Fungi - Florida State College at Jacksonville
Human Genetics
This section will concentrate on human genetic diseases and some of the recent advances in biotechnology that will affect us in the future.
A) Web site name: Learn. Genetics
Web URL
Click on “Cystic Fibrosis”
1) Which chromosome has a defective gene that causes cystic fibrosis? _____
2) Which chemical does this protein help to move in and out of cells?
____________________________
3) Why do people with cystic fibrosis often suffer from poor nutrition? __________________________________________________________________________________________________________________________
4) How do doctors diagnose cystic fibrosis?
_____________________________________________________________
_____________________________________________________________
5) What are carriers of cystic fibrosis resistant to? _____________________________________________________________
6) How many Americans carry the cystic fibrosis gene? ________________
Click on “Single-gene disorders” at the top of the page, then click on “Sickle cell disease”
7) Which subunit of hemoglobin protein is affected by sickle cell disease? _____________________________________________________________ _____________________________________________________________
8) Which organ is “often destroyed” in these patients? __________________
9) List three symptoms of sickle cell disease:
_______________________________________________________________________________________________________________________________________________________________________________________
10) How is sickle cell disease treated in babies and young children?
_______________________________________________________________________________________________________________________________________________________________________________________
11) How long do sickle shaped blood cells last? _____________________
12) Apart from Africa, which other areas in the world have a high rate of sickle cell disease? _____________________________________________ _____________________________________________________________
Once a particular gene has been found, the only way to cure the genetic disease is through “gene therapy”: replacing the defective gene with the normal, correct gene.
B) Web site name: BBC News
Web URL:
Read “Bubble boy bounces back”
13) What did this rare inherited condition X-SCID do to Christopher? __________________________________________________________________________________________________________________________
14) What does SCID stand for? ______________________________________ _____________________________________________________________
15) Which chromosome does this disorder affect? ______________________
16) Why was he barred from seeing other youngsters? __________________________________________________________________________________________________________________________
17) How was the artificial gene inserted into his body?____________________ _____________________________________________________________
18) Is this treatment a complete cure? _________ Explain why: __________________________________________________________________________________________________________________________
19) Why will their unborn daughter not suffer from this disease? ____________
_____________________________________________________________
C) Web site name: University of Utah
Web URL:
Read “The History of cloning”
20) What did Hans Dreisch’s experiment with sea urchins show?
_____________________________________________________________
21) What animal’s eggs did Hans Spemann use in his experiments in 1928? ___________________________________
22) What animal was cloned by nuclear transfer in 1952? __________________
23) Why are eggs from mammals harder to manipulate than eggs of frogs or salamanders? __________________________________________________ __________________________________________________________________________________________________________________________
24) What big advance did Ian Wilmont and Keith Campbell make in cloning? ____________________________________________________________ _____________________________________________________________
_______________________________________________________________________________________________________________________________________________________________________________________
25) Which two endangered species were cloned in 2001? _______________________________________________
26) When was the first use of somatic cell nuclear transfer to produce an embryo as a source of stem cells? ______________
D) Web site name: BBC News
Web URL:
Read “Pig cloning race hots up”
27) What are the tissues or organs of these pigs designed, or engineered, for? ____________________________________________________________
28) Why are pigs good candidates for “xenotransplantation”?
____________________________________________________________
29) What problem could be caused by xenotransplantation? _____________________________________________________________
_____________________________________________________________
30) Which human disease are the PPL scientists hoping to cure? _____________________________________________________________
E) Web site name: BBC News
Web URL:
A new technique called “therapeutic cloning” involves taking a cell, like a skin cell, from a patient, putting its nucleus into the cytoplasm of an egg and then growing cells that are genetically identical to the patient. Unlike “reproductive cloning”, which would produce a baby, therapeutic cloning would only produce cells that would be put back into the patient’s own body.
Read the article “Scientists given cloning go-ahead”.
31). Which three diseases could therapeutic cloning be useful for treating?
_____________________________________________________________
32). How long will it be before patients could receive stem cells? ____________
33). Where do the eggs for therapeutic cloning come from?
_____________________________________________________________
34). What alternative does the pro-life group suggest?
_____________________________________________________________
35). What is the punishment for reproductive cloning?
_____________________________________________________________
36). Do you personally think that research in therapeutic cloning is a good idea?
Explain your answer: ___________________________________________
________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________
F) Web site name: Genetic science learning center
Web URL:
Read “Gene therapy successes”
37). Why did scientists end the first clinical trials treating SCID?
___________________________________________________________
38). Which three animal models show that gene therapy can slow or reverse
vision loss? _______________________________________________
39). Why is the eye a “convenient compartment” for gene therapy?
_________________________________________________________________________________________________________________________________________________________________________________________________
40). What is the name for the missing clotting protein in hemophilia?
___________________________________
41). How long after the gene therapy treatment is the patient with beta-
Thalassemia still doing well? ________________________
42). How many years do you think a treatment should be shown to work before
you say the patient is cured of the disease? Explain your answer.
_________________________________________________________________________________________________________________________________________________________________________________________________
43). What 3 modifications were made to T-VEC to make it a treatment for melanoma?
_________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________
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