Thickening of the Carotid Wall : A Marker for ...
[Pages:28]Thickening of the Carotid Wall : A Marker for Atherosclerosis in the Elderly? -- O'Leary et al. 27 (2): 224 -- Stroke
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(Stroke. 1996;27:224-231.) ? 1996 American Heart Association, Inc.
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Thickening of the Carotid Wall
A Marker for Atherosclerosis in the Elderly?
Daniel H. O'Leary, MD; Joseph F. Polak, MD; Richard A. Kronmal, PhD; Peter J. Savage, MD ; Nemat O. Borhani, MD; Steven J. Kittner, MD, MPH; Russell Tracy, PhD; Julius M. Gardin, MD ; Thomas R. Price, MD; Curt D. Furberg, MD, PhD for the Cardiovascular Health Study Collaborative Research Group
From the Department of Radiology, Tufts?New England Medical Center (D.H.O.), and the Department of Radiology, Brigham and Women's Hospital (J.F.P.), Boston, Mass; the Department of Biostatistics, University of Washington, Seattle, Wash (R.K., N.O.B.); the Department of Neurosurgery, University of Pittsburgh (Pa) (S.K.W.); the Division of Epidemiology and Clinical Applications, National Heart, Lung, and Blood Institute, Bethesda, Md (P.J.S.); the Department of Neurology, University of Maryland (Baltimore) (S.J.K., T.R.P.); the Department of Pathology, University of Vermont (Colchester) (R.T.); the University of California (Irvine) (J.M.G.); and the Department of Public Health Sciences, Bowman Gray School of Medicine, Winston-Salem, NC (C.D.F.).
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Correspondence to Daniel H. O'Leary, MD, Department of Radiology, New England Medical Center, 750 Washington St, Boston, MA 02111.
Abstract
(1 of 28)7/10/2007 3:44:53 PM
Thickening of the Carotid Wall : A Marker for Atherosclerosis in the Elderly? -- O'Leary et al. 27 (2): 224 -- Stroke
Background and Purpose We investigated the relationships between prevalent coronary heart disease (CHD), clinically manifest atherosclerotic disease (ASD), and major established risk factors for atherosclerosis and intima-media thickness (IMT) in the common carotid arteries (CCA) and internal carotid arteries (ICA) separately and in combination in older adults. We wished to determine whether a noninvasive measurement can serve as an indicator of clinically manifest atherosclerotic disease and to determine which of the two variables, CCA IMT or ICA IMT, is a better correlate.
Top Abstract Introduction Subjects and Methods Results Discussion References
Methods IMT of the CCA and ICA was measured with duplex ultrasound in 5117 of 5201 individuals enrolled in the Cardiovascular Health Study, a study of the risk factors and the natural history of cardiovascular disease in adults aged 65 years or more. Histories of CHD, peripheral arterial disease, and cerebrovascular disease were obtained during baseline examination. Risk factors included cholesterol levels, cigarette smoking, elevated blood pressure, diabetes, age, and sex. Relationships between risk factors and IMT were studied by multiple regression analysis and canonical variate analysis. Prediction of prevalent CHD and ASD by IMT measurements in CCAs and ICAs were made by logistic regression, adjusting for age and sex.
Results IMT measurements of the CCAs and ICAs were greater in persons with CHD and ASD than those without, even after controlling for sex (P ................
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