INFORMATION ONLY TO BE USED BY TEAM PREVENT

Appendix 8

INFORMATION ONLY TO BE USED BY TEAM PREVENT

Post Exposure Prophylaxis ? Staff Information

Your doctor has decided that you may be at risk of HIV Infection following exposure to body fluids that may contain HIV. Current opinion suggests that taking anti-HIV medicines can help prevent HIV infection. We call this Post Exposure Prophylaxis or PEP.

Post Exposure Prophylaxis consists of a 4-week course of:

Truvada Tablets ONE tablet to be taken ONCE a day (A combination of Emtricitabine 200mg and Tenofovir Disoproxil 245mg)

and

Kaletra Tablets TWO tablets to be taken TWICE a day (A combination of Lopinavir 200mg and Ritonavir 50mg)

This leaflet gives you some basic information about the medicines you will be taking. You should also read the information leaflets supplied in the boxes of Truvada and Kaletra as these contain more detailed information about these medicines.

Side Effects

Most of the side effects of PEP are not life threatening and are discussed later in this leaflet but if you if you experience any of the following you must obtain medical advice immediately.

Sudden severe stomach cramps, with feeling and being sick. Sudden wheeziness, chest pain, tightness of the chest Swelling of the eyelids, face, or lips Skin Rash or `Hives' anywhere on your body

Truvada

What does it contain?

Truvada contains two drugs called Emtricitabine and Tenofovir Disoproxil. These drugs are part of a family of drugs called Nucleoside Reverse Transcriptase Inhibitors, and work by interfering with the way HIV infects the blood cells.

How do I take it?

You should swallow the tablet whole with a drink of water and something to eat. You should take the tablet ONCE a day at the same time each day.

Northumberland, Tyne and Wear NHS Foundation Trust

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Appendix 8 ? Post Exposure Prophylaxis ? Staff Information ? V 02 ? Issue 1 ? Nov13

Part of NTW(C)46 ? Inoculation Policy

What side effects might I experience?

Truvada is generally well tolerated, however side effects can occur. If they do you should discuss them with your doctor or nurse.

Headaches (sometimes severe), feeling and being sick, diarrhoea, tiredness, numbness, changes in your dreams, tingling sensations or sensation of weakness in your arms and legs.

Interactions with other medicines

It is important that you have told your doctor of any other medication you are currently taking (including over the counter and herbal medicines). These may affect the action of Truvada or Truvada may change the action of these in a negative way.

Truvada should not be given with Lamivudine or Zalcitabine.

Because Truvada can affect your kidneys it is important that the doctor knows if you are taking any medicines that may damage your kidneys. These are listed in the Patient Information Leaflet supplied in the box of Truvada.

Kaletra

What does it contain?

Kaletra contains two drugs called Lopinavir and Ritonavir. These drugs are part of a family of drugs called Protease Inhibitors; these prevent HIV replicating. They are given together as Ritonavir even in small doses makes the Lopinavir work better.

How do I take it?

You should swallow the tablets whole with some water. You should not chew, break or crush them. You may take them with or without food. You should take the doses TWELVE hours apart.

What side effects might I experience?

The commonest side effects of Kaletra are diarrhoea, changes in the amount of cholesterol in your blood, feeling and being sick, changes in the amount of sugar in your blood, headaches, numbness, tingling sensations or sensation of weakness in your arms and legs.

Interactions with other medicines

It is very important that you tell your doctor of ANY medicines including Over the Counter Products and Herbal Medicines that you are taking. This is because lots of medicines either affect the action of Kaletra or Kaletra changes the action of them in a negative way. Also if a Doctor wants to start you on any new medication, you must tell them that you are taking Kaletra.

Northumberland, Tyne and Wear NHS Foundation Trust

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Appendix 8 ? Post Exposure Prophylaxis ? Staff Information ? V 02 ? Issue 1 ? Nov13

Part of NTW(C)46 ? Inoculation Policy

Medicines that have very important interactions include:

Amiodarone, Diazepam, Fluticasone Midazolam, Pimozide, Ergot Derivatives (for Migraine), Rifampicin, Simvastatin, St John's Wort, and Vardenafil

The following medicines are not available in the UK, but are available elsewhere in the world. They must not be taken with Kaletra: Astemizole, Bepridil, Cisapride, Estazolam, Lovastatin, Terfenadine, Triazolam

Kaletra also affects a number of other medicines; these are listed in the Patient Information Leaflet supplied in the box of Kaletra.

If you are using Oral or Patch Contraceptives, you should use another Non-Hormonal form of contraception such as Condoms.

If you are taking Anticonvulsants or Anticoagulants you should consult your Doctor, as it is very likely that you will require extra monitoring whilst taking Kaletra

Northumberland, Tyne and Wear NHS Foundation Trust

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Appendix 8 ? Post Exposure Prophylaxis ? Staff Information ? V 02 ? Issue 1 ? Nov13

Part of NTW(C)46 ? Inoculation Policy

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