Australian public assessment report for Canakinumab
The committee was also concerned that elevations in serum transaminases (alanine transaminase (ALT) and/or aspartate transaminase (AST)) occurred in approximately 41% of patients and that 1.5% of patients had elevated bilirubin levels. Most notably, ALT/AST values which were three times the upper limit of normal were reported in 2 (4.1% ... ................
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