Drug Testing
Drug Testing
An Overview of Mayo Clinic Tests Designed for Detecting Drug Abuse
Printed on December 11, 2012 4:13 pm CST
?2012 Mayo Foundation for Medical Education and Research (MFMER). All rights reserved. MAYO, MAYO CLINIC, MAYO MEDICAL LABORATORIES and the triple-shield Mayo logo are trademarks and/or service marks of MFMER.
Table of Contents
3
Limits of Detection (LOD) Table -
4
Approximate Detection Times Table -
9
Alcohol
12
Amphetamine-Type Stimulants (ATS)
14
Barbiturates
15
Benzodiazepines
16
Buprenorphine
18
Cocaine and Metabolite
19
Fentanyl
20
Ketamine
21
Lysergic Acid Diethylamide (LSD)
22
Marijuana delta9-Tetrahydrocannabinol (THC)
23
Methadone
24
Methaqualone
25
Opiates
26
Phencyclidine (PCP)
28
Propoxyphene
29
Masking Agents/Adulterants
30
Printed on December 11, 2012 4:13 pm CST
Page 3
Limits of Detection (LOD) Table -
Prescription and OTC Drugs
Last Updated January 2011
The limits of detections (LODs) listed below reflect the concentrations at which the specific drugs can be reliably detected. If the drug is detected at a level below the listed LOD, it will be reported only if it meets laboratory quality criteria for identification.
Drugs other than those listed below may be detected by GC-MS library matching and will be reported if they meet laboratory quality criteria for identification.
Note: Submission of less than the minimum sample volume requires increasing the limit of detection.
Generic Name Acetaminophen Amitriptyline Amobarbital
Bupropion Butabarbital
Butalbital
Caffeine Carbamazepine Carisoprodol Chlordiazepoxide
Chlorpheniramine Chlorpromazine Chlorpropamide Citalopram
LOD (mcg/mL)
Notes
Urine
10.0
1.0
Variability in
the LOD
1.0 Preferred test for detection of barbiturates is a specific request; see Specific Drug Group Confirmation
1.0
1.0 Preferred test for detection of barbiturates is a specific request; see Specific Drug Group Confirmation
10.0 Preferred test for detection of barbiturates is a specific request; see Specific Drug Group Confirmation
15.0
2.0
5.0
5.0 Preferred test for detection of
Variability in
benzodiazepines is a specific request; the LOD
see Specific Drug Group Confirmation
1.0
5.0
5.0
1.0 Unable to differentiate between Rand S-citalopram, reported as citalopram.
Variability in the LOD
Serum
Printed on December 11, 2012 4:13 pm CST
Page 4
Generic Name
Clomipramine
Clozapine Cyclobenzaprine Desipramine
Dextromethorphan Diazepam
Diltiazem Diphenhydramine Doxepin
Doxylamine EDDP (methadone metabolite)
Ethosuximide Etomidate Felbamate Fentanyl
Fluconazole Fluoxetine Gemfibrozil Hydrocodone
Hydroxyzine
Ibuprofen
Imipramine
Lamotrigine
LOD (mcg/mL)
Notes
Urine
Serum
1.0
Variability in
the LOD
1.0
1.0
5.0
Variability in Variability in
the LOD
the LOD
5.0
0.5 Preferred test for detection of benzodiazepines is a specific request; see Specific Drug Group Confirmation
1.0
0.5
1.0
Variability in
the LOD
5.0
2.5 Preferred test for detection of methadone and metabolite is a specific request; see Specific Drug Group Confirmation
Only detected in urine
5.0
1.0
5.0
1.0 Preferred test for detection of fentanyl is a specific request; see Specific Drug Group Confirmation
5.0
4.0
5.0
5.0 Preferred test for detection of opiates Variability in is a specific request; see Specific Drug the LOD Group Confirmation
5.0
Variability in
the LOD
25.0
Variability in
the LOD
0.5
Variability in
the LOD
25.0
Variability in
the LOD
Printed on December 11, 2012 4:13 pm CST
Page 5
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