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Supplementary Figure 1. Expression changes (hypoxia-high vs. hypoxia-low) of target genes of increased oxygen delivery involved in HIF-1 KEGG pathway. (A)-(J) show genes that are highly expressed in Cluster 1 compared to Cluster 3, (K) and (J) show genes not highly expressed in Cluster 1 compared Cluster 3.Supplementary Figure 2. Expression changes (hypoxia-high vs. hypoxia-low) of target genes of reduce oxygen consumption involved in HIF-1 KEGG pathway. (A)-(I) show genes that are highly expressed in Cluster 1 compared to Cluster 3, (J) and (L) show genes not highly expressed in Cluster 1 compared Cluster 3.Supplementary Figure 3. Significantly enriched (A) Cellular component GO terms and (B) molecular function GO terms.Supplementary Figure 4. Scatter plots visualizing signi?cantly different expression of (A) hypoxia-inducible factor-1α (HIF-1α), (B) HIF-2α, (C) snail family transcriptional repressor 1 (SNAI1), (D) Twist family BHLH transcription factor 1 (TWIST-1), (E) CDH1 (E-cadherin), and (F) CDH2 (N-cadherin). between high-risk and low-risk cases.Supplementary Table 1. General characteristics of the Gene Oncology terms of Biological Process differently enriched by marker genes in hypoxia-high group with regard to TCGAIDDescriptionGeneRatiop-Valuep-adjustq-valueCountGO:0006007glucose catabolic process8/741.14E-121.90E-091.42E-098GO:0046031ADP metabolic process11/742.48E-121.90E-091.42E-0911GO:0009135purine nucleoside diphosphate metabolic process11/746.75E-121.90E-091.42E-0911GO:0009179purine ribonucleoside diphosphate metabolic process11/746.75E-121.90E-091.42E-0911GO:0005996monosaccharide metabolic process14/747.55E-121.90E-091.42E-0914GO:0009185ribonucleoside diphosphate metabolic process11/747.91E-121.90E-091.42E-0911GO:0001666response to hypoxia15/748.86E-121.90E-091.42E-0915GO:0006735NADH regeneration7/749.58E-121.90E-091.42E-097GO:0061621canonical glycolysis7/749.58E-121.90E-091.42E-097GO:0061718glucose catabolic process to pyruvate7/749.58E-121.90E-091.42E-097GO:0061615glycolytic process through fructose-6-phosphate7/741.27E-112.08E-091.55E-097GO:0061620glycolytic process through glucose-6-phosphate7/741.27E-112.08E-091.55E-097GO:0036293response to decreased oxygen levels15/741.36E-112.08E-091.55E-0915GO:0006024glycosaminoglycan biosynthetic process10/741.74E-112.48E-091.84E-0910GO:0006090pyruvate metabolic process11/742.24E-112.97E-092.21E-0911GO:0006023aminoglycan biosynthetic process10/742.73E-113.11E-092.31E-0910GO:0006096glycolytic process10/742.73E-113.11E-092.31E-0910GO:0009132nucleoside diphosphate metabolic process11/742.97E-113.11E-092.31E-0911GO:0006757ATP generation from ADP10/742.97E-113.11E-092.31E-0910GO:0070482response to oxygen levels15/743.31E-113.29E-092.44E-0915GO:0042866pyruvate biosynthetic process10/743.84E-113.64E-092.71E-0910GO:0019320hexose catabolic process8/745.84E-115.28E-093.92E-098GO:0006165nucleoside diphosphate phosphorylation10/741.26E-101.07E-087.97E-0910GO:0009166nucleotide catabolic process11/741.37E-101.07E-087.97E-0911GO:0009127purine nucleoside monophosphate biosynthetic process11/741.45E-101.07E-087.97E-0911GO:0009168purine ribonucleoside monophosphate biosynthetic process11/741.45E-101.07E-087.97E-0911GO:0046939nucleotide phosphorylation10/741.46E-101.07E-087.97E-0910GO:0006734NADH metabolic process7/741.93E-101.33E-089.88E-097GO:1901292nucleoside phosphate catabolic process11/741.94E-101.33E-089.88E-0911GO:0046365monosaccharide catabolic process8/742.23E-101.48E-081.10E-088GO, gene oncology; TCGA, The Cancer Genome Atlas.Supplementary Table 2. General characteristics of the Gene Oncology terms of Biological Process differently enriched by marker genes in hypoxia-low group with regard to TCGAIDDescriptionGeneRatiop-Valuep-adjustq-valueCountGO:0006027glycosaminoglycan catabolic process5/359.48E-084.85E-053.45E-055GO:0006006glucose metabolic process7/351.03E-074.85E-053.45E-057GO:0006026aminoglycan catabolic process5/351.31E-074.85E-053.45E-055GO:0019318hexose metabolic process7/353.37E-079.38E-056.67E-057GO:0030203glycosaminoglycan metabolic process6/354.77E-070.000105997.53E-056GO:0006022aminoglycan metabolic process6/356.80E-070.000126098.96E-056GO:0005996monosaccharide metabolic process7/359.84E-070.000156370.000111177GO:0006024glycosaminoglycan biosynthetic process5/351.83E-060.000253030.000179885GO:0030207chondroitin sulfate catabolic process3/352.17E-060.000253030.000179883GO:0006023aminoglycan biosynthetic process5/352.28E-060.000253030.000179885GO:0005977glycogen metabolic process4/351.08E-050.000964640.000685774GO:0006073cellular glucan metabolic process4/351.14E-050.000964640.000685774GO:0044042glucan metabolic process4/351.14E-050.000964640.000685774GO:0009152purine ribonucleotide biosynthetic process6/351.21E-050.000964640.000685776GO:0044262cellular carbohydrate metabolic process6/351.37E-050.001015450.000721896GO:0009260ribonucleotide biosynthetic process6/351.57E-050.001091730.000776126GO:0006164purine nucleotide biosynthetic process6/351.80E-050.001109020.000788416GO:0046390ribose phosphate biosynthetic process6/351.80E-050.001109020.000788416GO:0006112energy reserve metabolic process4/352.06E-050.001207060.00085814GO:0072522purine-containing compound biosynthetic process6/352.28E-050.001267850.000901326GO:1901136carbohydrate derivative catabolic process5/352.76E-050.001460760.001038465GO:0044264cellular polysaccharide metabolic process4/354.01E-050.002027090.001441074GO:0016051carbohydrate biosynthetic process5/354.63E-050.002239610.001592155GO:0030204chondroitin sulfate metabolic process3/355.27E-050.002440010.001734613GO:1903510mucopolysaccharide metabolic process4/355.57E-050.002476090.001760274GO:0005976polysaccharide metabolic process4/355.97E-050.00255120.001813664GO:0009165nucleotide biosynthetic process6/357.34E-050.002979490.002118136GO:0050654chondroitin sulfate proteoglycan metabolic process3/357.58E-050.002979490.002118133GO:1901293nucleoside phosphate biosynthetic process6/357.77E-050.002979490.002118136GO:0005978glycogen biosynthetic process3/358.67E-050.003060080.002175423GO, gene oncology; TCGA, The Cancer Genome Atlas.Supplementary Table 3. 29 Immune signatures (gene sets)aDCsAPC co inhibitionAPC co stimulationB cellsCCRCD8+ T cellsCheck-pointCytolytic activityDCsHLAiDCsInflammation-promotingMacrophagesMast cellsMHC class INeutrophilsNK cellsParainflammationpDCsT cell co-inhibitionT cell co-stimulationT helper cellsTfhTh1 cellsTh2 cellsTILTregType I IFN ResponseType II IFN ResponseCD83C10orf54CD40BACH2CCL16CD8AIDO1PRF1CCL17HLA-ECD1ACCL5C11orf45CMA1B2MEVI2BKLRC1CXCL10CLEC4CBTLACD2CD4PDCD1IFNGPMCHITM2CIL12RB2DDX4GPR146LAMP3CD274CD58BANK1TPOLAG3GZMACCL22HLA-DPB2CD1ECD19CD68MS4A2HLA-AHSD17B11KLRF1PLATCXCR3C10orf54CD226CXCL13TBX21LAIR2CD38TMPRSS6IFIT1SELPCCL1LGALS9CD70BLKTGFBR2CTLA4CD209HLA-CCD8BCLEC5ATPSAB1TAP1KDM6BCCND1GZMBCD160CD27CXCR5CTLA4SMAD2THEMIS2CTSCIFIT2AHRPDCD1LG2ICOSLGBTLACXCL2TNFRSF9CCL13HLA-JCXCL10CYBBMEGF9LGMNIL3RACD244CD28STAT4CXCR6GLYR1LAPTM4BIFIT3PVRL3SLAMF1CD79ACCL14ICOSHLA-DQB1CXCL13FUCA1MNDAPLAURIRF7CD274CD40LGCD38GATA3ICOSTFRCIRF7TNFSF14CD79BTGFBR3CD80HLA-DQB2CXCL9GPNMBNLRP12AIM2IRF8CTLA4ICOSIL12RB2IL26F5RNF145ISG20TNFSF15FCRL1IL11RAPDCD1LG2HLA-DQA2GNLYHS3ST2PADI4MMP7LILRA4HAVCR2SLAMF1LTATIGITNETO2MX1TNFSF18FCRL3CCL11TIGITHLA-DQA1GZMBLGMNSELLICAM1PHEXLAG3TNFRSF18CSF2KLRD1ADAT2MX2TNFSF4HVCN1IL4I1CD70HLA-AIFNGMMP9TRANK1MX2PLD4LAIR1TNFRSF25IRF4CHST2RSAD2TNFSF8RALGPS2IL33TNFSF9HLA-DMAIL12ATM4SF19VNN3CXCL9PTCRATIGITTNFRSF4PRKCQCTLA4TNFSF10TNFSF9CXCL12ICOSLGHLA-DOBIL12BANXA1TNFRSF8FCRL5NFE2L3CXCL10KIR3DL1HLA-DRB1IRF1TLR2TNFRSF9SIRPGLIMA1BMPERCD86HLA-HPRF1PLA2G2DTNFSF14LPXNIL1R2BMP8APDCD1HLA-BSTAT1ITGA2IL2RGICOSCXCL11LAIR1HLA-DRB5TBX21MX1CCL5HSDL2IL21RTNFRSF8HLA-DOAHMOX1LCKHTATIP2IL17BTNFSF15HLA-DPB1CD276TRAF3IP3FKBP1ATNFRSF9TNFRSF14HLA-DRATIRAPCD86TIGITILF2IDO2HLA-DRB6IL33MALCCR8CX3CR1CD276HLA-LPTGESLILRB1LTACCR8CD40HLA-FTNFRSF12ADOK2SLC35F2TNFSF12TNFRSF4HLA-GSCARB1CD6IL21RCSF3TNFSF14HLA-DMBCD14PAG1AHCYL1TNFSF4HHLA2HLA-DPA1BLNKLAX1SOCS2BMP3CD244IFIT3PLEKETV7CX3CL1CD274RETNLBPIK3CDBCL2L1BMP5HAVCR2IFIT2SLAMF1RRAGBCXCR2CD27ISG15XCL1ACSL4TNFRSF10DBTLAOAS2GPR171CHRNA6BMP2LGALS9RELXCL2BATFCXCL14TMIGD2OAS3TBX21LAX1CCL28CD28CD44CD2ADPRHCXCL3CD48PPARGCD53TNFRSF4BMP6TNFRSF25BST2KLHL6ANKRD10CCL21CD40LGOAS1SLAMF6CD274CXCL9ADORA2ANOX1CD40CASP1CCL23VTCN1PLA2G2ASIT1LY75IL6CD160IFIT1TNFRSF4NPTNTNFRSF18CD44IFITM3CD79ASSTR3IL17RDTNFSF18IL1RNCD247GRSF1IL17DTNFRSF18LCP2CSF2RBIL27BTNL2CD3DTMEM184CCCL7C10orf54CD27NDFIP2IL1R1CD200R1SH2D1AZBTB38CXCR4TNFSF4FYBERI1CXCR2P1CD200ARHGAP30TRAF3TGFB1I1NRP1ACAP1NAB1IFNGR1CST7HS3ST3B1IL9RCD3GLAYNIL1RAPL1IL2RBJAK1IL11CD3EVDRCSF1FCRL3LEPROTIL20RACORO1AGCNT1IL25ITKPTPRJTNFRSF4TCL1AIKZF2IL18CYBBCSF1ILF3CSF2RBENTPD1CCL20IKZF1TNFRSF18TNFRSF12ANCF4METTL7AIL6STDOCK2KSR1CXCL13CCR2SSH1IL12BPTPRCCADM1TNFRSF8PLAC8IL1R1IL6RNCKAP1LACP5BMPR2IL7RCHST7IFNE6-SepTHADAIL1RAPL2CD28CD177IL3RASTAT4NFAT5BMP4CD8AZNF282CCL24LY9MAGEH1TNFSF13BCD48CCR4HCSTIL2RAPTPRCAPIL32SASH3TNFRSF10CARHGAP25IL22RA1LATBMPR1ATRAT1CXCR5IL10RACXCR3PAX5IFNA8CCR7IL17RELDOCK11IFNB1PARVGIFNAR1SPNS1TNFRSF1BCD52CCL17HCLS1IFNL1ARHGAP9IL16GIMAP6IL1RL1PRKCBILKMS4A1CCL25GPR18ILDR2TBC1D10CCXCR1GVINP1IL36RNP2RY8IL34EVI2BTGFB1VAMP5IFNGKLRK1IL19SELLILKAPMPEG1BMP2KMS4A6ACCR10ARHGAP15ILDR1MFNGEPOGZMKCCR7SELPLGIL17CTARPIL23AGIMAP7CCR5FAM65BIL7INPP5DEPORITGA4CCL13MZB1IL2RGGPSM3IL31RASTK10TNFAIP6CLEC2DIFNL2IL16BMP1NLRC3IL12RB1GIMAP5TNFAIP8GIMAP4IL4RIFFO1TNFRSF6BCFHTNFAIP8L1PVRIGTNFRSF10BCFHR1IFNL3CCL5CXCL6CXCL1CCR3TNFSF11CSF1RIL21IL1RAPIL12RB2CCL1IL17RACCR1IL1RNTNFRSF11BTNFRSF14IL13IL2RBBMP8BCCL2IL24IL18RAPTGFBITNFSF10TNFRSF11ACXCL5IL5RATNFSF9IL1RL2TNFRSF13CIL36GIL15RATNFRSF21CXCL8IL22RA2TNFAIP8L2IL18R1IFNLR1CXCR6CCL3L3TNFRSF1AIL17REIFNGR2IL17RCTNFAIP8L3ILVBLTGFBRAP1CCL4L1CSF2RACCRN4LCCL26TNFAIP1CCRL2IFNA10TNFRSF17IFNA13IL20IL18BPCCL3L1TNFSF12-TNFSF13IL5IL23RIL26TNFTGFACSF2IL1F10CXCL17TNFSF13IFNA4IL37IL12AIL7RIFNA1IL1AIL4IL2CCL22CSF3RIL10IFNKTGFB2IL1R2IL1BIL17FIL27RAIL15TNFSF8IL36BXCL1CXCL16TNFRSF19IL3CCL3IFNA2BMPR1BIFNA21TNFSF18CCL8IL17RBTNFRSF25IL22IL10RBIFNAR2CCL18IFNA16CSF2RBIL36ATNFAIP3IL13RA2IL13RA1CCR9TNFRSF10AIFNA7IFNW1XCL2TNFSF14CCR2BMP15BMP10CCL15-CCL14TGFBR1IFNA5BMP7IFNA14IL20RBIL10RAIFNA17CCR6TGFB3CCL15CCL4CCL27TNFRSF13BTNFAIP2IL31IL17ATNFSF15CCL19IFNA6IL9Supplementary Table 4. The GO (Biological Process) analysis of differentially expressed genes between high- and low-immune groupsIDDescriptionGeneRatiop-Valuep-adjustq-valueCountGO:0006959humoral immune response51/2574.36E-371.33E-331.12E-3351GO:0002460adaptive immune response based on somaticrecombination of immune receptors built from immunoglobulin superfamily domains50/2571.27E-351.94E-321.65E-3250GO:0006958complement activation, classical pathway35/2571.01E-349.57E-328.10E-3235GO:0002455humoral immune response mediated by circulating immunoglobulin36/2571.25E-349.57E-328.10E-3236GO:0006956complement activation37/2572.21E-331.35E-301.14E-3037GO:0019724B cell mediated immunity40/2573.21E-331.63E-301.38E-3040GO:0016064immunoglobulin mediated immune response39/2573.41E-321.49E-291.26E-2939GO:0002449lymphocyte mediated immunity46/2571.31E-315.00E-294.23E-2946GO:0072376protein activation cascade37/2572.72E-319.22E-297.80E-2937GO:0002429immune response-activating cell surface receptor signaling pathway51/2576.15E-311.88E-281.59E-2851GO:0002696positive regulation of leukocyte activation45/2574.80E-291.33E-261.13E-2645GO:0050867positive regulation of cell activation45/2572.31E-285.87E-264.96E-2645GO:0051249regulation of lymphocyte activation48/2572.04E-274.78E-254.05E-2548GO:0050853B cell receptor signaling pathway29/2573.84E-278.36E-257.08E-2529GO:0051251positive regulation of lymphocyte activation41/2574.20E-278.55E-257.23E-2541GO:0006909phagocytosis42/2572.00E-263.81E-243.22E-2442GO:0006910phagocytosis, recognition24/2572.23E-254.01E-233.39E-2324GO:0006911phagocytosis, engulfment26/2573.45E-245.85E-224.95E-2226GO:0050851antigen receptor-mediated signaling pathway37/2579.02E-241.45E-211.23E-2137GO:0099024plasma membrane invagination26/2572.63E-234.01E-213.39E-2126GO:0050871positive regulation of B cell activation27/2572.95E-234.28E-213.62E-2127GO:0050900leukocyte migration44/2574.26E-235.90E-215.00E-2144GO:0010324membrane invagination26/2571.39E-221.84E-201.56E-2026GO:0050864regulation of B cell activation28/2572.58E-213.28E-192.78E-1928GO:0042113B cell activation33/2575.62E-206.85E-185.80E-1833GO:0008037cell recognition28/2571.93E-192.26E-171.92E-1728GO:0002697regulation of immune effector process38/2574.25E-194.80E-174.06E-1738GO:0030449regulation of complement activation21/2576.02E-186.56E-165.55E-1621GO:2000257regulation of protein activation cascade21/2577.26E-187.64E-166.46E-1621GO:0002920regulation of humoral immune response22/2571.05E-171.06E-159.00E-1622GO, gene oncology. Supplementary Table 5. The GO (Cellular Component) analysis of differentially expressed genes between high- and low-immune groupsIDDescriptionGeneRatiop-valuep-adjustq-valueCountGO:0019814immunoglobulin complex46/2647.72E-492.12E-461.93E-4646GO:0042571immunoglobulin complex, circulating24/2641.72E-272.36E-252.14E-2524GO:0009897external side of plasma membrane41/2649.65E-258.85E-238.02E-2341GO:0062023collagen-containing extracellular matrix29/2642.16E-131.49E-111.35E-1129GO:0042101T cell receptor complex17/2641.22E-126.72E-116.10E-1117GO:0072562blood microparticle14/2641.15E-085.28E-074.79E-0714GO:0098802plasma membrane receptor complex19/2641.91E-087.50E-076.80E-0719GO:0005581collagen trimer10/2642.53E-078.69E-067.88E-0610GO:0044420extracellular matrix component6/2645.92E-050.00180770.001639916GO:0001772immunological synapse5/2640.000111230.003058840.002774915GO:0005604basement membrane7/2640.000288850.007221350.006551047GO:0098644complex of collagen trimers3/2640.001962090.044652920.040508113GO:0031225anchored component of membrane8/2640.002110870.044652920.040508118GO:0030665clathrin-coated vesicle membrane6/2640.004543740.08925210.080967456GO:0019897extrinsic component of plasma membrane7/2640.006911030.126702150.114941287GO:0005583fibrillar collagen trimer2/2640.009070490.146728590.13310882GO:0098643banded collagen fibril2/2640.009070490.146728590.13310882GO:0034774secretory granule lumen10/2640.011591480.177092050.1606538410GO:0060205cytoplasmic vesicle lumen10/2640.016101160.22552680.2045927310GO:0031983vesicle lumen10/2640.016401950.22552680.2045927310GO:0030669clathrin-coated endocytic vesicle membrane3/2640.020991980.273311190.247941643GO:0070820tertiary granule6/2640.023283610.273311190.247941646GO:0099092postsynaptic density, intracellular component2/2640.023728050.273311190.247941642GO:0005788endoplasmic reticulum lumen9/2640.023852610.273311190.247941649GO:0045121membrane raft9/2640.026561540.285929490.259388679GO:0098857membrane microdomain9/2640.027033330.285929490.259388679GO:0099091postsynaptic specialization, intracellular component2/2640.031725790.313017970.283962712GO:0098589membrane region9/2640.03316380.313017970.283962719GO:0031091platelet alpha granule4/2640.033958860.313017970.283962714GO:0031258lamellipodium membrane2/2640.034595640.313017970.283962712GO, gene oncology. Supplementary Table 6. The GO (Molecular Function) analysis of differentially expressed genes between high- and low-immune groupsIDDescriptionGeneRatiop-valuep-adjustq-valueCountGO:0003823antigen binding37/2305.96E-362.34E-332.03E-3337GO:0034987immunoglobulin receptor binding24/2303.32E-276.50E-255.64E-2524GO:0005201extracellular matrix structural constituent24/2301.11E-181.45E-161.25E-1624GO:0005125cytokine activity15/2301.97E-071.93E-051.67E-0515GO:0005539glycosaminoglycan binding15/2303.30E-072.59E-052.25E-0515GO:0005126cytokine receptor binding16/2301.10E-067.21E-056.26E-0516GO:0001965G-protein alpha-subunit binding5/2301.23E-050.000679990.000589785GO:0030020extracellular matrix structural constituent conferring tensile strength6/2301.39E-050.000679990.000589786GO:0008009chemokine activity6/2303.96E-050.001723750.001495096GO:0048018receptor ligand activity18/2306.24E-050.002444230.0021218GO:0042379chemokine receptor binding6/2300.000213990.007595710.006588116GO:0005518collagen binding6/2300.000232520.007595710.006588116GO:0048407platelet-derived growth factor binding3/2300.000331010.009981120.008657093GO:0008201heparin binding9/2300.000373770.010465650.009077359GO:0019838growth factor binding8/2300.000427910.010895970.009450598GO:1901681sulfur compound binding11/2300.000444730.010895970.0094505911GO:0005164tumor necrosis factor receptor binding4/2300.000663860.015307830.01327724GO:0042834peptidoglycan binding3/2300.001287740.028044220.024324073GO:0004866endopeptidase inhibitor activity8/2300.002088350.043085980.037370498GO:0004222metalloendopeptidase activity6/2300.002263260.044359930.038475456GO:0005540hyaluronic acid binding3/2300.002424030.045248480.039246133GO:0030414peptidase inhibitor activity8/2300.002663190.045390.039368888GO:0061135endopeptidase regulator activity8/2300.002663190.045390.039368888GO:0030021extracellular matrix structural constituent conferring compression resistance3/2300.002780060.045407640.039384183GO:0032813tumor necrosis factor receptor superfamily binding4/2300.002957570.046374650.040222914GO:0001664G protein-coupled receptor binding10/2300.003732780.056278830.0488132710GO:0043027cysteine-type endopeptidase inhibitor activity involved in apoptotic process3/2300.004034790.058579120.050808423GO:0005044scavenger receptor activity4/2300.004306430.060290030.052292384GO:0050839cell adhesion molecule binding14/2300.005843530.078988380.0685103314GO:0002020protease binding6/2300.006576260.08592980.074530956GO, Gene Oncology.Supplementary Table 7. The KEGG analysis of differentially expressed genes between high- and low-immune groupsIDDescriptionGeneRatiop-valuep-adjustq-valueCounthsa04060Cytokine-cytokine receptor interaction23/1041.87E-123.75E-103.30E-1023hsa04061Viral protein interaction with cytokine and cytokine receptor11/1045.49E-085.52E-064.86E-0611hsa05340Primary immunodeficiency7/1044.54E-073.04E-052.68E-057hsa04668TNF signaling pathway9/1041.32E-050.00066260.000582969hsa04640Hematopoietic cell lineage8/1043.92E-050.001574120.001384928hsa04659Th17 cell differentiation8/1046.85E-050.00229330.002017678hsa04062Chemokine signaling pathway10/1040.000158090.004248280.0037376910hsa04658Th1 and Th2 cell differentiation7/1040.000177770.004248280.003737697hsa05323Rheumatoid arthritis7/1040.000190220.004248280.003737697hsa04064NF-kappa B signaling pathway7/1040.000379750.007345390.006462567hsa04672Intestinal immune network for IgA production5/1040.000401990.007345390.006462565hsa05144Malaria5/1040.00044210.007405180.006515165hsa05145Toxoplasmosis7/1040.000595190.009202590.008096557hsa04151PI3K-Akt signaling pathway12/1040.001996930.028670270.0252244312hsa04621NOD-like receptor signaling pathway8/1040.002335140.031290840.027530048hsa04657IL-17 signaling pathway5/1040.007315990.084403460.074259135hsa05166Human T-cell leukemia virus 1 infection8/1040.007373950.084403460.074259138hsa04974Protein digestion and absorption5/1040.007644610.084403460.074259135hsa04215Apoptosis - multiple species3/1040.007978440.084403460.074259133hsa00590Arachidonic acid metabolism4/1040.00882370.088678170.078020074hsa04660T cell receptor signaling pathway5/1040.011077680.106029260.093285765hsa05219Bladder cancer3/1040.015769220.14407330.126757343hsa04630JAK-STAT signaling pathway6/1040.018434390.161100510.141738086hsa04926Relaxin signaling pathway5/1040.025778360.215893780.189945825hsa05150Staphylococcus aureus infection4/1040.035670630.27919120.245635624hsa05215Prostate cancer4/1040.036846460.27919120.245635624hsa04933AGE-RAGE signaling pathway in diabetic complications4/1040.040507390.27919120.245635624hsa05416Viral myocarditis3/1040.04248030.27919120.245635623hsa04514Cell adhesion molecules (CAMs)5/1040.042808780.27919120.245635625hsa05142Chagas disease (American trypanosomiasis)4/1040.043059340.27919120.245635624KEGG, Kyoto Encyclopedia of Genes and GenomesSupplementary Table 8. Overlapping genes of hypoxia related DEGs and immune related DEGsOverlapping GenesABHD1ABRAC002064.3AC004862.1AC007406.2AC013244.1AC019129.1AC040173.1AC046185.3AC069294.1AC098613.1AC131097.2AC135586.2ADAMDEC1ADAMTS15ADAMTS5ADORA2BP1ADRA2AAEBP1AL161935.3AL356490.1AL451069.1AL590483.2AL590764.1ALOX5ALOX5APANK2ANKFN1ANTXR1APOBEC3CAREGARL4CASB2ATP2A3B3GALT2BIRC3BIRC7C1QTNF3C3orf85C7CA14CAPGCCL13CCL2CCL22CCNJLCCR5CD177CD1ECD207CD27CD38CD3DCD3ECD40LGCD48CD5CD52CD6CD70CD79ACDCA8CDH11CDH17CEACAM6CELF2CFAP57CFDCFTRCHI3L2CIDEBCLIC6CLIP3CLMPCOL14A1COL16A1COL1A1COL5A1COL7A1COL8A2COX7A1CREB3L1CRLF2CSF2RACTNNA2CXCL17CXCL5CXCL6CXCL8CXCR6CYS1DEF6DIO3DPTDRD1DUOXA2DUSP4ECM1EID3EIPR1-IT1EMILIN2EPOFA2HFABP3FAPFCGR2AFCN3FPR1FXYD5FZD2GAL3ST4GALNT3GATA3GBP5GCNT1GGT5GNG8GPBAR1GPNMBGPR132GPR183GPR68GPR84GPRC5AGSTP1HAPLN3HAS1HAVCR1HAVCR2HCG14HLA-DQA1HOXB-AS1HPSEHSD11B1HTRA3ICOSIGFBP6IGHDIGHG2IGHGPIGHMIGHV1-24IGHV1-45IGHV1-69IGHV2-26IGHV2-5IGHV2-70IGHV2-70DIGHV3-13IGHV3-20IGHV3-23IGHV3-35IGHV3-43IGHV3-64IGHV3-7IGHV3-72IGHV3-74IGHV4-4IGHV4-55IGHV5-78IGKV1-12IGKV1-27IGKV1-5IGKV1-6IGKV1-9IGKV1D-42IGKV2-30IGKV2D-24IGKV2D-40IGKV3-11IGKV3D-11IGKV3D-20IGKV3OR2-268IGKV5-2IGKV6D-21IGLC2IGLC7IGLV1-44IGLV2-14IGLV3-10IGLV3-12IGLV3-21IGLV3-25IGLV3-9IGLV4-69IGLV6-57IGLV7-46IGLV8-61IKZF1IL18IL2RAIL34IRF4ISLRITGB2-AS1JAK3JCHAINKCNN4KELKLHL6KPNA2KRT6BLAMC2LCKLGI2LIFLIMD2LINC01480LINC01857LINC01943LINC02446LOXL1LPAR1LTALTFMAGEB17MARCOMBOAT4MEOX1MEX3AMFAP4MGPMICAL1MMP2MMP9MRC2MUC6MXRA5NFE4NGFRNTRK2OGNOLFM4OMGPAGE4PARM1PCED1B-AS1PDGFRAPDSS1PI3PIGZPLA2G4APLAC8PLOD2PMP22PODNPOSTNPOU2AF1PRNDPROM1PSRC1PSTPIP1PTGS1PTPN22RAB33ARAB42RCAN2RGS1RGS2RGS4RHOHRIPK3RRADRUBCNLS100A4SCARA5SEMA4ASGCASH2D1ASLAMF8SLC1A7SLC5A1SLC6A6SMIM25SOD3SORD2PSP140SPON1SRPXSTAP1SUSD5SYTL1TAGAPTECTBTESPA1TFPI2THBS2TIMP1TLR8TMEM119TMEM130TMEM158TMEM45ATNFRSF17TNFRSF18TNFSF13BTRACTRAV21TRAV8-3TRAV8-6TRAV9-2TRBC1TRBC2TRBJ2-1TRBV19TRBV2TRBV28TRBV30TRBV5-1TRBV5-6TRBV9TREM2TRGV10U62317.4UBASH3AUGT1A4VCANVNN2WISP2ZNF683DEGs, differentially expressed genes. ................
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