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Inc estrogen from palcenta; dec from ovaries – low estrogen levels assn with fetal death and anencephaly. Progesterone is produced by corpus luteum then the palcenta. HCG – doubles roughly every 48 hours; peaks at 10 – 12 weeks; the alpha subunit looks like LH, FSH and TSH but the beta subunit differs. Inc in thyroid binding globulins ................
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