Gastroesophageal Reflux Disease: Identification and Evaluation

6/11/2021

Gastroesophageal Reflux Disease: Identification and Evaluation

Kelly R. Haisley, MD

Assistant Professor Center for Minimally Invasive Surgery The Ohio State University Wexner Medical Center

Gastroesophageal Reflux Disease

Healthy

GERD

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Gastroesophageal Reflux Disease

6/11/2021

FAILURE OF THE LES

Healthy

GERD

A Vicious Spiral...

Dynamic Failure of the LES Esophageal exposure to excessive gastric juices Mucosal injury (by acid and bile) Inflammatory deterioration of LES components

Permanent failure of the LES = GERD

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Why is GERD a problem?

Symptoms of GERD greatly affect quality of

life!

Talley N, Gastroenterolo 2001

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Why is GERD a problem?

H+ direct ion Injury occurs at pH ................
................

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