Kpcv - Department of Neurology



CURRICULUM VITAEName: Keith R. Pennypacker Citizenship: United StatesCurrent Address: Department of Neurology College of MedicineUniversity of Kentucky741 S. Limestone StreetB457 BBSRB BuildingLexington, KY 40536Education and Training:1981B.A., Biology, Millersville University, Millersville, Pennsylvania1984M.S., Biology, Virginia Commonwealth University, Richmond, Virginia1987Ph.D., Pharmacology, Pennsylvania State University School of Medicine at Milton S. Hershey Medical Center, Hershey, PennsylvaniaChronology of Employment:1982 1984Teaching Assistant and Tutor, Biology, Virginia Commonwealth University, Richmond, Virginia1987 1990 Postdoctoral Research Fellow, Medical College of Pennsylvania1987 1990Instructor for Cell Biology and Organal Tissue Histology, Medical College of Pennsylvania 1990 1995IRTA Fellow, Neuropharmacology Section, Laboratory of Environmental Neuroscience, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina1995 - 2001Assistant Professor, Department of Pharmacology, University of South Florida, Tampa, FL2001- 2007Associate Professor, Department of Pharmacology, University of South Florida, Tampa, FL2007-2016Professor, Department of Pharmacology, University of South Florida, Tampa, FL2016-presentProfessor, Department of Neurology, University of Kentucky, Lexington, KY2016-presentAssociate Director of Center for Advanced Translational Stroke ScienceTeaching AccomplishmentsGraduate Courses TaughtGMS 6020 Neuroscience-2 hours currentGMS 6001 Foundations of Biomedical Sciences-4 hours currentGMS 6461 Systems Physiology and Pharmacology-6 hour currentGMS 6513 Principles in Pharmacology-6 hours currentGMS 6735 Neuropharmacology-2 hours currentGMS 6511 Current Literature in Pharmacology-15 hours currentBMS 4402 Principles in Human Pharmacology-3 hours currentPHT 6352 Pharmacology for Healthcare Professionals-2 hours-2010GMS 6501 Cell and Molecular Pharmacology-4 hours-2001, 2002GMS 7930 Therapeutics-8 hours-2003, 2005GMS 6502 Pharmacology of Physiological Systems-4 hours Spring 2001, Fall 2002Medical Courses TaughtBMS 6400 Medical Pharmacology-8 didactic lectures, 2 hours directing problem solving and 15 hours problem solving currentBCC 8190 Clerkship on the Topic of Sepsis-10 hours current from 2000Graduate Courses DirectedGMS 6706 Basic Medical Neurosciences-2013-CurrentGMS 6735 Neuropharmacology-2004-CurrentGMS 6513 Principles of Pharmacology Spring, 2003GMS 6502 Pharmacology of Physiological Systems Spring 2001, Fall 2002GMS 6511 Current Literature in Pharmacology Spring, 2002 Fall, 2001, Spring and Fall 2002GMS 6501 Cell and Molecular Pharmacology-Fall, 2002GMS 6503 Methods in Pharmacology until Spring 2003GMS 7930 Therapeutics-2003, 2005Teaching Awards2005Grasso Award for Commitment to Graduate Education 2014USF Outstanding Dissertation Hilary Seifert Graduate Student CommitteesCurrent Dissertation AdvisorStephanie DavisCurrent Doctoral Committee MemberAntoine FlowersNatasha AlvesDissertation AdvisorCheryl Kassed, 2002 Sr. Research Leader and Communicator at MedstatCraig T. Ajmo Jr., 2007LawyerChris Leonardo, 2008Postdoctoral Fellow at University of FloridaAaron Hall, 2009Undersea Medicine Department Naval Medical Research CenterDerrick Rowe, 2011George Washington University Law SchoolHilary Seifert, 2013Postdoctoral Fellow LSU-ShrieveportPast Dissertation Committee MembershipsWenjun Zhang, 1998Medical ResidentStan Benkovic, 1999Staff Scientist NIHTodd Samelman, 2000LawyerMike Lee, 2004 Postdoctoral Fellow at University of FloridaChad Dickey, 2004 Assistant Professor at USFWayne DeHaven, 2004 Postdoctoral Fellow at NIEHSDonna Herber, 2004 Licensing at USFMartina Vendrame, 2004 Medical Resident at Temple University HospitalDonna Wilcox, 2004 Postdoctoral Fellow at Duke UniversityHongling Zhang, 2005 Postdoctoral Fellow at Moffitt Cancer CenterMichelle Hamel, 2006 Medical Student at USFRachel Karlinoski, 2008Clinical ScientistJoanne Mayer, 2008Bach PharmaNiki Carty, 2009Postdoctoral Fellow at Harvard UniversityLori Lutz, 2009Postdoctoral FellowAdam Bachstetter, 2009Postdoctoral Fellow at University of ChicagoYelenis Herrera, 2009Postdoctoral Fellow at University of TexasJarod Ehrhart, 2010SaneronJoshua Halonen, 2012Postdoctoral Advisor-PastTanya ButlerUniversity of Sydney College of MedicineCraig T. Ajmo JrLawyerAaron HallUndersea Medicine Department Naval Medical Research CenterChristopher LeonardoPostdoctoral Fellow at University of FloridaGlenn RomaUniversity of Illinois at Chicago College of Pharmacy Master’s Thesis DirectorYang Xiao, 1998Wyeth PharmaceuticalsEd Duckworth, 2004 Neurosurgery ResidentDirson DeMesquita, 2004Aaron Hall, 2005 Undersea Medicine Department Naval Medical Research CenterRonnie Moorer, 2006Alexis Cohen, 2006Derrick Rowe, 2008George Washington University Law SchoolHilary Seifert, 2009PhD Doctoral Student at USFDaniel Lang, 2015Mike Britton, 2016Master’s Committee MemberLinda Cotto, 1999Paul Jantzen, 2001Digital ImagingAlia Radwan, 2005Sarice Smith, 2005 PhD Doctoral Student at University of MarylandVanessa Escobar, 2005 Medical StudentNiki Carty, 2005 PhD Doctoral Student at USFTiona Stephens, 2005 Medical Student at Howard UniversityJason Golden, 2011 Lisa Le, 2012Research Grant Support 1983 1984Phi Sigma Society Grant, Effects of gonadal steroids on neuronsize in the sonic motor nucleus of the oyster toadfish ($1,000).1994 - 1995Intramural Research Grant, Effects of EMF on proto-oncogene DNA binding activity during brain development ($45,000).1995 - 1996Research and Creative Scholarship, Neurotoxic induction of AP-1transcription factors in rat CNS ($7,500)1996 - 1997Institute on Aging, Regulation of the presenilin genes at the genomic level ($7,000).1999USF Travel Award to Warsaw, Poland for Presentation in workshop entitled “Inducible transcription factors in the brain” ($1,000)1999 - 2003American Heart Association, Nerve growth factor-induced changes in dementia-related genes after stroke ($260,000) PI.1999National Science Foundation Travel Award to Warsaw, Poland for Presentation in workshop entitled “Inducible transcription factors in the brain” which covers travel for eight US participants ($9,500).2000 - 2006NIH, NINDS, NF-?B signal transduction in brain injury ($843,076) PI.2001 - 2003American Heart Association Florida/Puerto Rico, The role of FRA-2 in neuronal survival using a rat MCAO model of ischemia; Postdoctoral Fellowship for Dr. Tanya Butler; Dr. Keith Pennypacker Sponsor ($70,000).2002 - 2004American Heart Association Florida/Puerto Rico, Fos-related antigen-2 expression in neurons surviving ischemia ($120,000) PI. 2007 - 2008James and Esther King Program Support Splenic Mechanisms of Cord Blood-Induced Brain Repair, (Willing PI, $200,000) $95, 000 for role as Co-I.2008 - 2009Florida Center of Excellence-Biomolecular Identification and Targeted Therapeutics Synthesis and screening of sigma ligands for stroke treatment at delayed time points, Keith Pennypacker co-PI, $25,0002008 - 2010NIH, NINDS, Expanding the therapeutic window of stroke, 1R21NS060907-01A1 ($275,000 direct costs for two years) Keith Pennypacker, PI.2006 - 2012NIH, NINDS, Cord blood is neuroprotective in a rat model of stroke (Willing, PI, $605,806) $106,415 direct, $151,451 per year for role as Co-I.2009 - 2012The James and Esther King Biomedical Research Program, Synthesis and screening of sigma ligands for stroke treatment at delayed time points ($764,174 for two years) Keith Pennypacker, PI2010 - 2012University of South Florida Neuroscience Program, Optimizing hypertonic saline therapy for cerebral edema after stroke, ($100,000 for two years) Keith Pennypacker co-I. 2011 - 2012James and Ester King Biomedical Research Program Technology Transfer/Commercialization Partnership, GLG-302 as a Novel Treatment for Stroke, ($86,000 per one year) Keith Pennypacker, PI. 2012- 2015NIH/NINDS R21, Anti-oxidant promoting cytokine LIF enhances neural cell survival during ischemia, ($275,000 for two years) Keith Pennypacker, PI. 2015- 2016NIH/NINDS R56, Anti-oxidant promoting cytokine LIF enhances neural cell survival during ischemia, ($250,000 for one year) Keith Pennypacker, PI.Current Grant Funding2016-2020NIH/NINDS R01, Anti-oxidant promoting cytokine LIF enhances neural cell survival during ischemia, ($872,000 for 4 years) Keith Pennypacker, PI.Bibliography 1Peer-Reviewed Publications1. Pennypacker, KR, Fine, ML, Stewart, JK: Effects of gonadal steroids on catecholamine levels in the brain of oyster toadfish. Neurosci. Lett. 55: 203206, 1985. PMID: 4000546.2. Billingsley, ML, Pennypacker, KR, Hoover, CG, Brigati, DJ, Kincaid, RL: A rapid and sensitive method for detection and quantification of calcineurin and calmodulinbinding proteins using biotinylated calmodulin. Proc. Natl. Acad. Sci. USA 82: 75857589, 1985. PMID: 3865179, PMCID: PMC391377.3. Pennypacker, KR, Fine, M.L, Mills, RR: Sexual differences and steroidinduced changes in metabolic activity in the toadfish sonic muscle. J. Exp. Zoo. 236: 259264, 1985. PMID: 4086985.4. Fine, ML, Pennypacker, KR: The hormonal basis for sexual dimorphism of the sound producing apparatus of the oyster toadfish. Exp. Neurol. 92: 289298, 1986. PMID: 395666.5. Fine, ML, Pennypacker, KR, Drummond, KA, Blem, CR: Concentration and location of metabolic substrates in fast toadfish sonic muscle. Copeia 4: 910915, 1986.6. Billingsley, ML, Pennypacker, KR, Hoover, CG, Kincaid, RL: Biotinylated proteins as probes of protein structure and protein:protein interactions. Biotechniques 5: 2231, 1987.7. Fine, ML, Pennypacker, KR: Histochemical typing of fast sonic muscle from the oyster toadfish. Copeia 35: 4749, 1988.8. Pennypacker, KR, Kyritsis, AP, Chader, GJ, Billingsley, ML: Calmodulinbinding proteins in Y79 retinoblastoma and HTB-14 glioma cell lines. J. Neurochem. 50: 16481654, 1988. PMID: 2834519.9. Pennypacker, KR, Kincaid, RL, Billingsley, ML: Expression of calmodulindependent phosphodiesterase, calmodulindependent protein phosphatase and other calmodulinbinding proteins in human SMSKCNR neuroblastoma cells. J. Neurochem. 52: 14381448, 1989. PMID: 245027.10. Pennypacker, KR, Kuhn, DM, Billingsley, ML: Changes in expression of tyrosine hydroxylase immunoreactivity in human SMSKCNR neuroblastoma following retinoic acid or phorbol ester-induced differentiation. Molec. Brain Res. 5: 251258, 1989. PMID: 2568572.11. Pennypacker, KR, Fischer, I, Levitt, P: In vitro genesis and differentiation of axons and dendrites by hippocampal neurons analyzed by quantitative immunocytochemistry. J. Exp. Neurol. 111: 2535, 1991. PMID: 1898595.12. McMillian, MK, He, XP, Hong, JS, Pennypacker, KR: Dopamine stimulates [3H]Phorbol12,13dibutyrate binding in cultured striatal cells. J. Neurochem. 58: 13081312, 1992. PMID: 1312574.13. Zhang, WQ, Pennypacker, KR, Ye, H, Merchenthaler, IJ, Grimes, L, Iadarola, MJ, Hong, JS: A 35 KDa Fosrelated antigen is colocalized with substance P and dynorphin in striatal neurons. Brain Res. 577: 312317, 1992. PMID: 1376635.14. He, XP, Lee, PHK, Pennypacker, KR, Tuominen, RK, Mar, EC, Thai, L, Hong, JS: Characterization of dynorphincontaining neurons on dissociated dentate gyrus cell cultures. Brain Res. 594: 9198, 1992. PMID: 1361409.15. Pennypacker, KR, Zhang, WQ, Ye, H, Hong, JS: Apomorphine induction of AP1 DNA binding in the rat striatum after dopamine depletion. Molec. Brain Res. 15: 151155, 1992. PMID: 1331662.16. Pennypacker, KR, Hong, JS, Douglass, J, McMillian, MK: Constitutive AP1 binding in the rat adrenal: Effect of nicotine. J. Biol. Chem. 267: 2014820152, 1992. PMID: 1400333.17. McMillian, MK, Hong, JS, Pennypacker, KR: Preferential activation of [3H]Phorbol-12,13-dibutyrate binding by ?-amino-3-hydroxy-5-methyloxazole-4- propionic acid (AMPA) in striatal cell cultures. Brain Res. 593: 307310, 1992. PMID: 1280525.18. Pennypacker, KR, Walczak, D, Thai, L, Fannin, R, Mason, E, Douglass, J, Hong, JS: Kainateinduced changes in opioid genes and AP1 protein expression in the rat hippocampus. J. Neurochem. 60: 204-211, 1993. PMID: 8417141.19. Suh, HH, McMillian, MK, Hudson, PM, Pennypacker, KR, Hong, JS: Expression of the proenkephalin A gene and [MET5] enkephalin secretion induced by prostaglandin E2 in bovine adrenal chromaffin cells. Molec. Cell. Neurosci. 4:113120, 1993. PMID: 19912914.20. Pennypacker, KR, Dreyer, D, Hong, JS, McMillian, MK: Elevated basal AP-1 DNA binding activity in developing rat brain. Molec. Brain Res. 19:349-352, 1993. PMID: 8231739.21. Pennypacker, KR, McMillian, MK, Douglass, J, Hong, JS: Ontogeny of kainateinduced gene expression in rat hippocampus. J. Neurochem. 62:438-444, 1994. PMID: 8294905.22. Bronstein, DM, Ye, H, Pennypacker, KR. Hudson, PM, Hong, JS: Role of a 35 kDa fos-related antigen (FRA) in the long-term induction of striatal dynorphin expression in the 6-hydroxydopamine lesioned rat. Molec. Brain Res. 23: 191-203, 1994. PMID: 7914658.23. Pennypacker, KR, Hong, JS, McMillian, MK: Pharmacological regulation of AP-1 transcription factor DNA binding activity. FASEB J. 8:475-478, 1994. PMID: 8181665.24. Pennypacker, KR, Thai, L, Hong, JS, McMillian, MK: Prolonged AP-1 DNA binding activity in the rat hippocampus after kainate administration. J. Neurosci. 14:3998-4006, 1994. PMID: 8027758.25. McMillian, MK, Thai, L, Hong, JS, O'Callaghan, JP, Pennypacker, KR: Brain injury in a dish: a model of reactive gliosis. TINS 17:138-142, 1994. PMID: 7517589.26. McMillian, MK, Mullis, SB, Wu, G-C, Hudson, PM, Pennypacker, KR, Hong, JS: Regulation of tyrosine hydroxylase in olfactory bulb cultures: selective inhibition of depolarization-induced increase in endogenous opioids. Brain Res. 658:105-111, 1994. PMID: 7834330.27. McMillian, MK, Hudson, PM, Simmons, KL, Dreyer, DA, Hong, JS, Pennypacker, KR: Acute repeated nicotine injections increase enkephalin and decrease AP-1 DNA binding in rat adrenal medulla. Mol. Brain Res. 30:210-214, 1995. PMID: 7476031.28. Pennypacker, KR: Pharmacological regulation of transcription factor DNA binding. Pharmacology 51:1-12, 1995. PMID: 7568339.29. Pennypacker, KR, Hong, JS: Kainate-induced changes in gene expression in the rat hippocampus. Prog. in Brain Res. 105:105-116, 1995. PMID: 7568869.30. Pennypacker, KR, Hudson, PM, Hong, JS, McMillian, MK: DNA binding activity of CREB transcription factors during ontogeny of the central nervous system. Dev. Brain Res. 86:242-249, 1995. PMID: 7656416.31. Pennypacker, KR, Lennard, D, Hudson, PM, Hong, JS, McMillian, MK: Basal levels of 35 kDa fos-related antigen in olfactory bulb. Mol. Brain. Res. 34:161-165, 1995. PMID: 8750873.32. Pennypacker, KR, Hong, JS, McMillian, MK: Implications for neuronal plasticity. TIPS 16:317-321, 1995. PMID: 7482997.33. McMillian, MK, Pennypacker, KR, Thai, L, Wu, G-C. Suh, HH, Simmons, KL, Hudson, PM, Sawin, SB, Hong, JS: Dexamethasone and forskolin synergistically increase [Met5]enkephalin accumulation in mixed cell cultures. Brain Res. 730:67-74, 1996. PMID: 8883890.34. Kim, HC, Pennypacker, KR, Bing, G, Bronstein, D, McMillian, MK, Hong, JS: The effects of dextromethorphan on kainic acid-induced seizures in the rats. Neurotox. 17:375-386, 1996. PMID: 8856734.35. Perez-Otano, I, McMillian, MK, Chen, J, Bing, G, Hong, JS, Pennypacker, KR: Induction of NF-kB-like transcription factors in brain areas susceptible to kainate toxicity. Glia 16:306-315, 1996. PMID: 8721671.36. Pennypacker, KR, Mullis, S, Hong, JS, Hudson, PM, McMillian, MK: Transcription factors in primary glial cultures: changes with neuronal interactions. Molec. Brain Res. 37:224-230, 1996. PMID: 8738155.37. Bing, G, McMillian, MK, Kim, H, Pennypacker, KR, Feng, Z, Qi, Q, Kong, L-Y, Iadorola, M, Hong, JS: Long-term expression of the 35 kDa Fos-related antigen in rat brain after kainic acid treatment. Neuroscience 73:1159-1174, 1996. PMID: 8809832.38. Blazka, M, Germolec, DR, Simeonova, P, Bruccoleri, A, Pennypacker, KR, Luster, MI: Acetominophen-induced hepatotoxicity is associated with early changes in NF-kB and NF-IL6 DNA binding activity. J. Inflam. 47:138-150, 1996. PMID:9117441.39. Blazka, M, Bruccoleri, A, Simeonova, P, Germolec, DR, Pennypacker, KR, Luster, MI: Acetominophen-induced hepatotoxicity is associated with changes in AP-1 DNA binding activity. Res. Comm. Mol. Path. Pharm. 92:259-273, 1996. PMID: 8827825.40. Bronstein, DM, Pennypacker, KR, Lee, H, Hong, JS: Methamphetamine-induced changes in AP-1 binding and dynorphin in the striatum: correlated, not causally related events? Biol. Signals 5:317-333, 1996. PMID: 9116798.41. Pennypacker, K.R, Xiao, Y, Xu, R, Harry, G.J: Lead-induced developmental changes in AP-1 DNA binding in rat brain. Intl. J. Neurosci. 15:321-328, 1997. PMID: 9253656.42. Pennypacker, KR: Transcription factors in brain injury. Histol. Histopath. 12:1125-1133, 1997. PMID: 9302571.43. Pennypacker, KR: AP-1 transcription factors: Short- and long-term modulators of gene transcription in the brain. Intl. Rev. Neurobiol. 42:169-197, 1998. PMID: 9476173.44. Pennypacker, KR, Fuldner, R, Xu, R, Hernandez, H, Dawbarn, D, Mehta, N, Perez-Tur, J, Baker, M, Hutton, M: Cloning and characterization of the presenilin-2 gene promoter. Molec. Brain Res. 56:57-65, 1998. PMID: 9602061.45. Pennypacker, KR, Hernandez, H, Benkovic, S, Morgan, DG, Willing, AE, Sanberg, PR: Induction of presenilins in the rat brain after middle cerebral arterial occlusion. Brain Res. Bull., 48:539-543, 1999. PMID: 10372515.46. Xiao, Y, Harry, GJ, Pennypacker, KR: Expression of AP-1 transcription factors in rat hippocampus and cerebellum after trimethyltin neurotoxicity. Neurotox. 20: 761-766, 1999. PMID: 10591512.47. Bruccoleri, A, Pennypacker, KR, Harry, GJ: Effect of dexamethasone on elevated cytokine mRNA levels in chemical-induced hippocampal injury. J. Neurosci. Res. 57:916-926, 1999. PMID: 10467263.48. O’Callaghan, JP, Miller, DB, Pennypacker, KR: Chronic dopaminergic signaling in the basal ganglia: a damage perspective on kinases and fos-related antigens. J. Addict. Biol. 5:369-377, 2000. PMID: 20575854.49. Pennypacker, KR, Kassed, CA, Eidizadeh, S, O'Callaghan, JP: Brain Injury: Prolonged induction of transcription factors. ACTA Neurobiol. Exp. 60: 515-528, 2000. PMID: 11200181.50. Pennypacker, KR, Eidizadeh, S, Kassed, CA, O'Callaghan, JP, Sanberg, P, Willing, A E: Expression of FRA-2 in rat hippocampus after middle cerebral arterial occlusion. Neurosci. Lett. 289:1-4, 2000. PMID: 10899394.51. Pennypacker, KR, Yang, X, Gordon, MN, Benkovic, S, Miller, D, O’Callaghan, JP: Long-Term induction of Fos-Related Antigen-2 after methamphetamine-, methylenedioxymethamphetamine-, 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine- and trimethyltin-induced brain injury. Neuroscience 101: 913-919, 2000. PMID: 11113340.52. Pennypacker, KR, Hong, JS: Fos-Related Antigen. Encyclo. Mol. Med. 5:1319-1320, 2002.53. Hakki, A, Pennypacker, KR*, Eidizadeh, S, Friedman, H, Pross, S: Nicotine inhibition of apoptosis in murine immune cells. Exp. Biol. Med. 226:947-953, 2001. *Co-first author. PMID: 11682702.54. Pennypacker, KR, Kassed, CA, Eidizadeh, S, Saporta, S, Sanberg, PR, Willing, AE: NF-B p50 is increased in neurons surviving hippocampal injury. Exp. Neurol. 172:307-319, 2002. PMID: 11716555.55. Butler, TL, Kassed, CA, Sanberg, P, Willing, A, Pennypacker, KR: Neurodegeneration in the rat hippocampus and striatum after middle cerebral artery occlusion. Brain Res. 929:252-260, 2002. PMID: 11864631.56. Kassed, CA, Willing, A, Garbuzova-Davis, S, Sanberg, P, Pennypacker, KR: Lack of NF-B p50 exacerbates degeneration of hippocampal neurons after chemical exposure and impairs learning. Exp. Neurol. 176:277-288, 2002. PMID: 12359170.57. Butler, TL, Kassed, CA, Pennypacker, KR: Signal transduction and neurosurvival in experimental models of brain injury. Brain Res. Rev. 6551:1-13, 2002. PMID: 12507684.58. Kassed, CA, Butler, TL, Navidomskis, MT, Gordon, MN, Morgan, DG, Pennypacker, KR: Mice expressing human mutant presenilin-1 exhibit decreased activation of NF-B p50 in hippocampal neurons after injury. Mol. Brain Res. 110:152-157, 2003. PMID: 12573544.59. Kassed, CA, Butler, TL, Patton, GW, De Mesquita, DD, Navidomski, M, Memet, S, Israel, A, Pennypacker, KR: Injury-induced NF-kB activation in the hippocampus: Implications for neuronal survival. FASEB J. 10.1096/fj03-0773, 2004. PMID: 14766792.60. Butler, TL, Pennypacker, KR: Temporal and regional expression of Fos-related proteins in response to ischemic injury Brain Res. Bull. 63:65-73, 2004. PMID: 15121240.61. Dickey, CA, De Mesquita, DD, Morgan, D, Pennypacker, KR: Induction of memory-associated immediate early genes by nerve growth factor in primary cortical neurons and differentiated Neuro2A cells. Neurosci. Lett. 366:10-14, 2004. PMID: 15265580.62. Vendrame, M, Casady, J, Newcomb, J, Butler, TL, Pennypacker, KR, Zigova, T, Davis, C, Sanberg, PR, Willing, AE: Infusion of human umbilical cord blood cells in a rat model of stroke dose-dependently rescues behavioral deficits and reduces infarct volume. Stroke 35:2390-2395, 2004. PMID:15322304.63. Butler, TL, Pennypacker, KR: The Transcriptional response to hypoxic insult controlled by FRA-2. Gene Expression 12:61-67, 2005. PMID: 15892448.64. Duckworth, EAM, Butler, TL, De Mesquita, DD, Collier, SN, Collier, L, Pennypacker, KR: Temporary focal ischemia in the mouse: Technical aspects and patterns of Fluoro-Jade evident neurodegeneration. Brain Res. 1042:29-36, 2005. PMID: 15823250.65. Pollock, G, Pennypacker, KR, Mémet, S, Isra?l, A, Saporta, S: Activation of NF-κB in the mouse spinal cord following sciatic nerve transection. Exp. Brain Res. 165(4):470-477, 2005. PMID: 15912368.66. Vendrame, M, Gemma, C, De Mesquita, D, Collier, L, Bickford, PC, Davis-Sanberg, CC, Sanberg, PR, Pennypacker, KR, Willing, AE: Anti-inflammatory effects of human cord blood cells in a rat model of stroke. Stem Cells and Development 14: 595-604, 2005. PMID: 16305344.67. Newcomb, JD, Ajmo, CT, Sanberg, CD, Sanberg, PR, Pennypacker, KR, Willing, AE: Timing of cord blood treatment after experimental stroke determines therapeutic efficacy. Cell Transplant. 15(3):213-223, 2006. PMID:16719056.68. Ajmo, Jr, CT, Vernon, DOL, Collier, LA, Pennypacker, KR*, Cuevas, J: Sigma receptor activation reduces infarct size at 24 hours after permanent middle cerebral artery occlusion in rats. Curr. Neurovasc. Res. 3(2):89-98, 2006. *Corresponding Author. PMID: 16719792.69. Duckworth, EAM, Butler, TL, Collier, L, Collier, S, Pennypacker, KR: NF-kB Protects neurons from ischemic injury after middle cerebral artery occlusion in mice. Brain Res. 1088:167-175, 2006. PMID: 16630592.70. Vendrame, M, Gemma, C, Pennypacker, KR, Bickford, PC, Davis-Sanberg, C, Sanberg, PR, Willing, AE: Cord blood rescues stroke-induced changes in splenocyte phenotype and function. Exp. Neurol. 199:191-200, 2006. PMID: 16713598.71. Vernon, DOL, Garbuzova-Davis, S, Desjarlais, T, Rasile, RS, Sanberg, PR, Willing, AE, Pennypacker, KR: Reduced nuclear factor kappaB activation in dentate gyrus after active avoidance training. Brain Res. 1104:39-44, 2006. PMID: 16814269.72. Katnik, C, Guerrero, WR, Pennypacker, KR, Herrera, Y, Cuevas, J: Sigma-1 receptor activation prevents intracellular calcium dysregulation in cortical neurons during in vitro ischemia. J. Pharm. Exp. Ther. 31:1355-1365, 2006. PMID: 16988055.73. Willing, AE, Pennypacker, KR: Alternate approach to understanding the molecular mechanisms of stroke-induced injury. Histol. Histopathol. 6:697-701, 2007. PMID: 17357099.74. Ajmo, CT Jr, Vernon, DOL, Collier, L, Hall, AA, Garbuzova-Davis, S, Willing, AW, Pennypacker, KR: The spleen contributes to stroke induced neurodegeneration. J. Neurosci. Res. 86:2227-2234, 2008. PMID: 18381759, PMCID: PMC2680137.75. Leonardo, CC, Eakin, AK, Ajmo, JM, Collier, LA, Pennypacker, KR, Strongin, AY, Gottschall, PE: Delayed administration of a small molecule MMP inhibitor protects the neonatal rat against hypoxia-ischemic brain injury. J. Neuroinflam. 5:34, 2008. PMID: 18694515, PMCID: PMC2527306.76. Herrera, Y, Katnik, C, Rodriguez, J, Hall, A, Willing, AE, Pennypacker, KR, Cuevas, J: Sigma-1 receptor modulation of ASIC1a channels and ASIC1a-induced Ca2+ influx in rat cortical neurons. J. Pharm Exp. Ther. 327(2):491-502, 2008. PMID: 18723775.77. Hall, A, Guyer, A, Leonardo, C, Ajmo, C Jr, Collier, L, Willing, A, Pennypacker, K: Human umbilical cord blood cells directly suppress ischemic oligodendrocyte cell death. J. Neurosci. Res. 87(2): 333-341 2009. PMID: 18924174, PMCID: PMC2651744.78. Hall, AA, Herrera, Y, Ajmo CT, Cuevas, J, Pennypacker KR: Sigma receptors suppress multiple aspects of microglial activation. Glia 57(7): 744-754, 2009. PMID: 19031439, PMCID: PMC2692292.79. Ajmo Jr., CT, Collier, LA, Leonardo, CC, Hall, AA, Green, SM, Womble, TA, Cuevas, J, Willing, AE, Pennypacker, KR: Blockade of adrenoreceptors inhibits the splenic response to stroke. Exp. Neurology 218:47-55, 2009. PMID: 19371742. PMCID: PMC2720830.80. Leonardo, CC, Hall, AA, Collier, LA, Gottschall, PE, and Pennypacker, KR: Inhibition of gelatinase activity reduces neural injury in an ex vivo model of hypoxia-ischemia. Neuroscience. 160(4):755-66, 2009. PMID: 19272421. PMCID: PMC2746919.81. Leonardo, CC, Pennypacker, KR: Neuroinflammation and MMPs: Potential Therapeutic Targets in Neonatal Hypoxic-ischemic Injury. J Neuroinflam. 6:13-19, 2009. PMID: 19368723, PMCID: PMC2674036.82. Hall, AA, Leonardo, CC, Collier, LA, Rowe, DD, Willing, AE, and Pennypacker, KR: Delayed treatment for stroke influence neuronal death in rat organotypic slice cultures subjected to oxygen glucose deprivation. Neuroscience 164(2):470-477, 2009. PMID: 19723565. PMCID: PMC2761985.83. Leonardo, CC, Hall, AA, Collier, LA, Ajmo Jr., CT, Willing, AE, and Pennypacker, KR: Human umbilical cord blood cell therapy blocks the morphological change and recruitment of CD11b-expressing, isolectin-binding proinflammatory cells after middle cerebral artery occlusion. J. Neuroscience Res. 88(6):1213-1222, 2010. PMID: 19998484. PMCID: PCM2830323.84. Hall, AA and Pennypacker KR: Implications of immune system in stroke for novel therapeutic approaches. Translational Stroke Res. 1(2):85-95, 2010. PMID: 24323491.85. Leonardo, CC, Hall, AA, Collier, LA, Green, SM, Willing, AE, and Pennypacker, KR: Administration of a sigma receptor agonist delays MCAO-induced neurodegeneration and white matter injury. Translational Stroke Res. 1(2):135-145, 2010. PMID: 20563232. PMCID: PMC2885737.86. Cortes-Salves, M., Nguyen, B., Cuevas, J., Pennypacker, K.R., and Antilla, J.: Copper-Catalyzed guanidinylation of aryl iodides: The formation of N,N’- distributed guanidines. Organic Letters. 12(6):1316-1319, 2010. PMID: 20170103. 87. Ajmo, J.M., Bailey, L.A., Howell, M.D., Cortez, L.K., Pennypacker, K.R., Mehta, H.N., Morgan, D., Gordon, M.N., and Gottschall, P.E.: Abnormal post-translational and extracellular processing of brevican in plaque-bearing mice overexpressing AAPsw. J. Neurochem 113(3):784-795, 2010. PMID: 20180882. PMCID: PMC2855738.88. Rowe, D., Leonardo, C., Hall, A., Shahaduzzaman, MD., Collier, L., Willing, A., Pennypacker, K.: Cord blood administration induces oligodendrocyte survival through alterations in gene expression. Brain Research 1366:172-188, 2010. PMID: 20883670. PMCID: PMC2993822.89. Leonardo, CC and Pennypacker, KR: The splenic response to ischemic stroke: What have we learned from rodent models? Translational Stroke Res. 2(3):328-338, 2011. PMID: 24323652.90. Das,M, Leonardo,C.C., Rangooni,S., Mohapatra, S.S., Mohapatra,S., and Pennypacker, K.R.: Lateral Fluid Percussion Injury of the brain induces CCL20 inflammatory chemokine expression in rats. J. Neuroinflammation 8(1):148-163, 2011. PMID: 22040257. PMCID: PMC3231817.91. Rowe, D.D., Leonardo,C.C., Recio, J.A., Collier, L.A., Willing, A.E., Pennypacker,K.R.: Human umbilical cord blood cells protect oligodendrocytes from brain ischemia through Akt signal transduction. J. BioChem. 287(6): 4177-4187, 2012. PMID: 22158864. PMCID: PMC3281708.92. Seifert, H.A., Leonardo, C.C., Hall, A.A., Rowe, D.D., Collier, L.A., Benkovic, S.A., Willing, A. E., Pennypacker, K.R.: The spleen contributes to stroke induced neurodegeneration through interferon gamma signaling. Metabolic Brain Disease Jun; 27(2):131-41, 2012. PMID: 22354752.93. Leonardo, C.C., Musso, J., Das, M., Rowe, D.D., Collier, L., Mohapatra, S., Pennypacker., K.R. CCL20 is associated with neurodegeneration following experimental traumatic brain injury and promotes cellular toxicity in vitro. Translational Stroke Res., 3(3):357-363, 2012. PMID: 24323811.94. Pennypacker, K.R. Peripheral immune response to CNS injury. Translational Stroke Res., 3(3):305, 2012. PMID: 24323804.95. Seifert, H.A., Hall, A.A., Chapman, C.B., Collier, L.A., Willing, A.E., Pennypacker, K.R. A transient decrease in spleen size following stroke corresponds to splenocyte release into Systemic Circulation. J. Neuroimmune Pharmacology 7(4):1017-124, 2012. PMID: 23054271. PMCID: PMC3517577.96. Golden, J.E., Shahaduzzaman, M., Wabnitz, A., Green, S., Womble, T.A., Sanberg, P.R., Pennypacker, K.R., Willing, A.E.: Human umbilical cord blood cells alter blood and spleen cell populations after stroke. Translational Stroke Res. 3(4):490-499, 2012. PMID: 23335948. PMCID: PMC3547401.97. Lloyd, M.C., Burke, N., Kalantapour,, F., Niesen, M.I., Hall,, A., Pennypacker, K., Citron, B., Pick, C.G., Adams, V., Das, M., Mohapatra, S., Cualing, H., Blanck, G.. Quantitative morphological and molecular pathology of the human thymus correlate with infant cause of death. Technology and Innovation 16(1):63-73, 2013. PMID: 25309682. PMCID: PMC4192662.98. Womble, T.A., Green, S., Shahaduzzaman, M., Sanberg, P.R., Pennypacker, K.R., Willing, A.E.: Monocytes are essential for the neuroprotective effect of human cord blood cells following middle cerebral artery occlusion in rat. Molec. Cell. Neurosci. 59:76-84, 2014. PMID: 24472845.99. Seifert, H.A and Pennypacker, K.R.: Molecular and cellular immune responses to ischemic brain injury. Translational Stroke Res. 5:543-553, 2014. PMID: 24895236.100. Rowe, D.D., Collier, L.A., Seifert, H.A., Chapman, C.B., Leonardo, C.C., Willing, A.E., Pennypacker, K.R.: Leukemia inhibitor factor promotes functional recovery and oligodendrocyte survival in rat models of focal ischemia. European J Neuroscience 40:3111-3119, 2014. PMID: 25041106.101. Seifert, H.A., Collier, L.A., Chapman, C.B., Benkovic, S.A., Willing, A.E., and Pennypacker, K.R. Pro-inflammatory interferon gamma signaling is directly associated with stroke induced neurodegeneration. J Neuroimmune Pharmacology, 9(5):679-689, 2014. PMID: 25104571.102. Pennypacker, K.R. Commentary: Different immunological mechanisms govern protectionfrom experimental stroke in young and older mice with recombinant TCR ligand therapy. Front. Cell. Neurosci., 8:339, 2014. PMID: 25368553. PMCID: PMC4201099.103. Pennypacker, K.R. Targeting the peripheral inflammatory response to stroke: role of the spleen. Translational Stroke Res. 5(6):635-637, 2014. PMID: 25252625.104. Shahaduzzaman, M., Mehta, V., Golden, J.E., Rowe, D.D., Green, S., Tadinada, R., Foran, E., Sanberg, P.R., Pennypacker, K.R., and Willing, A.E. Human umbilical cord blood cells induce neuroprotective change in gene expression profile in neurons after ischemia through activation of Akt pathway. Cell. Transplant. (Epub ahead of print) 2015. PMID: 25413246.105. Pennypacker, K.R., Offner, H. The role of the spleen in ischemic stroke. J. Cereb. Blood Flow Metab. 35:186-196, 2015. PMID: 25465042.106. Decker, D., Collier, L., Lau, T., Olivera, R., Roma, G., Leonardo, C., Seifert, H., Rowe, D., and Pennypacker, K. The effects of clinically relevant hypertonic saline and conivaptan administration on ischemic stroke. Acta Neurochir. Suppl. 121: 243-250, 2016. PMID: 26463956.107. Davis SM, Collier LA, Leonardo CC,?Seifert?HA, Ajmo CT Jr,?Pennypacker?KR. Leukemia inhibitory factor protects neurons from ischemic damage via upregulation of superoxide dismutase 3. Mol Neurobiol. Jan. 2016 [Epub ahead of print]. PMID: 26746670.Chapters, Technical Reports and Non-refereed ManuscriptsPennypacker, KR, Billingsley, ML: Purification of calmodulinbinding proteins from S20Y neuroblastoma cells using high performance calmodulin affinity. Chromatogram 8: 910, 1987.Billingsley, ML, Polli, JW, Pennypacker, KR, Kincaid, RL: Use of biotinylated calmodulin derivatives for the identification of calmodulinbinding proteins. Meth. Enzymol. 184: 451467, 1990. PMID: 2388584.Pennypacker, KR, Hudson, PM: Fos-related antigen expression in primary brain cultures: comparison of ECL and alkaline phosphatase western blotting. Biogenex Notes 1:2-3, 1994.Pennypacker, KR, Hudson, PM: Immunoreactivity of the c-Jun transcription factor in developing cerebellum: Comparison of chemiluminescent procedures. Biogenex Notes 1:5, 1994.Pennypacker, KR: Pharmacological regulation of opioid peptide regulation: second and third messenger systems. The Pharmacology of Opioid Peptides L. Tseng, ed. Harwood Academic Publishers, pp. 73-86, 1995.Pennypacker, KR: AP-1 transcription factor complexes in brain injury and development. J. Fla. Med. Assoc. 82:551-554, 1995. PMID: 7561734.Xiao, Y, Pennypacker, KR: Mobility shift DNA-binding assay using gel electrophoresis in Meth. Mol. Med. eds. J. Harry and H. Tilson, pp. 89-97, 1998.Kassed CA, Butler TL, Pennypacker KR: NF-B and neurotoxicity. In: Molecular Toxicity. N. Zawia, Ed. CRC Press pp. 65-86, 2004.Willing, A.E., Chen, N. Pennypacker, K.R. and Sanberg, P.R.: Human umbilical cord cells for stroke recovery. In D.M. Rosenbaum and S.I. Savitz, (Eds.), Stroke Recovery: Cellular and Genetic Therapies, Chapter 4, Humana Press, Totowa, NJ, 2007.Willing, AE, Cuevas, J, Pennypacker, KR: Treatment of Alzheimer Disease: New insights from the treatment of stroke at delayed time points. In R. Pluta (Ed.), Ischemia-Reperfusion Pathways in Alzheimer's Disease, Chapter 9, Nova Science Publishers, Inc. ed. Pluta, R 2007.Leonardo, CC, Seifert, H, and Pennypacker, KR: The splenic response to ischemic stroke: neuroinflammation, immune cell migration and experimental approaches to defining cellular mechanisms. In P.A. Lapchak and J.H. Zhang (Eds.), Translational Stroke Research:? From Target Selection to Clinical Trials, Chapter 23, Springer, 2012.Patents“Novel method of treatment for stroke using sigma receptor agonists”-Patent Pending June, 2006.“Identification of drugs for efficacy to treat stroke at delayed timepoints”- Patent Pending Sept, 2006.“Targeting the spleen in stroke therapy”-Provisional patent filed August, 2006.“Use of opipramol to treat stroke at delayed timepoints”-Patent Pending Sept. 2008.“N’-di-p-bromophenyl guanidine is an effective treatment in experimental stroke at delayed time points”?Provisional patent filed April, 2008.??“Carvedilol as a treatment for traumatic brain injury” USF ref no 10A008 Provisional Patent filed 2011.“Use of leukemia inhibitory factor in the treatment of stroke” USF ref no 10A074 Provisional Patent filed 2011.“Methods of reducing inflammation and methods of treating stroke-induced brain injury “ Provisional patent filed 2011.“GLG-302 as a treatment for stroke” Provisional patent filed 2011.“MIP3? as a therapeutic target for traumatic brain injury” Provisional patent filed 2011.N,N'-di-(naphthal-1-yl)gunadine HCL reduces infarct volume and increases functional recovery after stroke. Provisional patent filed 2011.N,N'-di-p-nitophenylguanidine HCL reduces infarct volume and increases functional recovery after stroke. Provisional patent filed 2012.Conivaptan as a treatment for stroke” IDF filed in June 2012Bibliography 2Abstracts1. Pennypacker, KR, Fine, ML, Mills, RR: Sexual differences and steroidinduced changes in metabolic activity in the toadfish sonic muscle. Soc. Neurosci. Abs. 10: 1326, 1984.2. Pennypacker, KR, Hoover, CG, Kincaid, RL, Billingsley, ML: Identification of calmodulin and S100 binding proteins in cultured neuroblastoma and glioma cells. Fed. Proc. Abs. 45: 1690, 1986.3. Billingsley, ML, Pennypacker, KR: Peptide mapping studies using biotinylated proteins. Fed. Proc. Abs. 45: 1498, 1986.4. Fine, ML, Burns, NM, Pennypacker, KR: Ontogeny and sexual dimorphism of fast toadfish sonic muscle. Soc. Neurosci. Abs. 12: 1118, 1986.5. Pennypacker, KR, Kincaid, RL, Billingsley, ML: Druginduced changes in human neuroblastoma differentiation and expression of calmodulinbinding proteins. Fed. Proc. Abs. 46: 657, 1987.6. Pennypacker, KR, Levitt, P: Compartmentalization of cytoskeletal and cell surface protein expression during initial process outgrowth of hippocampal neurons. Soc. Neurosci. Abs. 14: 561, 1988.7. Pennypacker, KR, Bhardwaj, B, Levitt, P, Schepart, B: Cloning of the cDNA encoding the limbicsystem associated membrane protein (LAMP). Soc. Neurosci. Abs. 15: 1268, 1989.8. McMillian, MK, Pennypacker, KR, He, XP, Hong, JS: Dopamine (DA) stimulates [3H]PdBu binding to cultured striatal cells. Soc. Neurosci. Abs. 17: 87, 1991.9. Suh, HH, Pennypacker, KR, He, XP, McMillian, MK, Fannin, R, Mar, EC, Hudson, P, Hong, JS: Effect of PGE2 on the secretion of met5enkephalin (ME) and the expression of proenkephalin A (ProENK) gene in bovine adrenal medullary cells. Soc. Neurosci. Abs. 17: 395, 1991.10. Pennypacker, KR, Thai, L, Fannin, R, Hong, JS: Kainateinduced increases in AP1 binding and FRA immunoreactivity in the rat hippocampus. Soc. Neurosci. Abs. 17: 905, 1991.11. Pennypacker, KR, McMillian, MK, Douglass, J, Hong, JS: Developmentalspecific changes in opioid peptide gene expression and AP1 proteins in rat hippocampi after seizures. Society for Neuroscience Annual Meeting, Anaheim, CA, 1992.12. Hudson, PM, McMillian, MK, Pennypacker, KR, Hong, JS: Nicotine increases [Met5]enkephalin (ME) in rat adrenal medulla and spleen. Society for Neuroscience Annual Meeting, Anaheim, CA, 1992.13. McMillian, MK, Suh, HH, Thai, L, Pennypacker, KR, Hudson, PM, Hong, JS: Glucocorticoids potentiate forskolin stimulation of enkephalin production in brain cell cultures. Society for Neuroscience Annual Meeting, Anaheim, CA, 1992.14. Bronstein, D, Ye, H, Zhang, WQ, Pennypacker, KR, Hong, JS: Interaction of dopamine and NMDA receptors in the regulation of dynorphin and cFOS/FRA expression. Soc. Neurosci. Abs1992.15. McMillian, MK, Thai, L, Wu, GC, Simmons, KL, O'Callaghan, JP, Hong, JS, Pennypacker, KR: Neuronal-glial co-cultures as a model to study reactive gliosis. Soc. Neurosci. Abs. 19:447, 1993.16. Pennypacker, KR, Hong, JS, McMillian, MK: Decrease in expression of GFAP and JUN transcription factors in neuron:glia co-cultures. Soc. Neurosci. Abs. 19:447, 1993. 17. Blazka, M, Pennypacker, KR, Luster, MI: Acetominophen-induced changes in hepatic NF-kB, AP-1 and NF-IL6 DNA binding activity in mice. Toxicology Abs., 1995.18. Bronstein, D, Merchanthaler, I, Pennypacker, KR, Perez-Otano, I, Hudson, P, Chalmers, D, and Hong, JS: Transcription factors involved in the methamphetamine-induced increase in striatal dynorphin expression: effects of cyclohexamide. Soc. Neurosci. Abs. 20:1620, 1994.19. Kim, H, Pennypacker, KR, Bing, G, Hong, JS: Effects of dextromethorphan on kainic acid-induced seizure in rat. Soc. Neurosci. Abs. 20:1240, 1994.20. Perez-Otano, I, Pennypacker, KR, McMillian, MK, Bing, G, Thai, L, Hong, JS: NF-kB transcription factors are increased in brain areas susceptible to kainate toxicity. Soc. Neurosci. Abs. 20:247, 1994.21. McMillian, MK, Mullis, SB, Wu, GC, Hudson, PM, Pennypacker, KR, Hong, JS, Banerje, SA, Chikaraishi, DM: Regulation of tyrosine hydroxylase in olfactory bulb cel cultures from rats and mice. Soc. Neurosci. Abs. 20:280, 1994.22. Pennypacker, KR, Hudson, PM, Hong, JS, Merchanthaler, I, McMillian, MK: AP-1 DNA binding activity during brain ontogeny. Soc. Neurosci. Abs. 20:219, 1994. 23. Pennypacker, KR, Lennard, D, Hudson, PM, Hong, JS, McMillian, MK: Elevated basal levels of 35 kDa fos-related antigen in olfactory bulb. Soc. Neurosci. Abs. 21:598, 1995.24. Pennypacker, KR: Transcriptional regulation of the presenilin genes. Soc. Neurosci. Abs. 22:1662, 1996.25. Kotchmar, DS, Pennypacker, KR, Swank, MW: Changes in the expression of bZIP proteins and DNA binding activity in mouse brainstem during taste aversion and learning. Soc. Neurosci. Abs. 22:440, 1996.26. Pennypacker, KR, Xu, R, Hernandez, H, Hutton, M: Transcriptional regulation of the presenilin-2 gene. Soc. Neurosci. Abs. 23: 2168, 1997.27. Xiao, Y, Xu, R, Sokolowski, BHA, Harry, GJ, Gordon, MN. Pennypacker, KR: Neurons adapt to neurotoxin insults by altering AP-1 binding activities in rat brain. Soc. Neurosci. Abs. 23: 2203, 1997.28. Xiao, Y, Hernandez, H, Gordon, MN, O’Callaghan, J, Pennypacker, KR: Neurons in the hippocampus increase FRA-2 expression after trimethyltin-induced brain injury. Soc. Neurosci. Abs. 24:43, 1998.29. Pennypacker, KR, Hernandez, H, Benkovic, S, Morgan, DG, Willing, AE, Sanberg, PR: Induction of presenilins in the rat brain after middle cerebral arterial occlusion. Soc. Neurosci. Abs. 24:40, 1998.30. Pennypacker, KR: Adaptation to brain injury: prolonged expression of transcription factors. Satellite meeting to ISN/ESN pg 23, 1999.31. Pennypacker, KR, Eidizadeh, S, Willing, AE, Sanberg, PR: Increased binding to presenilin-2 AP-1 and Sp1 regulatory sites in the rat brain after middle cerebral arterial occlusion. Soc. Neurosci. Abs. 25:824, 1999.32. Kassed, C, Phelps, CP, O’Callaghan, J, Pennypacker, KR: Increased NF-?B in the hippocampus after trimethyltin-induced brain injury. Soc. Neurosci. Abs. 25:1830, 1999.33. Pennypacker, KR, Eidizadeh, S, Kassed, CA. Sanberg, PR, Willing, AE: FRA-2 is expressed in rat hippocampal neurons surviving injury. Soc. Neurosci. Abs. 26:241, 2000.34. Kassed, C, Phelps, CP, O’Callaghan, J, Pennypacker, KR: Upregulation of NF-?Bp50 during neuronal adaptation after chemotaxic injury to the hippocampus. Soc. Neurosci. Abs. 26:263, 2000.35. Patton, GW, Hakki, A, Hallquist, N, Pennypacker, KR, Friedman, H, Pross, S: Modulation of immune parameters by nicotine, a molecular approach. SOT 60:122-123, 2001.36. Kassed, CA, Pennypacker, KR: Expression of human presenilin-1 gene mutations in mice leads to increased toxicant-induced neurodegeneration through the inhibition of nuclear factor kappaB. Tox. Sci. 60:188, 2001.37. Pross, S, Hakki, A, Pennypacker, KR, Friedman, H: Nicotine inhibits apoptosis of lymphocytes: role of specific receptors. CPDD Abs., 2001.38. Butler, TL, Eidizadeh, S, Pennypacker, KR: Expression of the AP-1 transcription factor FRA-2 following ischemic injury in the rat. Exp. Neurol. 170(1):119, 2001.39. Butler, TL, Pennypacker, KR: The transcription factor FRA-2 and MAP kinase proteins are associated with neuronal survival following MCAO. ASPET Southeastern Affiliate, 2001.40. Butler, TL, Pennypacker, KR: Expression of the AP-1 transcription factor FRA-2 and MAP kinase proteins following ischemic injury in the rat hippocampus. Soc. Neurosci. Abs. 2001.41. Kassed, CA, Pennypacker, KR: Human PS-1 gene mutations in mice increase neurodegeneration through inhibition of nuclear factor kB. Soc. Neurosci. Abs. 2001.42. Pennypacker, KR: Induction of transcription factors in neurons that survive neurotoxicity. Tox. Sci. 66: 270-271, 2002.43. Kassed, CA, Pennypacker, KR: NF-?B activation promotes survival of mouse hippocampal cells after acute trimethyltin exposure. Tox. Sci. 66:271, 2002.44. Kassed, CA, Pennypacker, KR: Role of NF-?B in neuroplastic changes in the brain. Keystone Symposium, NF-?B:Bench to Bedside pg 75, 2002.45. Pennypacker, KR, Willing, AE, Garbuzova-Davis, S, Sanberg, PR, Kassed, CA: NF-?B p50 in neuronal plasticity. Soc. Neurosci. Abs. 2002.46. Butler, TL, Hall, LB, Navidomskis, MT, Pennypacker, KR: Analysis of FRA-2 associated signaling in the injury response and neuronal survival. Soc. Neurosci. Abs. 2002.47. Chappell, D, Butler, TL, Navidomskis, MT, Patel, N, Kassed, CA, Sanchez-Ramos, J, Cooper, D, Pennypacker, KR: Protein kinase C?II is upregulated in discreet neurons after middle cerebral artery occlusion. Soc. Neurosci. Abs. 2002.48. Butler, TL, Navidomskis, MT, Pennypacker, KR: Expression of FRA-2 and associated signaling in the response of PC12 cells to hypoxic injury. Exp. Neurol. 181(1): 87, 2003.49. Duckworth, EAM, Butler, TL, Pennypacker, KR: Murine middle cerebral artery occlusion and neuronal plasticity: the role of nuclear factor kappa B. Soc. Neurosci. Abs. 2003.50. De Mesquita, D, Butler, TL, Navidomskis, MT, Pennypacker, KR: The role of NF-kB and related signaling in cortical neurons: in vitro. Soc. Neurosci. Abs. 2003.51. Vendrame, M, Cassady, JC, Newcomb, J, Butler, TL, Pennypacker, K, Zigova T, Davis, CD, Sanberg, PR, Willing, AE: Intravenous administration of human umbilical cord blood (HUCB) cells in a rat model of stroke: a dose dependency study. Soc. Neurosci. Abs. 2003.52. De Mesquita, D, Pennypacker, KR: NF-kB signaling in cortical neurons in vitro after hypoxia and NGF. Keystone Symposium, NF-kB: Pathology and Biology, pg 64, 2004.53. Zhang, H, Guerrero, W, De Mesquita, DD, Butler, TL, Pennypacker, KR, Catnik, C, Cuevas, J: Sigma-1 receptor activation exerts neuroprotection after chemical ischemia by attenuating ischemia-induced elevations in intracellular calcium. Soc. Neurosci. Abs. 2004.54. Vendrame, M, Gemma, C, Pennypacker, KR, Willing, AE: Cord blood infusion rescues stroke-induced alterations of splenocyte phenotype and function. Soc. Neurosci. Abs. 2004.55. Newcomb, JD, Ajmo, CT, Collier, L, Sanberg, CD, Pennypacker, KR, Sanberg, PR, Willing, AE: Infarct core rescued by intravenous treatment of human umbilical cord blood cells. Exp. Neurol. 193:255, 2005.56. *Ajmo Jr, CT, De Mesquita, D, Vernon, DOL, Collier, LA, Cuevas, J, Pennypacker, KR: Sigma receptor activation reduces infarct size after permanent middle cerebral artery occlusion in rats (pMCAO). Soc. Neurosci. Abs. 200557. Newcomb, JD, Ajmo Jr, CT, Collier, LA, Pennypacker, KR, Sanberg, PR, Willing, AE: Human umbilical cord blood cells rescue infarct core. Soc. Neurosci. Abs. 200558. Newcomb, JD, Ajmo, CT, Sanberg, CD, Sanberg, PR, Pennypacker, KR, Willing, AE: Cord blood treatment leads to full recovery in rats with experimental stroke. Exp. Neurol. 193:255, 2005.59. *Hall, A, Cruz, Y, Katnik, C, Cuevas, J, Pennypacker, KR: The sigma receptor agonist 1,3-di-o-tolylguanidine, suppresses activation of primary microglia and the subsequent release of TNF-a and nitric oxide. SEPS Meeting, 2005.60. *Ajmo Jr, CT, Vernon, DOL, Collier, LA, De Mesquita, D, Cuevas, J, Pennypacker, KR: Alternative treatments of embolic stroke in rats significantly reduce infarction size.Exp. Neurol. 198:558, 2006.61. Hall, A, Cruz, Y, Katnik, C, Cuevas, J, Pennypacker, KR: Sigma receptor agonists suppress activation of primary microglia and the subsequent release of TNF-? and nitric oxide. Exp. Neurol. 198:570, 2006.62. *Ajmo, CT, Vernon, DOL, Collier, LA, Newcomb, LA, Cuevas, J, Willing, A, Pennypacker, KR: The spleen, a novel target of cerebral embolic stroke, contributes to the neurodegeneration occurring within the infarction. Soc. Neurosci. Abst. 613.3, 2006.63. Herrera, Y, Katnik, C, Pennypacker, KR, Cuevas, J: Sigma receptor activation inhibits acid-sensing ion channels in rat cortical neurons. Soc. Neurosci. Abst. 625.13, 2006.64. *Hall, AA, Cruz, Y, Katnik, C, Cuevas, J, Pennypacker, KR: The sigma receptor agonist 1, 3-di-o-tolylguanidine suppresses the intracellular calcium signaling necessary for the activation of microglia. Soc. Neurosci. Abst. 711.5, 2006.65. *Ajmo, CT, Collier, LA, Hall, AA, Cuevas, J, Willing, AE, Pennypacker, KR: Splenic response to stroke is not dependent on neurotransmission via the splenic nerve. Soc. Neurosci. Abst. 2007. 66. *Hall, AA, Herrera, Y, Ajmo, CT, Cuevas, J, Willing, AE, Pennypacker, KR: Sigma receptor mediated suppression of microglial activation is a calcium dependent process. Soc. Neurosci. Abst. 2007. 67. Herrera, Y, Katnik, C, Hall, AA, Pennypacker, K, Cueva, J:. Modulation of acid-sensing ion channels by sigma receptors. Soc. Neurosci. Abst. 468.10/J25, 2007.68. Leonardo, CC, Eakin, A, Ajmo, JA, Collier, L, Pennypacker, KR, Strongin, AY, Gottschall, PE: Delayed administration of a small molecule MMP inhibitor improves the neuropathological outcome after hypoxia-ischemia in the rat neonate. Soc. Neurosci. Abst. 2007. 69. Womble, TA, Jiang, L, Green, S, Sanberg, PR, Pennypacker, KR, Willing, AE:Human umbilical cord blood (HUCB) induced recovery of function in a rat model of stroke is dependent upon the specific cord blood cell populations administered. Princeton Conference, 2008.70. Womble, TA, Greene, S, Sanberg, PR, Pennypacker, KR, Willing, AE: CD14+ Human Umbilical cord blood cells are essential for neurological recovery following MCAO. ASTNR, 2008.71. Behensky, A, Cortes-Salva, M, Ajmo, CT, Herrera, Y, Katnik, C, Antilla, JC, Pennypacker, KR, Cuevas, J: Development of Guanidine Analogues for Anti-Stroke Therapeutics. Fco-BITT conference 2008.72. *Willing, AE and Pennypacker, KR: .Role of Spleen in Mediating Inflammatory Signaling after Focal Ischemia. J Neurochem 108(s1): 59, 2009.73. *#Hall, AA, Leonardo, CC, Collier, LA, Cuevas, J, Willing, AE, Pennypacker, KR: Human Umbilical Cord Blood Treatment Inhibits Nitric Oxide Production and Neuronal Death in Organotypic Slice Cultures Subjected to Oxygen Glucose Deprivation. Stroke 40(4):e170, 2009.74. *#Leonardo, CC, Ajmo,, CTJr., Collier, LA, Green, SM, Cuevas, J, Willing, AE Pennypacker, KR: Delayed Administration of a Pan-Selective Sigma Receptor Agonist after MCAO: Effects on Neural Injury and Behavioral Recovery. Stroke 40(4):e133, 2009.75. Pennypacker, KR and Willing, AE: Investigations of the multiple mechanisms of cord blood cell therapy in stroke. Annals of Neuroscience 16(s):4, 2009.76. Cortes-Salva, MY, Ngugen, B, Behensky, A, Pennypacker, KR, Cuevas, J, and Antilla, J: Synthesis andscreen of sigma receptor ligands for post-stroke therapy. American Chemical Society 2009.77. #Rowe, DD, Leonardo, CC, Hall, AA, Shahaduzzaman, MD, Collier, LA, Willing, AE, and Pennypacker, KR: Cord blood administration induces oligodendrocyte survival by altered protein expression. Stroke conference 2010. 78. #Rowe, DD, Collier, LA, Willing, AE, and Pennypacker, KR: Akt activation mediates HUCB cell protection. Stroke 2010 40(4):e191, 2011.?79. #Seifert, H, Leonardo, C, Hall, Collier, L., Willing, A., and Pennypacker, K R.: Interferon gamma contributes to neural injury following ischemic stroke. Stroke 2010 40(4):e65, 2011.80. #Seifert H., Hall A., Recio J., Chapman C., Collier L., Willing A., and Pennypacker K.: A Transient Decrease in Spleen Size Following Stroke Corresponds to Splenocyte Release into Systemic Circulation. Stroke Feb; 43:A2494 2012.81. M. Shahaduzzaman, J. McAleer, J. Grieco, J. Golden, J. Glover, J. Hall, M. Cortes-Salva, J. Antilla, J. Cuevas, K. R. Pennypacker and A. E. Willing Sigma Receptor (σRs) Agonist NAPH Decreased Long-term Infarct Volume and Rescued White Matter After Middle Cerebral Artery Occlusion (MCAO)American Society for Neural Therapy and Repair, Clearwater, FL 2012.82. J. E. Golden, A. Wabnitz, S. Green, M. Shahaduzzaman, T. A. Womble, K. R. Pennypacker and A. E. Willing. Identification of the Subpopulation of Human Umbilical Cord Blood that Alters Spleen FunctionAmerican Society for Neural Therapy and Repair, Clearwater, FL 2012.83. M. Shahaduzzaman, V. Mehta, J. E. Golden, D. Rowe, K. R. Pennypacker and A. E. Willing. Human Umbilical Cord Blood (HUCB) Cells Protect Neurons Following Oxygen Glucose Deprivation through Activation of AKT Pathway. American Society for Neural Therapy and Repair, Clearwater, FL 2012.84. A. E. Willing, M. Shahaduzzaman, J. Grieco1, S. Green, K. Almerico, C. Huguet, and K. R. Pennypacker. Sigma Ligands as Potential Treatments for Cerebral Ischemia. American Society for Neural Therapy and Repair, Clearwater, FL 2012.85. M. Shahaduzzaman, J. Grieco, J. McAleer, S. Green, K. Almerico , C. Huguet , J. Antilla, J. Cuevas, K. R. Pennypacker, A. E. Willing. Do Sigma Receptor Agonists Provide Long Term Neuroprotection in the Rat Middle Cerebral Artery Occlusion Model of Stroke? National Association of Inventors USF 2012.86. M. Shahaduzzaman,J. McAleer, P. Venkatachalam, S. Jadeja, J. Glover, J. Antilla, J. Cuevas, K. R. Pennypacker and A. E. Willing . Newly Synthesized Sigma receptors (σRs) Agonist May Improve Motor function After Middle cerebral artery Occlusion (MCAO). National Association of Inventors USF 2012.#87. Seifert,?H.A., Collier, L.A., Willing, A.E., and Pennypacker, K.R.: Interferon-inducible Protein 10 Increases following Stroke,?Stroke.?2013;?44:AWP265. #88. Davis, S. M., Collier, L. A., Leonardo, C. C., Seifert, H. A., Ajmo, C. T., and Pennypacker, K. R. (2015). Abstract T P248: Leukemia Inhibitory Factor Induced-Akt Activation Protects Neurons from Ischemic Damage by Increasing Superoxide Dismutase Activity and Expression.?Stroke,?46 (Suppl 1), ATP248-ATP248. 89. Davis, S. M., Collier, L. A., Leonardo, C. C., Seifert, H. A., Ajmo, C. T., and Pennypacker, K. R. (2015). Leukemia Inhibitory Factor Induced-Akt Activation Protects Neurons from Ischemic Damage by Increasing Superoxide Dismutase 3 Activity and Expression.?ASTNR.90. Davis, S. M., Collier, L. A., Fazal, J.A., Leonardo, C.C., Ajmo, C. T., and Pennypacker, K. R. (2016) Leukemia Inhibitory Factor Upregulates Superoxide Dismutase 3 in Neurons via Myeloid Zinc Finger-1. International Stroke Conference. (in press)*Oral Presentations #Peer ReviewedSymposium:1993 ASPETchairperson, organizer, and coordinator of symposium, entitled, "Pharmacologic regulation of DNA binding activity of transcription factors," August 3, 1993. Prepared an introduction and summary of the symposium, as well as presenting the seminar titled "Tissue- and developmental-specific regulation of AP-1 DNA binding activity in neural tissues."1996University of Kansas Medical Center-participant In the Kansas Idea Symposium entitled“Oxidative regulation of gene expression: Role in neurodegenerative diseases. Presented a seminar entitled “Transcription factors in kainate-induced brain injury” and two workshops, “Redox regulation of transcription factors” and “Role of oxidative regulation in brain damage”.1999 Ryzdnya, Poland-participant and US coordinator for travel funds and publishing of workshop entitled “Inducible Transcription Factors in the Brain” and present a seminar entitled “Adaptation to Brain Injury: Long-term Expression of Transcription Factors”. Chaired a session on “Effects of Drugs of Abuse on Inducible Transcription Factors”.Society for Neuroscience, San Diego, CA-Chairperson of Neuroinflammation in Stroke Session 2009Symposium at American Society for Neurochemistry, Molecular Stroke Research: What is new? As co-chair, aided Dr. Raghu Vemuganti in developing, organizing and hosting this session2012Symposium at International Stroke Conference: Splenic and other immune responses to stroke. Proposed and co-chaired this session.Invited Presentations:1986 National Institutes of Health, National Eye Institute1989 Monell Institute, Institute of the Senses1989 Cephalon, Inc.1989 Upjohn1989 National Institute of Environmental Health Sciences, Laboratory of Integrative Biology1992 Burroughs Wellcome Co.1994Staten Island College, Neuroscience Program 1994Kansas Medical Center, Dept. Pharmacology1994University of South Florida, Dept. Pharmacology1994University of Southern California, Dept. Gerontology1994Abbott Pharmaceuticals1995NIEHS, Neuroscience Program1999NIOSH, Toxicology Program2002Soc. Tox. Symposium: Transcriptional Involvement in Neurotoxicity2005Merck Pharmaceuticals2005 Wright State University2006 University of Louisiana at Monroe2006 Association of University Technical Managers2007Ross University College of Medicine2008University of Central Florida College of Medicine2009American Society for Neurochemistry2009Loma Linda University2009Indian Academy of Neurosciences, Jaipur, India2010Mayo Clinic, Jacksonville, FL2011Chemistry Department, USF2012Molecular Medicine, USF2013Neurosurgery Conference Chongqing, China2014Edema Conference, Los Angeles20164th Annual Malcolm Feist Lecture on Translational Research in Cardiovascular Diseases, Louisiana State University at Shreveport2016Oregon Health and Sciences Center Portland, ORServiceProfessional SocietiesAmerican Society for Pharmacology and Experimental TherapeuticsAmerican Society for the Advancement of ScienceSociety for NeuroscienceSigma XiAmerican Heart AssociationHonors/Awards1982 1984 Teaching Assistantship, Virginia Commonwealth University1984 1987Research Fellowship, Hershey Medical Center, Department of Pharmacology2005 Grasso Award for Commitment to Graduate Education 2006USF Biotechnology Award20164th Annual Malcolm Feist Lecture on Translational Research in Cardiovascular DiseasesEditorKaczmarek L., Pennypacker K., Acta Neurobiologiae Experimentalis, editors of special issue on "Inducible transcription factors in the brain". Vol. 60, 2000Editorial Board Member of the journal “Pharmacology”Editorial Board Member of the journal “Translational Stroke Research”Selected Guest Editor for an issue of Translational Stroke Research, which focused on the immune response to brain injury 2011Editorial Board Member of the journal “Toxicology and Applied Pharmacology”Active Reviewer for the Following JournalsJournal of Neurochemistry, Neuroscience, Journal of Neuroscience, Neuroscience Letters, Neurotoxicology and Teratology, Brain Research, Brain Research BulletinJournal of Pharmacology and Experimental Therapeutics, Toxicology and Applied Pharmacology, Molecular Pharmacology, Pharmacology, Experimental Neurology, Life Sciences, Neurobiology of Aging, Bioelectromagnetics, Trends in Neuroscience, Cell Transplantation, BMC Neuroscience, FASEB J, Neurotoxicology, Journal of Neuroscience Research, Journal of European Neuroscience, European Psychoneuropharmacology, Stress, Molecular and Cellular Biology, Pharmacology, Hippocampus, Environmental Health Perspectives, Experimental Gerontology, Stroke, Journal of Neuroscience Methods, Translational Stroke Research, Brain, Glia, Journal of Cerebral Blood Flow and MetabolismGrant Reviewer:Human Frontier Science ProgramInternational Centre for Genetic Engineering and BiotechnologyNIEHS Lead-Induced Changes in Gene Transcription Program Project Site Visit 10/28-30 2002Institut Pasteur Transverse Program MUIR Program for Italian Universities 2000-presentNational Institutes of Health study sections-CMBII, CDIN and FO1National Science FoundationAmerican Heart Association Study Section, Florida/Puerto Rico AffiliateFlorida Agricultural and Mechanical University Minority Biomedical Research Support ProgramDepartment of the Defense ad hocNIH BDCN N03 study section ad hocAmerican Heart Association National, Brain 3 Study SectionAmerican Heart Association National, Brain 2 Study Section Fall, 2008American Heart Association National, Brain 4 Study Section Spring, 2009American Heart Association National, Brain 4 Study Section Fall, 2009Medical Research Counsel of Great BritainAmerican Heart Association National, Brain 3 Study Section Spring, 2010-CurrentAmerican Heart Association National, Innovative Grants Study Section Fall, 2012 American Heart Association National, co-Chair Brain 3 Study Section Spring, 2014American Heart Association National, Chair Brain 3 Study Section Fall, 2014American Heart Association National, Chair Brain 3 Study Section Spring, 2015American Heart Association National, Chair Brain 3 Study Section Fall, 2015American Heart Association National, Chair Brain 3 Study Section Spring, 2016University of Nazarbavev Grant ProposalsShota Rustaveli National Science Foundation GeorgiaUniversity/College/Department:Medical Student Selection Committee 1997-2003Vice Chair 2000-2003Pharmacology Graduate Student Program Coordinator 2003-2007Vice Chair 2006-2007Pharmacology Master’s Program Director 2003-2008Search Committee for Associate Vice President of Research at USF Departmental Search Committee memberChair, Departmental APT Committee 2009-presentChair, Radiation Committee 2003-presentCOM APT committee 2011-presentTreasurer COM Faculty Council 2014-2015University Senate 2014-CurrentCurriculum Committee member 2014-CurrentVice President COM Faculty Council 2015-Current ................
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