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Supplementary Table 1: Multinomial logistic regressions for combined models – young-old vs. old-oldNo dementia (n)Incident dementia (n)OR95% C.I. for Exp (B)p-valueBICROC – AUCLowerUpperYoung-old (<78)Model 0Covariates1278381073.27.832Model 1Category fluency1275372.611.624.22.0001069.90.867Model 2Category fluency1271372.101.283.45.0041072.74.879Word recall1.731.142.61.009OrModel 1Number cancellation1272342.811.824.33.0001035.13.867Model 2Number cancellation1269342.601.684.02.0001038.76.885Word recall1.961.292.99.002Old-old (≥78)Model 0Covariates455871008.64.642Model 1Category fluency455872.821.984.04.000982.23.731Model 2Category fluency449852.211.523.20.000955.56.750Word recall2.031.472.81.000Model 3Category fluency385561.771.132.78.013722.73.764Word recall2.021.363.00.001TMT B1.681.192.36.003Supplementary Table 2: Multinomial logistic regressions for combined models – female vs. maleNo dementia (n)Incident dementia (n)OR95% C.I. for Exp (B)p-valueBICROC – AUCLowerUpperFemaleModel 0Covariates10631781752.76.866Model 1Category fluency10601763.562.694.69.0001670.14.905Model 2Category fluency10431512.752.013.78.0001501.44.911Pattern comparison2.371.733.25.000Model 3Category fluency10401502.191.573.06.0001491.99.914Pattern comparison2.211.603.04.000Word recall1.761.342.32.000MaleModel 0Covariates670681127.76.878Model 1TMT A657582.081.532.83.0001013.49.909Model 2TMT A655581.811.292.52.001995.56.923Word recall2.851.904.27.000Model 3TMT A655571.531.072.19.019987.90.930Word recall2.631.724.00.000Category fluency1.731.122.67.013Supplementary Table 3: Multinomial logistic regressions for combined models – low vs. high educationNo dementia (n)Incident dementia (n)OR95% C.I. for Exp (B)p-valueBICROC – AUCLowerUpperLow EducationModel 0Covariates8631821814.21.820Model 1Category fluency8621803.662.794.79.0001843.28.878Model 2Category fluency8471542.962.194.00.0001660.62.887Number cancellation2.001.532.61.000Model 3Category fluency8451532.171.582.99.0001645.34.896Number cancellation1.931.472.53.000Word recall1.991.512.62.000High EducationModel 0Covariates87064905.87.902Model 1Category fluency868632.621.773.86.000923.55.924Model 2Category fluency863602.151.423.27.000898.42.933Word recall2.381.623.48.000Model 3Category fluency859571.731.122.70.014868.65.937Word recall2.151.443.20.000Pattern comparison2.511.564.04.000Supplementary Table 4: Multinomial logistic regressions for combined models – no ?4 vs. any ε4No dementia (n)Incident dementia (n)OR95% C.I. for Exp (B)p-valueBICROC – AUCLowerUpperNo ?4Model 0Covariates12231371814.26.887Model 1Category fluency12211373.852.835.23.0001741.57.922Model 2Category fluency12071163.382.404.76.0001593.83.927Number cancellation1.741.302.33.000Model 3Category fluency12051152.521.763.61.0001583.93.930Number cancellation1.651.232.21.001Word recall1.931.432.61.000Any ?4Model 0Covariates48587778.65.866Model 1Word recall482862.922.064.15.000727.21.899Model 2Word recall474792.531.733.71.000692.94.908Pattern comparison2.651.684.17.000Model 3Word recall474792.251.523.34.000698.52.910Pattern comparison2.191.363.53.001Category fluency1.701.102.62.018No dementia (n)Incident dementia (n)OR95% C.I. for Exp (B)p-valueBICROC – AUCLowerUpperModel 0Covariates1733962256.72.873Cognitive baseModel 1Word recall1722943.502.624.67.0002157.21.905OrModel 1Category fluency1730953.972.865.51.0002168.45.905Model 2Category fluency1720932.631.853.73.0002110.57.914Word recall2.541.863.46.000Model 3Category fluency1687832.321.583.40.0001960.32.920Word recall2.411.733.37.000TMT A 1.611.232.11.000Supplementary Table 5: Multinomial logistic regressions for combined models – AD type dementiaSupplementary Table 6: Multinomial regressions for individual variables – 12 year time to diagnosis subsample12 years before diagnosis6 years before diagnosis6 years before diagnosisNo dementia (n)Incident dementia (n)Exp(B)(C.I)p-valueROC - AUCNo dementia(n)Incident dementia (n)Exp(B)(C.I)p-valueROC - AUCNo dementia(n)Incident dementia (n)Exp(B)(C.I)p-valueROC - AUCCovariates28448.62928448.61328448.617Episodic MemoryWord recall 283471.56(1.10-2.22).012.662283471.76(1.24-2.50).001.692281442.14(1.50-3.05).000.712Word recognition 283471.33(.98-1.79).068.628283471.40(1.01-1.94).047.655280431.67(1.26-2.23).000.690Semantic MemoryVocabulary 283471.41(1.03-1.92).033.640282471.58(1.12-2.24).009.648280451.67(1.19-2.34).003.657General knowledge 281481.43(1.04-1.97).026.639284481.24 (.90-1.72) .189.614284481.50 (1.10-2.05).010.659Verbal FluencyLetter fluency 284471.36(.97-1.89).072.624284481.84(1.28-2.65).001.676284472.15(1.50-3.09).000.696Category fluency 284481.46(1.03-2.07).032.641284482.17(1.49-3.16).000.733284483.09(2.12-4.49).000.781Perceptual SpeedNumber cancellation 282451.21(.86-1.69).281.618279461.40(1.00-1.96).050.633277412.06(1.43-2.97).000.700Pattern comparison 281462.00(1.36-2.94).000.686281461.61(1.14-2.26).007.675275412.62(1.77-3.89).000.735Trail Making Task A 279451.26(.92-1.71).148.628279441.65(1.12-2.45).012.651273392.30(1.60-3.30).000.748Executive FunctionTrail Making Task B257421.91(1.35-2.69).000.663251382.22(1.45-3.38).000.715247261.95(1.24-3.06).004.711Supplementary Table 7 – Multinomial regressions for individual variables – participants with complete cognitive dataNo dementia (n)Incident dementia (n)Exp(B)95% C.I. for Exp (B)p-valueROC – AUCLowerUpperCovariates1556132.865Episodic MemoryWord recall 15561322.742.143.52.000.889Word recognition 15561321.941.612.34.000.884Semantic MemoryVocabulary 15561321.371.101.69.004.870General knowledge 15561321.441.181.75.000.871Verbal FluencyLetter fluency 15561321.391.111.74.004.868Category fluency 15561322.972.233.95.000.886Perceptual SpeedNumber cancellation 15561322.031.572.63.000.884Pattern comparison 15561322.661.993.56.000.883Trail-making task A15561321.931.542.41.000.882Executive FunctionTrail Making Task B 15561322.021.632.52.000.883 ................
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