Gastroesophageal Reflux Disease: Identification and Evaluation
6/11/2021
Gastroesophageal Reflux Disease: Identification and Evaluation
Kelly R. Haisley, MD
Assistant Professor Center for Minimally Invasive Surgery The Ohio State University Wexner Medical Center
Gastroesophageal Reflux Disease
Healthy
GERD
1
Gastroesophageal Reflux Disease
6/11/2021
FAILURE OF THE LES
Healthy
GERD
A Vicious Spiral...
Dynamic Failure of the LES Esophageal exposure to excessive gastric juices Mucosal injury (by acid and bile) Inflammatory deterioration of LES components
Permanent failure of the LES = GERD
2
6/11/2021
Why is GERD a problem?
Symptoms of GERD greatly affect quality of
life!
Talley N, Gastroenterolo 2001
3
6/11/2021
Why is GERD a problem?
H+ direct ion Injury occurs at pH ................
................
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