Glucocorticoid-related molecular signaling pathways ...
cortisol (11(-hydroxylase) Fludrocortisone Mineralocorticoid deficiency HTN, hypokalemia 10X affinity for MR than GR Spironolactone MR antagonist Mineralocorticoid excess Hyperkalemia, hyperchloremia High doses inhibit AR Calcium homeostasis Calcitriol 1,25-(OH)2-vit.D Vit.D-dependent rickets. Renal osteodystrophy. Psoriasis, leukemia ................
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