THE UNIVERSITY OF HONG KONG



THE UNIVERSITY OF HONG KONG

LI KA SHING FACULTY OF MEDICINE

Master of Research in Medicine (MRes[Med]) 2017-2018 – Research Topics

|Area & Topic of Research |Supervisor(s) |Department(s)/School(s) |

|Cancer | | |

|Biology of human mesenchymal stem cells |Professor GCF Chan |Paediatrics & Adolescent Medicine |

|Evaluate the efficacy and mechanisms of novel cytotoxic agents on |Professor GCF Chan |Paediatrics & Adolescent Medicine |

|neurogenic tumours | | |

|Genetic and cell biological studies of gynaecological diseases: |Professor ANY Cheung |Pathology |

|Exploration for molecular biomarkers of clinical use | | |

|Functional characterization of patient-derived aberrated genes in |Dr LWT Cheung |Biomedical Sciences |

|gynecological cancers | | |

|Elucidating the role of DEPDC1B in melanoma development |Dr MCH Cheung |Biomedical Sciences |

|Investigating the role of SoxE genes (Sox8, Sox9 and Sox10) in tumor |Dr MCH Cheung |Biomedical Sciences |

|metastatsis | | |

|Translational research in novel therapy for EBV-associated |Dr AKS Chiang |Paediatrics & Adolescent Medicine |

|lymphoproliferative diseases and epithelial cancers | | |

|Small Rho GTPases in cancer metastasis |Dr YP Ching |Biomedical Sciences |

|Molecular biology of gastric adenocarcinoma |Professor KM Chu |Surgery |

|Molecular biology of gastrointestinal stromal tumour (GIST) |Professor KM Chu |Surgery |

|Identification and characterization of metastatic associated genes in |Professor XY Guan |Clinical Oncology |

|gastric cancer | | |

|Molecular biology of endocrine-resistant breast cancer |Professor US Khoo |Pathology |

|The enigmatic epidemiology of nasopharyngeal carcinoma: decoding from the |Professor TH Lam |Public Health |

|molecular to the lifestyle level | | |

|Biomarkers and chemoresistance in esophageal squamous cell carcinoma |Professor SYK Law |Surgery |

|(ESCC) | | |

|In search for novel treatments for acute myeloid leukaemia |Professor AYH Leung |Medicine |

|Novel treatment approach for chemoresistant malignant glioma |Dr GKK Leung |Surgery |

|Identification of novel oncogenes and tumour suppressor genes involved in |Professor SY Leung |Pathology |

|gastrointestinal cancer development and stem cell regulation based on gene| | |

|expression profiling, chromosomal copy number profiling and epigenetic | | |

|studies in genomics scale | | |

|Novel therapies for liver cancer recurrence after transplantation |Professor CM Lo |Surgery |

| |Professor K Man | |

|Molecular signatures linked to graft injury and tumor recurrence after |Professor CM Lo |Surgery |

|liver transplantation |Professor K Man | |

|Genomics approaches to the study of inherited genetic susceptibility to |Professor ML Lung |Clinical Oncology |

|nasopharyngeal and esophageal carcinomas development and the study of | | |

|tumor suppressor genes (TSGs) contributing to cancer pathogenesis | | |

|Biomolecular studies in gynaecological cancers |Professor HYS Ngan |Obstetrics & Gynaecology |

| |Dr DW Chan | |

|Cellular and molecular biology of nasopharyngeal cancer |Professor GSW Tsao |Biomedical Sciences |

|Molecular basis of cell immortalization and malignant transformation |Professor GSW Tsao |Biomedical Sciences |

|Quantitative Radiomics in Predicting Cancer Outcomes incorporating Machine|Dr V Vardhanabhuti |Diagnostic Radiology |

|Learning | | |

|Deducing oncogenic pathways of lung cancer through integrated analysis of |Dr MP Wong |Pathology |

|next generation sequencing and GWAS data | | |

|Genome variations in the human 8q24 region and cancers |Dr MP Wong |Pathology |

|Study of caner stem cells as new targets of lung cancer therapy |Dr MP Wong |Pathology |

|Targeting ER-stress/Unfolded protein response as a means for annihilating |Dr NS Wong |Biomedical Sciences |

|cancer cells | | |

|Integrin-mediated signaling in cell adhesion, migration and invasion |Dr CH Yu |Biomedical Sciences |

|Heart, Brain, Hormone & Healthy Aging | | |

|Interventions for late-life depression |Dr WC Chan |Psychiatry |

|Adult--born neurons re-open plasticity of neural circuitry for rescuing |Professor YS Chan |Biomedical Sciences |

|dysfunctions in spatial cognition | | |

|Impact of neural plasticity on motor learning and spatial navigation |Professor YS Chan |Biomedical Sciences |

|Molecular signaling of neuronal death in neurodegenerative diseases |Dr RCC Chang |Biomedical Sciences |

|Neuroprotective effects of Chinese medicine in neurodegenerative diseases |Dr RCC Chang |Biomedical Sciences |

|Early intervention for psychosis |Professor EYH Chen |Psychiatry |

|Effects of ketamine in post-operative pain, side effects, inflammation and|Dr CW Cheung |Anaesthesiology |

|oedema and chronic pain after bilateral third molar surgery under general | | |

|anaesthesia | | |

|Functional brain mapping using high resolution electroencephalography |Professor RTF Cheung |Medicine |

|Neuroprotection in rodent stroke models |Professor RTF Cheung |Medicine |

|Novel 4-dimensional Echocardiographic Evaluation of Cardiac Function in |Professor YF Cheung |Paediatrics & Adolescent Medicine |

|Children with Congenital and Acquired Heart Diseases | | |

|Mood and sleep disorders |Dr KF Chung |Psychiatry |

|Pathogenesis of stroke |Professor SK Chung |Biomedical Sciences |

|Pathogenesis of diabetic neuropathy |Professor SK Chung |Biomedical Sciences |

|Molecular mechanisms of dementia associated with aging-related diseases, |Professor SK Chung |Biomedical Sciences |

|Alzheimer’s and Multi-infarct | | |

|Pathogenesis of diabetic retinopathy |Professor SK Chung |Biomedical Sciences |

|Molecular basis of neuronal mitochondria functions in normal aging and |Dr PWL Ho |Medicine |

|Parkinson’s disease using in vitro and in vivo experimental models |Professor SL Ho | |

|The pathogenesis of depression and the antidepressant effects of NMDA |Dr CSW Lai |Biomedical Sciences |

|receptor antagonist ketamine in animal depression model | | |

|A knock-in strategy to study protein localization and transport in human |Dr KO Lai |Biomedical Sciences |

|neuron through genome editing | | |

|Investigating the regulatory role of protein arginine methylation in |Dr KO Lai |Biomedical Sciences |

|dendritic spine development in neurons | | |

|Assessment of cardiovascular risk in patients with inflammatory rheumatic |Professor CS Lau |Medicine |

|diseases | | |

|Cytoskeletal regulation in axonal growth and guidance |Dr CW Lee |Biomedical Sciences |

|Deep brain stimulation in experimental animal models of dementia |Dr LW Lim |Biomedical Sciences |

|Effects of social enrichment on stress resilience and vulnerability |Dr LW Lim |Biomedical Sciences |

|Fear attenuation by electrical stimulation of the medial prefrontal cortex|Dr LW Lim |Biomedical Sciences |

|Cell-based intraocular drug delivery system |Dr ACY Lo |Ophthalmology |

|Neuroprotection in retinal and cerebral ischemia/reperfusion injury |Dr ACY Lo |Ophthalmology |

|Pathogenesis of retinopathy of prematurity |Dr ACY Lo |Ophthalmology |

|Structural Brain Connectivity Networks in Stroke and Neurodegenerative |Dr HKF Mak |Diagnostic Radiology |

|Patients |Dr ES Hui | |

|Perioperative coagulation problems |Professor JKF Ng |Anaesthesiology |

|Fibrosis, cirrhosis and steatosis in chronic liver disease |Dr WK Seto |Medicine |

|A Study on the Effect of Fluctuating Intraocular Pressure on Retinal |Dr KC Shih |Ophthalmology |

|Ganglion Cell Function and Survival |Dr JWY Lee | |

| |Dr ACY Lo | |

| |Professor JSM Lai | |

|Evaluation of optic nerve damage in non-glaucoma and glaucoma subjects |Dr KC Shih |Ophthalmology |

|undergoing hemodialysis |Professor JSM Lai | |

|The Development of a Novel Intra-arterial Mesenchymal Stem Cell Delivery |Dr KC Shih |Ophthalmology |

|System for Retinal Neuroprotection |Dr ACY Lo | |

| |Professor DSH Wong | |

|Modulating protease activity in chronic lung inflammation |Professor DKY Shum |Biomedical Sciences |

| |Professor MSM Ip |Medicine |

|The role of prostaglandin E2 in metabolism |Dr EHC Tang |Pharmacology & Pharmacy |

|1. Circulating stem cells in cardiovascular medicine |Professor HF Tse |Medicine |

|2. Outcome prediction of cardiac arrhythmias |Dr CW Siu | |

|3. Heart and hormones | | |

|4. Vascular function and diet | | |

|5. Genetic basic of cardiac arrhythmias and cardiomyopathy | | |

|6. Cardiac stem cell therapy | | |

|7. Modeling of heart disease with stem cell | | |

|Vascular protective functions of the anti-aging protein SIRT1 |Dr Y Wang |Pharmacology & Pharmacy |

| |Professor PMGR Vanhoutte | |

|Child neurology (Autism) |Professor VCN Wong |Paediatrics & Adolescent Medicine |

|Adipokines as diagnostic markers and therapeutic targets for |Professor AM Xu |Medicine |

|cardiovascular complications of obesity and diabetes |Professor PMGR Vanhoutte |Pharmacology & Pharmacy |

|Predictors of adverse events following valvular heart surgery: Chinese |Dr KH Yiu |Medicine |

|Valvular Heart Disease Study | | |

|Infection and Immunology | | |

|The effects of beta-glucans on human immune system |Professor GCF Chan |Paediatrics & Adolescent Medicine |

|AIDS Vaccine and Immunological Cure of HIV Infection |Professor ZW Chen |AIDS Institute |

|Basic immunology and immunotherapeutic approaches for Epstein-Barr virus |Dr AKS Chiang |Paediatrics & Adolescent Medicine |

|(EBV)-associated diseases | | |

|Mechanisms underlying the dichotomous functional activities of IL-33 on |Dr FP Huang |Pathology |

|Th1 versus Th2 responses in the presence or absence of IL-10 | | |

|Molecular basis of hepatitis B virus cccDNA transcription and maintenance |Professor DY Jin |Biomedical Sciences |

|Molecular mechanism of Epstein-Barr virus persistence and transformation |Professor DY Jin |Biomedical Sciences |

|Molecular pathogenesis of emerging human viral pathogen: viral |Professor DY Jin |Biomedical Sciences |

|perturbation of innate immune response | | |

|Development of a novel disease activity state criterion for systemic lupus|Professor CS Lau |Medicine |

|erythematosus (SLE) | | |

|Validation of clinical and radiological assessment of spondyloarthritis |Professor CS Lau |Medicine |

|- Susceptibility genes in SLE |Professor YL Lau |Paediatrics & Adolescent Medicine |

|- Primary immunodeficiencies | | |

|Lymphopoiesis and apoptosis in the development of autoimmune diseases |Professor LW Lu |Pathology |

|Study on the anti-viral effect of amantadine modified drug in cell model |Dr KP Mok |Public Health |

|Characterization of host factors involved in virus infections |Dr S Sanyal |Public Health |

|Targeting deubiquitylases as therapeutic strategies against viral |Dr S Sanyal |Public Health |

|infections | | |

|Development of Nucleic Acid Aptamers for Therapeutics and Diagnostics |Dr JA Tanner |Biomedical Sciences |

|Viral infection and cellular stress response mechanisms |Dr NS Wong |Biomedical Sciences |

|Novel pathogen discovery and microbial genomics |Professor PCY Woo |Microbiology |

|Public Health | | |

|Understanding healthcare decisions in mental health |Dr WC Chan |Psychiatry |

|Cognitive neuropsychology and psychopathology of psychotic disorders |Professor EYH Chen |Psychiatry |

|Treatment burden in primary care patients with multi-morbidity |Dr WY Chin |Family Medicine and Primary Care |

|Epidemiology and prognostic factors for peptic ulcer perforation |Professor KM Chu |Surgery |

|Communicable disease and environmental risk perception |Professor R Fielding |Public Health |

|Environmental health risk factors in Hong Kong |Professor R Fielding |Public Health |

|Psychosocial aspects of cancer care |Professor R Fielding |Public Health |

| |Dr WWT Lam | |

|Exercise for children with special needs |Dr SM Fong |Public Health |

|Obesity and physical activity in students |Dr DSY Ho |Public Health |

|Health, health-related quality of life and primary care services |Professor CLK Lam |Family Medicine & Primary Care |

|utilization of low-income families | | |

|Promotion of exercise and healthy eating in the Hong Kong Family Project |Professor TH Lam |Public Health |

|Lifestyle, lifecourse and molecularepidemiology study in Guangzhou |Professor TH Lam |Public Health |

| |Dr CQ Jiang | |

|Tobacco and alcohol control in Hong Kong and China Mainland |Professor TH Lam |Public Health |

|Knowledge, attitudes and practices of primary care doctors towards |Professor TP Lam |Family Medicine and Primary Care |

|antibiotic use and resistance in Hong Kong | | |

|The enablers and barriers of the public to comply with infection control |Professor TP Lam |Family Medicine and Primary Care |

|measures for influenza pandemic in Hong Kong | | |

|Use of digital data for disease surveillance |Dr EHY Lau |Public Health |

|FAMILY Cohort: Exploring factors related to Health, Happiness and/or |Dr MY Ni |Public Health |

|Harmony |Dr H Pang | |

| |Professor TH Lam | |

| |Professor GM Leung | |

|Novel Spinal Imaging Studies in Humans |Dr D Samartzis |Orthopaedics & Traumatology |

|Clinical Studies in Spine Imaging and Pain |Dr D Samartzis |Orthopaedics & Traumatology |

| |Dr JPY Cheung | |

|Epidemiology and Risk Factors of Chronic Low Back Pain |Dr D Samartzis |Orthopaedics & Traumatology |

| |Dr JPY Cheung | |

|3D Imaging Analyses of Spine Degeneration |Dr D Samartzis |Orthopaedics & Traumatology |

| |Dr JPY Cheung | |

| |Professor KMC Cheung | |

|Biomarker Discovery of Spine Degeneration and Low Back Pain |Dr D Samartzis |Orthopaedics & Traumatology |

| |Dr JPY Cheung | |

| |Professor KMC Cheung | |

|Body Fat, Spine Degeneration and Low Back Pain |Dr D Samartzis |Orthopaedics & Traumatology |

| |Dr VYL Leung | |

|Life course influences on health |Dr CM Schooling |Public Health |

|Promotion of respiratory health by improving awareness of environmental |Dr LW Tian |Public Health |

|exposure to air toxics among school children |Dr DKM Ip | |

|Public health effects of air pollution on mortality and admissions to |Dr LW Tian |Public Health |

|hospitals |Dr TQ Thach | |

|How to plan and implement chlamydia screening in Hong Kong? |Dr WCW Wong |Family Medicien and Primary Care |

|Reproduction, Development and Growth | | |

|Biology of human mesenchymal stem cells (hMSCs) |Professor GCF Chan |Paediatrics & Adolescent Medicine |

|Genetic manipulation in vivo and in vitro to study neuron function |Dr SY Chan |Paediatrics & Adolescent Medicine |

|Developmental studies on mouse mutants with inner ear defects |Professor KSE Cheah |Biomedical Sciences |

|Molecular control of neuromesodermal progenitors |Professor KSE Cheah |Biomedical Sciences |

|Role of Sox2 in regulation the stemness of dermal precursors |Professor KSE Cheah |Biomedical Sciences |

|The molecular basis of skeletal dysphasia caused by mutations in Sox9 |Professor KSE Cheah |Biomedical Sciences |

|Intervertebral disc regeneration by allogenic mesenchymal stem cells |Professor KMC Cheung |Orthopaedics & Traumatology |

| |Professor D Chan |Biomedical Sciences |

| |Dr VYL Leung | |

|Analysis of human genetic mutations in patients with growth disorders |Dr PT Cheung |Paediatrics & Adolescent Medicine |

| |Professor LCK Low | |

|Whole exome sequencing in Paediatric Rare Diseases |Dr BHY Chung |Paediatrics & Adolescent Medicine |

|Oviductal Secretory Proteins on Embryo Development |Dr CKF Lee |Obstetrics & Gynaecology |

| |Professor WSB Yeung | |

|Zebrafish model of human leukaemia |Professor AYH Leung |Medicine |

|Live-cell Imaging analysis of abnormal cell migration in enteric nervous |Professor MH Sham |Biomedical Sciences |

|system disorder | | |

|Genetic analysis of complex diseases |Professor PC Sham |Psychiatry |

| |Dr S Cherny | |

|Identifying susceptibility genes for degenerative disc disease and |Dr YQ Song |Biomedical Sciences |

|scoliosis |Professor KMC Cheung |Orthopaedics & Traumatology |

| |Professor KDK Luk | |

|Developmental biology, genetics and pathology of Hirschsprung’s disease |Professor PKH Tam |Surgery |

|and related neural crest disorders |Dr VCH Lui | |

| |Dr MM Garcia-Barcelo | |

|Molecular basis of anorectal malformations |Professor PKH Tam |Surgery |

| |Dr MM Garcia-Barcelo | |

|Development of Nucleic Acid Aptamers for Therapeutics and Diagnostics |Dr JA Tanner |Biomedical Sciences |

|Roles of microRNAs in endometrial cells during implantation |Professor WSB Yeung |Obstetrics & Gynaecology |

|Stem Cell & Regenerative Medicine |

|Modeling Monogenic Vascular Diseases with Human induced pluripotent stem |Professor KR Boheler |Biomedical Sciences |

|cells | | |

|Surfaceome studies of human induced pluripotent stem cell derived |Professor KR Boheler |Biomedical Sciences |

|cardiomyocytes | | |

|Regenerate motor neurons from spinal cord stem cells |Professor MH Sham |Biomedical Sciences |

|Stem cell-based therapy for post-traumatic regeneration of peripheral and |Professor DKY Shum |Biomedical Sciences |

|central nervous systems |Professor YS Chan | |

|Survival and regeneration of CNS neurons after spinal cord and peripheral |Professor WT Wu |Biomedical Sciences |

|nerve injury | | |

|Contribution of stem cell maintenance to aging |Professor ZJ Zhou |Biomedical Sciences |

|Stem cell decline in SIRT6 deficient aging mice |Professor ZJ Zhou |Biomedical Sciences |

|Others | | |

|Pathogenic mechanisms of fibrosis in the kidney and other organs |Professor TM Chan |Medicine |

| |Dr S Yung | |

|Immuno-pathogenetic mechanisms in kidney disease of systemic lupus |Professor TM Chan |Medicine |

|erythematous |Dr S Yung | |

|Developing the gene-knockdown epithelial model for the airway infection |Dr JH Chen |Biomedical Sciences |

|study | | |

|A retrospective study to assess the safety of postoperative acute pain |Dr CW Cheung |Anaesthesiology |

|service: change over the last decade | | |

|A comparison of patient-controlled propofol sedation with |Dr CW Cheung |Anaesthesiology |

|patient-controlled propofol and ketamine sedation |Professor MG Irwin | |

|School screening for scoliosis |Dr J Cheung |Orthopaedics & Traumatology |

| |Dr D Samartzis | |

|Clinical studies in chronic low back pain |Professor KMC Cheung |Orthopaedics & Traumatology |

| |Professor KDK Luk | |

| Next generation sequencing of Epstein-Barr virus genomes in cancer |Dr AKS Chiang |Paediatrics & Adolescent Medicine |

|tissues and saliva | | |

|Clinical electrophysiology in orthopaedics |Dr Y Hu |Orthopaedics & Traumatology |

|Intraoperative spinal evoked potential monitoring |Dr Y Hu |Orthopaedics & Traumatology |

|Biomechanical testing of new hand implants and prosthesis |Dr WY Ip |Orthopaedics & Traumatology |

|Motion analysis and electromyography of upper limb in neurological |Dr WY Ip |Orthopaedics & Traumatology |

|conditions | | |

|Propofol Keo |Professor MG Irwin |Anaesthesiology |

| |Dr GTC Wong | |

|The investigation of RNAi therapy against infectious diseases: from drug |Dr JKW Lam |Pharmacology & Pharmacy |

|delivery aspects | | |

|Neuroprotection for brain injury |Dr GKK Leung |Surgery |

|Bone cement and biomaterial application |Professor WW Lu |Orthopaedics & Traumatology |

|Bone Nano structure and Nano Biomechanics |Professor WW Lu |Orthopaedics & Traumatology |

|Screening of natural products or Chinese herbal medicines in the |Dr JCW Mak |Medicine |

|management of cigarette smoke-induced lung injury using an animal model | | |

|Generation of patient specific induced pluripotent stem cell (iPSC) from |Professor PKH Tam |Surgery |

|patient with Hirschsprung’s (HSCR) disease |Dr ESW Ngan | |

|The effects of an alpha 2 receptor agonist on perioperative renal function|Dr GTC Wong |Anaesthesiology |

| |Professor MG Irwin | |

|Analysis of cardiac glycoside content of native HKSAR Strophanthus species|Dr AJ Worsley |Pharmacology & Pharmacy |

|Analysis of Tuliposide content of Tulipa genus, and subsequent contact |Dr AJ Worsley |Pharmacology & Pharmacy |

|allergen properties | | |

|Quantification of quality and quantification of active constituents in |Dr AJ Worsley |Pharmacology & Pharmacy |

|several Traditional Chinese medicines purchased in HKSAR | | |

|Analysis of genomic data for clinical diagnosis and personalized treatment|Dr WL Yang |Paediatrics & Adolescent Medicine |

| |Professor YL Lau | |

|Chemical and optogentical approaches to investigate cellular |Dr CH Yu |Biomedical Sciences |

|phosphatidylinositol biogenesis | | |

March 13, 2017

VC/KL/es

C:\MRes[Med]\17-18\Research Areas or Topics\List of Research Topics 17-18 Final 3.doc

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