International Parkinson and Movement Disorder Society
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ADDIN EN.CITE.DATA 1Pure or complex; Silver-syndrome, allelic with hereditary sensory neuropathy type 1, cerebral palsy (infantile onset). GeneReviews 182600AD/ARSPG3AHSP-SPAST ADDIN EN.CITE <EndNote><Cite><Author>Nielsen</Author><Year>1997</Year><RecNum>313</RecNum><DisplayText><style face="superscript">2</style></DisplayText><record><rec-number>313</rec-number><foreign-keys><key app="EN" db-id="evt9rs9wb5sexces9voxv9txtzadt29aee0t" timestamp="0">313</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>Nielsen, J. E.</author><author>Koefoed, P.</author><author>Abell, K.</author><author>Hasholt, L.</author><author>Eiberg, H.</author><author>Fenger, K.</author><author>Niebuhr, E.</author><author>Sorensen, S. A.</author></authors></contributors><auth-address>Department of Medical Genetics, Panum Institute, University of Copenhagen, Denmark.</auth-address><titles><title>CAG repeat expansion in autosomal dominant pure spastic paraplegia linked to chromosome 2p21-p24</title><secondary-title>Hum Mol Genet</secondary-title></titles><periodical><full-title>Hum Mol Genet</full-title></periodical><pages>1811-6</pages><volume>6</volume><number>11</number><keywords><keyword>*Chromosomes, Human, Pair 2</keyword><keyword>Female</keyword><keyword>Genes, Dominant</keyword><keyword>Genetic Linkage</keyword><keyword>Humans</keyword><keyword>Male</keyword><keyword>Paraplegia/*genetics</keyword><keyword>Pedigree</keyword><keyword>*Trinucleotide Repeats</keyword><keyword>Tumor Cells, Cultured</keyword></keywords><dates><year>1997</year><pub-dates><date>Oct</date></pub-dates></dates><isbn>0964-6906 (Print)
0964-6906 (Linking)</isbn><accession-num>9302257</accession-num><urls><related-urls><url> or complex; dementia, epilepsy, Peripheral neuropathy, tremor, ataxia, TCC, cerebellar atrophy.GeneReviews 182601ADSPG4HSP-NIPA1 ADDIN EN.CITE <EndNote><Cite><Author>Rainier</Author><Year>2003</Year><RecNum>315</RecNum><DisplayText><style face="superscript">3</style></DisplayText><record><rec-number>315</rec-number><foreign-keys><key app="EN" db-id="evt9rs9wb5sexces9voxv9txtzadt29aee0t" timestamp="0">315</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>Rainier, S.</author><author>Chai, J. H.</author><author>Tokarz, D.</author><author>Nicholls, R. D.</author><author>Fink, J. K.</author></authors></contributors><auth-address>Department of Neurology, University of Michigan, Ann Arbor, MI 48109, USA.</auth-address><titles><title>NIPA1 gene mutations cause autosomal dominant hereditary spastic paraplegia (SPG6)</title><secondary-title>Am J Hum Genet</secondary-title></titles><periodical><full-title>Am J Hum Genet</full-title></periodical><pages>967-71</pages><volume>73</volume><number>4</number><keywords><keyword>Base Sequence</keyword><keyword>Female</keyword><keyword>Genes, Dominant</keyword><keyword>Humans</keyword><keyword>Male</keyword><keyword>Membrane Proteins/*genetics</keyword><keyword>Models, Molecular</keyword><keyword>*Mutation</keyword><keyword>Pedigree</keyword><keyword>Protein Structure, Secondary</keyword><keyword>Reference Values</keyword><keyword>Spastic Paraplegia, Hereditary/*genetics</keyword></keywords><dates><year>2003</year><pub-dates><date>Oct</date></pub-dates></dates><isbn>0002-9297 (Print)
0002-9297 (Linking)</isbn><accession-num>14508710</accession-num><urls><related-urls><url> or complex; Peripheral neuropathy, spinal cord atrophy, spastic dysarthria, facial dystonia, atrophy of the small hand muscles, upper limb spasticity, epilepsy.GeneReviews 600363ADSPG6HSP-KIAA0196PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5WYWxkbWFuaXM8L0F1dGhvcj48WWVhcj4yMDA3PC9ZZWFy
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ADDIN EN.CITE.DATA 4Pure spastic paraplegiaGeneReviews 603563ADSPG8HSP-KIF5A ADDIN EN.CITE <EndNote><Cite><Author>Reid</Author><Year>2002</Year><RecNum>319</RecNum><DisplayText><style face="superscript">5</style></DisplayText><record><rec-number>319</rec-number><foreign-keys><key app="EN" db-id="evt9rs9wb5sexces9voxv9txtzadt29aee0t" timestamp="0">319</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>Reid, E.</author><author>Kloos, M.</author><author>Ashley-Koch, A.</author><author>Hughes, L.</author><author>Bevan, S.</author><author>Svenson, I. K.</author><author>Graham, F. L.</author><author>Gaskell, P. C.</author><author>Dearlove, A.</author><author>Pericak-Vance, M. A.</author><author>Rubinsztein, D. C.</author><author>Marchuk, D. A.</author></authors></contributors><auth-address>Department of Medical Genetics, Cambridge Institute for Medical Research, University of Cambridge, United Kingdom. ereid@hgmp.mrc.ac.uk</auth-address><titles><title>A kinesin heavy chain (KIF5A) mutation in hereditary spastic paraplegia (SPG10)</title><secondary-title>Am J Hum Genet</secondary-title></titles><periodical><full-title>Am J Hum Genet</full-title></periodical><pages>1189-94</pages><volume>71</volume><number>5</number><keywords><keyword>Amino Acid Sequence</keyword><keyword>Animals</keyword><keyword>Axons/metabolism</keyword><keyword>Female</keyword><keyword>Humans</keyword><keyword>Kinesin/*genetics</keyword><keyword>Male</keyword><keyword>Molecular Sequence Data</keyword><keyword>*Mutation</keyword><keyword>Pedigree</keyword><keyword>Sequence Alignment</keyword><keyword>Spastic Paraplegia, Hereditary/*genetics</keyword></keywords><dates><year>2002</year><pub-dates><date>Nov</date></pub-dates></dates><isbn>0002-9297 (Print)
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ADDIN EN.CITE.DATA 8Complex; Silver syndrome, these mutations may also cause distal hereditary neuropathy type 5.GeneReviews 270685ADSPG17HSP-REEP1 ADDIN EN.CITE <EndNote><Cite><Author>Zuchner</Author><Year>2006</Year><RecNum>340</RecNum><DisplayText><style face="superscript">9</style></DisplayText><record><rec-number>340</rec-number><foreign-keys><key app="EN" db-id="evt9rs9wb5sexces9voxv9txtzadt29aee0t" timestamp="0">340</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>Zuchner, S.</author><author>Wang, G.</author><author>Tran-Viet, K. N.</author><author>Nance, M. A.</author><author>Gaskell, P. C.</author><author>Vance, J. M.</author><author>Ashley-Koch, A. E.</author><author>Pericak-Vance, M. A.</author></authors></contributors><auth-address>Center for Human Genetics, Duke University Medical Center, Durham, NC 27710, USA. szuchner@chg.duhs.duke.edu</auth-address><titles><title>Mutations in the novel mitochondrial protein REEP1 cause hereditary spastic paraplegia type 31</title><secondary-title>Am J Hum Genet</secondary-title></titles><periodical><full-title>Am J Hum Genet</full-title></periodical><pages>365-9</pages><volume>79</volume><number>2</number><keywords><keyword>Animals</keyword><keyword>Haplorhini</keyword><keyword>Humans</keyword><keyword>Membrane Transport Proteins/*genetics/metabolism</keyword><keyword>Mitochondrial Proteins/*genetics/metabolism</keyword><keyword>Molecular Sequence Data</keyword><keyword>*Mutation</keyword><keyword>Rats</keyword><keyword>Spastic Paraplegia, Hereditary/*genetics/metabolism</keyword></keywords><dates><year>2006</year><pub-dates><date>Aug</date></pub-dates></dates><isbn>0002-9297 (Print)
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ADDIN EN.CITE.DATA 10Pure or complex; distal motor neuronopathy, axonal Peripheral neuropathy, Silver-like syndrome, cerebellar ataxia, tremor, dementia.GeneReviews 610250ADSPG31HSP-ZFYV327PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5NYW5uYW48L0F1dGhvcj48WWVhcj4yMDA2PC9ZZWFyPjxS
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ADDIN EN.CITE.DATA 14Autosomal dominantPure or complex; cognitive impairment, congenital cataract, dysarthria, cerebellar signs, neuropathic pain, epilepsy, infantile psychosis, sensorineural hearing loss, vomiting, biochemical features of delta-1-pyrroline-5-carboxylate synthase deficiency.GeneReviews 601162Autosomal recessiveComplex; cognitive impairment.OMIM 616586GeneReviews phenotype: Cutis laxa, autosomal dominant 3 (OMIM 616603) and Cutis laxa, autosomal recessive, type IIIA (OMIM 219150).AD/ARSPG9A, autosomal dominantSPG 9B, autosomal recessiveAutosomal Recessive formsHSP-CYP7B1PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5Uc2FvdXNpZG91PC9BdXRob3I+PFllYXI+MjAwODwvWWVh
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ADDIN EN.CITE.DATA 15Pure or complex; white matter lesions, optic atrophy, cerebellar ataxia, sensory ataxia.GeneReviews 270800ARSPG5AHSP-SPG7PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5DYXNhcmk8L0F1dGhvcj48WWVhcj4xOTk4PC9ZZWFyPjxS
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ADDIN EN.CITE.DATA 17ParkinsonismPEVuZE5vdGU+PENpdGU+PEF1dGhvcj5SZW52b2lzZTwvQXV0aG9yPjxZZWFyPjIwMTQ8L1llYXI+
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ADDIN EN.CITE.DATA 18Pure or complex; May cause Kjellin syndrome; TCC, mental retardation, sensory neuropathy, amyotrophy, dysarthria, nystagmus, ataxia, maculopathy, white matter lesions. Occasional parkinsonism.GeneReviews 640360ARSPG11HSP-ZFYVE26PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5IYW5laW48L0F1dGhvcj48WWVhcj4yMDA4PC9ZZWFyPjxS
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ADDIN EN.CITE.DATA 20Complex; intellectual decline, speech involvement, seizures, congenital hip dislocation.GeneReviews 611225ARSPG18HSP-SPARTIN ADDIN EN.CITE <EndNote><Cite><Author>Patel</Author><Year>2002</Year><RecNum>329</RecNum><DisplayText><style face="superscript">21</style></DisplayText><record><rec-number>329</rec-number><foreign-keys><key app="EN" db-id="evt9rs9wb5sexces9voxv9txtzadt29aee0t" timestamp="0">329</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>Patel, H.</author><author>Cross, H.</author><author>Proukakis, C.</author><author>Hershberger, R.</author><author>Bork, P.</author><author>Ciccarelli, F. D.</author><author>Patton, M. A.</author><author>McKusick, V. A.</author><author>Crosby, A. H.</author></authors></contributors><auth-address>Department of Medical Genetics, St. George's Hospital Medical School, University of London, Cranmer Terrace, London SW17 0RE, UK.</auth-address><titles><title>SPG20 is mutated in Troyer syndrome, an hereditary spastic paraplegia</title><secondary-title>Nat Genet</secondary-title></titles><periodical><full-title>Nat Genet</full-title></periodical><pages>347-8</pages><volume>31</volume><number>4</number><keywords><keyword>Adenosine Triphosphatases</keyword><keyword>Adipose Tissue/metabolism</keyword><keyword>Calcium-Binding Proteins/genetics/metabolism</keyword><keyword>Chromosome Mapping</keyword><keyword>*Chromosomes, Human, Pair 13</keyword><keyword>Exons</keyword><keyword>Humans</keyword><keyword>Molecular Sequence Data</keyword><keyword>*Mutation</keyword><keyword>Polymorphism, Single-Stranded Conformational</keyword><keyword>Proteins/*genetics/*metabolism</keyword><keyword>Spastic Paraplegia, Hereditary/*genetics</keyword></keywords><dates><year>2002</year><pub-dates><date>Aug</date></pub-dates></dates><isbn>1061-4036 (Print)
1061-4036 (Linking)</isbn><accession-num>12134148</accession-num><urls><related-urls><url>; Troyer-syndrome. Early onset dysarthria, distal muscle wasting with contractures and cerebellar signs in some. Delayed cognition and dysmorphism.GeneReviews 275900ARSPG20HSP-ACP33PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5TaW1wc29uPC9BdXRob3I+PFllYXI+MjAwMzwvWWVhcj48
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ADDIN EN.CITE.DATA 24Pure and complex; cerebellar oculomotor disturbance, Peripheral neuropathy.GeneReviews 609340ARSPG28HSP-KIF1A ADDIN EN.CITE <EndNote><Cite><Author>Erlich</Author><Year>2011</Year><RecNum>339</RecNum><DisplayText><style face="superscript">25</style></DisplayText><record><rec-number>339</rec-number><foreign-keys><key app="EN" db-id="evt9rs9wb5sexces9voxv9txtzadt29aee0t" timestamp="0">339</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>Erlich, Y.</author><author>Edvardson, S.</author><author>Hodges, E.</author><author>Zenvirt, S.</author><author>Thekkat, P.</author><author>Shaag, A.</author><author>Dor, T.</author><author>Hannon, G. J.</author><author>Elpeleg, O.</author></authors></contributors><auth-address>Whitehead Institute for Biomedical Research, Cambridge, Massachusetts 02142, USA. yaniv@wi.mit.edu</auth-address><titles><title>Exome sequencing and disease-network analysis of a single family implicate a mutation in KIF1A in hereditary spastic paraparesis</title><secondary-title>Genome Res</secondary-title></titles><pages>658-64</pages><volume>21</volume><number>5</number><keywords><keyword>Adolescent</keyword><keyword>Adult</keyword><keyword>Amino Acid Sequence</keyword><keyword>Databases, Genetic</keyword><keyword>Exons/genetics</keyword><keyword>Genotype</keyword><keyword>Homozygote</keyword><keyword>Humans</keyword><keyword>Kinesin/*genetics</keyword><keyword>Male</keyword><keyword>Models, Molecular</keyword><keyword>Mutation</keyword><keyword>Pedigree</keyword><keyword>Phenotype</keyword><keyword>Polymorphism, Single Nucleotide</keyword><keyword>Sequence Analysis, DNA/*methods</keyword><keyword>Spastic Paraplegia, Hereditary/*genetics/pathology</keyword><keyword>Young Adult</keyword></keywords><dates><year>2011</year><pub-dates><date>May</date></pub-dates></dates><isbn>1549-5469 (Electronic)
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ADDIN EN.CITE.DATA 26Dystonia, parkinsonism, ataxia ADDIN EN.CITE <EndNote><Cite><Author>Kruer</Author><Year>2010</Year><RecNum>416</RecNum><DisplayText><style face="superscript">27</style></DisplayText><record><rec-number>416</rec-number><foreign-keys><key app="EN" db-id="evt9rs9wb5sexces9voxv9txtzadt29aee0t" timestamp="1444244399">416</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>Kruer, Michael C.</author><author>Paisán-Ruiz, Coro</author><author>Boddaert, Nathalie</author><author>Yoon, Moon Y.</author><author>Hama, Hiroko</author><author>Gregory, Allison</author><author>Malandrini, Alessandro</author><author>Woltjer, Randall L.</author><author>Munnich, Arnold</author><author>Gobin, Stephanie</author><author>Polster, Brenda J.</author><author>Palmeri, Silvia</author><author>Edvardson, Simon</author><author>Hardy, John</author><author>Houlden, Henry</author><author>Hayflick, Susan J.</author></authors></contributors><titles><title>Defective FA2H leads to a novel form of neurodegeneration with brain iron accumulation (NBIA)</title><secondary-title>Annals of Neurology</secondary-title></titles><periodical><full-title>Annals of Neurology</full-title></periodical><pages>611-618</pages><volume>68</volume><number>5</number><dates><year>2010</year></dates><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><isbn>1531-8249</isbn><urls><related-urls><url> Fatty Acid Hydroxylase-associated Neurodegeneration (FAHN) ADDIN EN.CITE <EndNote><Cite><Author>Kruer</Author><Year>2010</Year><RecNum>416</RecNum><DisplayText><style face="superscript">27</style></DisplayText><record><rec-number>416</rec-number><foreign-keys><key app="EN" db-id="evt9rs9wb5sexces9voxv9txtzadt29aee0t" timestamp="1444244399">416</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>Kruer, Michael C.</author><author>Paisán-Ruiz, Coro</author><author>Boddaert, Nathalie</author><author>Yoon, Moon Y.</author><author>Hama, Hiroko</author><author>Gregory, Allison</author><author>Malandrini, Alessandro</author><author>Woltjer, Randall L.</author><author>Munnich, Arnold</author><author>Gobin, Stephanie</author><author>Polster, Brenda J.</author><author>Palmeri, Silvia</author><author>Edvardson, Simon</author><author>Hardy, John</author><author>Houlden, Henry</author><author>Hayflick, Susan J.</author></authors></contributors><titles><title>Defective FA2H leads to a novel form of neurodegeneration with brain iron accumulation (NBIA)</title><secondary-title>Annals of Neurology</secondary-title></titles><periodical><full-title>Annals of Neurology</full-title></periodical><pages>611-618</pages><volume>68</volume><number>5</number><dates><year>2010</year></dates><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><isbn>1531-8249</isbn><urls><related-urls><url> accumulation: GP (more subtle than other NBIAs)Additional clinical features: Spastic tetraparesis, cognitive decline, cerebellar and brainstem atrophy, dysarthria, dysphagia, optic nerve atrophy, seizuresGeneReviews 612319ARSPG35HSP-PNPLA6/NT ADDIN EN.CITE <EndNote><Cite><Author>Rainier</Author><Year>2008</Year><RecNum>348</RecNum><DisplayText><style face="superscript">28</style></DisplayText><record><rec-number>348</rec-number><foreign-keys><key app="EN" db-id="evt9rs9wb5sexces9voxv9txtzadt29aee0t" timestamp="0">348</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>Rainier, S.</author><author>Bui, M.</author><author>Mark, E.</author><author>Thomas, D.</author><author>Tokarz, D.</author><author>Ming, L.</author><author>Delaney, C.</author><author>Richardson, R. J.</author><author>Albers, J. W.</author><author>Matsunami, N.</author><author>Stevens, J.</author><author>Coon, H.</author><author>Leppert, M.</author><author>Fink, J. K.</author></authors></contributors><auth-address>Department of Neurology, University of Michigan, Ann Arbor, MI 48109, USA.</auth-address><titles><title>Neuropathy target esterase gene mutations cause motor neuron disease</title><secondary-title>Am J Hum Genet</secondary-title></titles><periodical><full-title>Am J Hum Genet</full-title></periodical><pages>780-5</pages><volume>82</volume><number>3</number><keywords><keyword>Amino Acid Sequence</keyword><keyword>Axons/*physiology</keyword><keyword>Carboxylic Ester Hydrolases/*genetics</keyword><keyword>Chromosome Mapping</keyword><keyword>Female</keyword><keyword>Genetic Linkage</keyword><keyword>Humans</keyword><keyword>Male</keyword><keyword>Molecular Sequence Data</keyword><keyword>Motor Neuron Disease/*genetics</keyword><keyword>Mutation</keyword><keyword>Pedigree</keyword></keywords><dates><year>2008</year><pub-dates><date>Mar</date></pub-dates></dates><isbn>1537-6605 (Electronic)
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ADDIN EN.CITE.DATA 30: Dystonia, parkinsonismIron accumulation: GP - hyperintense streaking of medial medullary lamina between GPi and GPe; SNAdditional clinical features: Progressive spastic paresis, dysarthria, dysphagia, cognitive decline/dementia, motor axonal neuropathy, optic nerve atrophy, psychiatric symptoms, bowel/bladder incontinenceGeneReviews 614298ARNBIA4/SPG43HSP-NT5C2PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5Ob3ZhcmlubzwvQXV0aG9yPjxZZWFyPjIwMTQ8L1llYXI+
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ADDIN EN.CITE.DATA 33Complex; intellectual disability, seizures, TCC, white matter lesions.GeneReviews 614066ARSPG47HSP-KIAA0415 ADDIN EN.CITE <EndNote><Cite><Author>Slabicki</Author><Year>2010</Year><RecNum>357</RecNum><DisplayText><style face="superscript">34</style></DisplayText><record><rec-number>357</rec-number><foreign-keys><key app="EN" db-id="evt9rs9wb5sexces9voxv9txtzadt29aee0t" timestamp="0">357</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>Slabicki, M.</author><author>Theis, M.</author><author>Krastev, D. B.</author><author>Samsonov, S.</author><author>Mundwiller, E.</author><author>Junqueira, M.</author><author>Paszkowski-Rogacz, M.</author><author>Teyra, J.</author><author>Heninger, A. K.</author><author>Poser, I.</author><author>Prieur, F.</author><author>Truchetto, J.</author><author>Confavreux, C.</author><author>Marelli, C.</author><author>Durr, A.</author><author>Camdessanche, J. P.</author><author>Brice, A.</author><author>Shevchenko, A.</author><author>Pisabarro, M. T.</author><author>Stevanin, G.</author><author>Buchholz, F.</author></authors></contributors><auth-address>Max Planck Institute for Molecular Cell Biology and Genetics, Dresden, Germany.</auth-address><titles><title>A genome-scale DNA repair RNAi screen identifies SPG48 as a novel gene associated with hereditary spastic paraplegia</title><secondary-title>PLoS Biol</secondary-title></titles><pages>e1000408</pages><volume>8</volume><number>6</number><keywords><keyword>*DNA Repair</keyword><keyword>Gene Knockdown Techniques</keyword><keyword>*Genome, Human</keyword><keyword>Humans</keyword><keyword>*RNA Interference</keyword><keyword>Recombination, Genetic</keyword><keyword>Spastic Paraplegia, Hereditary/*genetics</keyword></keywords><dates><year>2010</year></dates><isbn>1545-7885 (Electronic)
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ADDIN EN.CITE.DATA 41Allelic with autosomal recessive spastic ataxia at the SAX2 locus.Dystonia, ataxiaPEVuZE5vdGU+PENpdGU+PEF1dGhvcj5Eb3I8L0F1dGhvcj48WWVhcj4yMDE0PC9ZZWFyPjxSZWNO
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ADDIN EN.CITE.DATA 41Pure and complicated, chorea, myoclonus, dysarthria, developmental delay, mild mental retardation, hypodontia, ptosis, short stature, sensorineural deafness, pes planus, white matter lesions.GeneReviews: 611302ARSPG58HSP-ERLIN1PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5Ob3ZhcmlubzwvQXV0aG9yPjxZZWFyPjIwMTQ8L1llYXI+
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ADDIN EN.CITE.DATA 42 Complex, generalized dystonia, no speechGeneReviewsOMIMARAlsinHSP-SACSIN ADDIN EN.CITE <EndNote><Cite><Author>Bouchard</Author><Year>1978</Year><RecNum>400</RecNum><DisplayText><style face="superscript">43</style></DisplayText><record><rec-number>400</rec-number><foreign-keys><key app="EN" db-id="evt9rs9wb5sexces9voxv9txtzadt29aee0t" timestamp="1443718139">400</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>Bouchard, J. P.</author><author>Barbeau, A.</author><author>Bouchard, R.</author><author>Bouchard, R. W.</author></authors></contributors><titles><title>Autosomal recessive spastic ataxia of Charlevoix-Saguenay</title><secondary-title>Can J Neurol Sci</secondary-title><alt-title>The Canadian journal of neurological sciences. Le journal canadien des sciences neurologiques</alt-title></titles><periodical><full-title>Can J Neurol Sci</full-title><abbr-1>The Canadian journal of neurological sciences. Le journal canadien des sciences neurologiques</abbr-1></periodical><alt-periodical><full-title>Can J Neurol Sci</full-title><abbr-1>The Canadian journal of neurological sciences. Le journal canadien des sciences neurologiques</abbr-1></alt-periodical><pages>61-9</pages><volume>5</volume><number>1</number><edition>1978/02/01</edition><keywords><keyword>Adolescent</keyword><keyword>Adult</keyword><keyword>*Ataxia/diagnosis/genetics</keyword><keyword>Child</keyword><keyword>Female</keyword><keyword>Friedreich Ataxia/genetics</keyword><keyword>Humans</keyword><keyword>Male</keyword><keyword>Middle Aged</keyword><keyword>Muscle Spasticity</keyword><keyword>Nystagmus, Pathologic</keyword><keyword>Quebec</keyword><keyword>Speech Disorders</keyword><keyword>Syndrome</keyword></keywords><dates><year>1978</year><pub-dates><date>Feb</date></pub-dates></dates><isbn>0317-1671 (Print)
0317-1671</isbn><accession-num>647499</accession-num><urls></urls><remote-database-provider>Nlm</remote-database-provider><language>eng</language></record></Cite></EndNote>43Spastic ataxiaGeneReviewsOMIMARSACSHSP- ALDH3A2 ADDIN EN.CITE <EndNote><Cite><Author>Sillen</Author><Year>1997</Year><RecNum>398</RecNum><DisplayText><style face="superscript">44</style></DisplayText><record><rec-number>398</rec-number><foreign-keys><key app="EN" db-id="evt9rs9wb5sexces9voxv9txtzadt29aee0t" timestamp="1443717861">398</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>Sillen, A.</author><author>Jagell, S.</author><author>Wadelius, C.</author></authors></contributors><auth-address>Department of Clinical Genetics, University Hospital, Uppsala, Sweden. Anna.Sillen@klingen.uu.se</auth-address><titles><title>A missense mutation in the FALDH gene identified in Sjogren-Larsson syndrome patients originating from the northern part of Sweden</title><secondary-title>Hum Genet</secondary-title><alt-title>Human genetics</alt-title></titles><periodical><full-title>Hum Genet</full-title><abbr-1>Human genetics</abbr-1></periodical><alt-periodical><full-title>Hum Genet</full-title><abbr-1>Human genetics</abbr-1></alt-periodical><pages>201-3</pages><volume>100</volume><number>2</number><edition>1997/08/01</edition><keywords><keyword>Aldehyde Oxidoreductases/*genetics</keyword><keyword>Canada/ethnology</keyword><keyword>Europe/ethnology</keyword><keyword>Female</keyword><keyword>Genotype</keyword><keyword>Haplotypes</keyword><keyword>Humans</keyword><keyword>Male</keyword><keyword>Middle East/ethnology</keyword><keyword>Pedigree</keyword><keyword>*Point Mutation</keyword><keyword>Sjogren-Larsson Syndrome/epidemiology/*genetics</keyword><keyword>Sweden/epidemiology/ethnology</keyword></keywords><dates><year>1997</year><pub-dates><date>Aug</date></pub-dates></dates><isbn>0340-6717 (Print)
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ADDIN EN.CITE.DATA 46Allelic with Pelizaeus-Merzbacher disease. Complex; infantile-onset Pelizaeus-Merzbacher disease-like phenotype, mental retardation, dysarthria, optic atrophy, peripheral neuropathy, demyelinating leukodystrophyGeneReviews HYPERLINK "" 616680ARSPG75X-linked recessiveHSP-L1CAMPEVuZE5vdGU+PENpdGU+PEF1dGhvcj5Kb3VldDwvQXV0aG9yPjxZZWFyPjE5OTQ8L1llYXI+PFJl
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ADDIN EN.CITE.DATA 47Complex; MASA-syndrome, hydrocephalus, TCC.GeneReviews 312920XRSPG1HSP-PLP1 ADDIN EN.CITE <EndNote><Cite><Author>Saugier-Veber</Author><Year>1994</Year><RecNum>311</RecNum><DisplayText><style face="superscript">48</style></DisplayText><record><rec-number>311</rec-number><foreign-keys><key app="EN" db-id="evt9rs9wb5sexces9voxv9txtzadt29aee0t" timestamp="0">311</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>Saugier-Veber, P.</author><author>Munnich, A.</author><author>Bonneau, D.</author><author>Rozet, J. M.</author><author>Le Merrer, M.</author><author>Gil, R.</author><author>Boespflug-Tanguy, O.</author></authors></contributors><auth-address>Service de Genetique, Unite de Recherches sur les Handicaps Genetiques de l'Enfant, INSERM U.393 Paris, France.</auth-address><titles><title>X-linked spastic paraplegia and Pelizaeus-Merzbacher disease are allelic disorders at the proteolipid protein locus</title><secondary-title>Nat Genet</secondary-title></titles><periodical><full-title>Nat Genet</full-title></periodical><pages>257-62</pages><volume>6</volume><number>3</number><keywords><keyword>Alleles</keyword><keyword>Base Sequence</keyword><keyword>Chromosome Mapping</keyword><keyword>DNA Primers/genetics</keyword><keyword>Diffuse Cerebral Sclerosis of Schilder/*genetics</keyword><keyword>Female</keyword><keyword>*Genetic Linkage</keyword><keyword>Humans</keyword><keyword>Male</keyword><keyword>Molecular Sequence Data</keyword><keyword>Mutation</keyword><keyword>Paraplegia/*genetics</keyword><keyword>Pedigree</keyword><keyword>Phenotype</keyword><keyword>Point Mutation</keyword><keyword>Proteolipids/genetics</keyword><keyword>*X Chromosome</keyword></keywords><dates><year>1994</year><pub-dates><date>Mar</date></pub-dates></dates><isbn>1061-4036 (Print)
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ADDIN EN.CITE.DATA 52HSP ADDIN EN.CITE <EndNote><Cite><Author>Blumkin</Author><Year>2014</Year><RecNum>500</RecNum><DisplayText><style face="superscript">53</style></DisplayText><record><rec-number>500</rec-number><foreign-keys><key app="EN" db-id="evt9rs9wb5sexces9voxv9txtzadt29aee0t" timestamp="1515178970">500</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>Blumkin, L.</author><author>Halevy, A.</author><author>Ben-Ami-Raichman, D.</author><author>Dahari, D.</author><author>Haviv, A.</author><author>Sarit, C.</author><author>Lev, D.</author><author>van der Knaap, M. S.</author><author>Lerman-Sagie, T.</author><author>Leshinsky-Silver, E.</author></authors></contributors><auth-address>Pediatric Neurology Unit, Wolfson Medical Center, Holon, Israel.</auth-address><titles><title>Expansion of the spectrum of TUBB4A-related disorders: a new phenotype associated with a novel mutation in the TUBB4A gene</title><secondary-title>Neurogenetics</secondary-title><alt-title>Neurogenetics</alt-title></titles><periodical><full-title>Neurogenetics</full-title><abbr-1>Neurogenetics</abbr-1></periodical><alt-periodical><full-title>Neurogenetics</full-title><abbr-1>Neurogenetics</abbr-1></alt-periodical><pages>107-13</pages><volume>15</volume><number>2</number><edition>2014/02/15</edition><keywords><keyword>Child</keyword><keyword>Heterozygote</keyword><keyword>Humans</keyword><keyword>Leukoencephalopathies/complications/*genetics</keyword><keyword>Male</keyword><keyword>*Mutation</keyword><keyword>Neurodegenerative Diseases/complications/*genetics</keyword><keyword>*Phenotype</keyword><keyword>Tubulin/*genetics</keyword></keywords><dates><year>2014</year><pub-dates><date>May</date></pub-dates></dates><isbn>1364-6745</isbn><accession-num>24526230</accession-num><urls></urls><electronic-resource-num>10.1007/s10048-014-0392-2</electronic-resource-num><remote-database-provider>NLM</remote-database-provider><language>eng</language></record></Cite></EndNote>53, PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5LYW5jaGV2YTwvQXV0aG9yPjxZZWFyPjIwMTU8L1llYXI+
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ADDIN EN.CITE.DATA 54Spasmodic dysphonia is most common dystonic presentation. Alternative, phenotype: Hypomyelinating leukodystrophy (see footnote) GeneReviews n/aOMIM: 128101ADTUBB4AHSP/ATX-CAPN1PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5HYW4tT3I8L0F1dGhvcj48WWVhcj4yMDE2PC9ZZWFyPjxS
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ADDIN EN.CITE.DATA 56Hereditary spastic paraplegia: pure or complex; cerebellar dysarthria, cerebellar ataxia, foot deformity, ocular movement abnormalities, peripheral neuropathy, amyotrophy.GeneReviews: 616907ARSPG76HSP/ATX-KCNA2PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5IZWxiaWc8L0F1dGhvcj48WWVhcj4yMDE2PC9ZZWFyPjxS
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ADDIN EN.CITE.DATA 57, ADDIN EN.CITE <EndNote><Cite><Author>Manole</Author><Year>2017</Year><RecNum>505</RecNum><DisplayText><style face="superscript">58</style></DisplayText><record><rec-number>505</rec-number><foreign-keys><key app="EN" db-id="evt9rs9wb5sexces9voxv9txtzadt29aee0t" timestamp="1515179458">505</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>Manole, A.</author><author>Mannikko, R.</author><author>Hanna, M. G.</author><author>Kullmann, D. M.</author><author>Houlden, H.</author></authors></contributors><auth-address>Department of Molecular Neuroscience and Neurogenetics Laboratory, UCL Institute of Neurology, London, United Kingdom.
MRC Centre for Neuromuscular Diseases, UCL Institute of Neurology, London, United Kingdom.
Department of Clinical and Experimental Epilepsy, UCL Institute of Neurology, London, United Kingdom.</auth-address><titles><title>De novo KCNA2 mutations cause hereditary spastic paraplegia</title><secondary-title>Ann Neurol</secondary-title><alt-title>Annals of neurology</alt-title></titles><periodical><full-title>Ann Neurol</full-title><abbr-1>Annals of neurology</abbr-1></periodical><alt-periodical><full-title>Annals of Neurology</full-title></alt-periodical><pages>326-328</pages><volume>81</volume><number>2</number><edition>2016/12/30</edition><dates><year>2017</year><pub-dates><date>Feb</date></pub-dates></dates><isbn>0364-5134</isbn><accession-num>28032718</accession-num><urls></urls><electronic-resource-num>10.1002/ana.24866</electronic-resource-num><remote-database-provider>NLM</remote-database-provider><language>eng</language></record></Cite></EndNote>58Hereditary spastic paraplegia: complex; learning disability, global developmental delay, autism spectrum disorder, sensory-motor peripheral neuropathy, seizures, ataxia.Alternative phenotype: Epileptic encephalopathy, early infantile, 32OMIM: HYPERLINK "" 616366GeneReviews: not assignedADTCC=thinning of the corpus callosum, SACS=Spastic Ataxia of Charlevoix-Saguenay, SMA=Spinal Muscular AtrophySilver syndrome: Complex HSP involving amyotrophy of the hand musclesKjellin syndrome: Complex HSP including thinning of the corpus callosum and central retinal degeneration* Note that some studies have suggested that some SPG7 mutations may have an autosomal dominant effect, particularly autosomal dominant optic atrophy.** Mutations in this gene more commonly cause a hypomyelinating leukodystrophy with developmental delay, dystonia,choreoathetosis, rigidity, opisthotonus, andoculogyric crises, progressive spastic tetraplegia, ataxia, and, more rarely, seizures. ADDIN EN.REFLIST 1.Zhao X, Alvarado D, Rainier S, et al. Mutations in a newly identified GTPase gene cause autosomal dominant hereditary spastic paraplegia. Nat Genet 2001;29(3):326-331.2.Nielsen JE, Koefoed P, Abell K, et al. CAG repeat expansion in autosomal dominant pure spastic paraplegia linked to chromosome 2p21-p24. Hum Mol Genet 1997;6(11):1811-1816.3.Rainier S, Chai JH, Tokarz D, Nicholls RD, Fink JK. NIPA1 gene mutations cause autosomal dominant hereditary spastic paraplegia (SPG6). Am J Hum Genet 2003;73(4):967-971.4.Valdmanis PN, Meijer IA, Reynolds A, et al. Mutations in the KIAA0196 gene at the SPG8 locus cause hereditary spastic paraplegia. Am J Hum Genet 2007;80(1):152-161.5.Reid E, Kloos M, Ashley-Koch A, et al. A kinesin heavy chain (KIF5A) mutation in hereditary spastic paraplegia (SPG10). Am J Hum Genet 2002;71(5):1189-1194.6.Montenegro G, Rebelo AP, Connell J, et al. Mutations in the ER-shaping protein reticulon 2 cause the axon-degenerative disorder hereditary spastic paraplegia type 12. J Clin Invest 2012;122(2):538-544.7.Hansen JJ, Durr A, Cournu-Rebeix I, et al. Hereditary spastic paraplegia SPG13 is associated with a mutation in the gene encoding the mitochondrial chaperonin Hsp60. Am J Hum Genet 2002;70(5):1328-1332.8.Windpassinger C, Auer-Grumbach M, Irobi J, et al. Heterozygous missense mutations in BSCL2 are associated with distal hereditary motor neuropathy and Silver syndrome. Nat Genet 2004;36(3):271-276.9.Zuchner S, Wang G, Tran-Viet KN, et al. Mutations in the novel mitochondrial protein REEP1 cause hereditary spastic paraplegia type 31. Am J Hum Genet 2006;79(2):365-369.10.Goizet C, Depienne C, Benard G, et al. REEP1 mutations in SPG31: frequency, mutational spectrum, and potential association with mitochondrial morpho-functional dysfunction. Hum Mutat 2011;32(10):1118-1127.11.Mannan AU, Krawen P, Sauter SM, et al. ZFYVE27 (SPG33), a novel spastin-binding protein, is mutated in hereditary spastic paraplegia. Am J Hum Genet 2006;79(2):351-357.12.Bourassa CV, Meijer IA, Merner ND, et al. VAMP1 mutation causes dominant hereditary spastic ataxia in Newfoundland families. Am J Hum Genet 2012;91(3):548-552.13.Coutelier M, Goizet C, Durr A, et al. Alteration of ornithine metabolism leads to dominant and recessive hereditary spastic paraplegia. Brain : a journal of neurology 2015;138(Pt 8):2191-2205.14.Panza E, Escamilla-Honrubia JM, Marco-Marin C, et al. ALDH18A1 gene mutations cause dominant spastic paraplegia SPG9: loss of function effect and plausibility of a dominant negative mechanism. Brain : a journal of neurology 2016;139(Pt 1):e3.15.Tsaousidou MK, Ouahchi K, Warner TT, et al. Sequence alterations within CYP7B1 implicate defective cholesterol homeostasis in motor-neuron degeneration. Am J Hum Genet 2008;82(2):510-515.16.Casari G, De Fusco M, Ciarmatori S, et al. Spastic paraplegia and OXPHOS impairment caused by mutations in paraplegin, a nuclear-encoded mitochondrial metalloprotease. Cell 1998;93(6):973-983.17.Stevanin G, Santorelli FM, Azzedine H, et al. Mutations in SPG11, encoding spatacsin, are a major cause of spastic paraplegia with thin corpus callosum. Nat Genet 2007;39(3):366-372.18.Renvoise B, Chang J, Singh R, et al. Lysosomal abnormalities in hereditary spastic paraplegia types SPG15 and SPG11. Annals of clinical and translational neurology 2014;1(6):379-389.19.Hanein S, Martin E, Boukhris A, et al. Identification of the SPG15 gene, encoding spastizin, as a frequent cause of complicated autosomal-recessive spastic paraplegia, including Kjellin syndrome. Am J Hum Genet 2008;82(4):992-1002.20.Yildirim Y, Orhan EK, Iseri SA, et al. A frameshift mutation of ERLIN2 in recessive intellectual disability, motor dysfunction and multiple joint contractures. Hum Mol Genet 2011;20(10):1886-1892.21.Patel H, Cross H, Proukakis C, et al. SPG20 is mutated in Troyer syndrome, an hereditary spastic paraplegia. Nat Genet 2002;31(4):347-348.22.Simpson MA, Cross H, Proukakis C, et al. Maspardin is mutated in mast syndrome, a complicated form of hereditary spastic paraplegia associated with dementia. Am J Hum Genet 2003;73(5):1147-1156.23.Boukhris A, Schule R, Loureiro JL, et al. Alteration of ganglioside biosynthesis responsible for complex hereditary spastic paraplegia. Am J Hum Genet 2013;93(1):118-123.24.Tesson C, Nawara M, Salih MA, et al. Alteration of fatty-acid-metabolizing enzymes affects mitochondrial form and function in hereditary spastic paraplegia. Am J Hum Genet 2012;91(6):1051-1064.25.Erlich Y, Edvardson S, Hodges E, et al. Exome sequencing and disease-network analysis of a single family implicate a mutation in KIF1A in hereditary spastic paraparesis. Genome Res 2011;21(5):658-664.26.Edvardson S, Hama H, Shaag A, et al. Mutations in the fatty acid 2-hydroxylase gene are associated with leukodystrophy with spastic paraparesis and dystonia. Am J Hum Genet 2008;83(5):643-648.27.Kruer MC, Paisán-Ruiz C, Boddaert N, et al. Defective FA2H leads to a novel form of neurodegeneration with brain iron accumulation (NBIA). Annals of Neurology 2010;68(5):611-618.28.Rainier S, Bui M, Mark E, et al. Neuropathy target esterase gene mutations cause motor neuron disease. Am J Hum Genet 2008;82(3):780-785.29.Hartig MB, Iuso A, Haack T, et al. Absence of an orphan mitochondrial protein, c19orf12, causes a distinct clinical subtype of neurodegeneration with brain iron accumulation. Am J Hum Genet 2011;89(4):543-550.30.Hogarth P, Gregory A, Kruer MC, et al. New NBIA subtype: genetic, clinical, pathologic, and radiographic features of MPAN. Neurology 2013;80(3):268-275.31.Novarino G, Fenstermaker AG, Zaki MS, et al. Exome sequencing links corticospinal motor neuron disease to common neurodegenerative disorders. Science 2014;343(6170):506-511.32.Martin E, Schule R, Smets K, et al. Loss of function of glucocerebrosidase GBA2 is responsible for motor neuron defects in hereditary spastic paraplegia. American Journal of Human Genetics 2013;92(2):238-244.33.Abou Jamra R, Philippe O, Raas-Rothschild A, et al. Adaptor protein complex 4 deficiency causes severe autosomal-recessive intellectual disability, progressive spastic paraplegia, shy character, and short stature. Am J Hum Genet 2011;88(6):788-795.34.Slabicki M, Theis M, Krastev DB, et al. A genome-scale DNA repair RNAi screen identifies SPG48 as a novel gene associated with hereditary spastic paraplegia. PLoS Biol 2010;8(6):e1000408.35.Oz-Levi D, Ben-Zeev B, Ruzzo EK, et al. Mutation in TECPR2 reveals a role for autophagy in hereditary spastic paraparesis. Am J Hum Genet 2012;91(6):1065-1072.36.Verkerk AJ, Schot R, Dumee B, et al. Mutation in the AP4M1 gene provides a model for neuroaxonal injury in cerebral palsy. Am J Hum Genet 2009;85(1):40-52.37.Moreno-De-Luca A, Helmers SL, Mao H, et al. Adaptor protein complex-4 (AP-4) deficiency causes a novel autosomal recessive cerebral palsy syndrome with microcephaly and intellectual disability. Journal of medical genetics 2011;48(2):141-144.38.Schuurs-Hoeijmakers JH, Geraghty MT, Kamsteeg EJ, et al. Mutations in DDHD2, encoding an intracellular phospholipase A(1), cause a recessive form of complex hereditary spastic paraplegia. Am J Hum Genet 2012;91(6):1073-1081.39.Gonzalez M, Nampoothiri S, Kornblum C, et al. Mutations in phospholipase DDHD2 cause autosomal recessive hereditary spastic paraplegia (SPG54). European Journal of Human Genetics 2013;21(11):1214-1218.40.Shimazaki H, Takiyama Y, Ishiura H, et al. A homozygous mutation of C12orf65 causes spastic paraplegia with optic atrophy and neuropathy (SPG55). Journal of medical genetics 2012;49(12):777-784.41.Dor T, Cinnamon Y, Raymond L, et al. KIF1C mutations in two families with hereditary spastic paraparesis and cerebellar dysfunction. Journal of medical genetics 2014;51(2):137-142.42.Eymard-Pierre E, Lesca G, Dollet S, et al. Infantile-onset ascending hereditary spastic paralysis is associated with mutations in the alsin gene. Am J Hum Genet 2002;71(3):518-527.43.Bouchard JP, Barbeau A, Bouchard R, Bouchard RW. Autosomal recessive spastic ataxia of Charlevoix-Saguenay. The Canadian journal of neurological sciences Le journal canadien des sciences neurologiques 1978;5(1):61-69.44.Sillen A, Jagell S, Wadelius C. A missense mutation in the FALDH gene identified in Sjogren-Larsson syndrome patients originating from the northern part of Sweden. Human genetics 1997;100(2):201-203.45.Oates E? C, Rossor A? M, Hafezparast M, et al. Mutations in BICD2 Cause Dominant Congenital Spinal Muscular Atrophy and Hereditary Spastic Paraplegia. Am J Hum Genet 2013;92(6):965-973.46.Lossos A, Elazar N, Lerer I, et al. Myelin-associated glycoprotein gene mutation causes Pelizaeus-Merzbacher disease-like disorder. Brain : a journal of neurology 2015;138(Pt 9):2521-2536.47.Jouet M, Rosenthal A, Armstrong G, et al. X-linked spastic paraplegia (SPG1), MASA syndrome and X-linked hydrocephalus result from mutations in the L1 gene. Nat Genet 1994;7(3):402-407.48.Saugier-Veber P, Munnich A, Bonneau D, et al. X-linked spastic paraplegia and Pelizaeus-Merzbacher disease are allelic disorders at the proteolipid protein locus. Nat Genet 1994;6(3):257-262.49.Dumitrescu AM, Liao XH, Best TB, Brockmann K, Refetoff S. A novel syndrome combining thyroid and neurological abnormalities is associated with mutations in a monocarboxylate transporter gene. Am J Hum Genet 2004;74(1):168-175.50.Pedroso JL, de Souza PV, Pinto WB, et al. SCA1 patients may present as hereditary spastic paraplegia and must be included in spastic-ataxias group. Parkinsonism & related disorders 2015;21(10):1243-1246.51.Song Y, Liu Y, Zhang N, Long L. Spinocerebellar ataxia type 3/Machado-Joseph disease manifested as spastic paraplegia: A clinical and genetic study. Experimental and therapeutic medicine 2015;9(2):417-420.52.Hersheson J, Mencacci NE, Davis M, et al. Mutations in the autoregulatory domain of beta-tubulin 4a cause hereditary dystonia. Annals of neurology 2013;73(4):546-553.53.Blumkin L, Halevy A, Ben-Ami-Raichman D, et al. Expansion of the spectrum of TUBB4A-related disorders: a new phenotype associated with a novel mutation in the TUBB4A gene. Neurogenetics 2014;15(2):107-113.54.Kancheva D, Chamova T, Guergueltcheva V, et al. Mosaic dominant TUBB4A mutation in an inbred family with complicated hereditary spastic paraplegia. Movement disorders : official journal of the Movement Disorder Society 2015;30(6):854-858.55.Gan-Or Z, Bouslam N, Birouk N, et al. Mutations in CAPN1 Cause Autosomal-Recessive Hereditary Spastic Paraplegia. Am J Hum Genet 2016;98(5):1038-1046.56.Wang Y, Hersheson J, Lopez D, et al. Defects in the CAPN1 Gene Result in Alterations in Cerebellar Development and Cerebellar Ataxia in Mice and Humans. Cell reports 2016;16(1):79-91.57.Helbig KL, Hedrich UB, Shinde DN, et al. A recurrent mutation in KCNA2 as a novel cause of hereditary spastic paraplegia and ataxia. Annals of neurology 2016;80(4).58.Manole A, Mannikko R, Hanna MG, Kullmann DM, Houlden H. De novo KCNA2 mutations cause hereditary spastic paraplegia. Annals of neurology 2017;81(2):326-328. ................
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