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The half-life of nicotine is about two hours; however nicotine concentration can vary depending on the time of the day when the last cigarette was smoked.30 Cotinine has a half-life of 15-20 hours and as such can be used to measure 24-48 hour smoking abstinence.30 In smokers, plasma cotinine is about 200 ng/ml, but may reach up to 1000 ng/ml ... ................
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