Effectiveness of Homeopathy for Clinical Conditions: Evaluation of the ...

Effectiveness of Homeopathy for Clinical Conditions: Evaluation of the Evidence

Review of Literature from Public Submissions

Prepared for the National Health and Medical Research Council Homeopathy Working Committee by ARCH November 2014

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Table of Contents

List of Abbreviations ............................................................................................................................... 6 1 Introduction ......................................................................................................................................... 7 2 Review of literature from public submissions ..................................................................................... 9

2.1 Methodology................................................................................................................................. 9 2.1.1 Study eligibility ....................................................................................................................... 9 2.1.2 Critical appraisal and data extraction .................................................................................... 9

2.2 Results of the review of evidence from public submissions ....................................................... 11 2.2.1 Overview of the submitted literature .................................................................................. 11

Conditions already considered in the Overview Report ................................................................... 21 2.2.2 Rheumatoid arthritis ............................................................................................................ 21 2.2.3 Influenza-like illness ............................................................................................................. 22 2.2.4 Menopausal hot flashes/flushes .......................................................................................... 24 2.2.5 Rhinosinusitis ....................................................................................................................... 27 2.2.6 Oral dryness ......................................................................................................................... 28 2.2.7 Psychophysiological onset insomnia....................................................................................30 2.2.8 Stress....................................................................................................................................31 2.2.9 Dermatological reactions (radiotherapy).............................................................................33 2.2.10 Warts/molluscum contagiosum.........................................................................................34 2.2.11 Chronic low back pain ........................................................................................................ 34 2.2.12 Upper respiratory tract infection.......................................................................................37 2.2.13 Otitis media........................................................................................................................39 2.2.14 Ankle sprain........................................................................................................................ 41 2.2.15 Osteoarthritis ..................................................................................................................... 43

Conditions not considered in the Overview Report ......................................................................... 44 2.2.16 Coffee-related insomnia .................................................................................................... 45 2.2.17 Arsenic toxicity...................................................................................................................46 2.2.18 Anal fissures ....................................................................................................................... 48 2.2.19 Haemorrhoidal disease ...................................................................................................... 49 2.2.20 Pulmonary tuberculosis ..................................................................................................... 51 2.2.21 Plantar fasciitis ................................................................................................................... 52 2.2.22 Mental fatigue....................................................................................................................53

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2.2.23 Acute febrile infections ...................................................................................................... 54 2.2.24 Varicose veins .................................................................................................................... 55 2.2.25 Vertigo................................................................................................................................55 2.2.26 Chronic periodontitis ......................................................................................................... 59 2.2.27 Cat allergy .......................................................................................................................... 61 2.2.28 Diaper dermatitis ............................................................................................................... 62 2.2.29 Diabetic polyneuropathy ................................................................................................... 63 2.2.30 Post-tonsillectomy pain ..................................................................................................... 64 2.2.31 Essential hypertension ....................................................................................................... 66 2.2.32 End-stage renal failure ....................................................................................................... 67 2.2.33 Subcutaneous mechanical injury ....................................................................................... 68 2.2.34 Mucositis in stem cell therapy ........................................................................................... 69 2.2.35 Post-rhinoplasty ecchymosis and oedema ........................................................................ 70 2.2.36 Malnourishment ................................................................................................................ 72 3 References ......................................................................................................................................... 74 Appendix A List of excluded submitted literature ................................................................................ 75 Appendix B List of included studies ...................................................................................................... 88 Appendix C Data extraction and quality assessment forms ................................................................. 92

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List of Tables

Table 1 The Cochrane Collaboration's tool for assessing risk of bias (Higgins and Green 2011) ......... 10 Table 2 Summary of the application of the exclusion criteria to evidence from public submissions based on title/abstract only..................................................................................................................11 Table 3 Summary of the application of the exclusion criteria to evidence from public submissions based on full text review.......................................................................................................................12 Table 4 Summary of results from included studies (N=16) assessing conditions already considered in the Overview Report.............................................................................................................................14 Table 5 Summary of results from included studies (N=24) assessing conditions not considered in the Overview Report ................................................................................................................................... 16 Table 6 Evidence summary table of Brien et al. (2007) on the effectiveness of homeopathy for the treatment of rheumatoid arthritis ........................................................................................................ 21 Table 7 Evidence summary table of Chakraborty et al. (2013b) on the effectiveness of homeopathy for the treatment of influenza-like illness ............................................................................................ 23 Table 8 Evidence summary table of Colau et al. (2012) and Relton et al. (2010) on the effectiveness of homeopathy for the treatment of menopausal hot flashes/flushes................................................25 Table 9 Evidence summary table of Friese and Zabalotnyi (2007) on the effectiveness of homeopathy for the treatment of acute rhinosinusitis ............................................................................................. 27 Table 10 Evidence summary table of Haila et al. (2005) on the effectiveness of homeopathy for the treatment of oral dryness ..................................................................................................................... 29 Table 11 Evidence summary table of Harrison et al. (2013) on the effectiveness of homeopathy for the treatment of psychophysiological onset insomnia.........................................................................30 Table 12 Evidence summary table of Hellhammer et al. (2013) on the effectiveness of homeopathy for the treatment of stress ................................................................................................................... 31 Table 13 Evidence summary table of Kulkarni et al. (1988) on the effectiveness of homeopathy for the prevention of dermatological reactions to radiotherapy...............................................................33 Table 14 Evidence summary table of Manchanda et al. (1997) on the effectiveness of homeopathy for the treatment of warts and molluscum contagiosum .................................................................... 34 Table 15 Evidence summary table of Pach et al. (2011) on the effectiveness of homeopathy for the treatment of chronic low back pain......................................................................................................35 Table 16 Evidence summary table of Steinsbekk et al. (2005) and Zanasi et al. (2014) on the effectiveness of homeopathy for the treatment of upper respiratory tract infection.........................38 Table 17 Evidence summary table of Taylor and Jacobs (2011) on the effectiveness of homeopathy for the treatment of acute otitis media in children..............................................................................40 Table 18 Evidence summary table of Gonz?lez de Vega et al. (2013) on the effectiveness of homeopathy for the treatment pain and improving mobility after acute ankle sprain.......................42 Table 19 Evidence summary table of Maronna et al. (2000) on the effectiveness of homeopathy for the treatment of osteoarthritis............................................................................................................. 44 Table 20 Evidence summary table of Bell et al. (2011) on the effectiveness of homeopathy for the treatment of coffee-related insomnia .................................................................................................. 45 Table 21 Evidence summary table of Belon et al. (2007) and Khuda-Bukhsh et al. (2011) on the effectiveness of homeopathy for the treatment of arsenic toxicity.....................................................47

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Table 22 Evidence summary table of Bignamini et al. (1991) on the effectiveness of homeopathy for the treatment of anal fissures .............................................................................................................. 49 Table 23 Evidence summary table of Chakraborty et al. (2013a) on the effectiveness of homeopathy for the treatment of haemorrhoidal disease ........................................................................................ 50 Table 24 Evidence summary table of Chand et al. (2014) on the effectiveness of homeopathy for the treatment of multi-drug resistant pulmonary tuberculosis..................................................................51 Table 25 Evidence summary table of Clark and Percivall (2000) on the effectiveness of homeopathy for the treatment of plantar fasciitis .................................................................................................... 52 Table 26 Evidence summary table of Dean et al. (2012) on the effectiveness of homeopathy for the treatment of mental fatigue ................................................................................................................. 53 Table 27 Evidence summary table of Derasse et al. (2005) on the effectiveness of homeopathy for the treatment of acute febrile infections ............................................................................................. 54 Table 28 Evidence summary table of Ernst et al. (1990) on the effectiveness of homeopathy for the treatment of varicose veins .................................................................................................................. 55 Table 29 Evidence summary table of Issing et al. (2005), Weiser et al. (1998) and Wolschner et al. (2011) on the effectiveness of homeopathy for the treatment of vertigo...........................................57 Table 30 Evidence summary table of Mour?o et al. (2013) on the effectiveness of homeopathy for the treatment of chronic periodontitis.................................................................................................60 Table 31 Evidence summary table of Naidoo and Pellow (2013) on the effectiveness of homeopathy for the treatment of cat allergy ............................................................................................................ 61 Table 32 Evidence summary table of Pellow and Swanepoel (2013) on the effectiveness of homeopathy for the treatment of diaper dermatitis ........................................................................... 62 Table 33 Evidence summary table of Pomposelli et al. (2009) on the effectiveness of homeopathy for the treatment of diabetic polyneuropathy...........................................................................................64 Table 34 Evidence summary table of Robertson et al. (2007) on the effectiveness of homeopathy for the treatment of post-tonsillectomy pain ............................................................................................ 65 Table 35 Evidence summary table of Saha et al. (2013) on the effectiveness of homeopathy for the treatment of essential hypertension .................................................................................................... 66 Table 36 Evidence summary table of Saruggia and Corghi (1992) on the effectiveness of homeopathy for the treatment of end-stage renal failure ........................................................................................ 68 Table 37 Evidence summary table of Schmidt (1996) on the effectiveness of homeopathy for the treatment of subcutaneous mechanical injuries .................................................................................. 69 Table 38 Evidence summary table of Sencer et al. (2012) on the effectiveness of homeopathy for the treatment of mucositis in stem cell therapy.........................................................................................70 Table 39 Evidence summary table of Totonchi and Guyuron (2007) on the effectiveness of homeopathy for the treatment of post-rhinoplasty ecchymosis and oedema .................................... 71 Table 40 Evidence summary table of Villanueva et al. (2012) on the effectiveness of homeopathy for the treatment of malnourishment........................................................................................................72

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