Drug Testing
Drug Testing
An Overview of Mayo Clinic Tests
Designed for Detecting Drug Abuse
Printed on December 11, 2012 4:13 pm CST
?2012 Mayo Foundation for Medical Education and Research (MFMER). All rights reserved.
MAYO, MAYO CLINIC, MAYO MEDICAL LABORATORIES and the triple-shield Mayo logo are trademarks and/or service marks of
MFMER.
Table of Contents
3
Limits of Detection (LOD) Table -
4
Approximate Detection Times Table -
9
Alcohol
12
Amphetamine-Type Stimulants (ATS)
14
Barbiturates
15
Benzodiazepines
16
Buprenorphine
18
Cocaine and Metabolite
19
Fentanyl
20
Ketamine
21
Lysergic Acid Diethylamide (LSD)
22
Marijuana delta9-Tetrahydrocannabinol (THC)
23
Methadone
24
Methaqualone
25
Opiates
26
Phencyclidine (PCP)
28
Propoxyphene
29
Masking Agents/Adulterants
30
Printed on December 11, 2012 4:13 pm CST
Page 3
Limits of Detection (LOD) Table Prescription and OTC Drugs
Last Updated January 2011
The limits of detections (LODs) listed below reflect the concentrations at which the specific drugs can be reliably
detected. If the drug is detected at a level below the listed LOD, it will be reported only if it meets laboratory
quality criteria for identification.
Drugs other than those listed below may be detected by GC-MS library matching and will be reported if they meet
laboratory quality criteria for identification.
Note: Submission of less than the minimum sample volume requires increasing the limit of detection.
Generic Name
Acetaminophen
LOD
(mcg/mL)
Notes
Urine
Serum
10.0
Amitriptyline
1.0
Amobarbital
1.0 Preferred test for detection of
barbiturates is a specific request; see
Specific Drug Group Confirmation
Bupropion
1.0
Butabarbital
1.0 Preferred test for detection of
barbiturates is a specific request; see
Specific Drug Group Confirmation
Butalbital
10.0 Preferred test for detection of
barbiturates is a specific request; see
Specific Drug Group Confirmation
Caffeine
15.0
Variability in
the LOD
Carbamazepine
2.0
Carisoprodol
5.0
Chlordiazepoxide
5.0 Preferred test for detection of
Variability in
benzodiazepines is a specific request; the LOD
see Specific Drug Group Confirmation
Chlorpheniramine
1.0
Chlorpromazine
5.0
Chlorpropamide
5.0
Citalopram
1.0 Unable to differentiate between Rand S-citalopram, reported as
citalopram.
Printed on December 11, 2012 4:13 pm CST
Variability in
the LOD
Page 4
Generic Name
LOD
(mcg/mL)
Notes
Urine
Clomipramine
1.0
Clozapine
1.0
Cyclobenzaprine
1.0
Desipramine
5.0
Dextromethorphan
5.0
Diazepam
0.5 Preferred test for detection of
benzodiazepines is a specific request;
see Specific Drug Group Confirmation
Diltiazem
1.0
Diphenhydramine
0.5
Doxepin
1.0
Doxylamine
5.0
EDDP (methadone
metabolite)
2.5 Preferred test for detection of
methadone and metabolite is a
specific request; see Specific Drug
Group Confirmation
Ethosuximide
5.0
Etomidate
1.0
Felbamate
5.0
Fentanyl
1.0 Preferred test for detection of fentanyl
is a specific request; see Specific Drug
Group Confirmation
Fluconazole
5.0
Fluoxetine
4.0
Gemfibrozil
5.0
Hydrocodone
5.0 Preferred test for detection of opiates
Variability in
is a specific request; see Specific Drug the LOD
Group Confirmation
Hydroxyzine
5.0
Variability in
the LOD
25.0
Variability in
the LOD
Imipramine
0.5
Variability in
the LOD
Lamotrigine
25.0
Variability in
the LOD
Ibuprofen
Printed on December 11, 2012 4:13 pm CST
Serum
Variability in
the LOD
Variability in
the LOD
Variability in
the LOD
Variability in
the LOD
Only detected
in urine
Page 5
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