Comparative Efficacy of Fipronil/(S)-Methoprene ...

Comparative Efficacy of Fipronil/(S)-Methoprene/Pyriproxyfen (FRONTLINE? Gold) and Sarolaner (SIMPARICA?) Against Ctenocephalides felis flea Infestations on Dogs

Doug Carithers1 William Russell Everett2 Sheila Gross3 Jordan Crawford1

1Boehringer Ingelheim, 3239 Satellite Blvd, Duluth, GA 30096, USA 2BerTek, Inc., 104 Wilson Bottoms Rd, Greenbrier, AR 72058, USA 3Independent Statistician, Piscataway, NJ 08854, USA

KEY WORDS: Ctenocephalides felis, fleas, cat fleas, flea control, dogs, efficacy.

ABSTRACT A study was performed to compare the 6-hour efficacy of FRONTLINE? Gold (fipronil/(S)-methoprene/pyriproxyfen) with that of SIMPARICA? (sarolaner) against Ctenocephalides felis flea infestations on dogs. Twenty-four dogs were allocated to one of three groups, eight dogs in each group. On Day 0, each dog in Group B was treated with a dose of commercially available FRONTLINE Gold for dogs appropriate for its weight, and each dog in Group C was treated with a dose of commercially available SIMPARICA appropriate for its weight. Group A dogs remained untreated throughout the duration of the study. On each of Days 1, 7, 14, 21, and 28, all dogs were infested with 100 live, unfed Ctenocephalides felis fleas, and 6 hours later, all fleas were removed and counted. Us-

ing arithmetic means for all calculations, dogs treated with FRONTLINE Gold had significantly (p ................
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