Effect of adenosine 5`-triphosphate (ATP) challenge vs
Contrasting Effects of ATP and Adenosine on Capsaicin-induced Cough
in Asthmatic Patients
Ozen K. Basoglu, MD1, Amir Pelleg, PhD2, Sergei A. Kharitonov, MD3,
Peter J. Barnes, Master FCCP3
1Department of Chest Diseases, Ege University Faculty of Medicine, Izmir, Turkey
2Drexel University, College of Medicine, Department of Medicine, Philadelphia Pennsylvania, USA
3Airway Disease Section, National Heart and Lung Institute, Imperial College, London, UK
Correspondence:
Amir Pelleg, Ph.D.
Drexel University, College of Medicine
Department of Medicine
245 N 25th Street; NCB Mail stop #470
Philadelphia, PA 19102, USA
Tel: +1-215-762-1627
Fax: +1-215-762-7222
E-mail: apelleg@drexelmed.edu
ABBREVIATIONS
AMP: Adenosine 5’-monophosphate
ATP: Adenosine 5’-triphosphate
B/L: Baseline
C5: Geometric mean of capsaicin causing (5 coughs
COPD: Chronic obstructive pulmonary disease
FEV1: Volume exhaled during the first second of a forced expiration
FeNO: Fractional exhaled NO
NO: Nitric oxide
P: Purinergic
PD20: A dose causing a 20% decrease in FEV1
R: Receptor
RAR: Rapidly adapting receptors
SEM: Standard error of the mean
VAS: Visual analog scale
VCD: Verbal category descriptive
ABSTRACT
Adenosine 5’-triphosphate (ATP) stimulates vagal pulmonary C- and Aδ-fibers that mediate the cough reflex. Pulmonary C but not Aδ-fibers with rapidly adapting receptors (RAR) are also sensitive to capsaicin. The aim of our study was to investigate the effects of ATP and adenosine (given as adenosine 5’-monophosphate, AMP) on capsaicin-induced cough (quantified as visual analogue scale, VAS), dyspnea (quantified as Borg score) and exhaled nitric oxide (NO) in healthy non-smokers (age 40±4y, 6 males), smokers (45±4y, 5 males) and asthmatic patients (37±3y, 5 males); n=10 in each group. None of the healthy non-smokers responded to either ATP or AMP. The geometric mean of capsaicin causing (5 coughs (C5) increased from 134 to 203µM in non-smokers and from 117 to 287µM in asthmatics after AMP, whereas it decreased from 203 to 165µM and 125 to 88µM, respectively after ATP (p ................
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