Regulation of Extracellular Volume and Blood Pressure
Regulation of Extracellular Volume
and Blood Pressure
Vra Cert?kov? Ch?bov? Department of Nephrology, 1st Medical Faculty, Charles University
BP = heart output x resistance Blood pressure
Water balance Input/output
Input/output Salt balance
Osmolality Osmolality = total osmoles/volume
Extracellular fluid volume regulation
OVLT ? organum vasculosum laminae terminalis SFO ? subfornical organ PVN ? periventricular nucleus SON ? supraoptic nucleus
Osmolality regulation
setpoint
Short term baroreceptor reflex
Long term water /salt output
Intermediate term RAS
BP regulation
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