International Journal of Health Sciences and Research
International Journal of Health Sciences and Research
ISSN: 2249-9571
Original Research Article
Efficacy of the Aquilaria Malaccensis Leaves Active Fraction in Glucose Uptake in Skeletal Muscle on Diabetic Wistar Rats
Fauzia Said1, M. T. Kamaluddin2, Theodorus2
1Fellowship in Biomedical Science of Medicine Sriwijaya University, Palembang, Indonesia 2Department of Pharmacology Faculty of Medicine Sriwijaya University, Palembang, Indonesia
Corresponding Author: Fauzia Said
Received: 29/05/2016
Revised: 15/06/2016
Accepted: 17/06/2016
ABSTRACT
This study was to know the efficacy of active fraction Aquilaria malaccensis leaves (fraction of ethanol water/AFEA and fractions of ethyl acetate/AFEC) in glucose uptake by measuring the levels of glucose transporter 4 (GLUT4) in muscle tissue on Wistar male rats diabetic model. Experimental research design of pre and post-test with control group. AFEA and AFEC was administered to High
Fat Diet (5 mL orally)/Dexamethasone (250 g/kg body weight intraperitoneally)-induced diabetic male Wistar rats at different doses (0.01, 0.1 and 1 g/kg b.w. /day) for 14 days. GLUT4 level in skeletal muscle tissue was significantly enhanced (p ................
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