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Primary biliary cirrhosis. Seen in women in their 50-60s, especially those with hypercholesterolemia. Bilirubin normal initially. AMA IgM highly suggestive of PBC. Definitive diagnosis by liver biopsy. Primary sclerosing cholangitis. Affects men in their 30-40s. History of inflammatory bowel disease (especially UC) suggestive. Diagnosis by ERCP ... ................
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