depending on the form of listeriosis. For invasive listeriosis, the median incubation period is 9 days (range 1-14 days) for central nervous system (CNS) involvement (e.g. meningitis) and 2 days (range 1-7 days) for bacteraemia ADDIN EN.CITE <EndNote><Cite><Author>Goulet</Author><Year>2013</Year><RecNum>101</RecNum><DisplayText>(9)</DisplayText><record><rec-number>101</rec-number><foreign-keys><key app="EN" db-id="9f55tddz1wdx2netsv25veadfevp9e5r5swv" timestamp="1428487249">101</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>Goulet, Véronique</author><author>King, Lisa A</author><author>Vaillant, Véronique</author><author>de Valk, Henriette</author></authors></contributors><titles><title>What is the incubation period for listeriosis?</title><secondary-title>BMC infectious diseases</secondary-title></titles><periodical><full-title>BMC infectious diseases</full-title></periodical><pages>11</pages><volume>13</volume><number>1</number><dates><year>2013</year></dates><isbn>1471-2334</isbn><urls></urls></record></Cite></EndNote>(9).The median incubation period for pregnancy-associated listeriosis is 27.5 days (range 17 – 67 days) ADDIN EN.CITE <EndNote><Cite><Author>Goulet</Author><Year>2013</Year><RecNum>101</RecNum><DisplayText>(9)</DisplayText><record><rec-number>101</rec-number><foreign-keys><key app="EN" db-id="9f55tddz1wdx2netsv25veadfevp9e5r5swv" timestamp="1428487249">101</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>Goulet, Véronique</author><author>King, Lisa A</author><author>Vaillant, Véronique</author><author>de Valk, Henriette</author></authors></contributors><titles><title>What is the incubation period for listeriosis?</title><secondary-title>BMC infectious diseases</secondary-title></titles><periodical><full-title>BMC infectious diseases</full-title></periodical><pages>11</pages><volume>13</volume><number>1</number><dates><year>2013</year></dates><isbn>1471-2334</isbn><urls></urls></record></Cite></EndNote>(9).Infectious periodAs horizontal person-to-person transmission generally does not occur this is not relevant to routine public health practice.Clinical presentation and outcomeListeriosis can manifest as an invasive or non-invasive infection.Invasive listeriosis manifestations include sepsis and/or CNS infection. The onset of meningoencephalitis (which is rare in pregnant women) may be sudden, with fever, intense headache, nausea, vomiting and signs of meningeal irritation, or may be subacute. Delirium and coma may appear early; occasionally there is circulatory collapse and shock ADDIN EN.CITE <EndNote><Cite><Year>2015</Year><RecNum>143</RecNum><DisplayText>(8)</DisplayText><record><rec-number>143</rec-number><foreign-keys><key app="EN" db-id="t0erfewpvsr2d6eexw8xxpfla50vzpe5stfx">143</key></foreign-keys><ref-type name="Edited Book">28</ref-type><contributors><authors><author>Heymann, D.L.</author></authors></contributors><titles><title>Control of Communicable Diseases Manual</title></titles><edition>20th</edition><dates><year>2015</year></dates><pub-location>Washington</pub-location><publisher>American Public Health Association</publisher><urls></urls></record></Cite></EndNote>(8).Pregnancy-associated listeriosis can result in signs in the mother and the baby. The infected mother may be asymptomatic or have mild influenza-like symptoms. Fetal infection results in fetal death, spontaneous abortion, stillbirth or neonatal infection. Neonatal infection typically presents as septicaemia or meningitis and is more common when the mother was infected during the third trimester. Late onset neonatal listeriosis (usually presenting as purulent meningitis) generally affects full-term babies who are usually healthy at birth.Invasive listeriosis is characterised by a high case fatality rate of 24 to 52% among non-pregnant adults despite adequate antimicrobial treatment ADDIN EN.CITE <EndNote><Cite><Author>Oevermann</Author><Year>2010</Year><RecNum>146</RecNum><DisplayText>(6)</DisplayText><record><rec-number>146</rec-number><foreign-keys><key app="EN" db-id="t0erfewpvsr2d6eexw8xxpfla50vzpe5stfx">146</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>Oevermann, A.</author><author>Zurbriggen, A.</author><author>Vandevelde, M.</author></authors></contributors><auth-address>Neurocenter, Department of Clinical Research and Veterinary Public Health, Vetsuisse Faculty, University of Bern, 3001 Bern, Switzerland.</auth-address><titles><title>Rhombencephalitis Caused by Listeria monocytogenes in Humans and Ruminants: A Zoonosis on the Rise?</title><secondary-title>Interdiscip Perspect Infect Dis</secondary-title><alt-title>Interdisciplinary perspectives on infectious diseases</alt-title></titles><periodical><full-title>Interdiscip Perspect Infect Dis</full-title><abbr-1>Interdisciplinary perspectives on infectious diseases</abbr-1></periodical><alt-periodical><full-title>Interdiscip Perspect Infect Dis</full-title><abbr-1>Interdisciplinary perspectives on infectious diseases</abbr-1></alt-periodical><pages>632513</pages><volume>2010</volume><edition>2010/03/06</edition><dates><year>2010</year></dates><isbn>1687-7098 (Electronic)
1687-708X (Linking)</isbn><accession-num>20204066</accession-num><urls><related-urls><url>;(6).The case fatality rate varies with underlying diseases. Neurological sequelae can occur ADDIN EN.CITE <EndNote><Cite><Author>Goulet</Author><Year>1996</Year><RecNum>103</RecNum><DisplayText>(10)</DisplayText><record><rec-number>103</rec-number><foreign-keys><key app="EN" db-id="9f55tddz1wdx2netsv25veadfevp9e5r5swv" timestamp="1428491875">103</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>Goulet, Veronique</author><author>Marchetti, Philippe</author></authors></contributors><titles><title>Listeriosis in 225 non-pregnant patients in 1992: clinical aspects and outcome in relation to predisposing conditions</title><secondary-title>Scandinavian journal of infectious diseases</secondary-title></titles><periodical><full-title>Scandinavian journal of infectious diseases</full-title></periodical><pages>367-374</pages><volume>28</volume><number>4</number><dates><year>1996</year></dates><isbn>0036-5548</isbn><urls></urls></record></Cite></EndNote>(10).Non-invasive listeriosis (food poisoning, also referred to as febrile listerial gastroenteritis) follows the consumption of food with exceptionally high levels of L. monocytogenes (>106cfu/g). It presents with vomiting and diarrhoea, sometimes progressing to bacteraemia but is usually self-resolving. Non-invasive listeriosis has been observed during a number of outbreaks and is characterised by a short incubation period ADDIN EN.CITE <EndNote><Cite><Author>Swaminathan</Author><Year>2007</Year><RecNum>102</RecNum><DisplayText>(11)</DisplayText><record><rec-number>102</rec-number><foreign-keys><key app="EN" db-id="9f55tddz1wdx2netsv25veadfevp9e5r5swv" timestamp="1428491472">102</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>Swaminathan, Bala</author><author>Gerner-Smidt, Peter</author></authors></contributors><titles><title>The epidemiology of human listeriosis</title><secondary-title>Microbes and Infection</secondary-title></titles><periodical><full-title>Microbes and Infection</full-title></periodical><pages>1236-1243</pages><volume>9</volume><number>10</number><dates><year>2007</year></dates><isbn>1286-4579</isbn><urls></urls></record></Cite></EndNote>(11). Individual cases of this form of listeriosis are not nationally notifiable.Persons at increased risk of diseaseThose at highest risk are generally the immunocompromised (by disease or treatment), elderly, pregnant, newborn and occasionally those who have certain chronic medical conditions (e.g. heart disease, diabetes, liver disease, renal disease, cancer, alcohol dependency) or are medicated (e.g. gastric acid inhibitors)PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5DaGF2YWRhPC9BdXRob3I+PFllYXI+MjAxNDwvWWVhcj48
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ADDIN EN.CITE.DATA (12-14).Disease occurrence and public health significanceAlthough invasive listeriosis is a relatively rare disease, the severity of the disease and the usual involvement of commercially manufactured foods, especially during outbreaks, mean that the social and economic impact of listeriosis is among the highest of the foodborne diseases ADDIN EN.CITE <EndNote><Cite><Author>World Health Organization</Author><Year>2004</Year><RecNum>7631</RecNum><DisplayText>(2)</DisplayText><record><rec-number>7631</rec-number><foreign-keys><key app="EN" db-id="vf2eve221fwdtme9pxspr9f9zz5ravx0zwar">7631</key></foreign-keys><ref-type name="Serial">57</ref-type><contributors><authors><author>World Health Organization,</author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Risk assessment of </style><style face="italic" font="default" size="100%">Listeria monocytogenes</style><style face="normal" font="default" size="100%"> in ready-to-eat foods. Technical report</style></title><tertiary-title>Microbiological Risk Assessment Series</tertiary-title></titles><volume>5</volume><dates><year>2004</year></dates><pub-location>Geneva</pub-location><publisher>World Health Organization</publisher><urls></urls></record></Cite></EndNote>(2). The clinical impact appears to be much less for non-invasive listeriosis (febrile gastroenteritis).Even though exposure to L. monocytogenes in food is probably relatively common ADDIN EN.CITE <EndNote><Cite><Author>Drevets</Author><Year>2008</Year><RecNum>105</RecNum><DisplayText>(15)</DisplayText><record><rec-number>105</rec-number><foreign-keys><key app="EN" db-id="9f55tddz1wdx2netsv25veadfevp9e5r5swv" timestamp="1428543490">105</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>Drevets, Douglas A</author><author>Bronze, Michael S</author></authors></contributors><titles><title>Listeria monocytogenes: epidemiology, human disease, and mechanisms of brain invasion</title><secondary-title>FEMS Immunology & Medical Microbiology</secondary-title></titles><periodical><full-title>FEMS Immunology & Medical Microbiology</full-title></periodical><pages>151-165</pages><volume>53</volume><number>2</number><dates><year>2008</year></dates><isbn>1574-695X</isbn><urls></urls></record></Cite></EndNote>(15), invasive listeriosis is an uncommon disease. In Australia, the five year mean (2011-2015) was 78 cases per year, with a notification rate of 0.3 per 100 000 population. Approximately equal numbers of cases were notified in males and females ADDIN EN.CITE <EndNote><Cite><Author>NNDSS</Author><Year>2015</Year><RecNum>108</RecNum><DisplayText>(16)</DisplayText><record><rec-number>108</rec-number><foreign-keys><key app="EN" db-id="9f55tddz1wdx2netsv25veadfevp9e5r5swv" timestamp="1428545225">108</key></foreign-keys><ref-type name="Web Page">12</ref-type><contributors><authors><author>NNDSS</author></authors><secondary-authors><author>Department of Health</author></secondary-authors></contributors><titles><title>Australia's National Notifiable Diseases Surveillance System (NNDSS) Summary Tables</title></titles><number>09/04/2015</number><dates><year>2015</year></dates><urls><related-urls><url>;(16).In the United States, among women of reproductive age (15–44 years), pregnant women had a markedly higher listeriosis risk than non-pregnant women ADDIN EN.CITE <EndNote><Cite><Author>Pouillot</Author><Year>2012</Year><RecNum>109</RecNum><DisplayText>(17)</DisplayText><record><rec-number>109</rec-number><foreign-keys><key app="EN" db-id="9f55tddz1wdx2netsv25veadfevp9e5r5swv" timestamp="1428545388">109</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>Pouillot, Régis</author><author>Hoelzer, Karin</author><author>Jackson, Kelly A</author><author>Henao, Olga L</author><author>Silk, Benjamin J</author></authors></contributors><titles><title>Relative risk of listeriosis in Foodborne Diseases Active Surveillance Network (FoodNet) sites according to age, pregnancy, and ethnicity</title><secondary-title>Clinical Infectious Diseases</secondary-title></titles><periodical><full-title>Clinical infectious diseases</full-title></periodical><pages>S405-S410</pages><volume>54</volume><number>suppl 5</number><dates><year>2012</year></dates><isbn>1058-4838</isbn><urls></urls></record></Cite></EndNote>(17). In Australia, there were 27 pregnancy-related cases between 2010 and 2014. There were 61 listeriosis-associated deaths in Australia between 2010 and 2014, comprising 51 adult and 10 fetal/neonatal deaths ADDIN EN.CITE <EndNote><Cite><Author>OzFoodNet</Author><Year>2015</Year><RecNum>150</RecNum><DisplayText>(18)</DisplayText><record><rec-number>150</rec-number><foreign-keys><key app="EN" db-id="t0erfewpvsr2d6eexw8xxpfla50vzpe5stfx">150</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>OzFoodNet</author></authors></contributors><titles><title>Listeriosis unpublished data</title></titles><dates><year>2015</year></dates><urls></urls></record></Cite></EndNote>(18).During recent years, the incidence of listeriosis in most countries has remained constant, with a number of countries reporting declines in the incidence of disease. These reductions likely reflect the efforts in those countries by industry( HYPERLINK \l "_ENREF_21" \o "Commission, 2007 #110" 21) and governments including:implementation of good hygienic practice and application of Hazard Analysis Critical Control Points (HACCP) principles to reduce the frequency and extent of L. monocytogenes in ready-to-eat (RTE) foods;improvement of the integrity of the cold chain through processing, distribution, retail and the home to reduce the incidence of temperature abuse conditions that foster the growth of L. monocytogenes; and,enhanced risk communication, particularly for pregnant women(20).Most cases of listeriosis are sporadic, but outbreaks occur. Listeriosis outbreaks recognised and reported in Australia since 2005 are summarised in Table 1.Table 1 Outbreaks of infection with Listeria monocytogenes reported by state/territory and year of onset of the first case, Australia, 2005-2013, OzFoodNet ADDIN EN.CITE <EndNote><Cite><Author>OzFoodNet</Author><Year>2015</Year><RecNum>150</RecNum><DisplayText>(18)</DisplayText><record><rec-number>150</rec-number><foreign-keys><key app="EN" db-id="t0erfewpvsr2d6eexw8xxpfla50vzpe5stfx">150</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>OzFoodNet</author></authors></contributors><titles><title>Listeriosis unpublished data</title></titles><dates><year>2015</year></dates><urls></urls></record></Cite></EndNote>(18)YearJurisdictionSetting where food was preparedInvasive CasesDeaths reported during the outbreak*Food implicated2005SAHospital53RTE meats: silverside-corned beef2009WARestaurant30Cooked chopped chicken2009MultijurisdictionalCommercially manufactured134Chicken wraps2010MultijurisdictionalPrimary produce92Melons2010VictoriaCommercially manufactured64Cold meat2012NSW/VictoriaCommercially manufactured31Smoked salmon suspected2012-2013MultijurisdictionalCommercially manufactured347 Cheese (brie/camembert)2013NSWCommercially manufactured31Profiteroles2013WACommercially manufactured30Pre-prepared frozen meals*deaths include fetal deaths3. Routine prevention activitiesThe main strategies for reducing exposure to L. monocytogenes are reducing contamination of food products and providing dietary recommendations to high risk groups to avoid potentially contaminated food. There is no evidence of acquired immunity ADDIN EN.CITE <EndNote><Cite><Year>2015</Year><RecNum>143</RecNum><DisplayText>(8)</DisplayText><record><rec-number>143</rec-number><foreign-keys><key app="EN" db-id="t0erfewpvsr2d6eexw8xxpfla50vzpe5stfx">143</key></foreign-keys><ref-type name="Edited Book">28</ref-type><contributors><authors><author>Heymann, D.L.</author></authors></contributors><titles><title>Control of Communicable Diseases Manual</title></titles><edition>20th</edition><dates><year>2015</year></dates><pub-location>Washington</pub-location><publisher>American Public Health Association</publisher><urls></urls></record></Cite></EndNote>(8) and no vaccine to prevent listeriosis.Reducing contamination of food productsA wide variety of foods may be contaminated with L. monocytogenes, but outbreaks and sporadic cases of listeriosis are predominantly associated with RTE foods ADDIN EN.CITE <EndNote><Cite><Author>World Health Organization</Author><Year>2004</Year><RecNum>7631</RecNum><DisplayText>(2)</DisplayText><record><rec-number>7631</rec-number><foreign-keys><key app="EN" db-id="vf2eve221fwdtme9pxspr9f9zz5ravx0zwar">7631</key></foreign-keys><ref-type name="Serial">57</ref-type><contributors><authors><author>World Health Organization,</author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Risk assessment of </style><style face="italic" font="default" size="100%">Listeria monocytogenes</style><style face="normal" font="default" size="100%"> in ready-to-eat foods. Technical report</style></title><tertiary-title>Microbiological Risk Assessment Series</tertiary-title></titles><volume>5</volume><dates><year>2004</year></dates><pub-location>Geneva</pub-location><publisher>World Health Organization</publisher><urls></urls></record></Cite></EndNote>(2). RTE foods include commercially manufactured foods that have a long recommended refrigerated shelf-life and fresh foods that are consumed without further bactericidal treatment, e.g. cooking. Five key factors contribute strongly to the risk of listeriosis associated with RTE foods:amount and frequency of consumption of a food;frequency and extent of contamination of a food with L. monocytogenes;ability of the food to support the growth of L. monocytogenes;temperature of refrigerated/chilled food storage; and,duration of refrigerated/chilled storage ADDIN EN.CITE <EndNote><Cite><Author>World Health Organization</Author><Year>2004</Year><RecNum>7631</RecNum><DisplayText>(2)</DisplayText><record><rec-number>7631</rec-number><foreign-keys><key app="EN" db-id="vf2eve221fwdtme9pxspr9f9zz5ravx0zwar">7631</key></foreign-keys><ref-type name="Serial">57</ref-type><contributors><authors><author>World Health Organization,</author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Risk assessment of </style><style face="italic" font="default" size="100%">Listeria monocytogenes</style><style face="normal" font="default" size="100%"> in ready-to-eat foods. Technical report</style></title><tertiary-title>Microbiological Risk Assessment Series</tertiary-title></titles><volume>5</volume><dates><year>2004</year></dates><pub-location>Geneva</pub-location><publisher>World Health Organization</publisher><urls></urls></record></Cite></EndNote>(2).Food Standards Australia New Zealand (FSANZ) has regard to the Codex Alimentarius Commission guidelines ADDIN EN.CITE <EndNote><Cite><Author>Codex</Author><Year>2007</Year><RecNum>110</RecNum><DisplayText>(19)</DisplayText><record><rec-number>110</rec-number><foreign-keys><key app="EN" db-id="9f55tddz1wdx2netsv25veadfevp9e5r5swv" timestamp="1428572430">110</key></foreign-keys><ref-type name="Government Document">46</ref-type><contributors><authors><author>Codex</author></authors><secondary-authors><author>Codex Alimentarius Commission</author></secondary-authors></contributors><titles><title>Guidelines on the application of general principles of food hygiene to the control of Listeria monocytogenes in foods</title><secondary-title>CAC/GL</secondary-title></titles><periodical><full-title>CAC/GL</full-title></periodical><pages>61-2007</pages><dates><year>2007</year></dates><urls></urls></record></Cite></EndNote>(19) in developing national standards for food processing controls. Regular testing programs for high risk foods to limit the maximum levels of L. monocytogenes in foods operate in Australian jurisdictions. Packaged RTE foods found to have an unacceptable level of contamination with L.?monocytogenes may be recalled from sale ADDIN EN.CITE <EndNote><Cite><Author>Food Standards Australia New Zealand</Author><Year>2012</Year><RecNum>151</RecNum><DisplayText>(20)</DisplayText><record><rec-number>151</rec-number><foreign-keys><key app="EN" db-id="t0erfewpvsr2d6eexw8xxpfla50vzpe5stfx">151</key></foreign-keys><ref-type name="Web Page">12</ref-type><contributors><authors><author>Food Standards Australia New Zealand,</author></authors></contributors><titles><title>Recall Guidelines for Ready-To-Eat foods</title></titles><dates><year>2012</year></dates><urls><related-urls><url>;(20).Local and State Government agencies responsible for the enforcement of the food safety standards regulate hygiene practices of food handlers in retail food establishments, including delicatessens and take away food premises, according to FSANZ Standards applied through jurisdictional Food Acts, to ensure the use of appropriate food handling and storage procedures ADDIN EN.CITE <EndNote><Cite><Author>Martin</Author><Year>2003</Year><RecNum>148</RecNum><DisplayText>(21)</DisplayText><record><rec-number>148</rec-number><foreign-keys><key app="EN" db-id="9f55tddz1wdx2netsv25veadfevp9e5r5swv" timestamp="1445483903">148</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>Martin, Tania</author><author>Dean, Elizabeth</author><author>Hardy, Brigid</author><author>Johnson, Tony</author><author>Jolly, Fiona</author><author>Matthews, Fiona</author><author>McKay, Ian</author><author>Souness, Richard</author><author>Williams, Jenny</author></authors></contributors><titles><title>A new era for food safety regulation in Australia</title><secondary-title>Food Control</secondary-title></titles><periodical><full-title>Food Control</full-title></periodical><pages>429-438</pages><volume>14</volume><number>6</number><dates><year>2003</year></dates><isbn>0956-7135</isbn><urls></urls></record></Cite></EndNote>(21). In the home, temperature control, limiting the length of storage periods and adequate cooking can mitigate increased risk of L. monocytogenes contamination ADDIN EN.CITE <EndNote><Cite><Author>Food Standards Australia New Zealand</Author><Year>2014</Year><RecNum>152</RecNum><DisplayText>(22)</DisplayText><record><rec-number>152</rec-number><foreign-keys><key app="EN" db-id="t0erfewpvsr2d6eexw8xxpfla50vzpe5stfx">152</key></foreign-keys><ref-type name="Web Page">12</ref-type><contributors><authors><author>Food Standards Australia New Zealand,</author></authors></contributors><titles><title><style face="italic" font="default" size="100%">Listeria</style><style face="normal" font="default" size="100%"> and food - advice for people at risk 2014</style></title></titles><dates><year>2014</year></dates><urls><related-urls><url> April 2015</custom2></record></Cite></EndNote>(22).Reducing exposure by provision of dietary recommendations to high risk groupsPeople in high risk groups for listeriosis should avoid high risk foods ADDIN EN.CITE <EndNote><Cite><Author>Food Standards Australia New Zealand</Author><Year>2014</Year><RecNum>152</RecNum><DisplayText>(22)</DisplayText><record><rec-number>152</rec-number><foreign-keys><key app="EN" db-id="t0erfewpvsr2d6eexw8xxpfla50vzpe5stfx">152</key></foreign-keys><ref-type name="Web Page">12</ref-type><contributors><authors><author>Food Standards Australia New Zealand,</author></authors></contributors><titles><title><style face="italic" font="default" size="100%">Listeria</style><style face="normal" font="default" size="100%"> and food - advice for people at risk 2014</style></title></titles><dates><year>2014</year></dates><urls><related-urls><url> April 2015</custom2></record></Cite></EndNote>(22), for example:cold meats: unpackaged ready-to-eat from delicatessen counters, sandwich bars, etc., and cold meats, packaged, sliced ready-to-eat;cold cooked chicken: purchased (whole, portions, or diced) ready-to-eat;pate: refrigerated pate or meat spreads;salads (fruit and vegetables): pre-prepared or pre-packaged salads e.g. from salad bars, smorgasbords, etc.;chilled seafood: raw (e.g. oysters, sashimi or sushi), smoked ready-to-eat, ready-to-eat peeled prawns (cooked) e.g. in prawn cocktails, sandwich fillings, and prawn salads;cheese: soft, semi soft and surface ripened cheeses (pre-packaged and delicatessen) e.g. brie, camembert, ricotta, feta and blue cheese;ice cream: soft serve; and,other dairy products: unpasteurised dairy products (e.g. raw milk).Dietary advice for people at risk of listeriosis can also be found at . Surveillance objectivesTo promptly investigate all cases.To detect clusters and outbreaks of disease, so as to enable prompt public health responses.To identify and control common sources of infection.To understand the local epidemiology of the disease to better inform prevention strategies.5. Data managementNotification dataDetails of confirmed cases should be entered on the jurisdictional Notifiable Disease Database using the jurisdictional notification form within 1 working day of notification.Patient-related interview dataAll cases or their next of kin are attempted to be interviewed. Once the case or next of kin has been interviewed, the local OzFoodNet epidemiologist enters enhanced surveillance data on the OzFoodNet NELSS database ADDIN EN.CITE <EndNote><Cite><Author>OzFoodNet</Author><Year>2012</Year><RecNum>113</RecNum><DisplayText>(23)</DisplayText><record><rec-number>113</rec-number><foreign-keys><key app="EN" db-id="9f55tddz1wdx2netsv25veadfevp9e5r5swv" timestamp="1428576103">113</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>OzFoodNet </author></authors></contributors><titles><title>Monitoring the incidence and causes of diseases potentially transmitted by food in Australia: Annual report of the OzFoodNet network, 2010</title><secondary-title>Communicable diseases intelligence quarterly report</secondary-title></titles><periodical><full-title>Communicable diseases intelligence quarterly report</full-title></periodical><pages>E213</pages><volume>36</volume><number>3</number><dates><year>2012</year></dates><isbn>1447-4514</isbn><urls></urls></record></Cite></EndNote>(23).Human isolates and their testing dataConfirm existence of a culture isolate and arrange transfer to jurisdictional reference laboratory for initial and further typing. Typing results should be added to NELSS by the local OzFoodNet epidemiologist as they become available.Food and food-related samples and isolate dataDuring an investigation consideration should be given to collecting samples of leftover food from cases. This is usually conducted by the local or state government environmental health officer. The results of any samples collected should be forwarded to the local OzFoodNet epidemiologist.Routine NELSS dataRoutine NELSS data is provided by jurisdictional PHUs and/or local OzFoodNet epidemiologists. OzFoodNet routinely analyses and disseminates this information on a fortnightly basis to OzFoodNet sites. Cases are also reported nationally to CDNA via OzFoodNet fortnightly surveillance reports.Multi-Jurisdictional Outbreak Investigation (MJOI) dataInvestigation data from a potential or declared MJOI are handled in accordance with the HYPERLINK "" OzFoodNet MJOI guidelines.6. CommunicationsImmediately post-notificationOn confirmation of a diagnosis of listeriosis, pathology laboratories and/or clinicians notify jurisdictions by urgent means, e.g. electronic laboratory notification or telephone, to the State/Territory communicable diseases branch (CDB).The jurisdiction should ensure that the treating doctor and local OzFoodNet epidemiologist are informed of the notification prior to case follow-up.OzFoodNet central routineOzFoodNet central disseminates a fortnightly summary, to stakeholders, with supplemental reports as needed. Cases are also reported nationally to CDNA via OzFoodNet fortnightly surveillance reports.Laboratory reportingLaboratory testing results should be communicated back to the investigating PHU and local OzFoodNet epidemiologist for inclusion on the NELSS database.MJOI under consideration or declaredThe OzFoodNet MJOI guidelines provide guidance around communications required during a MJOI.Suspect food under investigationWhen a specific food is suspected, jurisdictional food regulators need to be advised. National co-ordination of food recalls and subsequent communication is the responsibility of FSANZ. The National Food Incidence Response protocol exists to outline actions required by food regulators during investigations.International considerationsThe MJOI protocol includes guidance on when notification under the International Heath Regulations 2005 is required.7. Case definitionThe current case definition for listeriosis is:ReportingOnly confirmed cases should be notified. Where a mother and foetus (≥20 weeks gestation) /neonate are both confirmed, both cases should be notified. Confirmed caseA confirmed case requires either laboratory definitive evidence or clinical and epidemiological evidence.Laboratory definitive evidenceIsolation or detection of Listeria monocytogenes from a site that is normally sterile, including fetal gastrointestinal contents.Clinical evidence1.A fetus/neonate where the gestational outcome is one of the following:?Stillbirth ?Premature birth (<37 weeks gestation) ?Diagnosis (within the first month of life) with at least one of the following: ?Granulomatosis infantiseptica?Meningitis or meningoencephalitis?Septicaemia?Congenital pneumonia?Lesions on skin, mucosal membranes or conjunctivae?Respiratory distress and fever at birthANDIn the absence of another plausible diagnosisOR2.A mother has experienced at least one of the following conditions during pregnancy:?Fever of unknown origin?Influenza like illness?Meningitis or meningoencephalitis?Septicaemia?Localised infections such as arthritis, endocarditis and abscesses?Pre-term labour/abruption ANDIn the absence of another plausible diagnosisEpidemiological evidenceA maternal/fetal pair where one of either the mother or fetus/neonate is a confirmed case by laboratory definitive evidence (up to 2 weeks postpartum).Notes1.The clinical and epidemiological evidence criteria for a confirmed case means that if the mother is a confirmed case by laboratory definitive evidence, then the fetus/neonate is also a confirmed case if they have the defined (fetus/neonate) clinical evidence, and vice versa.2.Laboratory definitive evidence in a fetus <20 weeks gestation means the mother only is a confirmed case.Case definitions can be found on the Department of Health’s website.8. Laboratory testingCase confirmationListeria infection is confirmed when L. monocytogenes is identified, mostly by culture, from sterile sites (often cerebrospinal fluid or blood), foetus/neonate (including gastrointestinal contents) or associated products of conception (e.g. amniotic fluid, placental tissue).Listeria infection can also be identified by polymerase chain reaction (PCR) testing of specimens. Where listeriosis has been diagnosed using PCR, the sample should also be cultured to enable definitive characterisation of an isolate.L. monocytogenes is not routinely sought in stool from sporadic cases presenting with febrile diarrhoea (non-invasive listeriosis), nor in the stool of unaffected persons outside a specific investigation or cluster/outbreak.Serology is no longer used for the diagnosis of L. monocytogenes.Potential source detectionWhile non-culture methods for detection of Listeria spp. or L. monocytogenes in non-human samples (e.g. food and environmental) are often performed in routine testing, an isolate of L. monocytogenes should be sought as per the Australian Standard for food microbiology current at the time ADDIN EN.CITE <EndNote><Cite><Author>Standards Australia</Author><Year>2009</Year><RecNum>153</RecNum><DisplayText>(24)</DisplayText><record><rec-number>153</rec-number><foreign-keys><key app="EN" db-id="t0erfewpvsr2d6eexw8xxpfla50vzpe5stfx">153</key></foreign-keys><ref-type name="Report">27</ref-type><contributors><authors><author>Standards Australia,</author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Food microbiology - Method 24.1: Microbiology of food and animal feeding stuffs - Horizontal method for the detection and enumeration of </style><style face="italic" font="default" size="100%">Listeria monocytogenes</style><style face="normal" font="default" size="100%">—Detection method (ISO 11290-1:1996, MOD)</style></title></titles><dates><year>2009</year></dates><urls></urls></record></Cite></EndNote>(24).When an isolate is cultured from an epidemiologically implicated food or otherwise during a cluster/outbreak investigation, the L. monocytogenes therein should be enumerated as per the Australian Standard for food microbiology current at the time ADDIN EN.CITE <EndNote><Cite><Author>Standards Australia</Author><Year>1998</Year><RecNum>154</RecNum><DisplayText>(25)</DisplayText><record><rec-number>154</rec-number><foreign-keys><key app="EN" db-id="t0erfewpvsr2d6eexw8xxpfla50vzpe5stfx">154</key></foreign-keys><ref-type name="Report">27</ref-type><contributors><authors><author>Standards Australia,</author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Food microbiology - Method 24.2: Microbiology of food and animal feeding stuffs - Horizontal method for the detection and enumeration of </style><style face="italic" font="default" size="100%">Listeria monocytogenes</style><style face="normal" font="default" size="100%">—Enumeration method (ISO 11290-2:1998, MOD). Microbiology of food and animal feeding stuffs</style></title></titles><dates><year>1998</year></dates><urls></urls></record></Cite></EndNote>(25).Isolates of L. monocytogenes from relevant non-human detections e.g. implicated foods, recalled foods, samples taken for any purpose during an investigation, should be forwarded to the jurisdictional reference laboratory for further characterisation to help inform anism characterisationMethods of characterisation are evolving. There is a need for both rapid and definitive methods. Methods in use at any particular time will be decided by PHLN laboratories in consultation with OzFoodNet, jurisdictions and CDNA. All human L.?monocytogenes isolates are characterised as part of NELSS. Non-human L.?monocytogenes isolates should also be characterised.Current methods include molecular serotyping, binary typing, multi-locus variable number tandem repeat analysis, multi-locus sequence typing, pulsed field gel electrophoresis and phylogenetic relatedness based on whole genome sequencing. Classical serotyping is no longer widely used.Primary testing laboratories should refer isolates to jurisdictional public health laboratories for characterisation in a timely fashion.Cluster detection, investigation and source attributionClusters may become evident from notification details and/or isolate characterisation details as reported by the laboratory. Routine analysis of NELSS data helps identify listeria clusters based on organism characterisation.9. Case managementResponse timesThe case investigation should begin within 1 working day following the notification of a confirmed case.Response procedureCase investigationThe case investigation may be conducted by the PHU, CDB or local OzFoodNet, depending on the jurisdiction. The following actions should be plete the National OzFoodNet Listeria Case Questionnaire form ( REF _Ref441227084 \h \* MERGEFORMAT Appendix 3). This record covers:patient details;medical and diagnostic information;clinical history;environmental risk factors;potential food sources; and,comments and actions.Follow up of listeriosis cases can be particularly sensitive; cases may be deceased, and it is sometimes necessary to interview next of kin, or females who may have experienced a miscarriage or stillbirth.Confirm results of relevant pathology tests.Ensure clinical isolates are sent to the jurisdictional reference laboratory for typing.Ensure case interview information and typing results are entered on NELSSIf appropriate, secure any available residual suspected foods and refer to the jurisdictional food safety regulatory authority to arrange collection and testing.If cases were institutionalised (e.g. in hospital or aged care) for their entire incubation period, the food at the institution is the suspected source of infection. Refer environmental investigation of the institution to the local food safety regulatory authority. If the case was immunocompromised, check whether they had been placed on a ‘low listeria diet’ on admission.Assess the possibility of common source outbreaks if there is a cluster of cases.Maintain surveillance for further cases.Case treatmentAntibiotic treatment should be prescribed by the treating physician as per the Australian Therapeutic Guidelines – Antibiotic ADDIN EN.CITE <EndNote><Cite><Author>Anon</Author><Year>2014</Year><RecNum>135</RecNum><DisplayText>(26)</DisplayText><record><rec-number>135</rec-number><foreign-keys><key app="EN" db-id="9f55tddz1wdx2netsv25veadfevp9e5r5swv" timestamp="1433239659">135</key></foreign-keys><ref-type name="Book">6</ref-type><contributors><authors><author>Anon</author></authors><secondary-authors><author>Antibiotic Expert Groups</author></secondary-authors></contributors><titles><title>Therapeutic guidelines: antibiotic</title></titles><edition>Version 15</edition><dates><year>2014</year></dates><publisher>Melbourne: Therapeutic Guidelines Limited; 2014</publisher><isbn>9780992527211</isbn><urls><related-urls><url>;(26).EducationThe case or relevant care-giver should be provided with advice about the nature of the infection and the mode of transmission (refer to the listeriosis factsheets at REF _Ref441227094 \h \* MERGEFORMAT Appendix 1).Pregnant women and known immunocompromised persons should be educated about high risk foods and safe food handling and storage.Isolation and restrictionExclusion from childcare, preschool, school or work is not necessary.Active case findingActive case finding should be initiated if there is evidence of a cluster of cases or of common exposure to a suspect source. The local OzFoodNet epidemiologist should be alerted to any isolation of L. monocytogenes in food served to vulnerable populations (e.g. meals on wheels, aged care, hospitals). Refer also to Section REF _Ref443553371 \h \* MERGEFORMAT 12. Special situations.10. Environmental and Food evaluationL. monocytogenes is widely distributed in the environment and is frequently present in raw foods of both plant and animal origin. L. monocytogenes can survive and grow over a wide range of environmental conditions such as refrigeration temperatures (including the ability to survive freezing), low pH and high salt concentration and is resistant to a number of disinfectants, especially when organic matter is also present. It can remain viable in dry environments for long periods. 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ADDIN EN.CITE.DATA (27).Listeriosis is defined as a zoonosis, but direct transmission between ruminants and humans rarely occurs. In most cases of direct zoonotic transmission, the infections are non-life threatening cutaneous infections through contact with infected cattle or after handling of abortive material. However, ruminants, particularly cattle, contribute to amplification and dispersal of L. monocytogenes into the farm environment. Dairy farms and dairy processing facilities are frequently contaminated with L.?monocytogenes compared to other environments, and its subtype populations in the farm environment encompass commonly strains that have been associated with human illness, whether sporadic or epidemic ADDIN EN.CITE <EndNote><Cite><Author>Oevermann</Author><Year>2010</Year><RecNum>146</RecNum><DisplayText>(6)</DisplayText><record><rec-number>146</rec-number><foreign-keys><key app="EN" db-id="t0erfewpvsr2d6eexw8xxpfla50vzpe5stfx">146</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>Oevermann, A.</author><author>Zurbriggen, A.</author><author>Vandevelde, M.</author></authors></contributors><auth-address>Neurocenter, Department of Clinical Research and Veterinary Public Health, Vetsuisse Faculty, University of Bern, 3001 Bern, Switzerland.</auth-address><titles><title>Rhombencephalitis Caused by Listeria monocytogenes in Humans and Ruminants: A Zoonosis on the Rise?</title><secondary-title>Interdiscip Perspect Infect Dis</secondary-title><alt-title>Interdisciplinary perspectives on infectious diseases</alt-title></titles><periodical><full-title>Interdiscip Perspect Infect Dis</full-title><abbr-1>Interdisciplinary perspectives on infectious diseases</abbr-1></periodical><alt-periodical><full-title>Interdiscip Perspect Infect Dis</full-title><abbr-1>Interdisciplinary perspectives on infectious diseases</abbr-1></alt-periodical><pages>632513</pages><volume>2010</volume><edition>2010/03/06</edition><dates><year>2010</year></dates><isbn>1687-7098 (Electronic)
1687-708X (Linking)</isbn><accession-num>20204066</accession-num><urls><related-urls><url>;(6).Where a specific food has been identified as a suspected source, the premises where food was prepared and served should be investigated to determine the likelihood of disease transmission in that setting, and to ensure current food safety practices protect against contamination and infection. Leftover, implicated and related food should be forwarded to jurisdictional reference laboratories for testing, and environmental sampling should be considered.All L. monocytogenes isolates from foods subject to recalls should be forwarded to jurisdictional reference laboratories for further characterisation. L. monocytogenes isolated from foods implicated by cases should also be forwarded. A subset of jurisdictional food and environmental isolates should also be characterised on a regular basis.11. Contact managementIdentification of contactsPerson to person transmission does not usually occur, so identifying contacts is not usually relevant for listeriosis.Contact definitionNot usually applicable.ProphylaxisNot applicable.EducationNot applicable.Isolation and restrictionNot applicable.12. Special situationsCommunity OutbreaksWhen an outbreak of foodborne disease is identified, the CDB (PHU and/or OzFoodNet) and local or state government food safety regulatory authority work in partnership in investigating and controlling the outbreak and convene an outbreak control team. The CDB may undertake the epidemiological investigation and local or state government food safety regulatory authority may conduct environmental investigations, including traceback of implicated foods and sample collection and testing.Outbreak Situations:Jurisdictional outbreakIf two or more cases occur (other than maternal and fetal paired cases) that are epidemiologically linked e.g. common food source or common setting, or microbiologically linked (by typing), investigation should include the following:look for common source of infection;test any available suspected foods;characterisation of further related non-clinical L. monocytogenes isolates should be performed to confirm the outbreak and demonstrate whether case isolates and food isolates are indistinguishable;investigate the source of any foods found to be positive for L. monocytogenes to determine at what point they became contaminated;recall contaminated food if necessary through referral to food authorities;in some outbreak settings, active case finding and investigation of non-invasive listeriosis (such as acute febrile gastroenteritis) may be warranted; and,for non-invasive febrile gastroenteritis, the median incubation period is around 24 hours (range 6 hours – 10 days) ADDIN EN.CITE <EndNote><Cite><Author>Goulet</Author><Year>2013</Year><RecNum>101</RecNum><DisplayText>(9)</DisplayText><record><rec-number>101</rec-number><foreign-keys><key app="EN" db-id="9f55tddz1wdx2netsv25veadfevp9e5r5swv" timestamp="1428487249">101</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>Goulet, Véronique</author><author>King, Lisa A</author><author>Vaillant, Véronique</author><author>de Valk, Henriette</author></authors></contributors><titles><title>What is the incubation period for listeriosis?</title><secondary-title>BMC infectious diseases</secondary-title></titles><periodical><full-title>BMC infectious diseases</full-title></periodical><pages>11</pages><volume>13</volume><number>1</number><dates><year>2013</year></dates><isbn>1471-2334</isbn><urls></urls></record></Cite></EndNote>(9).Multi-jurisdictional outbreakWhen an outbreak is multi-jurisdictional as defined in the OzFoodNet MJOI guidelines, OzFoodNet, food safety officers and PHU/CDBs and jurisdictional reference laboratories of the relevant jurisdictions collaborate on the outbreak investigation. The investigation is conducted in accordance with the MJOI guidelines.Facilities such as hospitals, long term care facilities and aged care facilitiesA heightened level of concern is required for cases residing in a facility for all or part of their incubation period. Food served at the facility should be suspected until investigations determine otherwise. A single case in a facility may be sentinel for an outbreak and should trigger a thorough investigation of the source due to the vulnerability of facility populations, and be immediately reported to the facility’s manager and medical health officer. For hospitalised patients that are immunocompromised, determine whether the hospital has a ‘low listeria’ diet, and whether the case had been placed on such a diet when admitted. If the hospital does not have a ‘low listeria’ diet, discussions should be held with the hospital’s dietician, infection control and catering teams to implement such a diet and a mechanism for triaging patients into these diets when admitted.When an outbreak occurs in a facility, OzFoodNet, food safety regulatory officers, PHU/CDBs and reference laboratories of the relevant jurisdictions collaborate on the outbreak investigation in conjunction with the facility. Any epidemiologically implicated foods should be sampled and sent for laboratory testing.Vulnerable infant populationsIf a cluster of listeriosis associated with a susceptible infant population occurs, PHU/OzFoodNet staff should ensure that the facility’s infection control procedures are reviewed and an investigation conducted to determine the likelihood, place, source and means of disease transmission – which will most probably be other than via food.Cases among travellers on aeroplanesNot applicable13. References and additional sources of information ADDIN EN.REFLIST 1.Lamont RF, Sobel J, Mazaki-Tovi S, Kusanovic JP, Vaisbuch E, Kim SK, et al. Listeriosis in human pregnancy: a systematic review. J Perinat Med. 2011;39(3):227-36. Epub 2011/04/27.2.World Health Organization. Risk assessment of Listeria monocytogenes in ready-to-eat foods. Technical report. Geneva: World Health Organization; 2004.3.Ho JL, Shands KN, Friedland G, Eckind P, Fraser DW. An outbreak of type 4b Listeria monocytogenes infection involving patients from eight Boston hospitals. Archives of internal medicine. 1986;146(3):520-4. Epub 1986/03/01.4.Mu?oz P, Rojas L, Bunsow E, Saez E, Sánchez-Cambronero L, Alcalá L, et al. Listeriosis: An emerging public health problem especially among the elderly. Journal of Infection. 2012;64(1):19-33.5.Martins IS, Faria FC, Miguel MA, Dias MP, Cardoso FL, Magalhaes AC, et al. A cluster of Listeria monocytogenes infections in hospitalized adults. American journal of infection control. 2010;38(9):e31-6. Epub 2010/06/24.6.Oevermann A, Zurbriggen A, Vandevelde M. Rhombencephalitis Caused by Listeria monocytogenes in Humans and Ruminants: A Zoonosis on the Rise? Interdisciplinary perspectives on infectious diseases. 2010;2010:632513. Epub 2010/03/06.7.McLauchlin J. Human listeriosis in Britain, 1967-85, a summary of 722 cases. 2. Listeriosis in non-pregnant individuals, a changing pattern of infection and seasonal incidence. Epidemiology and infection. 1990;104(2):191-201. Epub 1990/04/01.8.Heymann DL, editor. Control of Communicable Diseases Manual. 20th ed. Washington: American Public Health Association; 2015.9.Goulet V, King LA, Vaillant V, de Valk H. What is the incubation period for listeriosis? BMC infectious diseases. 2013;13(1):11.10.Goulet V, Marchetti P. Listeriosis in 225 non-pregnant patients in 1992: clinical aspects and outcome in relation to predisposing conditions. Scandinavian journal of infectious diseases. 1996;28(4):367-74.11.Swaminathan B, Gerner-Smidt P. The epidemiology of human listeriosis. Microbes and Infection. 2007;9(10):1236-43.12.Chavada R, Keighley C, Quadri S, Asghari R, Hofmeyr A, Foo H. Uncommon manifestations of Listeria monocytogenes infection. BMC infectious diseases. 2014;14:641. Epub 2014/12/04.13.Ryser E, Marth E, editors. Listeria, Listeriosis, and Food Safety. 3rd ed: CRC Press; 2007.14.Dalton C, Merritt T, Unicomb L, Kirk M, Stafford R, Lalor K. A national case-control study of risk factors for listeriosis in Australia. Epidemiology and infection. 2011;139(03):437-45.15.Drevets DA, Bronze MS. Listeria monocytogenes: epidemiology, human disease, and mechanisms of brain invasion. FEMS Immunology & Medical Microbiology. 2008;53(2):151-65.16.NNDSS. Australia's National Notifiable Diseases Surveillance System (NNDSS) Summary Tables. 2015 [09/04/2015]; Available from: R, Hoelzer K, Jackson KA, Henao OL, Silk BJ. Relative risk of listeriosis in Foodborne Diseases Active Surveillance Network (FoodNet) sites according to age, pregnancy, and ethnicity. Clinical Infectious Diseases. 2012;54(suppl 5):S405-S10.18.OzFoodNet. Listeriosis unpublished data. 2015.19.Codex. Guidelines on the application of general principles of food hygiene to the control of Listeria monocytogenes in foods. In: Commission CA, editor. CAC/GL2007. p. 61-2007.20.Food Standards Australia New Zealand. Recall Guidelines for Ready-To-Eat foods. 2012; Available from: T, Dean E, Hardy B, Johnson T, Jolly F, Matthews F, et al. A new era for food safety regulation in Australia. Food Control. 2003;14(6):429-38.22.Food Standards Australia New Zealand. Listeria and food - advice for people at risk 2014. 2014; Available from: . Monitoring the incidence and causes of diseases potentially transmitted by food in Australia: Annual report of the OzFoodNet network, 2010. Communicable diseases intelligence quarterly report. 2012;36(3):E213.24.Standards Australia. Food microbiology - Method 24.1: Microbiology of food and animal feeding stuffs - Horizontal method for the detection and enumeration of Listeria monocytogenes—Detection method (ISO 11290-1:1996, MOD). 2009.25.Standards Australia. Food microbiology - Method 24.2: Microbiology of food and animal feeding stuffs - Horizontal method for the detection and enumeration of Listeria monocytogenes—Enumeration method (ISO 11290-2:1998, MOD). Microbiology of food and animal feeding stuffs. 1998.26.Anon. Therapeutic guidelines: antibiotic. Version 15 ed. Groups AE, editor: Melbourne: Therapeutic Guidelines Limited; 2014; 2014.27.Xayarath B, Freitag NE. Optimizing the balance between host and environmental survival skills: lessons learned from Listeria monocytogenes. Future microbiology. 2012;7(7):839-52. Epub 2012/07/26.14. AppendicesThe following documents are included in the appendices: REF _Ref441226569 \h \* MERGEFORMAT Appendix 1: Listeriosis factsheets REF _Ref441226570 \h \* MERGEFORMAT Appendix 2: Listeriosis Case Investigation Checklist REF _Ref441226572 \h \* MERGEFORMAT Appendix 3: Listeriosis Disease Investigation form15. Jurisdiction specific issuesNotification of Listeria isolations in food products to the respective health departments is only required by certain jurisdictions.Links to State and Territory Public Health Legislation and the National Health Security Act 2007.Appendix SEQ Appendix \* ARABIC 1: Listeriosis factsheetsFSANZ: .au/publications/Pages/listeriabrochuretext.aspxNSW: health..au/Infectious/factsheets/Factsheets/listeriosis.PDFWA: healthywa..au/Healthy-WA/Articles/J_M/Listeria-infectionQLD: conditions.health..au/HealthCondition/media/pdf/14/33/89/listeriosis-v2VIC: betterhealth..au/bhcv2/bhcarticles.nsf/pages/Food_poisoning_listeriaTAS: dhhs..au/peh/communicable_diseases_prevention_unit/infectious_diseases/listeriosisNT: health..au/library/scripts/objectifyMedia.aspx?file=pdf/45/21.pdf&siteID=1&str_title=Listeriosis.pdfSA: sahealth..au/wps/wcm/connect/public+content/sa+health+internet/health+topics/health+conditions+prevention+and+treatment/infectious+diseases/listeria+infectionACT: health..au/sites/default/files/Fact%20sheets/Listeriosis%20Fact%20Sheet%20%28October%202014%29.pdfAppendix SEQ Appendix \* ARABIC 2: Listeriosis Case Investigation ChecklistThings to be done include:Alwaysconfirm case complies with case definitionidentify isolating clinical laboratory and obtain a copy of positive reportscontact clinician, and interview case and other relevant parties using the National OzFoodNet Listeria Case Questionnaireensure clinical isolates are forwarded to jurisdictional reference laboratoryensure possibly implicated food and related isolates secured and forwarded to jurisdictional reference laboratoryenter case data onto jurisdictional notifiable diseases databasenotify local OzFoodNet epidemiologistassess the possibility of a cluster and of a common source outbreaksenter interview and isolate typing data on NELSSmaintain surveillance for further casesWhen indicatedOzFoodNetconsider and implement MJOI according to guidelinesOzFoodNet/Jurisdictionimplement investigation of food sourceonce a specific food source is suspected/identified, inform relevant food safety regulatory authorityarrange testing of any available suspected foodsfind the source of any foods found to be positive for L. monocytogenesLocal Government / Jurisdictional food safety regulatory authorityinspect premises, secure foods and associated samplessupport pursuing information regarding food source, including means of contaminationAppendix SEQ Appendix \* ARABIC 3: Listeriosis Disease Investigation formRefer to National OzFoodNet Listeria Case Questionnaire.(sites.site/outbreaktoolkit/products-services/generating-a-hypothesis ) ................
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