Genetic Defects in Thyroid Hormone Synthesis and Action
hormone synthesis or secretion, and normal fertility (58). The physiological role of . IGSF1 . is unknown, but it’s lack is responsible for a variety of symptoms such as hypothyroidism, prolactin deficiency, macroorchidism and delayed puberty. IGSF1. is important for the pituitary-thyroid axis and the development puberty and thus represents a new player controlling growth and puberty in ... ................
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