Mitochondrial dysfunction-related genes in hepatocellular ...

The LASS2 gene may increase intracellular H(+) of HCC cells via interaction with V-ATPase, thereby inducing cell apoptosis through the mitochondrial pathway. Transforming growth factor-beta (TGF-beta) is a potent inhibitor of hepatocyte growth (26), and is known to induce apoptosis in both hepatocytes and HCC cell lines (27,28). ................
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