Diet, Exercise, NSAIDs, and Inclusion Body Myositis

Diet, Exercise, NSAIDs, and Inclusion Body Myositis

M. Paul Murphy

Associate Professor Molecular and Cellular Biochemistry & Sanders-Brown Center on Aging

University of Kentucky

What is AD?

Amyloid Precursor Protein and -Amyloid

sAPP-

A region sAPP-

Extracellular Intracellular

AICD

-secretase -secretase

C83 APP

-secretase

ACmoynlsotiidtuotgiveeniPcrPocroecsessinsgin(g~9(~01%0)%)

Adam Weidner

Is AD a loss of Repression on the A Producing Enzymes?

Normal Aging

Pathologic Aging

-Secretase

-Secretase

-Secretase

A

-Secretase

Healthy Brain

Alzheimer's Disease

Amyloid Pathology is Generic

AD (Plaque)

FTD (Tangle)

PD (Lewy Body)

HD (Nuclear Inclusion)

ALS (Cytoplasm Inclusion) CJD (PrPres Plaques)

Adapted from: Forman et. al., Nature Medicine, 10: 1055-63, 2004

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