Complex Inheritence/Human Genetics Study Guide (Chapter 12)



Complex Inheritence/Human Genetics Study Guide (Chapter 12)

• Understand the following modes of inheritance, and examples of each:

1) Incomplete dominance

2) Codominance

3) Simple Recessive Inheritance

4) Simple Dominant Inheritance

5) X-linked traits

6) Multiple alleles

7) Polygenic Inheritance

*Know how to complete Punnett squares and determine probabilities for #1-#5.

• What diseases have both genetic and environmental factors that can cause them? What are the environmental factors?

• Expect problems concerning: snapdragons, blood types, Fruit Fly eye color, or any of the following diseases/conditions:

1) Hemophilia (A.K.A. Royal Hemophilia)

2) Cystic Fibrosis

3) Huntington’s Disease

4) Color Blindness

5) Sickle Cell Anemia

6) Down’s Syndrome

*Know the basic symptoms and modes of inheritance for all of the above

• What is nondisjunction? How is this related to Trisomy 21 (A.K.A. Down’s Syndrome)?

• Why is the trait for Sickle Cell so prevalent in African Americans? What is the link between Sickle Cell and Malaria?

• Which disease can be recognized by a karyotype?

• What is a pedigree? Be able to interpret a pedigree, including:

1) Male/Female, relationships of individuals using the Roman Numeral and number

2) Predict genotypes of individuals

3) Predict the mode of inheritance

4) Predict the probability of offspring genotypes

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