Template for Electronic Submission to ACS Journals
An unexploited dimension: new software for mixture analysis by 3D diffusion-ordered NMR spectroscopyGuilherme Dal Poggetto*, Laura Casta?ar, Mohammadali Foroozandeh, Peter Kiraly, Ralph W. Adams, Gareth A. Morris and Mathias Nilsson*School of Chemistry, University of Manchester, Oxford Road, Manchester M13 9PL, United Kingdom46755051714500ABSTRACT: 3D DOSY experiments have the potential to provide unique and valuable information but are underused, in part due to the lack of efficient processing software. Here we illustrate the power of 3D DOSY and present MAGNATE (Multidimensional Analysis for the GNAT Environment), an open-source and free software package for the analysis of pulsed field gradient (PFG) 3D NMR diffusion data, distributed under the GNU General Public Licence. The new software makes it possible for the first time to efficiently analyse and visualise 3D diffusion (e.g. 3D HSQC-DOSY) data using both univariate (e.g. DOSY) and multivariate methods (e.g. OUTSCORE) in a user-friendly graphical interface. The software can be used either independently, or as a module in the GNAT programme.Diffusion NMR is a powerful technique for the study of intact mixtures, providing valuable information about both relative and absolute sizes of, and interactions between, species.PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5TdGlsYnM8L0F1dGhvcj48WWVhcj4xOTgxPC9ZZWFyPjxS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ADDIN EN.CITE PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5TdGlsYnM8L0F1dGhvcj48WWVhcj4xOTgxPC9ZZWFyPjxS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ADDIN EN.CITE.DATA 1-9 (The general term “Diffusion NMR” is used here in preference to common terms such as PGSE and DOSY, which refer only to specific subsets of NMR methods for the study of diffusion). A typical experiment consists of a series of 1D (e.g. 1H) spectra recorded using a pulsed field gradient (PFG) spin or stimulated echo. ADDIN EN.CITE <EndNote><Cite><Author>Pelta</Author><Year>1998</Year><RecNum>252</RecNum><DisplayText><style face="superscript">10</style></DisplayText><record><rec-number>252</rec-number><foreign-keys><key app="EN" db-id="w5vd92dtlwexxmespva5fve7eswpaswp0rfa" timestamp="1529936764">252</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>Pelta, M. D.</author><author>Barjat, H.</author><author>Morris, G. A.</author><author>Davis, A. L.</author><author>Hammond, S. J.</author></authors></contributors><titles><title>"Pulse sequences for high-resolution diffusion-ordered spectroscopy (HR-DOSY)"</title><secondary-title>Magn. Reson. Chem.</secondary-title></titles><periodical><full-title>Magn. Reson. Chem.</full-title></periodical><pages>706-714</pages><volume>36</volume><number>10</number><section>706</section><dates><year>1998</year></dates><urls></urls></record></Cite></EndNote>10 The diffusion coefficient (D) is measured by fitting the net signal attenuation (S(g)) as a function of gradient strength (g) to the Stejskal-Tanner equation: ADDIN EN.CITE <EndNote><Cite><Author>Stejskal</Author><Year>1965</Year><RecNum>117</RecNum><DisplayText><style face="superscript">11</style></DisplayText><record><rec-number>117</rec-number><foreign-keys><key app="EN" db-id="w5vd92dtlwexxmespva5fve7eswpaswp0rfa" timestamp="1461335805">117</key><key app="ENWeb" db-id="">0</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>Stejskal, E. O.</author><author>Tanner, J. E.</author></authors></contributors><titles><title>"Spin Diffusion Measurements: Spin Echoes in the Presence of a Time-Dependent Field Gradient"</title><secondary-title>J. Chem. Phys.</secondary-title></titles><periodical><full-title>J. Chem. Phys.</full-title></periodical><pages>288-292</pages><volume>42</volume><number>1</number><section>288</section><dates><year>1965</year></dates><isbn>00219606</isbn><urls></urls><electronic-resource-num>10.1063/1.1695690</electronic-resource-num></record></Cite></EndNote>11S(g)=S0 e-(D γ2 δ2 g2 ?') (1)where S0 is the signal amplitude (or signal integral) at zero gradient, γ is the magnetogyric ratio of the analysed nucleus, δ is the gradient pulse duration, and ?' is the time between the midpoints of the defocusing and refocusing periods less a small correction for diffusion during the gradient pulses.The most useful presentation of such data is arguably a pseudo-2D spectrum, in which the indirect dimension is the diffusion coefficient (Figure 1). This processing method is referred to as Diffusion-Ordered SpectroscopY (DOSY). ADDIN EN.CITE <EndNote><Cite><Author>Morris</Author><Year>1993</Year><RecNum>170</RecNum><DisplayText><style face="superscript">12-13</style></DisplayText><record><rec-number>170</rec-number><foreign-keys><key app="EN" db-id="w5vd92dtlwexxmespva5fve7eswpaswp0rfa" timestamp="1529936757">170</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>Morris, K. F.</author><author>Johnson Jr, C. S.</author></authors></contributors><titles><title>"Resolution of Discrete and Continuous Molecular Size Distributions by Means of Diffusion-Ordered 2D NMR Spectroscopy"</title><secondary-title>J. Am. Chem. Soc.</secondary-title></titles><periodical><full-title>J. Am. Chem. Soc.</full-title></periodical><pages>4291-4299</pages><volume>115</volume><number>10</number><section>4291</section><dates><year>1993</year></dates><urls></urls></record></Cite><Cite><Author>Morris</Author><Year>2009</Year><RecNum>171</RecNum><record><rec-number>171</rec-number><foreign-keys><key app="EN" db-id="w5vd92dtlwexxmespva5fve7eswpaswp0rfa" timestamp="1529936757">171</key></foreign-keys><ref-type name="Book Section">5</ref-type><contributors><authors><author>Morris, G. A.</author></authors></contributors><titles><title>"Diffusion-Ordered Spectroscopy"</title><secondary-title><style face="italic" font="default" size="100%">eMagRes</style></secondary-title></titles><periodical><full-title>eMagRes</full-title></periodical><dates><year>2009</year></dates><urls><related-urls><url> In liquid state NMR, at high fields, the High-Resolution DOSY (HR-DOSY) ADDIN EN.CITE <EndNote><Cite><Author>Barjat</Author><Year>1995</Year><RecNum>172</RecNum><DisplayText><style face="superscript">2</style></DisplayText><record><rec-number>172</rec-number><foreign-keys><key app="EN" db-id="w5vd92dtlwexxmespva5fve7eswpaswp0rfa" timestamp="1529936757">172</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>Barjat, H.</author><author>Morris, G. A.</author><author>Smart, S.</author><author>Swanson, A. G.</author><author>Williams, S. C. R.</author></authors></contributors><titles><title>"High-Resolution Diffusion-Ordered 2D Spectroscopy (HR-DOSY) - A New Tool for the Analysis of Complex Mixtures"</title><secondary-title>J. Magn. Reson. Series B</secondary-title></titles><periodical><full-title>J. Magn. Reson. Series B</full-title></periodical><pages>170-172</pages><volume>108</volume><number>2</number><section>170</section><dates><year>1995</year></dates><urls></urls></record></Cite></EndNote>2 approach is commonly used to determine the number, and physical properties, of molecular species in a mixture. In HR-DOSY, every signal in the 1D spectrum is fitted to an appropriate form of the mono-exponential Stejskal-Tanner equation (Equation 1), implicitly assuming that any individual signal derives only from one species.PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5Db25uZWxsPC9BdXRob3I+PFllYXI+MjAwOTwvWWVhcj48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ADDIN EN.CITE PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5Db25uZWxsPC9BdXRob3I+PFllYXI+MjAwOTwvWWVhcj48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ADDIN EN.CITE.DATA 14-15 The DOSY spectrum is then constructed with a Gaussian shaped signal in the diffusion dimension, centred on the diffusion coefficient and with a width reflecting the fitting uncertainty. DOSY is commonly used to identify signals from distinct components in a mixture. Provided that the species in solution show different diffusion coefficients, this works very well when there is no signal overlap in the spectrum. When signals do overlap, however, as is common (especially for 1H NMR), the HR-DOSY assumption breaks down. The fitted diffusion coefficient is now a compromise between those of the species that contribute to the signal fitted, making useful interpretation of the DOSY spectrum difficult, or even impossible. An example of a 2D DOSY spectrum for a system showing significant overlap in the proton spectrum is given in Figure 1, presenting data obtained from a mixture of five different vitamin B species.Figure 1. 2D DOSY plot for a mixture of five B vitamins (biotin B7, pyridoxine hydrochloride B6, pantothenic acid calcium complex B5, niacin B3, and thiamine hydrochloride B1), in DMSO-d6, obtained using the Oneshot pulse sequence. ADDIN EN.CITE <EndNote><Cite><Author>Pelta</Author><Year>2002</Year><RecNum>73</RecNum><DisplayText><style face="superscript">16</style></DisplayText><record><rec-number>73</rec-number><foreign-keys><key app="EN" db-id="w5vd92dtlwexxmespva5fve7eswpaswp0rfa" timestamp="1461153509">73</key><key app="ENWeb" db-id="">0</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>Pelta, M. D.</author><author>Morris, G. A.</author><author>Stchedroff, M. J.</author><author>Hammond, S. J.</author></authors></contributors><titles><title>"A one-shot sequence for high-resolution diffusion-ordered spectroscopy"</title><secondary-title>Magn. Reson. Chem.</secondary-title></titles><periodical><full-title>Magn. Reson. Chem.</full-title></periodical><pages>147-152</pages><volume>40</volume><number>13</number><section>147</section><dates><year>2002</year></dates><isbn>0749-1581
1097-458X</isbn><urls></urls><electronic-resource-num>10.1002/mrc.1107</electronic-resource-num></record></Cite></EndNote>16 Here it is impossible, due to spectral overlap, to determine unambiguously how many species are present in the mixture. Advanced processing methods can restore interpretability, but they typically require both a difference in diffusion coefficient of 30% or more, and very high quality experimental data.PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5OaWxzc29uPC9BdXRob3I+PFllYXI+MjAwNjwvWWVhcj48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ADDIN EN.CITE PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5OaWxzc29uPC9BdXRob3I+PFllYXI+MjAwNjwvWWVhcj48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ADDIN EN.CITE.DATA 17-18 A more desirable solution, by far, is to eliminate spectral overlap so that the HR-DOSY assumption holds. An increase in field strength is an obvious (if expensive) solution to the signal overlap problem, but even with bottomless coffers this cannot provide better than a factor of 2 improvement over a standard 500 MHz spectrometer. Fortunately, we are not limited to simple 1H NMR as the base experiment; diffusion encoding can be added to virtually any NMR experiment, of arbitrary dimensionality. The use of nuclei with sparse spectra (such as 19F,PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5EYWwgUG9nZ2V0dG88L0F1dGhvcj48WWVhcj4yMDE0PC9Z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 EN.CITE PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5EYWwgUG9nZ2V0dG88L0F1dGhvcj48WWVhcj4yMDE0PC9Z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 EN.CITE.DATA 19-21 31P,PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5LYWdhbjwvQXV0aG9yPjxZZWFyPjIwMDk8L1llYXI+PFJl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ADDIN EN.CITE PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5LYWdhbjwvQXV0aG9yPjxZZWFyPjIwMDk8L1llYXI+PFJl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ADDIN EN.CITE.DATA 22-23 or 13C,PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5XdTwvQXV0aG9yPjxZZWFyPjE5OTY8L1llYXI+PFJlY051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ADDIN EN.CITE PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5XdTwvQXV0aG9yPjxZZWFyPjE5OTY8L1llYXI+PFJlY051
bT4xODE8L1JlY051bT48RGlzcGxheVRleHQ+PHN0eWxlIGZhY2U9InN1cGVyc2NyaXB0Ij4yNC0y
NTwvc3R5bGU+PC9EaXNwbGF5VGV4dD48cmVjb3JkPjxyZWMtbnVtYmVyPjE4MTwvcmVjLW51bWJl
cj48Zm9yZWlnbi1rZXlzPjxrZXkgYXBwPSJFTiIgZGItaWQ9Inc1dmQ5MmR0bHdleHhtZXNwdmE1
ZnZlN2Vzd3Bhc3dwMHJmYSIgdGltZXN0YW1wPSIxNTI5OTM2NzU4Ij4xODE8L2tleT48L2ZvcmVp
Z24ta2V5cz48cmVmLXR5cGUgbmFtZT0iSm91cm5hbCBBcnRpY2xlIj4xNzwvcmVmLXR5cGU+PGNv
bnRyaWJ1dG9ycz48YXV0aG9ycz48YXV0aG9yPld1LCBELjwvYXV0aG9yPjxhdXRob3I+Q2hlbiwg
QS48L2F1dGhvcj48YXV0aG9yPkpvaG5zb24gSnIsIEMuIFMuPC9hdXRob3I+PC9hdXRob3JzPjwv
Y29udHJpYnV0b3JzPjx0aXRsZXM+PHRpdGxlPiZxdW90O0hldGVyb251Y2xlYXItRGV0ZWN0ZWQg
RGlmZnVzaW9uLU9yZGVyZWQgTk1SIFNwZWN0cm9zY29weSB0aHJvdWdoIENvaGVyZW5jZSBUcmFu
c2ZlciZxdW90OzwvdGl0bGU+PHNlY29uZGFyeS10aXRsZT5KLiBNYWduLiBSZXNvbi4gU2VyaWVz
IEE8L3NlY29uZGFyeS10aXRsZT48L3RpdGxlcz48cGVyaW9kaWNhbD48ZnVsbC10aXRsZT5KLiBN
YWduLiBSZXNvbi4gU2VyaWVzIEE8L2Z1bGwtdGl0bGU+PC9wZXJpb2RpY2FsPjxwYWdlcz4yMTUt
MjE4PC9wYWdlcz48dm9sdW1lPjEyMzwvdm9sdW1lPjxudW1iZXI+MjwvbnVtYmVyPjxzZWN0aW9u
PjIxNTwvc2VjdGlvbj48ZGF0ZXM+PHllYXI+MTk5NjwveWVhcj48L2RhdGVzPjx1cmxzPjwvdXJs
cz48L3JlY29yZD48L0NpdGU+PENpdGU+PEF1dGhvcj5Cb3RhbmE8L0F1dGhvcj48WWVhcj4yMDEx
PC9ZZWFyPjxSZWNOdW0+MTgyPC9SZWNOdW0+PHJlY29yZD48cmVjLW51bWJlcj4xODI8L3JlYy1u
dW1iZXI+PGZvcmVpZ24ta2V5cz48a2V5IGFwcD0iRU4iIGRiLWlkPSJ3NXZkOTJkdGx3ZXh4bWVz
cHZhNWZ2ZTdlc3dwYXN3cDByZmEiIHRpbWVzdGFtcD0iMTUyOTkzNjc1OCI+MTgyPC9rZXk+PC9m
b3JlaWduLWtleXM+PHJlZi10eXBlIG5hbWU9IkpvdXJuYWwgQXJ0aWNsZSI+MTc8L3JlZi10eXBl
Pjxjb250cmlidXRvcnM+PGF1dGhvcnM+PGF1dGhvcj5Cb3RhbmEsIEEuPC9hdXRob3I+PGF1dGhv
cj5Ib3dlLCBQLiBXLjwvYXV0aG9yPjxhdXRob3I+Q2FlciwgVi48L2F1dGhvcj48YXV0aG9yPk1v
cnJpcywgRy4gQS48L2F1dGhvcj48YXV0aG9yPk5pbHNzb24sIE0uPC9hdXRob3I+PC9hdXRob3Jz
PjwvY29udHJpYnV0b3JzPjxhdXRoLWFkZHJlc3M+U2Nob29sIG9mIENoZW1pc3RyeSwgVW5pdmVy
c2l0eSBvZiBNYW5jaGVzdGVyLCBPeGZvcmQgUm9hZCwgTWFuY2hlc3RlciBNMTMgOVBMLCBVSy48
L2F1dGgtYWRkcmVzcz48dGl0bGVzPjx0aXRsZT48c3R5bGUgZmFjZT0ibm9ybWFsIiBmb250PSJk
ZWZhdWx0IiBzaXplPSIxMDAlIj4mcXVvdDtIaWdoIHJlc29sdXRpb24gPC9zdHlsZT48c3R5bGUg
ZmFjZT0ic3VwZXJzY3JpcHQiIGZvbnQ9ImRlZmF1bHQiIHNpemU9IjEwMCUiPjEzPC9zdHlsZT48
c3R5bGUgZmFjZT0ibm9ybWFsIiBmb250PSJkZWZhdWx0IiBzaXplPSIxMDAlIj5DIERPU1k6IHRo
ZSBERVBUU0UgZXhwZXJpbWVudCZxdW90Ozwvc3R5bGU+PC90aXRsZT48c2Vjb25kYXJ5LXRpdGxl
PkouIE1hZ24uIFJlc29uLjwvc2Vjb25kYXJ5LXRpdGxlPjwvdGl0bGVzPjxwZXJpb2RpY2FsPjxm
dWxsLXRpdGxlPkouIE1hZ24uIFJlc29uLjwvZnVsbC10aXRsZT48L3BlcmlvZGljYWw+PHBhZ2Vz
PjI1LTI5PC9wYWdlcz48dm9sdW1lPjIxMTwvdm9sdW1lPjxudW1iZXI+MTwvbnVtYmVyPjxrZXl3
b3Jkcz48a2V5d29yZD5BbGNvaG9scy9jaGVtaXN0cnk8L2tleXdvcmQ+PGtleXdvcmQ+QWxnb3Jp
dGhtczwva2V5d29yZD48a2V5d29yZD5Db21wbGV4IE1peHR1cmVzL2FuYWx5c2lzPC9rZXl3b3Jk
PjxrZXl3b3JkPkRhdGEgSW50ZXJwcmV0YXRpb24sIFN0YXRpc3RpY2FsPC9rZXl3b3JkPjxrZXl3
b3JkPkRldXRlcml1bTwva2V5d29yZD48a2V5d29yZD5EaWZmdXNpb248L2tleXdvcmQ+PGtleXdv
cmQ+TWFnbmV0aWMgUmVzb25hbmNlIFNwZWN0cm9zY29weS8qbWV0aG9kczwva2V5d29yZD48a2V5
d29yZD5XYXRlcjwva2V5d29yZD48L2tleXdvcmRzPjxkYXRlcz48eWVhcj4yMDExPC95ZWFyPjxw
dWItZGF0ZXM+PGRhdGU+SnVsPC9kYXRlPjwvcHViLWRhdGVzPjwvZGF0ZXM+PGlzYm4+MTA5Ni0w
ODU2IChFbGVjdHJvbmljKSYjeEQ7MTA5MC03ODA3IChMaW5raW5nKTwvaXNibj48YWNjZXNzaW9u
LW51bT4yMTUwNzY5MjwvYWNjZXNzaW9uLW51bT48dXJscz48cmVsYXRlZC11cmxzPjx1cmw+aHR0
cHM6Ly93d3cubmNiaS5ubG0ubmloLmdvdi9wdWJtZWQvMjE1MDc2OTI8L3VybD48dXJsPmh0dHBz
Oi8vd3d3LnNjaWVuY2VkaXJlY3QuY29tL3NjaWVuY2UvYXJ0aWNsZS9waWkvUzEwOTA3ODA3MTEw
MDExNDU/dmlhJTNEaWh1YjwvdXJsPjwvcmVsYXRlZC11cmxzPjwvdXJscz48ZWxlY3Ryb25pYy1y
ZXNvdXJjZS1udW0+MTAuMTAxNi9qLmptci4yMDExLjAzLjAxNjwvZWxlY3Ryb25pYy1yZXNvdXJj
ZS1udW0+PC9yZWNvcmQ+PC9DaXRlPjwvRW5kTm90ZT5=
ADDIN EN.CITE.DATA 24-25) in DOSY experiments can be very effective when such isotopes can be used, facilitating the study of complex mixtures. However, when using 1H (the most abundant and most widely used nucleus in liquid state NMR) the need to solve the problem of overlap of signals has been the focus of research into new acquisition and Figure 2. a) Pseudo-3D DOSY plot of the Oneshot-HSQC spectrum of the same sample as in Figure 1, b) 2D projection along F2, and c) 2D projection along F1. F1 and F2 are the 13C and 1H dimensions respectively. Dashed lines are used to aid visualization and indicate biotin B7 (red), hydrochloride B6 (purple), pantothenic acid B5 (blue), pyridoxine and niacin B3 (orange) and thiamine hydrochloride B1 (green) peaks respectively. The spectra from the five components are easily distinguished, with diffusion coefficients of 1.05, 1.12, 1.18, 1.36 and 1.64 ×10-10 m2 s-1 for vitamins B1, B7, B5, B6 and B3, respectively. Data acquisition took 45 h, but a much shorter acquisition would have sufficed.processing methods since the early days of NMR. The advent of pure shift NMR spectroscopy,PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5BZGFtczwvQXV0aG9yPjxZZWFyPjIwMTQ8L1llYXI+PFJl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ADDIN EN.CITE PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5BZGFtczwvQXV0aG9yPjxZZWFyPjIwMTQ8L1llYXI+PFJl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ADDIN EN.CITE.DATA 26-29 in which the effects of homonuclear couplings are suppressed and a single peak is observed for each chemically distinct site, has allowed an impressive improvement in resolution and reduction in signal overlap. The usefulness of pure shift 1H DOSY methods to solve overlapping problems has been proved, albeit at a cost in signal-to-noise ratio that reduces resolution in the diffusion domain.PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5OaWxzc29uPC9BdXRob3I+PFllYXI+MjAwNzwvWWVhcj48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ADDIN EN.CITE PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5OaWxzc29uPC9BdXRob3I+PFllYXI+MjAwNzwvWWVhcj48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ADDIN EN.CITE.DATA 30-33Another efficient way to minimise signal overlap is to add a diffusion dimension to a 2D (or higher dimensionality) NMR experiment, generating 3D (or higher) DOSY spectrum (Figure 2a).PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5XdTwvQXV0aG9yPjxZZWFyPjE5OTY8L1llYXI+PFJlY051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ADDIN EN.CITE PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5XdTwvQXV0aG9yPjxZZWFyPjE5OTY8L1llYXI+PFJlY051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ADDIN EN.CITE.DATA 34-47 Thus Figure 2a shows that the mixture yielding the unresolved 2D DOSY spectrum of Figure 1 is perfectly resolved using 3D HSQC-DOSY. The use of HSQC as the base experiment provides a major reduction in the probability of overlap by increasing the sparsity of the spectral dimensions, spreading correlation signals out over the full 2D plane instead of along a single frequency axis. Each peak in the diffusion dimension (i.e. the third dimension) is, as in 2D DOSY,?generated by fitting cross-peak volumes as a function of gradient amplitude to the appropriate form of the Stejskal-Tanner equation and constructing a Gaussian peak centred at the fitted diffusion coefficient and with a width determined by the statistics of the fit. ADDIN EN.CITE <EndNote><Cite><Author>Barjat</Author><Year>1995</Year><RecNum>172</RecNum><DisplayText><style face="superscript">2</style></DisplayText><record><rec-number>172</rec-number><foreign-keys><key app="EN" db-id="w5vd92dtlwexxmespva5fve7eswpaswp0rfa" timestamp="1529936757">172</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>Barjat, H.</author><author>Morris, G. A.</author><author>Smart, S.</author><author>Swanson, A. G.</author><author>Williams, S. C. R.</author></authors></contributors><titles><title>"High-Resolution Diffusion-Ordered 2D Spectroscopy (HR-DOSY) - A New Tool for the Analysis of Complex Mixtures"</title><secondary-title>J. Magn. Reson. Series B</secondary-title></titles><periodical><full-title>J. Magn. Reson. Series B</full-title></periodical><pages>170-172</pages><volume>108</volume><number>2</number><section>170</section><dates><year>1995</year></dates><urls></urls></record></Cite></EndNote>2 Thus, 3D DOSY spectra are made up of F1-F2 planes (or layers) containing signals of species diffusing with the same diffusion coefficient D.The potential of 3D diffusion experiments has been explored in the literature in a significant number of publications. Perhaps the most obvious way to construct a 3D diffusion experiment is by concatenating a conventional 2D pulse sequence with a diffusion-encoding sequence, as in COSY-DOSY, ADDIN EN.CITE <EndNote><Cite><Author>Wu</Author><Year>1996</Year><RecNum>187</RecNum><DisplayText><style face="superscript">34</style></DisplayText><record><rec-number>187</rec-number><foreign-keys><key app="EN" db-id="w5vd92dtlwexxmespva5fve7eswpaswp0rfa" timestamp="1529936759">187</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>Wu, D.</author><author>Chen, A.</author><author>Johnson Jr, C. S.</author></authors></contributors><titles><title>"Three-Dimensional Diffusion-Ordered NMR Spectroscopy: The Homonuclear COSY–DOSY Experiment"</title><secondary-title>J. Magn. Reson. Series A</secondary-title></titles><periodical><full-title>J. Magn. Reson. Series A</full-title></periodical><pages>88-91</pages><volume>121</volume><number>1</number><section>88</section><dates><year>1996</year></dates><urls></urls></record></Cite></EndNote>34 DOSY-TOCSY, ADDIN EN.CITE <EndNote><Cite><Author>Jerschow</Author><Year>1996</Year><RecNum>188</RecNum><DisplayText><style face="superscript">35</style></DisplayText><record><rec-number>188</rec-number><foreign-keys><key app="EN" db-id="w5vd92dtlwexxmespva5fve7eswpaswp0rfa" timestamp="1529936759">188</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>Jerschow, A.</author><author>Muller, N.</author></authors></contributors><titles><title>"3D Diffusion-Ordered TOCSY for Slowly Diffusing Molecules"</title><secondary-title>J. Magn. Reson. Series A</secondary-title></titles><periodical><full-title>J. Magn. Reson. Series A</full-title></periodical><pages>222-225</pages><volume>123</volume><number>2</number><section>222</section><dates><year>1996</year></dates><urls></urls></record></Cite></EndNote>35 DOSY-NOESY, ADDIN EN.CITE <EndNote><Cite><Author>Gozansky</Author><Year>1996</Year><RecNum>189</RecNum><DisplayText><style face="superscript">36</style></DisplayText><record><rec-number>189</rec-number><foreign-keys><key app="EN" db-id="w5vd92dtlwexxmespva5fve7eswpaswp0rfa" timestamp="1529936759">189</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>Gozansky, E. K.</author><author>Gorenstein, D. G.</author></authors></contributors><titles><title>"DOSY-NOESY: Diffusion-Ordered NOESY"</title><secondary-title>J. Magn. Reson. Series B</secondary-title></titles><periodical><full-title>J. Magn. Reson. Series B</full-title></periodical><pages>94-96</pages><volume>111</volume><number>1</number><section>94</section><dates><year>1996</year></dates><urls></urls></record></Cite></EndNote>36 2DJ-DOSY, ADDIN EN.CITE <EndNote><Cite><Author>Lucas</Author><Year>2002</Year><RecNum>190</RecNum><DisplayText><style face="superscript">39</style></DisplayText><record><rec-number>190</rec-number><foreign-keys><key app="EN" db-id="w5vd92dtlwexxmespva5fve7eswpaswp0rfa" timestamp="1529936759">190</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>Lucas, L. H.</author><author>Otto, W. H.</author><author>Larive, C. K.</author></authors></contributors><titles><title>"The 2D-J-DOSY Experiment: Resolving Diffusion Coefficients in Mixtures"</title><secondary-title>J. Magn. Reson.</secondary-title></titles><periodical><full-title>J. Magn. Reson.</full-title></periodical><pages>138-145</pages><volume>156</volume><number>1</number><section>138</section><dates><year>2002</year></dates><isbn>10907807</isbn><urls><related-urls><url> DOSY-TROSY,PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5EaWRlbmtvPC9BdXRob3I+PFllYXI+MjAxMTwvWWVhcj48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ADDIN EN.CITE PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5EaWRlbmtvPC9BdXRob3I+PFllYXI+MjAxMTwvWWVhcj48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ADDIN EN.CITE.DATA 46 DOSY-HSQC ADDIN EN.CITE <EndNote><Cite><Author>Brand</Author><Year>2007</Year><RecNum>217</RecNum><DisplayText><style face="superscript">44</style></DisplayText><record><rec-number>217</rec-number><foreign-keys><key app="EN" db-id="w5vd92dtlwexxmespva5fve7eswpaswp0rfa" timestamp="1529936761">217</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>Brand, T.</author><author>Cabrita, E. J.</author><author>Morris, G. A.</author><author>Gunther, R.</author><author>Hofmann, H. J.</author><author>Berger, S.</author></authors></contributors><auth-address>Institute of Analytical Chemistry, University of Leipzig, Linnestrasse 3, Leipzig 04103, Germany.</auth-address><titles><title>"Residue-specific NH exchange rates studied by NMR diffusion experiments"</title><secondary-title>J. Magn. Reson.</secondary-title></titles><periodical><full-title>J. Magn. Reson.</full-title></periodical><pages>97-104</pages><volume>187</volume><number>1</number><section>97</section><keywords><keyword>Algorithms</keyword><keyword>Amides/*chemistry</keyword><keyword>Carbon Isotopes/chemistry</keyword><keyword>Databases, Factual</keyword><keyword>Diffusion</keyword><keyword>Magnetic Resonance Spectroscopy/*methods</keyword><keyword>Nitrogen Isotopes/chemistry</keyword><keyword>Proteins/chemistry</keyword><keyword>Protons</keyword><keyword>Quantum Theory</keyword><keyword>Ubiquitin/chemistry</keyword></keywords><dates><year>2007</year><pub-dates><date>Jul</date></pub-dates></dates><isbn>1090-7807 (Print)
1090-7807 (Linking)</isbn><accession-num>17475526</accession-num><urls><related-urls><url> and DOSY-HMQC, ADDIN EN.CITE <EndNote><Cite><Author>Barjat</Author><Year>1998</Year><RecNum>192</RecNum><DisplayText><style face="superscript">38</style></DisplayText><record><rec-number>192</rec-number><foreign-keys><key app="EN" db-id="w5vd92dtlwexxmespva5fve7eswpaswp0rfa" timestamp="1529936759">192</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>Barjat, H.</author><author>Morris, G. A.</author><author>Swansom, A. G.</author></authors></contributors><titles><title>"A Three-Dimensional DOSY–HMQC Experiment for the High-Resolution Analysis of Complex Mixtures"</title><secondary-title>J. Magn. Reson.</secondary-title></titles><periodical><full-title>J. Magn. Reson.</full-title></periodical><pages>131-138</pages><volume>131</volume><number>1</number><section>131</section><dates><year>1998</year></dates><urls></urls></record></Cite></EndNote>38 among others. The nomenclature used here reflects the order in which pulse sequence blocks are concatenated: thus the COSY-DOSY sequence consists of a COSY sequence followed by a diffusion-encoding step. An alternative strategy for designing 3D diffusion experiments is to incorporate diffusion encoding into the conventional 2D experiment (an approach known as iDOSY), where the parent pulse sequence can accommodate a diffusion delay of several tens of ms. ADDIN EN.CITE <EndNote><Cite><Author>Birlirakis</Author><Year>1996</Year><RecNum>193</RecNum><DisplayText><style face="superscript">37</style></DisplayText><record><rec-number>193</rec-number><foreign-keys><key app="EN" db-id="w5vd92dtlwexxmespva5fve7eswpaswp0rfa" timestamp="1529936759">193</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>Birlirakis, N.</author><author>Guittet, E.</author></authors></contributors><titles><title>"A New Approach in the Use of Gradients for Size-Resolved 2D-NMR Experiments"</title><secondary-title>J. Am. Chem. Soc.</secondary-title></titles><periodical><full-title>J. Am. Chem. Soc.</full-title></periodical><pages>13083-13084</pages><volume>118</volume><number>51</number><section>13083</section><dates><year>1996</year></dates><urls></urls></record></Cite></EndNote>37 This approach can be simpler, and usually has less sensitivity loss due to relaxation. A number of 3D iDOSY experiments can be found in the literature, including TOCSY-iDOSY, ADDIN EN.CITE <EndNote><Cite><Author>Birlirakis</Author><Year>1996</Year><RecNum>193</RecNum><DisplayText><style face="superscript">37</style></DisplayText><record><rec-number>193</rec-number><foreign-keys><key app="EN" db-id="w5vd92dtlwexxmespva5fve7eswpaswp0rfa" timestamp="1529936759">193</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>Birlirakis, N.</author><author>Guittet, E.</author></authors></contributors><titles><title>"A New Approach in the Use of Gradients for Size-Resolved 2D-NMR Experiments"</title><secondary-title>J. Am. Chem. Soc.</secondary-title></titles><periodical><full-title>J. Am. Chem. Soc.</full-title></periodical><pages>13083-13084</pages><volume>118</volume><number>51</number><section>13083</section><dates><year>1996</year></dates><urls></urls></record></Cite></EndNote>37 COSY-iDOSY,PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5OaWxzc29uPC9BdXRob3I+PFllYXI+MjAwNTwvWWVhcj48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ADDIN EN.CITE PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5OaWxzc29uPC9BdXRob3I+PFllYXI+MjAwNTwvWWVhcj48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ADDIN EN.CITE.DATA 41 2DJ-iDOSY, ADDIN EN.CITE <EndNote><Cite><Author>Birlirakis</Author><Year>1996</Year><RecNum>193</RecNum><DisplayText><style face="superscript">37, 48</style></DisplayText><record><rec-number>193</rec-number><foreign-keys><key app="EN" db-id="w5vd92dtlwexxmespva5fve7eswpaswp0rfa" timestamp="1529936759">193</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>Birlirakis, N.</author><author>Guittet, E.</author></authors></contributors><titles><title>"A New Approach in the Use of Gradients for Size-Resolved 2D-NMR Experiments"</title><secondary-title>J. Am. Chem. Soc.</secondary-title></titles><periodical><full-title>J. Am. Chem. Soc.</full-title></periodical><pages>13083-13084</pages><volume>118</volume><number>51</number><section>13083</section><dates><year>1996</year></dates><urls></urls></record></Cite><Cite><Author>Nilsson</Author><Year>2004</Year><RecNum>195</RecNum><record><rec-number>195</rec-number><foreign-keys><key app="EN" db-id="w5vd92dtlwexxmespva5fve7eswpaswp0rfa" timestamp="1529936759">195</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>Nilsson, M.</author><author>Gil, A. M.</author><author>Delgadillo, I.</author><author>Morris, G. A.</author></authors></contributors><titles><title>"Improving Pulse Sequences for 3D Diffusion-Ordered NMR Spectroscopy: 2DJ-IDOSY"</title><secondary-title>Anal. Chem.</secondary-title></titles><periodical><full-title>Anal. Chem.</full-title></periodical><pages>5418-5422</pages><volume>76</volume><number>18</number><section>5418</section><dates><year>2004</year></dates><urls><related-urls><url>, 48 HSQC-iDOSYPEVuZE5vdGU+PENpdGU+PEF1dGhvcj5WaXRvcmdlPC9BdXRob3I+PFllYXI+MjAwNjwvWWVhcj48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ADDIN EN.CITE PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5WaXRvcmdlPC9BdXRob3I+PFllYXI+MjAwNjwvWWVhcj48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ADDIN EN.CITE.DATA 43, 45, 47 and HMQC-iDOSY ADDIN EN.CITE <EndNote><Cite><Author>Stchedroff</Author><Year>2004</Year><RecNum>198</RecNum><DisplayText><style face="superscript">40</style></DisplayText><record><rec-number>198</rec-number><foreign-keys><key app="EN" db-id="w5vd92dtlwexxmespva5fve7eswpaswp0rfa" timestamp="1529936759">198</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>Stchedroff, Marc J.</author><author>Kenwright, Alan M.</author><author>Morris, Gareth A.</author><author>Nilsson, Mathias</author><author>Harris, Robin K.</author></authors></contributors><titles><title>"2D and 3D DOSY methods for studying mixtures of oligomeric dimethylsiloxanes"</title><secondary-title>Phys. Chem. Chem. Phys.</secondary-title></titles><periodical><full-title>Phys. Chem. Chem. Phys.</full-title></periodical><pages>3221-3227</pages><volume>6</volume><number>13</number><section>3221</section><dates><year>2004</year></dates><isbn>1463-9076
1463-9084</isbn><urls><related-urls><url>. One potential drawback of 3D experiments is that they can be time-consuming, but great reductions in experiment time are possible with modern non-uniform sampling (NUS) schemes.PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5KYXJhdmluZTwvQXV0aG9yPjxZZWFyPjIwMDY8L1llYXI+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ADDIN EN.CITE PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5KYXJhdmluZTwvQXV0aG9yPjxZZWFyPjIwMDY8L1llYXI+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ADDIN EN.CITE.DATA 49-553D DOSY experiments have, however, failed to find much real application, in part due to the lack of a suitable processing platform. Naturally, the extra dimension, although offering a great advantage, adds a layer of complexity to the processing, and current processing software leaves much to be desired in capabilities and user-friendliness. In this work we aim to harness the power of 3D diffusion experiments through a new free and open source software package, MAGNATE (Multidimensional Analysis for the General NMR Analysis Toolbox Environment). The new software is written in MATLAB? and comes with a user-friendly graphical user interface (GUI), illustrated in Figure 3. MAGNATE complements the popular GNAT (General NMR Analysis Toolbox, ADDIN EN.CITE <EndNote><Cite><Author>Casta?ar</Author><Year>2018</Year><RecNum>241</RecNum><DisplayText><style face="superscript">56</style></DisplayText><record><rec-number>241</rec-number><foreign-keys><key app="EN" db-id="w5vd92dtlwexxmespva5fve7eswpaswp0rfa" timestamp="1529936764">241</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>Casta?ar, L.</author><author>Dal Poggetto, G.</author><author>Colbourne, A. A.</author><author>Morris, G. A.</author><author>Nilsson, M.</author></authors></contributors><auth-address>School of Chemistry, University of Manchester, Oxford Road, Manchester, M13 9PL, UK.</auth-address><titles><title>"The GNAT: A new tool for processing NMR data"</title><secondary-title>Magn. Reson. Chem.</secondary-title></titles><periodical><full-title>Magn. Reson. Chem.</full-title></periodical><pages>546–558</pages><volume>56</volume><number>6</number><section>546</section><keywords><keyword>Dosy</keyword><keyword>Matlab</keyword><keyword>Nmr</keyword><keyword>analysis</keyword><keyword>diffusion</keyword><keyword>multiway</keyword><keyword>processing</keyword><keyword>relaxation</keyword><keyword>software</keyword><keyword>toolbox</keyword></keywords><dates><year>2018</year><pub-dates><date>Feb 2</date></pub-dates></dates><isbn>1097-458X (Electronic)
0749-1581 (Linking)</isbn><accession-num>29396867</accession-num><urls><related-urls><url> former DOSYToolbox ADDIN EN.CITE <EndNote><Cite><Author>Nilsson</Author><Year>2009</Year><RecNum>131</RecNum><DisplayText><style face="superscript">57</style></DisplayText><record><rec-number>131</rec-number><foreign-keys><key app="EN" db-id="w5vd92dtlwexxmespva5fve7eswpaswp0rfa" timestamp="1461604556">131</key><key app="ENWeb" db-id="">0</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>Nilsson, M.</author></authors></contributors><auth-address>School of Chemistry, University of Manchester, Manchester, UK. mathias.nilsson@manchester.ac.uk</auth-address><titles><title>"The DOSY Toolbox: a new tool for processing PFG NMR diffusion data"</title><secondary-title>J. Magn. Reson.</secondary-title></titles><periodical><full-title>J. Magn. Reson.</full-title></periodical><pages>296-302</pages><volume>200</volume><number>2</number><section>296</section><keywords><keyword>*Algorithms</keyword><keyword>Computer Simulation</keyword><keyword>*Diffusion</keyword><keyword>Magnetic Resonance Spectroscopy/*methods</keyword><keyword>*Models, Chemical</keyword><keyword>Sensitivity and Specificity</keyword><keyword>*Software</keyword></keywords><dates><year>2009</year><pub-dates><date>Oct</date></pub-dates></dates><isbn>1096-0856 (Electronic)
1090-7807 (Linking)</isbn><accession-num>19666235</accession-num><urls><related-urls><url>). In its present incarnation, MAGNATE is a free standing programme but will also in the future be incorporated into the GNAT. It runs under Matlab (we recommend version 2017a or newer) on any platform, and free-standing compiled versions will be made available for compatible versions of Windows, Mac and Linux. Detailed instructions on practical processing are given in the supporting information, and the Matlab code and test data are available for download at demonstrate the new software we present a new 3D DOSY experiment, Oneshot-HSQC (see supporting information). This concatenates the Oneshot,PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5QZWx0YTwvQXV0aG9yPjxZZWFyPjIwMDI8L1llYXI+PFJl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=
ADDIN EN.CITE PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5QZWx0YTwvQXV0aG9yPjxZZWFyPjIwMDI8L1llYXI+PFJl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=
ADDIN EN.CITE.DATA 16, 58 and echo/anti-echo HSQC sequences, using adiabatic chirp pulses for 13C inversion and refocusing. It has a short minimum phase cycle, and allows flexible setting of diffusion parameters. As with all HSQC experiments which use broadband heteronuclear decoupling, there will be some sample heating due to the extra radio frequency power during acquisition. This is reflected in the slightly higher diffusion coefficients, due both to the decrease in sample viscosity caused by the temperature increase and to slight convection,PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5Td2FuPC9BdXRob3I+PFllYXI+MjAxNTwvWWVhcj48UmVj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ADDIN EN.CITE PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5Td2FuPC9BdXRob3I+PFllYXI+MjAxNTwvWWVhcj48UmVj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ADDIN EN.CITE.DATA 59-60 seen in Figures 2-4 than in the 2D DOSY spectrum of Figure 1. If the experiment is carried out without decoupling, the diffusion coefficients are in good agreement with those of the 2D experiment (see ESI).ExperimentalThe sample of a mixture of B vitamins contained 32 mg of thiamine hydrochloride, 43 mg of pantothenic acid calcium hemicomplex, 15 mg of nicotinic acid, 23 mg of pyridoxine hydrochloride, and 25 mg of biotin in approximately 500 ?L of DMSO-d6 and 50 ?L of D2O. The flavonoid sample contained 20 mg of quercetin and 30 mg of rutin in 600 ?L DMSO-d6. Both samples were prepared with around 8 mM concentration of tetramethylsilane (TMS) as reference signal.Data were acquired on a Bruker Avance Neo 500 spectrometer using a 5 mm diameter direct detection probe (BBO) with a nominal z-gradient of 49.9 G cm-1, at 25 ?C, without spinning. For the flavonoid sample, in the Oneshot-HSQC experiment the diffusion encoding time (Δ) used was 0.12 s, the total diffusion-encoding pulse width (δ) 4 ms, the stabilization delay for gradient pulses 1 ms, and the nominal gradient strength ranged from 3.1 to 25.4 G cm-1 in equal steps of gradient squared, with an imbalance factor α of 0.2. For each of the 8 gradient amplitudes, 32 scans with 2048 complex data points in the direct and 128 points in the indirect dimension were acquired. For the vitamin B sample, the diffusion encoding time (Δ) used was Figure 3. Main window of the graphical user interface of MAGNATE: The spectrum shows a small region of the least attenuated 2D spectrum of 3D Oneshot-HSQC of a sample of a mixture of B vitamins in DMSO-d6, which demonstrates one of the available display modes, where each peak is labelled (in light blue) with its diffusion coefficients and corresponding statistical error (in black). Signals 8 and 9 are from pyridoxine hydrochloride B6; 10, 11, and 16 are from biotin B7; 12, 14, and 16 are from pantothenic acid B5; and 13 is from thiamine hydrochloride B1.0.115 s, the total diffusion-encoding pulse width (δ) 4.4 ms, the stabilization delay for the gradient pulses 600 ?s, and the nominal gradient strength ranged from 3.18 to 22.24 G cm-1 in equal steps of gradient squared, with an imbalance factor α of 0.2. For each of the 8 gradient amplitudes, 32 scans with 4096 complex data points in the direct and 256 points in the indirect dimension were acquired. Constant-adiabaticity WURST-40 decoupling was applied during FID acquisition in all HSQC experiments. More detailed experimental and processing parameters for the Oneshot-HSQC experiment are given in the supporting information. All the experimental data, and MAGNATE itself, are available for free download from DOI: 10.17632/67t9s63nby.1.Analysing diffusion dataThe current version of MAGNATE imports 2D frequency domain data that have previously been processed by double Fourier transformation using TopSpin?, the proprietary software used in the majority of current high resolution NMR spectrometers. This lets the user take full advantage of the standard multidimensional processing capabilities of that package, and allows the full range of potential 2D base experiments to be easily accessed. Support for data from other packages should be straightforward to implement in future versions. The imported data can be efficiently analysed in MAGNATE using both univariate (where each signal is processed individually) and multivariate methods (where whole spectra, or chosen sections thereof, are processed simultaneously). An extended description of the processing capabilities of MAGNATE is given in the ESI.Univariate analysisThe most straightforward way of analysing diffusion NMR data is by univariate analysis. This treats each signal independently (e.g. by assuming that it decays according to a single exponential, or a sum of exponentials ADDIN EN.CITE <EndNote><Cite><Author>Nilsson</Author><Year>2006</Year><RecNum>244</RecNum><DisplayText><style face="superscript">17</style></DisplayText><record><rec-number>244</rec-number><foreign-keys><key app="EN" db-id="w5vd92dtlwexxmespva5fve7eswpaswp0rfa" timestamp="1529936764">244</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>Nilsson, M.</author><author>Connell, M. A.</author><author>Davis, A. L.</author><author>Morris, G. A.</author></authors></contributors><titles><title>"Biexponential Fitting of Diffusion-Ordered NMR Data: Practicalities and Limitations"</title><secondary-title>Anal. Chem.</secondary-title></titles><periodical><full-title>Anal. Chem.</full-title></periodical><pages>3040-3045</pages><volume>78</volume><number>9</number><section>3040</section><dates><year>2006</year></dates><urls></urls></record></Cite></EndNote>17) and results in data that can be represented as a 3D DOSY plot (Figure 2a). The analysis is performed by defining peak regions in the 2D plot, integrating to find the peak volumes, and fitting these to an appropriate form of the Stejskal-Tanner equation. ADDIN EN.CITE <EndNote><Cite><Author>Stejskal</Author><Year>1965</Year><RecNum>117</RecNum><DisplayText><style face="superscript">11, 15</style></DisplayText><record><rec-number>117</rec-number><foreign-keys><key app="EN" db-id="w5vd92dtlwexxmespva5fve7eswpaswp0rfa" timestamp="1461335805">117</key><key app="ENWeb" db-id="">0</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>Stejskal, E. O.</author><author>Tanner, J. E.</author></authors></contributors><titles><title>"Spin Diffusion Measurements: Spin Echoes in the Presence of a Time-Dependent Field Gradient"</title><secondary-title>J. Chem. Phys.</secondary-title></titles><periodical><full-title>J. Chem. Phys.</full-title></periodical><pages>288-292</pages><volume>42</volume><number>1</number><section>288</section><dates><year>1965</year></dates><isbn>00219606</isbn><urls></urls><electronic-resource-num>10.1063/1.1695690</electronic-resource-num></record></Cite><Cite><Author>Sinnaeve</Author><Year>2012</Year><RecNum>169</RecNum><record><rec-number>169</rec-number><foreign-keys><key app="EN" db-id="w5vd92dtlwexxmespva5fve7eswpaswp0rfa" timestamp="1529936757">169</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>Sinnaeve, D.</author></authors></contributors><titles><title>"The Stejskal-Tanner equation generalized for any gradient shape-an overview of most pulse sequences measuring free diffusion"</title><secondary-title>Concepts Magn. Reson. Part A</secondary-title></titles><periodical><full-title>Concepts Magn. Reson. Part A</full-title></periodical><pages>39-65</pages><volume>40A</volume><number>2</number><section>39</section><dates><year>2012</year></dates><isbn>15466086</isbn><urls><related-urls><url>, 15 MAGNATE then constructs a 3D spectrum using the fitted parameters and displays the result in an interactive GUI that facilitates user investigation. Different 2D projections from the 3D plot can be extracted (Figures 2b-c), as well as the 2D spectrum obtained by integrating the 3D spectrum between given diffusion coefficients. The latter functionality allows the user to perform a virtual separation of the components of a mixture, based on their diffusion coefficients, and to obtain the 2D sub-spectrum for each component (Figure 4). An alternative display mode is provided, in the main MAGNATE window, in which each peak in the 2D spectrum is labelled with its fitted diffusion coefficient (Figure 2). In cases where cross-peaks overlap, monoexponential fitting procedure will generate an apparent diffusion coefficient intermediate between those of the overlapped signals, just as in 2D DOSY. Where data with very high signal-to-noise ratio are available, multiexponential fitting may be performed, but in most cases the best recourse is multivariate analysis.Figure 4. 2D slices extracted from the 3D spectrum (Figure 2) of the results of a Oneshot-HSQC experiment of Figure 2 on a mixture of vitamins B, in DMSO-d6. a) 2D spectrum obtained by integrating the region between 1.13 and 1.20 × 10-10 m2 s-1 in the diffusion dimension, where only pantothenic acid B5 correlations are observed. b) Corresponding 2D spectrum for the region between 1.07 and 1.11 × 10-10 m2 s-1 of the diffusion dimension, where only biotin B7 correlations are observed. Multivariate analysisMultivariate methods use the whole spectrum (or chosen parts thereof) simultaneously, extracting whole (or partial) spectra for individual mixture components. Many different multivariate methods have been applied to 2D diffusion data, including SCORE, ADDIN EN.CITE <EndNote><Cite><Author>Nilsson</Author><Year>2008</Year><RecNum>219</RecNum><DisplayText><style face="superscript">61</style></DisplayText><record><rec-number>219</rec-number><foreign-keys><key app="EN" db-id="w5vd92dtlwexxmespva5fve7eswpaswp0rfa" timestamp="1529936761">219</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>Nilsson, M.</author><author>Morris, G. A.</author></authors></contributors><titles><title>"Speedy Component Resolution An Improved Tool"</title><secondary-title>Anal. Chem.</secondary-title></titles><periodical><full-title>Anal. Chem.</full-title></periodical><pages>3777-3782</pages><volume>80</volume><number>10</number><section>3777</section><dates><year>2008</year></dates><urls></urls></record></Cite></EndNote>61 OUTSCORE, ADDIN EN.CITE <EndNote><Cite><Author>Colbourne</Author><Year>2013</Year><RecNum>220</RecNum><DisplayText><style face="superscript">18</style></DisplayText><record><rec-number>220</rec-number><foreign-keys><key app="EN" db-id="w5vd92dtlwexxmespva5fve7eswpaswp0rfa" timestamp="1529936761">220</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>Colbourne, A. A.</author><author>Meier, S.</author><author>Morris, G. A.</author><author>Nilsson, M.</author></authors></contributors><auth-address>School of Chemistry, University of Manchester, Oxford Road, Manchester, M13 9PL, UK. mathias.nilsson@manchester.ac.uk.</auth-address><titles><title>"Unmixing the NMR spectra of similar species - vive la difference"</title><secondary-title>Chem. Commun.</secondary-title></titles><periodical><full-title>Chem. Commun.</full-title></periodical><pages>10510-10512</pages><volume>49</volume><number>89</number><section>10510</section><keywords><keyword>*Algorithms</keyword><keyword>Diffusion</keyword><keyword>Estradiol/chemistry</keyword><keyword>*Magnetic Resonance Spectroscopy</keyword><keyword>Progesterone/chemistry</keyword></keywords><dates><year>2013</year><pub-dates><date>Nov 18</date></pub-dates></dates><isbn>1364-548X (Electronic)
1359-7345 (Linking)</isbn><accession-num>24088897</accession-num><urls><related-urls><url> DECRA,PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5XaW5kaWc8L0F1dGhvcj48WWVhcj4xOTk3PC9ZZWFyPjxS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ADDIN EN.CITE PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5XaW5kaWc8L0F1dGhvcj48WWVhcj4xOTk3PC9ZZWFyPjxS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ADDIN EN.CITE.DATA 62-63 and MCR, ADDIN EN.CITE <EndNote><Cite><Author>Karakach</Author><Year>2009</Year><RecNum>239</RecNum><DisplayText><style face="superscript">64</style></DisplayText><record><rec-number>239</rec-number><foreign-keys><key app="EN" db-id="w5vd92dtlwexxmespva5fve7eswpaswp0rfa" timestamp="1529936763">239</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>Karakach, T. K.</author><author>Knight, R.</author><author>Lenz, E. M.</author><author>Viant, M. R.</author><author>Walter, J. A.</author></authors></contributors><auth-address>National Research Council of Canada, Institute for Marine Biosciences, 1411 Oxford Street, Halifax, Nova Scotia, Canada. tobias.karakach@nrc.ca</auth-address><titles><title><style face="normal" font="default" size="100%">"Analysis of time course </style><style face="superscript" font="default" size="100%">1</style><style face="normal" font="default" size="100%">H NMR metabolomics data by multivariate curve resolution"</style></title><secondary-title>Magn. Reson. Chem.</secondary-title></titles><periodical><full-title>Magn. Reson. Chem.</full-title></periodical><pages>105-117</pages><volume>47</volume><number>2</number><section>105</section><keywords><keyword>*Algorithms</keyword><keyword>Animals</keyword><keyword>*Embryonic Development</keyword><keyword>Fishes</keyword><keyword>Magnetic Resonance Spectroscopy</keyword><keyword>*Metabolomics</keyword><keyword>Multivariate Analysis</keyword><keyword>Nephrosis/*urine</keyword><keyword>Rats</keyword><keyword>Time Factors</keyword><keyword>Urine/*chemistry</keyword></keywords><dates><year>2009</year><pub-dates><date>Dec</date></pub-dates></dates><isbn>1097-458X (Electronic)
0749-1581 (Linking)</isbn><accession-num>19899105</accession-num><urls><related-urls><url> and a variety of others,PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5Ub3VtaTwvQXV0aG9yPjxZZWFyPjIwMTM8L1llYXI+PFJl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ADDIN EN.CITE PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5Ub3VtaTwvQXV0aG9yPjxZZWFyPjIwMTM8L1llYXI+PFJl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ADDIN EN.CITE.DATA 65-69 but they have not hitherto been applied to 3D diffusion data. The MAGNATE software package extends both the SCORE ADDIN EN.CITE <EndNote><Cite><Author>Nilsson</Author><Year>2008</Year><RecNum>219</RecNum><DisplayText><style face="superscript">61</style></DisplayText><record><rec-number>219</rec-number><foreign-keys><key app="EN" db-id="w5vd92dtlwexxmespva5fve7eswpaswp0rfa" timestamp="1529936761">219</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>Nilsson, M.</author><author>Morris, G. A.</author></authors></contributors><titles><title>"Speedy Component Resolution An Improved Tool"</title><secondary-title>Anal. Chem.</secondary-title></titles><periodical><full-title>Anal. Chem.</full-title></periodical><pages>3777-3782</pages><volume>80</volume><number>10</number><section>3777</section><dates><year>2008</year></dates><urls></urls></record></Cite></EndNote>61 and OUTSCORE ADDIN EN.CITE <EndNote><Cite><Author>Colbourne</Author><Year>2013</Year><RecNum>220</RecNum><DisplayText><style face="superscript">18</style></DisplayText><record><rec-number>220</rec-number><foreign-keys><key app="EN" db-id="w5vd92dtlwexxmespva5fve7eswpaswp0rfa" timestamp="1529936761">220</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>Colbourne, A. A.</author><author>Meier, S.</author><author>Morris, G. A.</author><author>Nilsson, M.</author></authors></contributors><auth-address>School of Chemistry, University of Manchester, Oxford Road, Manchester, M13 9PL, UK. mathias.nilsson@manchester.ac.uk.</auth-address><titles><title>"Unmixing the NMR spectra of similar species - vive la difference"</title><secondary-title>Chem. Commun.</secondary-title></titles><periodical><full-title>Chem. Commun.</full-title></periodical><pages>10510-10512</pages><volume>49</volume><number>89</number><section>10510</section><keywords><keyword>*Algorithms</keyword><keyword>Diffusion</keyword><keyword>Estradiol/chemistry</keyword><keyword>*Magnetic Resonance Spectroscopy</keyword><keyword>Progesterone/chemistry</keyword></keywords><dates><year>2013</year><pub-dates><date>Nov 18</date></pub-dates></dates><isbn>1364-548X (Electronic)
1359-7345 (Linking)</isbn><accession-num>24088897</accession-num><urls><related-urls><url> methods to the analysis of 3D data. In Figure 5 the OUTSCORE method is demonstrated on DOSY-HSQC data for a mixture of flavonoids. To the best of our knowledge, this is the first time any multivariate method has been used to generate 2D sub-spectra of individual mixture components from a 3D diffusion data set. The only user input necessary is the number of components to fit; a successful analysis provides the 2D (here HSQC) spectra for each of the mixture components, together with their estimated diffusion coefficients. OUTSCORE and SCORE use closely-related fitting algorithms, differing only in their minimisation criterion. Their use is largely complementary. OUTSCORE allows the separation of spectra where the components have as little as 5 % difference in diffusion coefficient, provided that the signal overlap is only moderate. SCORE, on the other hand, can handle more extensive spectral overlap but requires that components differ in diffusion coefficient by 20 % or more. We expect this new tool to be of great help in mixture analysis, speeding up and simplifying the interpretation of multidimensional diffusion datasets. Figure 5. 2D HSQC spectra, obtained by OUTSCORE analysis of Oneshot-HSQC data, for the components of the mixture of flavonoids in DMSO-d6: (a) quercetin and (b) rutin. The estimated diffusion coefficients are 1.63 and 1.25 ×10-10 m2 s-1 for quercetin and rutin, respectively.Miscellaneous featuresIn addition to the methods described, MAGNATE contains a variety of additional tools for the analysis of diffusion and related data; it is under continuous development and we expect to keep adding useful features. It is well known that DOSY results are strongly influenced by i) the quality of the input diffusion data and ii) the quality of the processing and analysis methods used. There are many factors that can degrade the quality of experimental data, for example accidental refocussing of unwanted coherences or spectrometer instabilities, and convection, which is an ever-present problem in diffusion experiments. ADDIN EN.CITE <EndNote><Cite><Author>Swan</Author><Year>2015</Year><RecNum>83</RecNum><DisplayText><style face="superscript">59</style></DisplayText><record><rec-number>83</rec-number><foreign-keys><key app="EN" db-id="w5vd92dtlwexxmespva5fve7eswpaswp0rfa" timestamp="1461258375">83</key><key app="ENWeb" db-id="">0</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>Swan, I.</author><author>Reid, M.</author><author>Howe, P. W.</author><author>Connell, M. A.</author><author>Nilsson, M.</author><author>Moore, M. A.</author><author>Morris, G. A.</author></authors></contributors><auth-address>School of Chemistry, University of Manchester, Oxford Road, Manchester M13 9PL, UK.
Syngenta, Jealott's Hill Research Centre, Bracknell RG42 6EY, UK.
School of Physics and Astronomy, University of Manchester, Oxford Road, Manchester M13 9PL, UK.
School of Chemistry, University of Manchester, Oxford Road, Manchester M13 9PL, UK. Electronic address: g.a.morris@manchester.ac.uk.</auth-address><titles><title>"Sample convection in liquid-state NMR: why it is always with us, and what we can do about it"</title><secondary-title>J. Magn. Reson.</secondary-title></titles><periodical><full-title>J. Magn. Reson.</full-title></periodical><pages>120-129</pages><volume>252</volume><section>120</section><keywords><keyword>Convection</keyword><keyword>Dosy</keyword><keyword>Diffusion</keyword></keywords><dates><year>2015</year><pub-dates><date>Mar</date></pub-dates></dates><isbn>1096-0856 (Electronic)
1090-7807 (Linking)</isbn><accession-num>25681799</accession-num><urls><related-urls><url> There are various ways of reducing the impact of convection during experiments, such as convection compensation, ADDIN EN.CITE <EndNote><Cite><Author>Nilsson</Author><Year>2005</Year><RecNum>82</RecNum><DisplayText><style face="superscript">41</style></DisplayText><record><rec-number>82</rec-number><foreign-keys><key app="EN" db-id="w5vd92dtlwexxmespva5fve7eswpaswp0rfa" timestamp="1461258221">82</key><key app="ENWeb" db-id="">0</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>Nilsson, M.</author><author>Morris, G. A.</author></authors></contributors><auth-address>School of Chemistry, University of Manchester, Oxford Road, Manchester M13 9PL, UK. mathias.nilsson@manchester.ac.uk</auth-address><titles><title>"Improving pulse sequences for 3D DOSY: convection compensation"</title><secondary-title>J. Magn. Reson.</secondary-title></titles><periodical><full-title>J. Magn. Reson.</full-title></periodical><pages>203-211</pages><volume>177</volume><number>2</number><section>203</section><keywords><keyword>Convection</keyword><keyword>Diffusion</keyword><keyword>Nuclear Magnetic Resonance, Biomolecular/*methods</keyword><keyword>Quinine/*chemistry</keyword><keyword>Terpenes/*chemistry</keyword></keywords><dates><year>2005</year><pub-dates><date>Dec</date></pub-dates></dates><isbn>1090-7807 (Print)
1090-7807 (Linking)</isbn><accession-num>16140552</accession-num><urls><related-urls><url> using transverse pulse field gradients, ADDIN EN.CITE <EndNote><Cite><Author>Kiraly</Author><Year>2016</Year><RecNum>199</RecNum><DisplayText><style face="superscript">70</style></DisplayText><record><rec-number>199</rec-number><foreign-keys><key app="EN" db-id="w5vd92dtlwexxmespva5fve7eswpaswp0rfa" timestamp="1529936759">199</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>Kiraly, P.</author><author>Swan, I.</author><author>Nilsson, M.</author><author>Morris, G. A.</author></authors></contributors><auth-address>School of Chemistry, University of Manchester, Oxford Road, Manchester M13 9PL, UK. Electronic address: peter.kiraly@manchester.ac.uk.
School of Chemistry, University of Manchester, Oxford Road, Manchester M13 9PL, UK.</auth-address><titles><title>"Improving accuracy in DOSY and diffusion measurements using triaxial field gradients"</title><secondary-title>J. Magn. Reson.</secondary-title></titles><periodical><full-title>J. Magn. Reson.</full-title></periodical><pages>24-30</pages><volume>270</volume><keywords><keyword>Convection</keyword><keyword>Dosy</keyword><keyword>Diffusion</keyword><keyword>Nmr</keyword><keyword>Triaxial gradient</keyword></keywords><dates><year>2016</year><pub-dates><date>Sep</date></pub-dates></dates><isbn>1096-0856 (Electronic)
1090-7807 (Linking)</isbn><accession-num>27389639</accession-num><urls><related-urls><url> using very viscous solvents, or even modifying the active volume of the NMR tube.PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5CYXJib3NhPC9BdXRob3I+PFllYXI+MjAxNjwvWWVhcj48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ADDIN EN.CITE PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5CYXJib3NhPC9BdXRob3I+PFllYXI+MjAxNjwvWWVhcj48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ADDIN EN.CITE.DATA 60, 71 A different problem is that if the fitting is not done using the appropriate form of the Stejskal-Tanner equation,PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5OaWxzc29uPC9BdXRob3I+PFllYXI+MjAwNjwvWWVhcj48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ADDIN EN.CITE PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5OaWxzc29uPC9BdXRob3I+PFllYXI+MjAwNjwvWWVhcj48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ADDIN EN.CITE.DATA 14, 17, 63, 67 and therefore the quality of the results can leave much to be desired. Any problem with the experimental data, or with its fitting, will typically be reflected in systematic residuals and increased estimated uncertainties in diffusion coefficient (leading to broad signals in the diffusion dimension). It is therefore very useful to have tools that allow users to diagnose such problems. In MAGNATE, questionable data can be conveniently investigated by simultaneously plotting diffusion data (signal decay as function of the gradient strength squared), fitted function and residuals (see supporting information, Figure S9). MAGNATE also offers the option to prune (exclude from analysis) identified outliers from the data to be fitted, allowing more reliable results to be produced.MAGNATE is intended to have applications beyond the processing and analysis of diffusion data, and as open source software it has the potential to be a versatile tool for implementation of new (and existing) methods by any user. In the current version we have incorporated a powerful tool for resolution enhancement: covariance NMR.PEVuZE5vdGU+PENpdGUgRXhjbHVkZUF1dGg9IjEiIEV4Y2x1ZGVZZWFyPSIxIj48QXV0aG9yPlpo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ADDIN EN.CITE PEVuZE5vdGU+PENpdGUgRXhjbHVkZUF1dGg9IjEiIEV4Y2x1ZGVZZWFyPSIxIj48QXV0aG9yPlpo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ADDIN EN.CITE.DATA 72-75 Covariance processing uses statistical treatment of NMR data, and sets to transfer the high resolution of one spectral dimension to another dimension of lower resolution, improving the interpretability of the data. An impressive application of this methodology is its use with 2D pure shift NMR experiments to produce high-resolution spectra in which multiplet structure is suppressed in both dimensions.PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5Nb3JyaXM8L0F1dGhvcj48WWVhcj4yMDEwPC9ZZWFyPjxS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ADDIN EN.CITE PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5Nb3JyaXM8L0F1dGhvcj48WWVhcj4yMDEwPC9ZZWFyPjxS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ADDIN EN.CITE.DATA 76-80 Some other NMR software packages include covariance tools, but the processing times can be painfully long; in MAGNATE we have found that our implementation is capable of treating large datasets (typically 2k by 2k points) very efficiently in about a few seconds on a standard desktop computer (see supporting information, Figure S12). Covariance processing can be applied to any 2D spectra (including nD arrayed datasets). Another helpful tool is the possibility to measure (and plot) the signal-to-noise ratio of 2D (and 3D) data, again using the user-friendly interface. Specifically for diffusion measurements, we have implemented an independent module for the estimation of the hydrodynamic radius or molecular weight of a solute from its diffusion coefficient, and vice versa, using either the classic Stokes-Einstein equation or the recently-proposed Stokes-Einstein-Gierer-Wirtz estimation (SEGWE) method.PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5FdmFuczwvQXV0aG9yPjxZZWFyPjIwMTM8L1llYXI+PFJl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ADDIN EN.CITE PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5FdmFuczwvQXV0aG9yPjxZZWFyPjIwMTM8L1llYXI+PFJl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ADDIN EN.CITE.DATA 81-82ConclusionThe availability of the user-friendly MAGNATE software can, as illustrated here, help end users to exploit the power of 3D diffusion experiments in many applications. There are already many published pulse sequences to choose from, and some already available as part of manufacturers’ pulse sequence packages. We hope that this work will spur the development of even more. MAGNATE is, and will continue to be, free and open source GNU (General Public License) software, and is under continued development. We will make further versions available via our website ( HYPERLINK "" ). ASSOCIATED CONTENT Supporting InformationThe Supporting Information is available free of charge on the ACS Publications website.Additional figures as noted in the text, full NMR pulse sequence, experimental parameters, recommended processing protocol, and pulse program code for Bruker spectrometers. (PDF)AUTHOR INFORMATIONCorresponding Author* Emails: guilherme.dalpoggetto@manchester.ac.uk and mathias.nilsson@manchester.ac.uk Author ContributionsAll authors have given approval to the final version of the manuscript. ACKNOWLEDGMENT This work was supported by the Engineering and Physical Sciences Research Council (grant numbers EP/M013820/1, EP/N033949/1 and EP/R018790/1) and by a studentship to GDP from Science Without Borders – Brazil (CNPq reference number 233163/2014-0). REFERENCES ADDIN EN.REFLIST 1.Stilbs, P., "Molecular Self-Diffusion Coefficients in Fourier Transform Nuclear Magnetic Resonance Spectrometric Analysis of Complex Mixtures". Anal. Chem. 1981, 53 (13), 2135-2137.2.Barjat, H.; Morris, G. A.; Smart, S.; Swanson, A. G.; Williams, S. C. R., "High-Resolution Diffusion-Ordered 2D Spectroscopy (HR-DOSY) - A New Tool for the Analysis of Complex Mixtures". J. Magn. Reson. Series B 1995, 108 (2), 170-172.3.Luo, R.; Liu, M.; Mao, X., "NMR Diffusion and Relaxation Study on Ibuprofen-HSA Interaction". Appl. Spectrosc. 1999, 53 (7), 776-779.4.Cohen, Y.; Avram, L.; Frish, L., "Diffusion NMR spectroscopy in supramolecular and combinatorial chemistry: an old parameter--new insights". Angew. Chem. Int. Ed. 2005, 44 (4), 520-554.5.Trefi, S.; Gilard, V.; Malet-Martino, M.; Martino, R., "Generic ciprofloxacin tablets contain the stated amount of drug and different impurity profiles: A 19F, 1H and DOSY NMR analysis". J. Pharm. Biomed. Anal. 2007, 44 (3), 743-754.6.Trefi, S.; Gilard, V.; Balayssac, S.; Malet-Martino, M.; Martino, R., "Quality assessment of fluoxetine and fluvoxamine pharmaceutical formulations purchased in different countries or via the Internet by 19F and 2D DOSY 1H NMR". J. Pharm. Biomed. Anal. 2008, 46 (4), 707-722.7.Balayssac, S.; Trefi, S.; Gilard, V.; Malet-Martino, M.; Martino, R.; Delsuc, M. A., "2D and 3D DOSY 1H NMR, a useful tool for analysis of complex mixtures: application to herbal drugs or dietary supplements for erectile dysfunction". J. Pharm. Biomed. Anal. 2009, 50 (4), 602-612.8.Howe, P. W., "Selective diffusion spectroscopy using excitation sculpting". Magn. Reson. Chem. 2017, 55 (5), 433-437.9.Pregosin, P. S., "Applications of NMR diffusion methods with emphasis on ion pairing in inorganic chemistry: a mini-review". Magn. Reson. Chem. 2017, 55 (5), 405-413.10.Pelta, M. D.; Barjat, H.; Morris, G. A.; Davis, A. L.; Hammond, S. J., "Pulse sequences for high-resolution diffusion-ordered spectroscopy (HR-DOSY)". Magn. Reson. Chem. 1998, 36 (10), 706-714.11.Stejskal, E. O.; Tanner, J. E., "Spin Diffusion Measurements: Spin Echoes in the Presence of a Time-Dependent Field Gradient". J. Chem. Phys. 1965, 42 (1), 288-292.12.Morris, K. F.; Johnson Jr, C. S., "Resolution of Discrete and Continuous Molecular Size Distributions by Means of Diffusion-Ordered 2D NMR Spectroscopy". J. Am. Chem. Soc. 1993, 115 (10), 4291-4299.13.Morris, G. A., "Diffusion-Ordered Spectroscopy". In eMagRes, 2009.14.Connell, M. A.; Bowyer, P. J.; Adam Bone, P.; Davis, A. L.; Swanson, A. G.; Nilsson, M.; Morris, G. A., "Improving the accuracy of pulsed field gradient NMR diffusion experiments: Correction for gradient non-uniformity". J. Magn. Reson. 2009, 198 (1), 121-131.15.Sinnaeve, D., "The Stejskal-Tanner equation generalized for any gradient shape-an overview of most pulse sequences measuring free diffusion". Concepts Magn. Reson. Part A 2012, 40A (2), 39-65.16.Pelta, M. D.; Morris, G. A.; Stchedroff, M. J.; Hammond, S. J., "A one-shot sequence for high-resolution diffusion-ordered spectroscopy". Magn. Reson. Chem. 2002, 40 (13), 147-152.17.Nilsson, M.; Connell, M. A.; Davis, A. L.; Morris, G. A., "Biexponential Fitting of Diffusion-Ordered NMR Data: Practicalities and Limitations". Anal. Chem. 2006, 78 (9), 3040-3045.18.Colbourne, A. A.; Meier, S.; Morris, G. A.; Nilsson, M., "Unmixing the NMR spectra of similar species - vive la difference". Chem. Commun. 2013, 49 (89), 10510-10512.19.Dal Poggetto, G.; Favaro, D. C.; Nilsson, M.; Morris, G. A.; Tormena, C. F., "19F DOSY NMR analysis for spin systems with nJFF couplings". Magn. Reson. Chem. 2014, 52 (4), 172-177.20.Power, J. E.; Foroozandeh, M.; Moutzouri, P.; Adams, R. W.; Nilsson, M.; Coombes, S. R.; Phillips, A. R.; Morris, G. A., "Very broadband diffusion-ordered NMR spectroscopy: 19F DOSY". Chem. Commun. 2016, 52 (42), 6892-6894.21.Xu, C.; Wan, Y.; Chen, D.; Gao, C.; Yin, H.; Fetherston, D.; Kupce, E.; Lopez, G.; Ameduri, B.; Twum, E. B.; Wyzgoski, F. J.; Li, X.; McCord, E. F.; Rinaldi, P. L., "19F DOSY diffusion-NMR spectroscopy of fluoropolymers". Magn. Reson. Chem. 2017, 55 (5), 472-484.22.Kagan, G.; Li, W.; Hopson, R.; Williard, P. G., "Internally Referenced Diffusion Coefficient-Formula Weight (D-FW) Analysis of 31P Diffusion-Ordered NMR Spectroscopy (DOSY)". Org. Lett. 2009, 11 (21), 4818-4821.23.Shestakova, P.; Absillis, G.; Martin-Martinez, F. J.; De Proft, F.; Willem, R.; Parac-Vogt, T. N., "Integrating 31P DOSY NMR spectroscopy and molecular mechanics as a powerful tool for unraveling the chemical structures of polyoxomolybdate-based amphiphilic nanohybrids in aqueous solution". Chem. Eur. J. 2014, 20 (18), 5258-5270.24.Wu, D.; Chen, A.; Johnson Jr, C. S., "Heteronuclear-Detected Diffusion-Ordered NMR Spectroscopy through Coherence Transfer". J. Magn. Reson. Series A 1996, 123 (2), 215-218.25.Botana, A.; Howe, P. W.; Caer, V.; Morris, G. A.; Nilsson, M., "High resolution 13C DOSY: the DEPTSE experiment". J. Magn. Reson. 2011, 211 (1), 25-29.26.Adams, R. W., "Pure Shift NMR Spectroscopy". eMagRes 2014, 295-310.27.Casta?ar, L.; Parella, T., "Broadband 1H homodecoupled NMR experiments: recent developments, methods and applications". Magn. Reson. Chem. 2015, 53 (6), 399-426.28.Zangger, K., "Pure shift NMR". Prog. Nucl. Magn. Res. Sp. 2015, 86-87, 1-20.29.Casta?ar, L., "Pure shift 1H NMR: what is next?". Magn. Reson. Chem. 2017, 55 (1), 47-53.30.Nilsson, M.; Morris, G. A., "Pure shift proton DOSY: diffusion-ordered 1H spectra without multiplet structure". Chem. Commun. 2007, (9), 933-935.31.Aguilar, J. A.; Faulkner, S.; Nilsson, M.; Morris, G. A., "Pure shift 1H NMR: a resolution of the resolution problem?". Angew. Chem. Int. Ed. 2010, 49 (23), 3901-3903.32.Glanzer, S.; Zangger, K., "Directly decoupled diffusion-ordered NMR spectroscopy for the analysis of compound mixtures". Chem. Eur. J. 2014, 20 (35), 11171-11175.33.Foroozandeh, M.; Casta?ar, L.; Martins, L. G.; Sinnaeve, D.; Dal Poggetto, G.; Tormena, C. F.; Adams, R. W.; Morris, G. A.; Nilsson, M., "Ultrahigh-Resolution Diffusion-Ordered Spectroscopy". Angew. Chem. Int. Ed. 2016, 55 (50), 15579-15582.34.Wu, D.; Chen, A.; Johnson Jr, C. S., "Three-Dimensional Diffusion-Ordered NMR Spectroscopy: The Homonuclear COSY–DOSY Experiment". J. Magn. Reson. Series A 1996, 121 (1), 88-91.35.Jerschow, A.; Muller, N., "3D Diffusion-Ordered TOCSY for Slowly Diffusing Molecules". J. Magn. Reson. Series A 1996, 123 (2), 222-225.36.Gozansky, E. K.; Gorenstein, D. G., "DOSY-NOESY: Diffusion-Ordered NOESY". J. Magn. Reson. Series B 1996, 111 (1), 94-96.37.Birlirakis, N.; Guittet, E., "A New Approach in the Use of Gradients for Size-Resolved 2D-NMR Experiments". J. Am. Chem. Soc. 1996, 118 (51), 13083-13084.38.Barjat, H.; Morris, G. A.; Swansom, A. G., "A Three-Dimensional DOSY–HMQC Experiment for the High-Resolution Analysis of Complex Mixtures". J. Magn. Reson. 1998, 131 (1), 131-138.39.Lucas, L. H.; Otto, W. H.; Larive, C. K., "The 2D-J-DOSY Experiment: Resolving Diffusion Coefficients in Mixtures". J. Magn. Reson. 2002, 156 (1), 138-145.40.Stchedroff, M. J.; Kenwright, A. M.; Morris, G. A.; Nilsson, M.; Harris, R. K., "2D and 3D DOSY methods for studying mixtures of oligomeric dimethylsiloxanes". Phys. Chem. Chem. Phys. 2004, 6 (13), 3221-3227.41.Nilsson, M.; Morris, G. A., "Improving pulse sequences for 3D DOSY: convection compensation". J. Magn. Reson. 2005, 177 (2), 203-211.42.Nilsson, M.; Gil, A. M.; Delgadillo, I.; Morris, G. A., "Improving pulse sequences for 3D DOSY: COSY-IDOSY". Chem. Commun. 2005, (13), 1737-1739.43.Vitorge, B.; Jeanneat, D., "NMR Diffusion Measurements in Complex Mixtures Using Constant-Time-HSQC-IDOSY and Computer-Optimized Spectral Aliasing for High Resolution in the Carbon Dimension". Anal. Chem. 2006, 78 (15), 5601-5606.44.Brand, T.; Cabrita, E. J.; Morris, G. A.; Gunther, R.; Hofmann, H. J.; Berger, S., "Residue-specific NH exchange rates studied by NMR diffusion experiments". J. Magn. Reson. 2007, 187 (1), 97-104.45.McLachlan, A. S.; Richards, J. J.; Bilia, A. R.; Morris, G. A., "Constant time gradient HSQC-iDOSY: practical aspects". Magn. Reson. Chem. 2009, 47 (12), 1081-1085.46.Didenko, T.; Boelens, R.; Rudiger, S. G., "3D DOSY-TROSY to determine the translational diffusion coefficient of large protein complexes". Protein Eng. Des. Sel. 2011, 24 (1-2), 99-103.47.Augustyniak, R.; Ferrage, F.; Paquin, R.; Lequin, O.; Bodenhausen, G., "Methods to determine slow diffusion coefficients of biomolecules. Applications to Engrailed 2, a partially disordered protein". J. Biomol NMR 2011, 50 (3), 209-218.48.Nilsson, M.; Gil, A. M.; Delgadillo, I.; Morris, G. A., "Improving Pulse Sequences for 3D Diffusion-Ordered NMR Spectroscopy: 2DJ-IDOSY". Anal. Chem. 2004, 76 (18), 5418-5422.49.Jaravine, V.; Ibraghimov, I.; Orekhov, V. Y., "Removal of a time barrier for high-resolution multidimensional NMR spectroscopy". Nat. Meth. 2006, 3 (8), 605-607.50.Urbanczyk, M.; Kozminski, W.; Kazimierczuk, K., "Accelerating diffusion-ordered NMR spectroscopy by joint sparse sampling of diffusion and time dimensions". Angew. Chem. Int. Ed. 2014, 53 (25), 6464-6467.51.Hassanieh, H.; Mayzel, M.; Shi, L.; Katabi, D.; Orekhov, V. Y., "Fast multi-dimensional NMR acquisition and processing using the sparse FFT". J . Biomol. NMR 2015, 63 (1), 9-19.52.Qu, X.; Mayzel, M.; Cai, J. F.; Chen, Z.; Orekhov, V., "Accelerated NMR spectroscopy with low-rank reconstruction". Angew. Chem. Int. Ed. 2015, 54 (3), 852-854.53.Kazimierczuk, K.; Orekhov, V., "Non-uniform sampling: post-Fourier era of NMR data collection and processing". Magn. Reson. Chem. 2015, 53 (11), 921-926.54.Hansen, A. L.; Bruschweiler, R., "Absolute Minimal Sampling in High-Dimensional NMR Spectroscopy". Angew. Chem. Int. Ed. 2016, 55 (45), 14169-14172.55.Aguilar, J. A.; Belda, R.; Botana, A.; Kenwright, A. M., "HD-2D: routine high-dispersion two-dimensional NMR spectra at no extra cost". RSC Adv. 2016, 6 (86), 83380-83385.56.Casta?ar, L.; Dal Poggetto, G.; Colbourne, A. A.; Morris, G. A.; Nilsson, M., "The GNAT: A new tool for processing NMR data". Magn. Reson. Chem. 2018, 56 (6), 546–558.57.Nilsson, M., "The DOSY Toolbox: a new tool for processing PFG NMR diffusion data". J. Magn. Reson. 2009, 200 (2), 296-302.58.Botana, A.; Aguilar, J. A.; Nilsson, M.; Morris, G. A., "J-modulation effects in DOSY experiments and their suppression: the Oneshot45 experiment". J. Magn. Reson. 2011, 208 (2), 270-278.59.Swan, I.; Reid, M.; Howe, P. W.; Connell, M. A.; Nilsson, M.; Moore, M. A.; Morris, G. A., "Sample convection in liquid-state NMR: why it is always with us, and what we can do about it". J. Magn. Reson. 2015, 252, 120-129.60.Barbosa, T. M.; Rittner, R.; Tormena, C. F.; Morris, G. A.; Nilsson, M., "Convection in liquid-state NMR: expect the unexpected". RSC Adv. 2016, 6 (97), 95173-95176.61.Nilsson, M.; Morris, G. A., "Speedy Component Resolution An Improved Tool". Anal. Chem. 2008, 80 (10), 3777-3782.62.Windig, W.; Antalek, B., "Direct exponential curve resolution algorithm (DECRA) - A novel application of the generalized rank annihilation method for a single spectral mixture data set with exponentially decaying contribution profiles". Chem. Int. Lab. Sys. 1997, 37 (2), 241-254.63.Nilsson, M.; Morris, G. A., "Improved DECRA processing of DOSY data: correcting for non-uniform field gradients". Magn. Reson. Chem. 2007, 45 (8), 656-660.64.Karakach, T. K.; Knight, R.; Lenz, E. M.; Viant, M. R.; Walter, J. A., "Analysis of time course 1H NMR metabolomics data by multivariate curve resolution". Magn. Reson. Chem. 2009, 47 (2), 105-117.65.Toumi, I.; Torresani, B.; Caldarelli, S., "Effective processing of pulse field gradient NMR of mixtures by blind source separation". Anal. Chem. 2013, 85 (23), 11344-11351.66.Zhong, J.; DiDonato, N.; Hatcher, P. G., "Independent component analysis applied to diffusion-ordered spectroscopy: separating nuclear magnetic resonance spectra of analytes in mixtures". J. Chemom. 2012, 26 (5), 150-157.67.Nilsson, M.; Morris, G. A., "Correction of systematic errors in CORE processing of DOSY data". Magn. Reson. Chem. 2006, 44 (7), 655-660.68.Van Gorkom, L. C. M.; Hancewicz, T. M., "Analysis of DOSY and GPC-NMR Experiments on Polymers by Multivariate Curve Resolution". J. Magn. Reson. 1998, 130 (1), 125-130.69.Nuzillard, D.; Bourg, S.; Nuzillard, J. M., "Model-Free Analysis of Mixtures by NMR Using Blind Source Separation". J. Magn. Reson. 1998, 133 (2), 358-363.70.Kiraly, P.; Swan, I.; Nilsson, M.; Morris, G. A., "Improving accuracy in DOSY and diffusion measurements using triaxial field gradients". J. Magn. Reson. 2016, 270, 24-30.71.Iwashita, T.; Konuma, T.; Harada, E.; Mori, S.; Sugase, K., "Use of glass capillaries to suppress thermal convection in NMR tubes in diffusion measurements". Magn. Reson. Chem. 2016, 54 (9), 729–733.72.Zhang, F.; Bruschweiler, R., "Indirect Covariance NMR Spectroscopy". J. Am. Chem. Soc. 2004, 126 (41), 13180-13181.73.Bruschweiler, R.; Zhang, F., "Covariance nuclear magnetic resonance spectroscopy". J. Chem. Phys. 2004, 120 (11), 5253-5260.74.Bruschweiler, R., "Theory of covariance nuclear magnetic resonance spectroscopy". J. Chem. Phys. 2004, 121 (1), 409-14.75.Snyder, D. A.; Bruschweiler, R., "Multidimensional covariance spectroscopy by Covariance NMR". eMagRes 2009.76.Morris, G. A.; Aguilar, J. A.; Evans, R.; Haiber, S.; Nilsson, M., "True Chemical Shift Correlation Maps: A TOCSY Experiment with Pure Shifts in Both Dimensions". J. Am. Chem. Soc. 2010, 132 (37), 12770-12772.77.Aguilar, J. A.; Colbourne, A. A.; Cassani, J.; Nilsson, M.; Morris, G. A., "Decoupling two-dimensional NMR spectroscopy in both dimensions: pure shift NOESY and COSY". Angew. Chem. Int. Ed. 2012, 51 (26), 6460-6463.78.Foroozandeh, M.; Adams, R. W.; Nilsson, M.; Morris, G. A., "Ultrahigh-Resolution Total Correlation NMR spectroscopy". J. Am. Chem. Soc. 2014, 136 (34), 11867-11869.79.Fredi, A.; Nolis, P.; Cobas, C.; Martin, G. E.; Parella, T., "Exploring the use of Generalized Indirect Covariance to reconstruct pure shift NMR spectra: Current Pros and Cons". J. Magn. Reson. 2016, 266, 16-22.80.Fredi, A.; Nolis, P.; Cobas, C.; Parella, T., "Access to experimentally infeasible spectra by pure-shift NMR covariance". J. Magn. Reson. 2016, 270, 161-168.81.Evans, R.; Deng, Z.; Rogerson, A. K.; McLachlan, A. S.; Richards, J. J.; Nilsson, M.; Morris, G. A., "Quantitative interpretation of diffusion-ordered NMR spectra: can we rationalize small molecule diffusion coefficients?". Angew. Chem. Int. Ed. 2013, 52 (11), 3199-3202.82.Evans, R.; Dal Poggetto, G.; Nilsson, M.; Morris, G. A., "Improving the Interpretation of Small Molecule Diffusion Coefficients". Anal. Chem. 2018, 90 (6), 3987-3994.TOC ................
................
In order to avoid copyright disputes, this page is only a partial summary.
To fulfill the demand for quickly locating and searching documents.
It is intelligent file search solution for home and business.
Related searches
- fda electronic submission guidance
- fda electronic submission requirements
- electronic submission guidelines
- fda electronic submission guidelines
- how to writing template for first grade
- to do list template for word
- best electronic websites to buy
- how to write journals examples
- electronic submission guidance fda
- free website submission to 1000 search engines
- electronic submission gateway fda
- template for introduction to a research paper