Page 1 of 10 BDS SECOND PROFESSIONAL EXAMINATION 2007 ...

Page 1 of 10

BDS SECOND PROFESSIONAL EXAMINATION 2007 PHARMACOLOGY AND DENTAL MATERIA MEDICA (MCQs)

Model Paper

Tot a l N o. of M CQs 4 5 Marks: 4 5

T im e 45 m inutes

Topic Spe cifica t ion: General Pharm acology ( MCQ 1 ? 3) Re fe r e n ce : Lippincot t 's Phar m acology, 3rd Ed.

0 1 . The steady - state concentration of a drug can be double by: a. Doubling the both rate of infusion and concentration of drug. b. Doubling the rate of infusion only. c. Doubling the loading dose but m aintaining the infusion rate. d. Tripling t he rat e of infusion. e. Duadrupling the rate of infusion. Key: b

0 2 . Phase I I reactions of a drug biotransform ation: a. Decreases its water solubility. b. I ncludes act ivit y of cyt ochrom P- 450. c. Usually leads t o inact ivat ion of t he drug. d. Does not include acetylation. e. Occur at t he sam e rat e in adult s and t he new born. Key: c

0 3 . Half- life of a drug m ay be helpful to determ ine: a. Dosage schedule of the drug. b. Level of absorpt ion. c. Distribution into different body system s. d. Rat e of absorpt ion t hrough GI T. e. Tim e t o get t he st eady st at e. Key: e

Topic Spe cifica t ion: Aut onom ic Nervous Syst em ( MCQ 4 ? 6)

Re fe r e n ce : Lippincot t 's Phar m acology, 3rd Ed.

0 4 . A 3 year old child has been adm itted to em ergency w ith suspicious of at ropine overdose as the re are: a. Abdom inal cram ps. b. I ncreased gastric secretion. c. I ncreased cardiac rate. d. Papillary const rict ion. e. I ncreased urinary frequency. Key: c

0 5 . Epinephrine does not ca use increa se concent ra t ions of: a. Glucose in blood. b. Lact at e in blood. c. Free fat t y acids in blood. d. cAMP in heart m uscle. e. Triglycerides in fat cells. Key: e

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BDS SECOND PROFESSIONAL EXAMINATION 2007 PHARMACOLOGY AND DENTAL MATERIA MEDICA (MCQs)

Model Paper

0 6 . A 5 0 year old patient is having propranolol due to his cardiac problem s but his physician now w ants to stop this drug; w hich of the follow ing is the m ost im portant reason for this step? a. Fam ilial t rem or. b. Part ial AV heart block. c. Mild hypert ension. d. Angina pectoris. e. Supraventricular t achycardias. Key: b

Topic Spe cifica t ion: Sedat ive - Hypnot ics/ Anxiolyt ics ( MCQ 7 ? 9)

Re fe r e n ce : Lippincot t 's Phar m acology, 3rd Ed.

0 7 . A young m an of 2 4 years is suffering from Generalized Anxiety Disorder; w hich drug m ay be preferred for his problem ? a. Zolpidem. b. Buspiron. c. Midazolam . d. Triazolam . e. Phenobarbit al. Key: b

0 8 . W hich of t he follow ing st at em ent s best describes t he m echanism of action of benzodiazepines? a. Benzodiazepines act ivat e GABAB- recept ors in t he spinal cord. b. They inhibit GABA- t ransam inase leading t o increased levels of GABA. c. They block glut am at e recept ors in hierarchical neuronal pat hways in the brain. d. Benzodiazepines increase t he frequency of Cl- - channels opening which are coupled t o GABAA recept ors. e. They are direct - act ing GABA recept or agonist s in t he CNS. Key: d

0 9 . W hich of the follow ing drugs w hen used for prolonge d period in t he m a int e na nce t r e a t m e nt of t onic- clonic seizures can lead to increased m etabolism of w arfarin like drugs? a. Phenobarbit al. b. Meprobam at e. c. Chlordiazepoxide. d. Triazolam . e. Zolpidum. Key: a

Topic Spe cifica t ion: Skelet al Muscle Relaxant s & Drug Act ing on CNS

( MCQ 10 ? 12)

Re fe r e n ce : Lippincot t 's Phar m acology, 3rd Ed.

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BDS SECOND PROFESSIONAL EXAMINATION 2007 PHARMACOLOGY AND DENTAL MATERIA MEDICA (MCQs)

Model Paper

1 0 . Cha r a ct e r ist ics of non- de pola r izing ne ur om uscula r block a de include w hich of the follow ing? a. Block of post- tetanic potentiation. b. Histam ine blocking action. c. Poorly sust ained t et anic t ension. d. Significant m uscle fasciculations during onset of block. e. Stim ulation of autonom ic ganglia. Key: c

1 1 . W hich of the follow ing drugs given preoperatively is used to prevent postoperative pain caused by succinylcholine? a. Dant rolene. b. Tubocurarine. c. Diazepam . d. Lidocaine. e. Baclofen. Key: b

1 2 . W ith prolonged use in seizure states, w hich of the follow ing drugs can cause coarsening of facial features, hirsutism , gingival hyperplasia and osteom alacia? a. Valproic acid. b. Carbam azepine. c. Et hosuxim ide. d. Phenyt oin. e. Gabapent in. Key: d

Topic Spe cifica t ion: Analgesics; NSAI DS ( MCQ 13 ? 15)

Re fe r e n ce : Lippincot t 's Phar m acology, 3rd Ed.

1 3 . Only Aspirin can: a. Reduce fever. b. I rreversible inhibit its target enzym e. c. Prevent episodes of gout y art hrit is wit h long t erm use. d. Reduce t he risk of colo n cancer. e. Select ively inhibit t he COX- 2 enzy m e. Key: b

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BDS SECOND PROFESSIONAL EXAMINATION 2007 PHARMACOLOGY AND DENTAL MATERIA MEDICA (MCQs)

Model Paper

1 4 . I ndom e t ha cin is pr e fe r r e d ove r Colchicine for Acut e At t a ck of Gout because it is: a. Less likely t o cause gast roint est inal bleeding. b. Less likely t o cause diarrhea. c. Less likely t o cause acut e renal failur e. d. More likely t o reduce inflam m at ion. e. More likely t o prevent furt her acut e at t acks. Key: b

1 5 . W hich of the follow ing drugs is used in the treatm ent of rheum atoid arthritis? a. Naproxen. b. Allopurinol. c. Colchicine. d. Sulfinpyrazone. e. Leflunom ide. Key: a

Topic Spe cifica t ion : Analgesics; Opioids ( MCQ 16 ? 18)

Re fe r e n ce : Lippincot t 's Phar m acology, 3rd Ed.

1 6 . The m ost dangerous adverse effect by using Fentanyl patches is: a. Diarrhea. b. Relaxat ion of respirat ory m uscles. c. Hypertension. d. Respirat ory depression. e. Skin reactions. Key: d

1 7 . Morphine should be used w ith extrem e caution in all of the follow ing conditions but not in: a. Biliary tract surgery. b. Pulm onary edem a. c. Last st age of labor. d. Hypothyroidism . e. Adrenal insufficiency. Key: b

1 8 . A 3 5 year old patient com plaining of severe pain a long the right side of the jaw and face; the best choice for this neuralgic pain is: a. Met hadone. b. I buprofen. c. Carbam azepine. d. Lorazepam . e. Am phetam ine. Key: c

Topic Spe cifica t ion: Local Anest het ics ( MCQ 19 ? 21)

Re fe r e n ce : Lippincot t 's Phar m acology, 3rd Ed.

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BDS SECOND PROFESSIONAL EXAMINATION 2007 PHARMACOLOGY AND DENTAL MATERIA MEDICA (MCQs)

Model Paper

1 9 . W hich of the follow ing local anesthetics is used exclusively for its good surface activity and low toxic potential: a. Cocaine. b. Benzocaine. c. Bupivacaine. d. Procaine. e. Lidocaine. Key: b

2 0 . W hich of the follow ing drugs can cause m ethem oglobinem ia w hen used in larger doses for regional anesthesia? a. Cocaine. b. Lidocaine. c. Bupivacaine. d. Procaine. e. Prilocaine. Key: e

2 1 . Epinephrine added t o a solut ion of lidocaine for local anesthesia w ill: a. Cause cyanosis locally. b. I ncrease the risk of convulsions. c. I ncrease the duration of local anest hesia. d. I ncrease the absorption of lidocaine. e. Decrease the heart rate when absorbed. Key: c

Topic Spe cifica t ion: General Anest het ics ( MCQ 22 ? 24)

Re fe r e n ce : Lippincot t 's Phar m acology, 3rd Ed.

2 2 . W hich of the follow ing inhalational anesthetic agents is having fastest onset of action? a. Nitric oxide. b. I soflurane. c. Nitrous oxide. d. Enflurane. e. Nitrogen dioxide. Key: c

2 3 . To attem pt reduction of a dislocated shoulder joint w hen Ketam ine is used alone it w ill ccause: a. Respirat ory depression. b. Skeletal m uscle rigidity. c. Hypotension. d. Bradycardia. e. Analgesia. Key: e

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