LECTURE 1 INTRO TO GENETICS - University of Alberta
LECTURE 1 ? INTRO TO GENETICS
- 20% genetic disease ? classic Medical genetics, single gene, early onset (pediatric) - 80% genetic susceptibility ? common gene variation and environment, delayed onset (adult) Pedigree
- Children, siblings, parents - Nuclear family ? age/date birth, health status, age/date death, cause of death - Proband ? individual who brings pedigree to your attention, does not necessarily have to be affected General Info - DNA RNA Protein Function - Changes in environment:
Both have common DNA variants o Change in gene transcription profile o Change in protein profile - SNP ? single nucleotide polymorphism (single nucleotide difference) - Human genome ? 3,000 Mbp o 25,000 ? 30,000 genes o Exons contain ................
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