Post Cardiac Arrest Induced Hypothermia Protocol



Purpose:

To improve mortality and neurological outcomes in patients who have survived cardiac arrest. The goal of therapy is to achieve and maintain therapeutic hypothermia for a 24 hour period with a target of 33°C.

Policy:

Therapeutic Hypothermia (TH) shall be initiated on all adult cardiac arrest patients with return of spontaneous circulation (ROSC) that fit the inclusion criteria, and does not have any of the following: eye opening to painful stimuli, pre-existing coma, traumatic arrest (either penetrating or blunt), body temperature less than 30˚C, or an apparent gravid uterus.

1. Therapeutic Hypothermia will be initiated, when possible, pre-hospital.

2. Upon arrival in Emergency Department or post cardiac arrest in DHLC, a “Code Chill” will be called through the hospital beeper system. Team will consist of ED Attending or Floor Attending, Intensivist, ICU Attending, ICU Fellow, ICU Code Nurse and nursing supervisor. DHLC nursing will attend in an advisory capacity to facilitate transfer into DHLC system

3. After patient is identified as a candidate, TH will begin immediately in the form of ice packs to axilla, groin and neck.

4. Protocol will follow procedure outline once patient stabilization and therapies (anti-arrhythmics, vasopressors/fluids with target SBP 90-100 mm Hg, and advanced airway management with O2 sat >85%) are implemented.

5. Patient will be moved to the Critical Care Unit or the Cath Lab (for intervention) as soon as possible after stabilization with cooling measures in place.

6. Discontinue cooling and begin active rewarming in the presence of any cardiovascular instability ( i.e. persistent uncontrollable arrhythmias or refractory hypotension), or if patient awakens.

Inclusion Criteria:

• Nontraumatic cardiac arrest with Return of Spontaneous Circulation (ROSC)

• Cardiopulmonary Resuscitation (CPR) initiated within 10 minutes of cardiac arrest

• ROSC within 30 minutes of recognition of the cardiac arrest; MAP ≥ 60 for at least 30 minutes post ROSC with or without vasoactive medication

• Initiation of Induced Hypothermia begun within 6 hours of collapse

• Initial body temperature must be greater than 30°C

• No purposeful movement to command and Glasgow Coma Scale < 6

● Age > 18; Female < 50 must have negative urine HCG

Exclusion Criteria:

• Prolonged arrest time longer than 60 minutes or down time without BLS longer than 10 minutes

• Age less than 18 years

• Pregnancy

• Uncontrolled bleeding, thrombocytopenia or other coagulopathy

• DNR or DNI status

• Severely impaired pre-arrest cognitive status

• Other causes of coma (mass lesions, metabolic coma, seizures, drug overdose, head trauma, cerebrovascular accident, etc.)

• Existing multi-organ dysfunction syndrome; severe sepsis or co-morbidities with minimal chance of meaningful survival independent of neurological status; known terminal illness.

• Refractory arrhythmias

• Hypoxemia with Saturation 34.5( C, infuse an additional 500 ml over 30 minutes

← Repeat 500 ml infusions until core temperature ( 34.5( C to a maximum of 30 ml/kg total

Cardiac Shock/LV failure/low EF is present:

← Infuse 1500 ml 4( C 0.9NS over 60 minutes

← If core temperature remains > 34.5( C, infuse an additional 500 ml over 30 minutes

← Repeat 500 ml infusions until core temperature ( 34.5( C to a maximum of 30 ml/kg total

4. If unable to obtain target core temperature within 5 hours, contact provider

5. Completely expose patient and place cooling blankets above and below patient with a sheet between patient and cooling blanket

6. Attach both blankets to the cooling machine.

7. Set cooling machine to autocontrol and goal temperature to 33(C

8. Once patient reaches 34(C, allow patient to drift down to goal temperature of 33(C

9. Be alert for early signs of shivering and initiate shivering protocol

Maintenance with Cooling Blanket Machine

1. Acetaminophen 650 mg OGT/NGT/PR Q 6 hours during induction and maintanence; Q 4 hr. PRN during re-warming phase and for a temperature > 37(C after warming. Clamp NG/OG tube for 30 minutes after administration.

2. Maintain patient temperature at 33( C for 24 hours from initiation of cooling.

3. If patient is in pain or agitated, medicate with as ordered; otherwise sedation should be limited to facilitate frequent neurologic exam checks.

4. If shivering develops see shivering orders

5. If hypotension develops (MAP ( 80 mmHg) see BP & Volume Management orders

6. If hypokalemia develops see electrolyte replacement orders

7. If dysrhythmia or bleeding develops see rewarming phase below

8. Maintenance of therapeutic hypothermia should be provided with cooling blankets and if temperature > 33.5( C, infuse an additional intravenous 4(C 0.9NS bolus of 250 ml Q 10 minutes until temperature < 33.5(C.

9. Replace urine output every hour with 0.9NSS in a ratio of 1:1 or 0.5:1

BP & Volume Management

For patients on the therapeutic hypothermia protocol who develop hypotension (MAP ( 80 mmHg) the following steps should be attempted:

• Assess for medical causes of hypotension

• Adjust/titrate down any analgesic/sedative/shivering medications. If shivering, consider neuromuscular blockade

• Observe closely for fluid overload

• Initiate Vasopressors if MAP continues ( 80 after fluid resuscitation

Hypertension: For patients on the therapeutic hypothermia protocol who develop hypertension (MAP > 100 mmHg), consult orders for initiation of NITROglycerin IV.

Electrolyte Replacement

• Have provider evaluate electrolyte replacements if serum creatinine is > 2 mg/dl

• Check STAT potassium and magnesium for any cardiac dysrhythmia and every 4 hours

• After any replacement, check electrolyte level 1 hr after completion of replacement.

• During cooling phase: replace K+ < 3.5

replace Mg++ < 2.0

replace ionized Ca++ < 1.0 or serum Ca++ < 7.5

• Discontinue K replacements 8 hours prior to rewarming

• Discontinue Mg and Ca replacements once warming has begun

Analgesia/Sedation and Shivering

• Use Numeric, Faces or FLACC scale for pain assessments with a goal of less than 3 or minimal pain behaviors. Refer to orders for analgesia orders.

• Propofol or Dexmedetomidine will be utilized to maintain a RASS (Richmond Agitation –Sedation Scale) score of -3.

• Buspirone, Acetaminophen, Midazolam, and/or Neuromuscular Blocking Agents (NMBA) will be administered on an as needed basis to prevent shivering and maintain the BSAS (Bedside Shivering Assessment Scale) a score of 0.

DVT Prophylaxis

• Utilize antiembolic hose and sequential compression devices

• Administer Enoxaparin unless patient on heparin.

PUD Prophylaxis

• Administer Famotidine as ordered

Blood Product Transfusion

Blood Warmer is required when cold agglutinins are present (see comments on the transfusion tag).

Rewarming

The rewarming process should be gradual and take place ideally over 12 or more hours. For patients with severe bleeding despite measures recommended in the BP & Volume Management section, a rapid “active rewarming” process should take place over 8 hours.

← Standard Rewarming Protocol – Cooling Blanket

1. Monitor for hyperthermia, hypotension and hyperkalemia

2. May discontinue paralytics when temperature is 36( C

3. Consult Neurology services once normothermia (37( C) has been achieved

4. Once a temperature of 37( C is reached, leave a cooling blanket on top of the patient with machine set to 37( C for the remainder of the 48hr period of therapy to avoid rebound hyperthermia

5. Target is 37( C over approximately 12 hours at a rewarming rate of 0.33( C/hour

6. Manually increase temperature setting on the cooling machine by 1.0( C every 3 hours.

If the patient develops severe bleeding, the patient should be actively rewarmed according to the following protocol:

← Active Rewarming Protocol – Cooling Blanket

1. Target temperature is 37( C over approximately 8 hours at 0.5( C/hour

2. Manually increase temperature setting on cooling machine by 0.5( C every hour

3. Discontinue paralytics when temperature is 36( C if appropriate.

Nursing Interventions

• Review Appendix A: Physiologic Effects of Hypothermia

• Accurate weight should be obtained as soon as patient arrives in ICU.

• Infusion therapies, vasopressors and vasodilators may effect heat transfer, increase potential for skin injury and contribute to adverse hemodynamic response

• The cooling system requires a dedicated rectal temperature probe; correlate with a secondary temperature probe (foley or CVC) and monitoring of the water temperature setting on cooling device.

• The heater on the ventilator should be turned off and room temperature should be lowered to facilitate cooling.

● Assess rectal, foley and water temperature setting every 15 minutes during induction of hypothermia and rewarming, and every 30 minutes during maintenance.

● All hemodynamic values and signs are recorded hourly

• Arterial line or NIBP is required for BP monitoring

• Place the patient on continuous cardiac monitor

• Lab work: (CBC, Chemistry Panel, Amylase, Lipase, Lactate, Cardiac Enzymes (CK, CK-MB, Troponin I) Coagulation profile (PT/INR/PTT), ABG with ionized Ca++. Reassess at 12 and 24 hrs. Potassium and magnesium levels will be monitored every 4 hours. Consider blood cultures with rewarming. Assess glucose every 4 hours and obtain order for the IV Insulin Infusion Protocol for BS > 150. (Sub-cu insulin should not be given.)

• Assess baseline LOC and neurological status (Glasgow Coma Scale and TOF, document on Sedation Flowsheet)

• Assess ventilatory function, because of vasoconstriction, pulse oximetry can be unreliable; use forehead when possible.

• Assess Continuous ETCO2 monitor to maintain ETCO at 35-45.

• Observe VAP bundle (HOB elevated > 30 degrees, oral care, peptic ulcer disease prophylaxis, DVT prophylaxis) with exception of sedation weaning and assessment of readiness to wean until after neurological evaluation when rewarmed

• Assess GI function, abdomen, bowel sounds

• Assess skin integrity. External cooling devices can cause or exacerbate skin injury in patients without intact skin. Skin check areas covered by cooling blankets every hour.

• Assess for signs of shivering: palpate masseter, deltoids and pectoralis muscles for vibration. Observe skeletal muscle movement that may be first detected as ECG artifact.

• Hands, head, and feet should be covered with socks or blankets to help reduce shivering.

• No bathing of patients during therapeutic hypothermia protocol

• Apply antiembolism hose (knee) and sequential compression devices

• Utilize Sport Bed with rotational therapy

• Assess urine output and utilize replacement fluids as ordered

• Utilize hands free defibrillator pads for arrhythmia management

• Do not pull any lines until patient warming is completed.

• No subcutaneous injections (except Lovenox) should be given until patient is rewarmed.

• Report the following to provider:

1. Loss of oxygen saturation signal

2. Inability to reach or maintain target temperature

3. Inability to control shivering

4. Deterioration in coma scale level

5. Loss of bowel sounds

6. ECG changes

7. Cardiac arrhythmias

8. HR < 50 or > 120

9. Urine output < 0.5 ml/kg/hr

Related Policies/Documents:

Pharmacy: Guidelines for Medication Administration via Feeding Tubes

ACM 23: Pain Management

PCS A-7: Application of Antiembolism Stockings

PCS C-5: Use of Pneumatic Compression Sleeve

PCS B-7.1: Blood and Blood Product Transfusion

Neurovascular Flowsheet (Glasgow Coma Scale)

RASS (Richmond Agitation-Sedation Scale)

BSAS (Bedside Shivering Assessment Scale)

IV Insulin Protocol

VAP Bundle

Physiologic Affects of Hypothermia (Appendix A)

Blanketrol II Instructions

Appendix A. Physiologic Effects of Hypothermia

(Adapted from Burns, S. (2001). Revisiting Hypothermia: A Critical Concept. Critical Care Nurse, 21 (2) 83-86)

Cardiovascular

• Ventricular arrhythmias (hypothermic patients are more susceptible to atrial and ventricular fibrillation).

• Myocardial depression, bradycardia, angina

• Increased SVR, decreased CO, decreased contractility (hypothermia has a negative chronotropic effect on pacemaker tissue, which may lead to bradycardia or AV block).

• Increased PR, QRS, QT intervals

• Hypothermia may cause repolarization abnormalities, producing ST segment elevation and T-wave inversion.

Respiratory

• Decreased RR (hypoventilation, suppression of cough, and mucociliary reflexes associated with hypothermia may lead to hypoxemia, atelectasis and pneumonia.)

• Shift in oxyhemoglobin dissociation curve to the left (less oxygen is released from oxyhemoglobin to the tissues)

• Decreased cough & increased secretions

Metabolic

• Decreased basal metabolic rate (hypothermia inhibits insulin release from pancreas, but glucose levels remain normal in mild HT because shivering increases glucose utilization. Shivering increases metabolic rate, CO2 production, O2 consumption and myocardial work).

• Decreased drug biotransformation

• Decreased tissue perfusion

Gastrointestinal

• Decreased motility, liver function, insulin release

• Ileus

• Stress ulceration

Renal

• Decreased renal plasma flow, Decreased urine output

• Increased specific gravity

• Decreased ADH

Hematologic

• Increased blood viscosity (hemoconcentration)

• Platelet dysfunction

Neurologic

• Confusion

• Coma

• Decreased LOC, decreased reflexes, decreased muscular tone

Appendix B. Hypothermia Protocol Flow Sheet

Yes No

-----------------------

• Insert Arterial Line

• Insert CVC

• STEMI: consider TNK / Heparin / PCI / ASA.

STOP

EXCLUSION CRITERIA

• Prolonged arrest time longer than 60 minutes or down time without BLS longer than 10 minutes

• tÌl ª ¬ ´ ¶ Ä Æ ö †®ÍÎëÙɹɹ©™©‡r`P@P0P0h |J+@ˆþÿB*[pic]OJQJ^JphhqdS@ˆþÿB*[pic]OJQJ^Jphhõ34.5( C and no cardiac shock present: infuse 1500 ml of 4(C 0.9 NSS over 30 min and repeat 500 ml infusions until core temp < 34.5(C or max of 30 ml/kg

• If Temp > 34.5(C and cardiac shock /LV failure/low EF present: infuse 1500 ml of 4(C 0.9 NSS over 60 min and repeat 500 ml infusions until core temp < 34.5(C or max of 30 ml/kg

• Initiate cooling with cooling blanket with target temperature 33( C x 24 hr

• Rewarming: After 24 hr. increase temperature 0.33( C every hour

• May discontinue NMBA and then wean sedation when patient temp reaches 36(C

• Maintain patient at 37( C for the remaining 24 hours of therapy

•

Order:

• Acetaminophen 650 OGT/NGT/PR Q 6 h x 24 h, then Q4 h prn temp > 37( C

• Buspirone 30 mg OGT/NGT Q 8 h x 24 h

• PVD prophylaxis

• PUD prophylaxis

• Analgesia

• Sedation assessment and interventions

• Shivering assessment and interventions

• Electrolyte replacements

• BP and volume management

• Lab work

Active Rewarming: Discontinue protocol and actively rewarm at 0.5( C per hour if patient develops hemodynamically unstable arrhythmias; sustained MAP < 60 x 15 min. after resuscitation, severe bleeding, or awakens.

................
................

In order to avoid copyright disputes, this page is only a partial summary.

Google Online Preview   Download