Nichole A - Zanvyl Krieger School of Arts and Sciences



Nichole A. Broderick

Johns Hopkins University

Zanvyl Krieger School of Arts & Sciences

Department of Biology

3400 N. Charles St, Mudd Hall 144, Baltimore, MD  21218

nbroder1@jhu.edu



EDUCATION & EXPERIENCE

1998 B.S., Genetics, University of Wisconsin, Madison WI

2001 M.S., Entomology and Plant Pathology, University of Wisconsin, Madison, WI

2009 Ph.D, Entomology and Microbiology, University of Wisconsin, Madison, WI

2007-2012 Postdoctoral Fellow, Ecole Polytechnique Federale de Lausanne, Switzerland

2013-2015 Associate and Lead Research Scientist, Yale University, New Haven, CT

2015-2020 Assistant Professor, University of Connecticut, Storrs, CT

2020-Present Assistant Professor, Johns Hopkins University, Baltimore, MD

HONORS & AWARDS

2000-2001 National Science Foundation K-Through-Infinity Fellow

2003-2004 P.E.O. Scholar, P.E.O. International

2006 President’s Prize, First Place, Entomological Society of America

2008-2012 Human Frontiers Science Program Long-term Postdoctoral Fellow

2020 Faculty Mentor Award, McNair & LSAMP Scholars Programs, University of Connecticut

PUBLICATIONS (*denotes equal contribution, #denotes corresponding author))

1. Broderick, NA, RM Goodman, KF Raffa, J Handelsman. 2000. Synergy between zwittermicin A and Bacillus thuringiensis subsp. kurstaki against gypsy moth (Lepidoptera: Lymantriidae). Environ Entomol 29:101-107.

2. Broderick, NA, RM Goodman, J Handelsman, KF Raffa. 2003. Effect of host diet and insect source on synergy of gypsy moth (Lepidoptera: Lymantriidae) mortality to Bacillus thuringiensis subsp. kurstaki by zwittermicin A. Environ Entomol 32: 387-391.

3. Broderick, NA#, KF Raffa, RM Goodman, J Handelsman. 2004. Census of the bacterial community of the gypsy moth larval midgut using culturing and culture-independent methods. Appl Environ Microbiol. 70: 293-300.

4. Lucas, D, N Broderick, R Lehrer, R Bohanan, 2005. Making the grounds of scientific inquiry visible in the classroom. Science Scope 29: 39-42.

5. Broderick, NA, KF Raffa, J Handelsman. 2006. Midgut bacteria required for Bacillus thuringiensis insecticidal activity. Proc Natl Acad Sci USA. 103: 15196-15199.

6. Allen, HK, KA Cloud-Hansen, JM Wolinski, C Guan, S Greene, S Lu, M Boeyink, NA Broderick, KF Raffa, J Handelsman. 2009. Resident microbiota of the gypsy moth midgut harbor antibiotic resistance determinants. DNA Cell Biol. 28: 109-117.

7. Broderick, NA, CJ Robinson, MD McMahon, J Holt, J Handelsman, KF Raffa. 2009. Contributions of gut bacteria to Bacillus thuringiensis induced mortality vary across a range of Lepidoptera. BMC Biol 7:11.

8. Buchon, N, NA Broderick, M Poidevin, S Pradervand, B Lemaitre. 2009. Host defense and stem cell proliferation in the gut of bacteria-infected Drosophila. Cell Host Microbe 5: 200-211.

9. Buchon, N, NA Broderick, S Chakrabarti, B Lemaitre. 2009. Invasive and indigenous microbiota impact intestinal stem cell activity through multiple pathways in Drosophila. Genes Dev 23:2333-2344.

10. Broderick, NA, DP Welchman, B Lemaitre. 2009. Recognition and response to microbial infection of Drosophila. In S. Reynolds and J. Rolff (eds.) Insect Infection and Immunity: evolution, ecology, and mechanisms. Oxford University Press

11. Broderick, NA, KF Raffa, J Handelsman. 2010. Chemical modulators of the innate immune response alter gypsy moth larval susceptibility to Bacillus thuringiensis. BMC Microbiol 10:129.

12. Broderick, NA, E Vasquez, J Handelsman, KF Raffa. 2010. Effect of clonal variation among hybrid poplars on susceptibility of gypsy moth (Lepidoptera: Lymantriidae) to Bacillus thuringiensis subsp. kurstaki. J Econ Entomol 103: 718-725.

13. Buchon, N*, NA Broderick*, T Kuraishi, B Lemaitre. 2010. Drosophila EGFR pathway coordinates stem cell proliferation and gut remodeling following infection. BMC Biol 22:152.

14. Broderick, NA*#, B Lemaitre*. Gut associated bacteria of Drosophila. 2012. Gut Microbes 3: 307-321.

15. Buchon, N*#, NA Broderick*#, B Lemaitre#. 2013. Gut homeostasis in a microbial world: insights from Drosophila melanogaster. Nature Rev Microbiol 11: 615–626.

16. Gendrin, M, A Zaidman-Rémy*, NA Broderick*, J Paredes*, M Poidevin, A Roussel, B Lemaitre. 2013. Functional analysis of PGRP-LA in Drosophila immunity. PLoS One 8: e69742.

17. Broderick, NA#, N Buchon, B Lemaitre. 2014. Microbiota-induced changes in Drosophila melanogaster gene expression and gut morphology. mBio 5(3):e01117-14.

18. Udikovic-Kolic*, N, F Wichmann*, NA Broderick, J Handelsman. 2014. Bloom of resident antibiotic resistant bacteria in soil following manure fertilization. Proc Natl Acad Sci. USA 111:15202-15207.

19. Holt, JF, MR Kiedrowski, KL Frank, J Du, C Guan, NA Broderick, GM Dunny, J Handelsman. 2015. Enterococcus faecalis 6-phosphogluconolactonase is required for both commensal and pathogenic interactions with Manduca sexta. Infect Immun 83:396-404

20. Broderick, NA# 2015. A common origin for digestion and immunity. Front Immunol 6:72

21. Stulberg E, GL Lozano, JB Morin, H Park, EG Baraban, C Mlot, C Heffelfinger, GM Phillips, JS Rush, AJ Phillips, NA Broderick, MG Thomas, EV Stabb, J Handelsman. 2016. Genomic and secondary metabolite analyses of Streptomyces sp. 2AW provide insight into the evolution of the cycloheximide pathway. Front Microbiol 7:573

22. Broderick, NA# 2016. Friend, foe or food? Recognition and the role of antimicrobial peptides in gut immunity and Drosophila–microbe interactions. Phil Trans R Soc B 371:20150295

23. Broderick NA. 2016. More wrinkles to Bt susceptibility. Virulence 7:853

24. Fischer CN, E Trautman, JM Crawford, EV Stabb, J Handelsman, NA Broderick#. 2017. Metabolite exchange within the microbiome influences Drosophila behavior. eLife 6:e18855

25. Benoit JB, A Vigneron, NA Broderick, Y Wu, S Aksoy, BL Weiss. 2017. Symbiont-induced odorant binding proteins mediate insect host hematopoiesis. eLife 6:e19535

26. Broderick NA# and A Casadevall#. 2017. Disequilibrium in gender ratios among authors who contributed equally. bioRxiv, 241554; published as ‘Meta-Research: Gender inequalities among authors who contributed equally’ 2019 eLife 8:e36399

27. Sivakumar R, J Ranjani, US Vishnu, S Jayashree, GL Lozano, J Miles, N Broderick, C Guan, P Gunasekaran, J Handelsman, J Rajendhran. 2018. Evaluation of InSeq to identify genes essential for Pseudomonas aeruginosa PGPR2 corn root colonization. bioRxiv, 377168; published G3: Genes, Genomes, Genetics 9: 651

28. Lozano GL, JI Bravo, MF Garavito Diago, HB Park, A Hurley, SB Peterson, EV Stabb, JM. Crawford, NA Broderick, J Handelsman. 2018. Introducing THOR, a model microbiome for genetic dissection of community behavior. bioRxiv, 499715; published mBio 10: e02846-18

29. Lozano GL, HB Park, JI Bravo, EA Armstrong, JM Denu, EV Stabb, NA Broderick, JM Crawford, J Handelsman. 2018. Bacterial analogs of plant piperidine alkaloids mediate microbial interactions in a rhizosphere model system. bioRxiv 499731, published (2019) Appl Environ Microbiol 85: e03058-18

30. MJ Mandel, NA Broderick, EC Martens, K Guillemin. 2019. Reports from a Healthy Community: the 7th Conference on Beneficial Microbes. Appl Environ Microbiol 85: e02562-18

31. GL Lozano, C Guan, Y Cao, BR Borlee, NA Broderick, EV Stabb, J Handelsman. 2019. A chemical counterpunch: Chromobacterium violaceum ATCC31532 produces violacein in response to translation-inhibiting antibiotics. bioRxiv, 589192

32. Derke RM, AJ Barron, IF Chaple, SE Lapi, NA Broderick, MJ Gray. RclA is a thermostable copper (II) reductase required for reactive chlorine resistance and host colonization in Escherichia coli. bioRxiv, 690669

33. Lesperance, DNA, NA Broderick. 2020. Meta-analysis of diets used in Drosophila microbiome research and introduction of the Drosophila Dietary Composition Calculator (DDCC). bioRxiv, 995936, published (2020) G3: Genes, Genomes, Genetics X:YY

34. Lesperance, DNA, NA Broderick. 2020. Microbiomes as modulators of Drosophila melanogaster homeostasis and disease. Curr Opin Insect Sci.

35. Lesperance, DNA, NA Broderick. 2020. Gut bacteria mediate nutrient availability in Drosophila diets. bioRxiv 2020.05.28.120832

36. Miles J, GL Betancourt, J Rajendhran, EV Stabb, NA Broderick#, J Handelsman#. Massively parallel mutant selection identifies genetic determinants of Pseudomonas aeruginosa colonization of Drosophila melanogaster. (in review, mSystems)

INVITED PRESENTATIONS (additional 7 selected talks, 13 poster presentations)

2002 Life at pH extremes: Microbial life in caterpillar guts and acid mine drainage. Gordon Research Conference-Microbial Stress, Newport, RI, USA

2005 The role of bacteria in gypsy moth susceptibility to Bacillus thuringiensis. Society for Industrial Microbiology Annual Meeting, Chicago, IL, USA

2007 From benign to insidious: role of midgut commensal bacteria in insect disease. Gordon Research Conference-Microbial Population Biology, Andover, NH, USA

2009 Bugs in bugs: What insects and their associated gut bacteria can teach us about host-microbe interactions. Beloit College- Department of Biology Seminar series, Beloit, WI, USA

2010 The microbiota of Drosophila as a model system for insect interactions with symbiotic microorganisms. Society for General Microbiology, Harrogate, England

2011 Impacts and interactions of benign and pathogenic microbes in the gut of Drosophila. FEMS 2011- 4th Congress of European Microbiologists, Geneva, Switzerland

2011 Benign and pathogenic microbes in the gut of Drosophila. University of Geneva- Centre of Excellence in Bacteriology Seminar series, Geneva, Switzerland

2011 Benign and pathogenic microbes in the Drosophila gut environment. Microorganisms facing their environment, Museum of Natural History, Paris, France

2013 The gut microbiome of insects: a moving target? NIH (DMID/NIAID) Workshop- Effect of Vector Innate Immunity and Human-Derived Immune Molecules on the Transmission of Vector-Borne Pathogens, Bethesda, MD, USA

2014 Host immunity as mediator: bidirectional interactions between Drosophila and its microbiota. American Society for Microbiology 114th General Meeting, Boston, MA, USA

2015 The role of Drosophila melanogaster gut microbiota in host health and disease. 3rd International Conference of Model Hosts. Chania, Greece

2015 The Small World Initiative: Crowdsourcing the Search for New Antibiotics. 50th Annual North East Branch Meeting, American Society for Microbiology, Randolph, MA, USA

2016 The Small World Initiative: current and future vision. Annual Meeting Microbiology Society, Liverpool, UK

2016 Drosophila melanogaster gut microbiota: emergent and dependent properties. Annual Meeting Microbiology Society, Liverpool, UK

2016 Engaging Future of Microbiome Research: The Small World Initiative. White House announcement National Microbiome Initiative, May 13, 2016. Washington D.C., USA

2016 Contributions of Drosophila gut microbiota to host health and disease states. The Allied Genetics Conference, Orlando, FL, USA

2016 Differing impacts of the microbiome on Drosophila lethality following bacterial infection. 6th ASM Conference on Beneficial Microbes, Seattle, WA, USA

2016 Gut, Immunity, Microbiota and the Problem of Universals. International Conference of Entomology, Orlando, FL, USA

2016 Invited Seminar: Providence College, Department of Biology, Providence, Rhode Island, USA; University of Indiana, Department of Biology Seminar Series, Bloomington, IN, USA

2017 Invited Seminar: Connecticut Agricultural Extension Service, New Haven, CT, USA; University of Michigan, Department of Microbiology and Immunology, Ann Arbor, MI, USA; Emory University, Department of Population Biology, Ecology and Evolution, Atlanta, GA, USA; UConn Health Center, Department of Molecular Biology and Biochemistry, Farmington, CT, USA. UConn Department of Nutritional Sciences, Storrs, CT.

2017 Probing immune and non-immune roles of AMPs in Drosophila melanogaster. GRC Antimicrobial Peptides, Ventura, CA USA

2017 Communicating Microbial Science to Society: Small World Initiative. FEMS 2017, Valencia, Spain

2017 Immunity at the interface of Drosophila melanogaster-microbiome interactions. Ecological Immunology Workshop 2017, Blossin, Germany.

2017 Intrinsic and Extrinsic Properties that Shape Drosophila-microbiota Interactions. 4th International Conference of Model Hosts. Rhodes, Greece

2018 Properties and Impacts of the Drosophila Microbiome. Keynote Speaker, Pioneer Valley Microbiology Symposium. Amherst, MA, USA.

2018 Invited Seminar: The Ohio State University, Department of Evolution, Ecology and Organismal Biology, Columbus, OH; Christian-Albrechts-Universitaet zu Kiel, Department of Evolutionary Ecology and Genetics, Kiel, Germany.

2019 Invited Seminar: University of Alabama-Birmingham, Dept of Microbiology, Birmingham, AL; Carnegie Institution, Carnegie Science Seminar Series, Baltimore MD; University of Massachusetts-Dartmouth, Department of Biology, Dartmouth, MA; Johns Hopkins University, Department of Biology, Baltimore, MD.

2019 ASM Microbe 2019 San Francisco, CA; 2019 Jacques Monod International Conference, Integrated Insect Immunology: Controlling Infections, Roscoff, France; 5th International Conference of Model Hosts, Chania, Crete.

TEACHING AND MENTORSHIP

Summer 1998 Mentored high school student Jason Ludden (Madison Metropolitan School District Research Internship Program).

Summer 1999 Mentored undergraduate Vieng Bounkeua (University of New Mexico; NSF REU).

2000-2002 K Through Infinity Fellow (NSF-GK12, 2000-2001) and Project Assistant (2001-2002), University of Wisconsin, Madison, WI. Project assistant to “Modeling Nature: A Route to Understanding Central Themes in Elementary and Middle School Science.” Project leaders: Drs. Rich Lehrer and Leona Schauble

Summer 2000 Project Kaleidoscope Fellow- PKAL Institute

2002 -2003 Teaching Assistant, Microbiology 526 & 527, Physiology of Microorganisms Laboratory, University of Wisconsin, Madison, WI

Fall 2004 Teaching Assistant, Zoology 152, Introductory Biology, University of Wisconsin, Madison, WI

2005-2006 HHMI Teaching Fellow, Symbiosis Summer Program, University of Wisconsin, Madison, WI. 2005: Mentored undergraduates Nicole Johnson (Xavier University of Louisiana; 2005), Matthew McMahon (UW-Madison; 2006.

2006-2007 Mentored high school student Eleanor Anderson (Madison Metropolitan School District Research Internship Program and Independent Study).

Summer 2008 Mentored undergradate Alice Tzeng (Harvard; EPFL International Summer Science Program).

Spring 2014 Lecturer, MCDB 123, Genes and Environment, Yale University, New Haven, CT

Spring 2015 Lecturer, MCDB 166, Microbes to Molecules, Yale University, New Haven, CT

2016-present Instructor, MCB 2612, Microbe Hunting: Crowdsourcing the discovery of new antibiotics, University of Connecticut, Storrs, CT

2016-present Mentoring graduate students: Alex Barron, Madison Condon, Rose Dziedzic, Danielle Lesperance; undergraduates: Glory Adekanye (MARC Scholar), Sandro Cloiseau (McNair Scholar), Samantha Huebner, Micheala Flore, Laura Nelson, Tasaya Northover, Michael Zhu (Holster Scholar ’18, IDEA grant ’18-’19). Staff: Marika David. Alumni: Elizabeth Bolte (MS 2018); Hanako Agresta, Kevin Burke, Kristin Burnham, Sthefany Calle, Jon Daniels, Jeremy Doucette (thesis), Paulina Henao, Alexa Friedman (McNair Scholar, thesis), Jonathan Stern, Sabrina Yum Chan (IDEA grant ‘18). Luoxuan Ouyang. Intern: Justine Mollier (France)

2017-present Instructor, MCB 3895-002, Host-Associated Microbiomes, University of Connecticut, Storrs, CT

PROFESSIONAL ACTIVITIES

2000-2006 Insect Ambassadors- Entomology Department UW-Madison

2000-2001 SyMBiosis Student assistant/facilitator

2006 Organising committee for SymSym: Symbiosis Symposium, Madison, WI

2006-2007 Student/PostDoc organizing committee Microbial Symbiosis UW-Madison

2011 co-chair FEMS 2011 Symposium- The gut microbiota: role in health and diseases

2015-2018 SWI Director of Science and Training, The Small World Initiative ()

2015-present Editorial Board member, Applied and Environmental Microbiology

2015-present Editorial Board member, Frontiers in Microbiology (Cellular and Infection Microbiology)

2015-present UConn MARS advisory board

2016-present Program Committee Member, Conference on Beneficial Microbes, co-Organizer 8th meeting (2020)

2016-present UConn SURF Review Committee

2016-2018 UConn Faculty Representative for CT Microbiome Initiative Working Group (UConn-Jax Genome Med-Yale)

2017 Faculty organizer, 6th Connecticut Symbiosis Symposium, Storrs, CT

2017-present Co-Director, UConn Microbiome Initiative, Provost Academic Plan Proposal

2018-present Director of Science & Training, Tiny Earth ()

2018-present Board of Directors, Skype a Scientist ()

2019 Session Co-Chair “Immunity and the microbiome”; 60th Annual Drosophila Research Conference, Dallas, TX

2019 Invited Participant, NSF Workshop “Deciphering the Microbiome: Empowering theory, cross-system analyses, and innovative analytics to propel advances in microbiome science”

Ad-hoc reviewer: Applied and Environmental Microbiology, Biology Letters, Biology Open, BMC Microbiology, CBE Life Sciences Education, Cell Death and Differentiation, Cell Host & Microbe, Cell Reports, Current Biology, Current Microbiology, Development, Developmental and Comparative Immunology, Ecological Entomology, FEBS, FEMS Microbiological Letters, FEMS Microbiology Ecology, Frontiers in Microbiology, Gut Microbes, Infection & Immunity, Journal of Chemical Ecology, Journal of Innate Immunity, Journal of Insect Physiology, JoVE, mBio, Microbial Ecology, Molecular Ecology, Molecular Evolution, Nature, Nature Communications, PNAS, PLOS One, PLOS Biology, PLOS Pathogens, Proceedings B Royal Society, Science Signaling, Virulence

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