1 - University of California, San Diego
Furosemide (not relevant) Ipratropium. Nifedipine (not relevant) Local anesthetics display a signifcantly reduced effect in inflammed tissue due to the acidic pH in that environment. Explain the molecular mechanism! (15) Local anaesthetics are weak bases with pKa 8-9 (only partially ionized at physiologic pH). ................
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