2009 BCH/BIO/MI/PLS/PPA 601



2016 BCH/BIO/MI/PLS/PPA 601, Special Topics in Molecular and Cellular Genetics

Faculty Coordinators:

Brian Rymond, Dept. of Biology, 335 T.H. Morgan Biology Bldg., 257-5530, rymond@uky.edu

Seth DeBolt, Dept. of Horticulture, N324 Ag. Sci. Center North, 257-8654, sdebo2@email.uky

The syllabus and required reading assignments will be distributed by email and also posted at:

Description: For over 25 years, distinguished scientists from around the world have visited the UK campus each Spring semester to deliver lectures and participate in informal discussions with graduate students enrolled in the Special Topics in Molecular and Cellular Genetics course. Emphasis is placed on the selection of established investigators of international stature who present exciting new research in the areas of molecular and cellular genetics. This one-credit course may be repeated for a maximum of six credits. This course is cross-listed as BCH/BIO/MI/PLS/PPA 601.

Class meeting times: This seminar program for graduate students and advanced undergraduate students meets at irregular times episodically over the semester. The course will host 4 guest speakers in 2016. Each speaker will provide an introductory lecture to the enrolled students plus deliver a scientific seminar open to the entire UK Scientific Community. The lectures are scheduled for 8:00 AM on Monday mornings and the seminars presented on Monday afternoons at 4:00 PM. In addition, the 601 students will meet with each speaker for an informal lunch on the Monday of the visit (typically 12:30-1:30 PM) and also participate in a 30 minute question and answer period immediately following each seminar. In order for us to derive the greatest value from each visit, the 601 class will assemble the Friday before a scheduled visit for a pre-meeting of student-lead presentations and discussion based on selected scientific publications suggested by the visitor. The relevant research papers will be posted on the class web site at least two weeks before each pre-meeting. The course coordinators will advise the student teams in preparing materials prior to these presentations. To promote student participation, every enrolled student will provide each student presenter with one question concerning his/her paper by noon on the Wednesday preceding the pre-meeting session.

Requirements and grading: The enrolled students are expected to attend the scheduled pre-meetings, lectures, and seminars (including the post-seminar question and answer period). In addition, it is anticipated that each student will attend for at least 30 minutes two of the student/speaker lunchtime meetings – you are welcome to attend all four. Attendance will be taken at each event. Students are expected to be prepare and participate (that is, ask questions) in each event. Information about the speakers visits will be posted on the class website during the semester, consequently, each student should check the class site at least once each week. Grades will be assigned based on the level of student participation. Unexcused absence from two scheduled events will decrease your final grade by one letter, three absences by two letter grades. More than three unexcused absences will result in a grade of E.

Special Topics in Molecular and Cellular Genetics Schedule

Orientation meeting: January 15, 2016, 4:00 PM in room 109 of the TH Morgan Biology Building.

SPEAKER LIST & READING ASSIGNMENTS

IMPORTANT NOTE: Course updates will be sent by email to the enrolled students and posted on the class web site ( ).

Derik Lovely, Ph.D., Distinguished University Professor, Microbiology Department, University of Massachusetts, Amherst,

Topic: Genome scale studies related to the complex physiology and ecology of novel anaerobic microorganisms

Pre-meeting: February 19, 2016 (Friday – first of 601 event), 4:00-5:30 PM, Cameron Williams Lecture Hall (Plant Sciences Building)

Student Lecture: February 22, 2016 (Monday), 8:00-8:50 AM, Cameron Williams Lecture Hall (Plant Sciences Building)

Student Lunch: February 22, 2016 (Monday), 12:30-1:30 PM, Room 460 Plant Sciences Building

Seminar: February 22 (Monday) 4:00 PM, Cameron Williams Lecture Hall (Plant Sciences Building)

Title: TBA

Host: Seth DeBolt, sdebo2@email.uky

Reading list for Dr. Lovely:

Raymond Trievel, Ph.D., Associate Professor, Biological Chemistry, University of Michigan



Topic: Structures, mechanisms, and substrate specificities of chromatin modifying enzymes

Pre-meeting: March 11, 2016 (Friday), 4:00-5:30 PM, Cameron Williams Lecture Hall (Plant Sciences Building)

Student Lecture: March 21, 2016 (Monday), 8:00-8:50 AM, Cameron Williams Lecture Hall (Plant Sciences Building)

Student Lunch: March 21, 2016 (Monday), 12:30-1:30 PM, Room 460 Plant Sciences Building

Seminar: March 21 (Monday) 4:00 PM, Cameron Williams Lecture Hall (Plant Sciences Building)

Title: TBA

Host: Seth DeBolt, sdebo2@email.uky

Reading list for Dr. Trievel: TBA

Marisa Bartolomei, Ph.D., Professor, Cell and Developmental Biology, Co-director of the Epigenetics Program, University of Pennsylvania,



Topic: Epigenetics and genetic imprinting in mammals

Pre-meeting: April 1, 2016 (Friday), 4:00-5:30 PM 109 TH Morgan Building

Student Lecture: April 4, 2016 (Monday8:00-8:50 AM, 109 TH Morgan Building

Student Lunch: April 4, 2016 (Monday), 12:30-1:30 PM, 305 TH Morgan Building

Seminar: April 4, 2016 (Monday) 4:00 PM, 116 TH Morgan Building

Title: Why Parents Matter (Epigenetically): Genomic Imprinting in Health and Disease

Host: Brian Rymond, rymond@uky.edu

Reading list for Dr. Bartolomei:

Antagonism between DNA hypermethylation and enhancer-blocking activity at the H19 DMD is uncovered by CpG mutations. Engel N, West AG, Felsenfeld G, Bartolomei MS.

Nat Genet. 2004 Aug;36(8):883-888.

The cumulative effect of assisted reproduction procedures on placental development and epigenetic perturbations in a mouse model. de Waal E, Vrooman LA, Fischer E, Ord T, Mainigi MA, Coutifaris C, Schultz RM, Bartolomei MS. Hum Mol Genet. 2015 Dec 15;24(24):6975-6985.

Genomic imprinting in development, growth, behavior and stem cells. Plasschaert RN, Bartolomei MS. Development. 2014 May;141(9):1805-1813. Review

Ronald Breaker, Ph.D., Henry Ford II Professor of Molecular, Cellular, and Developmental Biology and Professor of Molecular Biophysics and Biochemistry, HHMI Investigator, Member of the National Academy of Sciences, Yale University

Topic: Expanding biological roles for non-coding RNA

Pre-meeting: April 22, 2016 (Friday), 4:00-5:30 PM 109 TH Morgan Building

Student Lecture: April 25, 2016 (Monday8:00-8:50 AM, 109 TH Morgan Building

Student Lunch: April 25, 2016 (Monday), 12:30-1:30 PM, 305 TH Morgan Building

Seminar: April 25, 2016 (Monday) 4:00 PM, 116 TH Morgan Building

Title: Prospects for Bacterial Noncoding RNA Discovery

Host: Brian Rymond, rymond@uky.edu

Reading list for Dr. Breaker:

Widespread genetic switches and toxicity resistance proteins for fluoride. Baker JL, Sudarsan N, Weinberg Z, Roth A, Stockbridge RB, Breaker RR. Science. 2012 Jan 13;335(6065):233-235.

New classes of self-cleaving ribozymes revealed by comparative genomics analysis.

Weinberg Z, Kim PB, Chen TH, Li S, Harris KA, Lünse CE, Breaker RR. Nat Chem Biol. 2015 Aug;11(8):606-610

An ancient riboswitch class in bacteria regulates purine biosynthesis and one-carbon metabolism. Kim PB, Nelson JW, Breaker RR. Mol Cell. 2015 Jan 22;57(2):317-328.

Prospects for riboswitch discovery and analysis. Breaker RR. Mol Cell. 2011 Sep 16;43(6):867-879. Review.

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