Comparative Efficacy of (FRONTLINE Gold) and Sarolaner ...
Comparative Efficacy of fipronil/(S)-methoprene-pyriproxyfen (FRONTLINE? Gold) and Sarolaner (Simparica?) Against Induced Infestations of Ixodes scapularis on Dogs
Doug Carithers1 William Russell Everett2 Sheila Gross3 Jordan Crawford1
1Boehringer Ingelheim, 3239 Satellite Blvd, Duluth, GA 30096, USA 2BerTek, Inc., 104 Wilson Bottoms Rd, Greenbrier, AR 72058, USA 3Independent Statistician, Piscataway, NJ 08854, USA
KEY WORDS: Ixodes scapularis, deer tick, blacklegged tick, control, dogs, efficacy
ABSTRACT A study was performed to compare the 12-hour efficacy of FRONTLINE? Gold (fipronil/(S)-methoprene/pyriproxyfen) with that of SIMPARICA? (sarolaner) against Ixodes scapularis tick infestations on dogs. Based on pre-treatment tick count, 24 dogs were allocated to one of three groups, eight dogs in each group. On Day 0, each dog in Group B was treated with a dose of commercially available FRONTLINE Gold for Dogs appropriate for its weight, and each dog in Group C was treated with a dose of commercially available SIMPARICA appropriate for its weight. Group A dogs remained untreated throughout the duration of the study. On each of Days 1, 7, 14, 21, and 28, all dogs were infested with 50 live, unfed Ixodes scapularis ticks, and at 12 hours post-infestation on Days 2, 8, 15, 22, and 29, ticks were removed from all dogs and counted.
Using arithmetic means for all calculations, dogs treated with FRONTLINE Gold had significantly (p ................
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