Scholarship and Research



Scholarship and Research

I. Research Support

Past Support from NIH (Foundation and Industrial Support Not Listed):

1. Identification and Quantitation of Cystic Fibrosis Factors. (Co-Investigator) RFP‑NHLBI‑HR‑77‑3, NIH. 1977 - 1981.

2. Human Milk Peptide, Metallo‑Peptides and Trace Metals (Co-PI). RO1 HD 12465, NIH. 1978 - 1981.

3. Nutritional Role of Manganese Binding Molecules in Milk (PI). RO1 HD 16730, NIH. 1983 -1986.

4. Genetic Studies of Pregnancy Specific b1 Glycoprotein (PI). RO1 HD 21793, NIH. 1986 -1993.

5. Project 1: Role of PSG Proteins in the Testis (PI). Program Project: Cell Biology of Testis. PO1HD24633, NIH, 1992 – 1996.

6. Molecular Genetics of Pregnancy Specific Glycoproteins (PI). IPA, NCHGRI, NIH. 1995.

7. The Promonocyte Receptor for PSG11s. (PI) RO1 HD31553, NIH. 1995 – 1998.

8. Experimental Emphysema: Studies on Remediation. (Co-Investigator) RO1 HL59432, NIH. 1997 - 1999.

9. Research Training in Developmental Immunology.T32 HD07185-11. NIH. 1994 - 1999.

10. Remediation of Emphysema: Mechanism, Characterization. (Co-Investigator) 1RO1 HL60115-01A, NIH, 1998 - 2002.

Current Support:

1. Establishment of a developmental genomics program in NICHD. IPA, NICHD, NIH. 100%, 01/01/2001 - 09/30/2005. $ 942,143.00, current year $ 228,652.50.

2. Section on Developmental Genomics, NICHD intramural support for the laboratory, 100%, 01/01/2001 - 09/30/2005. (Excluding personnel) $ 2,072,350, current year $ 575,170.

3. Fate of Spermatogonial Stem Cells. 2 R01-HD33728-05A1. 10% effort. (no monetary support requested) PI: Martin Dym, Ph.D. 12/01/2002 - 11/30/2007 $ 1,250,000 (Total Direct) ($250,000, 1st Year Direct) Goal: To understand the regulation of the initial steps of spermatogenesis.

II. Publications

Dissertation:

1. To Purify and Characterize Metallothionein from Human Tissues, and to Investigate Its Roles in Mammalian Copper Metabolism and in the Menkes Kinky Hair Disease. Ph.D. Dissertation, Department of Biochemistry and Molecular Biology, University of Florida, Gainesville, Florida, 1977.

Books and Monographs:

1. Rennert OM and Chan WY. (Editors) Metabolism of Trace Metals in Man: Volume 1. Developmental Aspects. CRC Press, Inc., Boca Raton, FL. 1984.

2. Rennert OM, and Chan WY. (Editors) Metabolism of Trace Metals in Man: Volume 2. Genetic Implications. CRC Press, Inc., Boca Raton, FL. 1984.

3. Garnica AD, Chan WY, and Rennert OM. Trace Elements in Development and Disease. Current Problems in Pediatrics. Volume XVI, Number 2. Year Book Medical Publishers, Inc., Chicago, IL. 1986.

4. Chris YF Lau, Chan WY. (Editors) Y chromosome, Germ Cell Development and Fertility. World Scientific Publishing Co. Pte. Ltd., Singapore, 2004 (In preparation).

Chapter in Book:

1. Chan WY, Leung KK. Body fluid glucose determination - An o-toluidine method. Journal of the Science Society of the Chinese University of Hong Kong. Vol 3, pp. 40-44, 1971.

2. Rennert OM, Garnica AD, Chan WY. Hyperornithinemia and hyperammonemia: a rare disorder of ammonia metabolism. In: The Liver-Quantitative Aspects of Structure and Function. Preisig R, Qaumgartner G. (eds.). Gstaad, Switzerland. pp.198-303, 1975.

3. Chan WY, Griesmann GE, Rennert OM. Polyamine derivatives in growing cells. In: Advances in Polyamine Research Caldarera CM, Zappia V, Bachrach U. (eds.). Vol. 3, Raven Press, New York, NY. pp. 213-223, 1981.

4. Rennert OM, Chan WY, Seale TW, Perlman M. Polyamine metabolism in humans: Clinical implications. In: Polyamines in Biology and Medicine. Morris DR, Marton LJ. (eds.). Marcel Dekker, New York, NY. Chapter 20, pp.384-400, 1981.

5. Chan WY, Ramadan TZ, Perlman M, McCaffree MA, Rennert OM. Manganese and copper metabolism in the mother and in the neonate. In: Nutrition and Child Health Perspectives for the 1980's. Tsang RC, Nichols BL Jr. (eds.). Alan R. Liss, New York, NY. p.191, 1981.

6. Rennert OM, Chan WY, Ramadan TZ, McCaffree MA. Trace metal concentration in the term and premature infant. In: Proceedings of the Second Ross Clinical Research Conference. Meeting Nutritional Goals for Low-Birth Weight Infants. Sauls HS, Bachhuber WL, Lewis LA. (eds.). Ross Laboratories, Columbus, OH. pp.122-124, 1982.

7. McCaffree MA, Chan WY, Rennert OM. Evaluation of trace metal homeostasis in low-birth-weight infants. In Proceedings of the Second Ross Clinical Research Conference. Meeting Nutritional Goals for Low-Birth Weight Infants. Sauls HS, Bachhuber WL, Lewis LA (eds.). Ross Laboratories, Columbus, OH. pp.125-127, 1982.

8. Chan WY, Tease LA, Liu HC, Rennert OM. Cell culture studies of Wilson's disease (Hepatolenticular Degeneration). In: Biological Aspects of Metals and Metal Related Diseases. Sarkar B. (ed.). Raven Press, New York, NY. pp.147-158, 1983.

9. Chan WY, Bates J Jr, Rennert OM. Trace metals in milk, In: Metabolism of Trace Metals in Man. Vol. 1: Developmental Aspects. Rennert OM, Chan WY. (eds.). CRC Press, Boca Raton, FL. pp. 63-78, 1984.

10. Sarale C, Chan WY, Rennert OM. Wilson's disease: Recent advances, In: Metabolism of Trace Metals in Man. Vol. 2: Genetic Implications. Rennert OM, Chan WY. (eds.). CRC Press, Boca Raton, FL. pp.53-70, 1984.

11. Rennert OM, Chan WY. Genetic diseases: model for the study of trace metals, In: Metabolism of Trace Metals in Man. Vol. 2: Genetic Implications. Rennert OM, Chan WY (eds.). CRC Press, Boca Raton, FL. pp.133-140, 1984.

12. Chan WY, Bates JM Jr, Raghib MH, Rennert OM. Bioavailability of manganese in milk studied with in vitro and in vivo systems. In: Manganese in Metabolism and Enzyme Function. Wedler FC, Schramm VL. (eds.). Academic Press, New York, NY. pp.17-34, 1986.

13. Chan WY. Enzymology, In: Oklahoma Notes: Biochemistry. Briggs T, Chandler A. (eds.). Springer- Verlag, New York, NY. pp.18-32, 1987.

14. Chan WY. Human biochemical genetics. In: Oklahoma Notes: Biochemistry. Briggs T, Chandler A. (eds.). Springer-Verlag, New York, NY. pp.175-194, 1987.

15. Chan WY, Raghib MH. Absorption studies of manganese from various milk diets in suckling rats. In: Nutritional Bioavailability of Manganese. Kies C. (ed.). ACS, Washington, D.C. pp. 80-89, 1987.

16. Chan WY. Pregnancy-specific (1-glycoproteins: Laboratory findings and clinical potential. Georgetown Medicine. Georgetown University, Vol 1, pp. 11-15, 1991.

17. Laue L, Wu SM, Kudo M, Hsueh AJW, Griffin JE, Wilson JD, Grant DB, Berry AC, Cutler GB Jr, Chan WY. The Gene defect that causes genetically XY males to develop as apparent females (Leydig cell hypoplasia). In: Third Annual Press Book. American Society for Cell Biology, Bethesda, MD. pp. 1-3, 1994.

18. Chan WY, Garnica AD, Rennert OM. Genetic trace metal disturbances. In: Handbook of Metal-Ligand Interactions in Biological Fluids. Berthon G. (ed.). Volume 2: Bioinorganic Medicine, Part 4, Chapter 2, Section A, Marcel Dekker, Inc., New York, NY. pp. 792-802, 1995.

19. Chan WY. Education, R&D, and the Biotech Industry in Hong Kong. In: Biotechnology in Hong Kong. Chan, AWK. (ed.), US-China Intellectual Property Institute, New York, pp. 451-471, 1999.

Peer-Reviewed Articles:

1. Ho WKK, Chan WY. Serum lipid and lipoprotein levels in normal Chinese. Clin Chim Acta. 7:149-154, 1974.

2. Ho WKK, Chan WY. Evaluation of serum lipid and lipoprotein levels in normal Chinese. The influence of dietary habit, body weight, exercise and familial record of coronary heart disease. Clin Chim Acta. 61:19- 25, 1975.

3. Garnica AD, Chan WY, Rennert OM. The role of the metallothioneins in intracellular copper transport: Studies using skin fibroblasts of patients with Menkes' Syndrome. Ann Clin Lab Sci. 8:302- 309, 1978.

4. Chan WY, Garnica AD, Rennert OM. Metal binding studies of metallothioneins in Menkes' Kinky Hair Disease. Clin Chim Acta. 88:221- 228, 1978.

5. Chan WY, Garnica AD, Rennert OM. Cell culture studies of Menkes' Kinky Hair Disease. Clin Chim Acta. 88:495-507, 1978.

6. Chan WY, Seale TW, Shukla JB, Rennert OM. Polyamine conjugates and total polyamine concentration in human amniotic fluid. Clin Chim Acta. 91:233-242, 1979.

7. Chan WY, Garnica AD, Rennert OM. Inducibility of metallothionein biosynthesis in cultured normal and Menkes' Kinky Hair Disease fibroblasts: Effects of copper and cadmium. Pediat Res. 13(4):197-203, 1979.

8. Rennert OM, Chan WY. Menkes' metallothionein and copper metabolism. Pediat Res. 13(4):204-205, 1979.

9. Seale TW, Chan WY, Shukla JB, Rennert OM. Isolation and characterization of a polyamine-peptide conjugate from human amniotic fluid. Clin Chim Acta. 95:461-472, 1979.

10. Seale TW, Chan WY, Shukla JB, Rennert OM. A polyamine-peptide conjugate isolated from normal human plasma. Arch Biochem Biophys. 189:164-174, 1979.

11. Chan WY, Seale TW, Rennert OM. Fluorescence micro-disc electrophoresis in sodium dodecylsulfate: A simple and sensitive method applicable for routine laboratory analysis. J Chromat. 181(2):259-265, 1980.

12. Chan WY, Cushing W, Coffman MA, Rennert OM. Genetic expression of Wilson's Disease in cell culture: A diagnostic marker. Science. 208:299-300, 1980.

13. Rennert OM, Chan WY, Hildago H, Cushing W, Griesmann GE. Polyamines in Menkes' Kinky Hair Disease. Clin Chim Acta. 103:375- 380, 1980.

14. Chan WY, Rennert OM. Comparative study of Menkes' and Wilson's Disease. Cien Biol. 5(2):73-75, 1980

15. Chan WY, Richichi J, Griesmann GE, Cushing W, Kling OR, Rennert OM. Copper and ceruloplasmin activity in human amniotic fluid. Am J Obstet Gynecol. 138(3):257-259, 1980

16. Chan WY, Ramadan TZ, Perlman M, McCaffree MA, Rennert OM. Copper and manganese in the mother and in the neonate. Nutr Rep Internat. 22(6):939-948, 1980.

17. Rennert OM, Chan WY, Griesmann GE. Polyamine-peptide conjugates: Proposed functions. Physiol Chem Phys. 12(5):441-450, 1980.

18. Chan WY, Rennert OM. The role of copper in iron metabolism. Ann Clin Lab Sci. 10(4):338-344, 1980.

19. Chan WY, Rennert OM. Cadmium nephropathy. Ann Clin Lab Sci. 11(3):229-238, 1981.

20. Chan WY, Mosca P, Rennert OM. Lithium nephrotoxicity: A review. Ann Clin Lab Sci. 11(4):343-349, 1981.

21. Perlman M, Chan WY, Ramadan TZ, Rennert OM. Urinary polyamine in preterm infants. Clin Chim Acta. 113:1-6, 1981.

22. Chan WY, Chung KW, Bates J, Blomberg LA, Rennert OM. Organ specific zinc deficiency in testicular feminization rats: Hormone-metal interaction. Biochem Biophys Res Comm. 102(2):630-635, 1981.

23. Seiler N, Knodgen B, Gittos MW, Chan WY, Griesmann GE, Rennert OM. On the formation of amino acids deriving from spermidine and spermine. Biochem J. 200(1):123-132, 1981.

24. Chan WY, Bates J, Rennert OM. Comparative studies of manganese binding in human breast milk, bovine milk and infant formula. J Nutr. 112(4):642-651, 1982.

25. Chan WY, Rennert OM. Prenatal and postnatal diagnosis of diseases of copper metabolism. Ann Clin Lab Sci. 12(5):372-380, 1982.

26. Griesmann GE, Chan WY, Rennert OM. Determination of gamma-aminobutyric acid by reverse-phase HPLC and pre-column labeling for fluorescence detection. J Chromat. 230:121-124, 1982.

27. Perlman M, Chan WY, Ramadan TZ, McCaffree MA, Rennert OM. Serum copper and ceruloplasmin in preterm infants: Prospective study. J Am Coll Nutr. 1:155-163, 1982.

28. Liu HC, Chan WY, Rennert OM. Histochemical studies of fibroblasts from patients with Menkes' Kinky Hair Disease and Wilson's Disease. Histochem J. 14:781-789, 1982.

29. Chan WY, Chung KW, Bates JM Jr, LeBlanc M, Tease LA, Griesmann GE, Rennert OM. Zinc metabolism in testicular feminization and cryptorchid testes in rats. Life Sci. 32(11):1279-1284, 1983.

30. Chung KW, Chan WY, Dressler JB, Allison JE, Rennert OM. Androgen receptors in the brain of neonatal normal male and androgen insensitive rats. Biochem Biophys Res Comm. 111(2):717-722, 1983.

31. Rixon MW, Chan WY, Davie EW, Chung DW. Characterization of a cDNA coding for (-chain of human fibrinogen. Biochemistry. 22(13): 3237-3244, 1983.

32. Chung DW, Chan WY, Davie EW. Characterization of a cDNA coding for the (-chain of human fibrinogen. Biochemistry. 22(13): 3250-3256, 1983.

33. Fan MZ, Chan WY, Griesmann G, Rennert OM. Polyamine metabolism in McCoy cells: I. Comparative studies of extracellular polyamine conjugated proteins of human fibroblast and McCoy cultures. Physiol Chem Phys. 15(1):57-68, 1983.

34. Fan MZ, Chan WY, Rennert OM. Polyamine metabolism in McCoy cells: II. Cellular origin of excreted polyamine conjugated proteins. Physiol Chem Phys. 15(1):69-80, 1983.

35. Fan MZ, Chan WY, Griesmann G, Rennert OM. Polyamine metabolism in McCoy cells: III. Comparative studies of metabolic fate of exogenous putrescine in human fibroblast cultures and McCoy cultures. Physiol Chem Phys. 15(1):81-86, 1983.

36. Wang CS, Chan WY, Kloer H-U. Comparative studies on the chemical and immunochemical properties of human milk, human pancreatic juice and bovine milk lactoferrin. Comp Biochem Physiol. 78B (3):575-580, 1984.

37. Blackett PR, Lee DM, Donaldson DL, Fesmire JD, Chan WY, Holcombe JH, Rennert OM. Studies of lipids, lipoproteins and apolipoproteins in Menkes Disease. Pediat Res. 18(9):864-870, 1984.

38. Chan WY, Bates JM. Jr, Rennert OM, Mamood A, Torres-Pinedo R. Intestinal transport of manganese from human milk, bovine milk and infant formula in rats. Life Sci. 35(24):2415-2419,1984.

39. Raghib H, Chan WY, Rennert OM. Effect of age, method of feeding and prior fasting on the absorption of milk manganese in suckling rats. Nutr Rep Internat. 32(5):1201-1210, 1985.

40. Garnica AD, Chan WY, Rennert OM. Trace metals in genetic disease. Trace Metals Med. 2(2):47-58, 1985.

41. Chan WY, Rennert OM. Genetic trace metal disturbances. J Am Coll Nutr. 4(1):39-48, 1985.

42. Chung KW, Kim SY, Chan WY, Rennert OM. Androgen receptors in prostate glands of zinc deficient rats. Life Sci. 38(1):351356, 1986.

43. Raghib MH, Chan WY, Rennert OM. Comparative bioavailability of manganese from extrinsically labeled milk diets using suckling rats as a model. Brit J Nutr. 55(1):49-58, 1986.

44. Chan WY, Bates JM Jr, Rennert OM, Chung KW. Abnormal zinc metabolism in unilateral maldescended testes of a mutant rat strain. Proc Soc Expt Biol Med. 182(4):549-558, 1986.

45. Raghib H, Chan WY, Rennert OM. Comparative studies of selenium-75 (Selenite and Selenomethionine) absorption from various milk diets in suckling rats. J Nutr. 116(8):1456-1463, 1986.

46. Chan PK, Chan WY, Yung BY-M, Cook RG, Aldrich MB, Ku D, Goldknopf LL, Busch H. Amino acid sequence of a specific antigenic peptide of protein B23. J Biol Chem. 261(30):14335-14341, 1986.

47. Chan WY, Bates JM Jr, Rennert OM, Chung KW. Absence of a 23kd protein in testes of testicular feminization rats. Life Sci. 40(22):2169-2173, 1987.

48. Raghib HM, Chan WY, Rennert OM. Absorption of milk manganese in suckling rats. Nutr Rep Internat. 35(6):1111-1121, 1987.

49. Chan WY, Tease LA, Borjigin J, Chan PK, Rennert OM, Srinivasan B, Shupert WL, Cook RG. Pregnancy-specific (1-glycoprotein mRNA is present in placental as well as non-placental tissues. Hum Reprod. 3(5):677-686, 1988.

50. Chan WY, Tease LA, Bates JM Jr, Borjigin J, Shupert WL. Pregnancy-specific (1-glycoprotein in rats: Tissue distribution of the mRNA and identification of testicular cDNA clones. Hum Reprod. 3(5):687-692, 1988.

51. Chan WY, Qiu WR. Human Pregnancy-specific (1-glycoprotein is encoded by multiple genes localized on two chromosomes. Am J Hum Genet. 43(2):152-159, 1988.

52. Chan WY, Borjigin J, Zheng QX, Shupert WL. Characterization of cDNA encoding human pregnancy-specific (1-glycoprotein from placenta and extraplacental tissues and their comparison with carcinoembryonic antigen. DNA. 7(8):545-555, 1988.

53. Chan WY, Liu QR, Borjigin J, Busch H, Rennert OM, Tease LA, Chan PK. Characterization of a cDNA encoding human nucleophosmin and studies of its function in normal and abnormal growth. Biochemistry. 28(3):1033-1039, 1989.

54. Tease LA, Fazleabas AG, Chan WY. Expression of pregnancy-specific (1-glycoprotein in baboon placenta. Biol Reprod. 41:1113-1121, 1989.

55. Borjigin J, Tease LA, Barnes W, Chan WY. Expression of pregnancy-specific (1-glycoprotein in human testis. Biochem Biophys Res Comm. 166(2):622-629, 1990.

56. Ogilvie S, Shiverick KT, Larkin LH, Romrell LJ, Shupert WL, Chan WY. Pregnancy-specific (1-glycoprotein mRNA and immunoreactive-protein in the testis of rat. Endocrinology. 126(1):292-298,1990.

57. Zheng QX, Tease LA, Shupert WL, Chan WY. Characterization of cDNAs of the human pregnancy-specific (1-glycoprotein family - A new subfamily of the immunoglobulin gene superfamily. Biochemistry. 29(11): 2845-2852, 1990.

58. Jose P, Felder RA, Felder CC, Chan WY. Molecular biology of adrenergic and dopamine receptors and the study of developmental nephrology. Pediat Nephrol. 4:679-685, 1990.

59. Ho WKK, Liu SC, Shaw PC, Yeung HW, Ng TB, Chan WY. Cloning of the cDNA of (-momorcharin: A ribosome inactivating protein. Biochim Biophys Acta 1088:311-314, 1991.

60. Chan WY, Zheng QX, McMahon J, Tease LA. Characterization of new members of the pregnancy specific (1-glycoprotein family. Mol Cell Biochem. 106:161-170, 1991.

61. Richardson LL, Chan WY, Dym M. Localization of a "pregnancy-specific" (1-glycoprotein in the male reproductive tract of the rat by in situ hybridization. Biol Reprod. 45: 704-710, 1991.

62. Chan WY. The pregnancy-specific (1-glycoprotein family. Adv Contr Deliv Syst. 7:21-52, 1991.

63. Shupert WL, Chan WY. Pregnancy-specific (1-glycoprotein (PSG) in human intestine. Mol Cell Biochem. 120:159-170, 1993.

64. Wu SM, Bazar L, Cohn M J, Cahill R, Chan WY. Expression of pregnancy-specific (1-glycoproteins in hematopoietic cells. Mol Cell Biochem. 122:147-158, 1993.

65. Ida H, Rennert OM, Eto Y, Chan WY. Identification of a cDNA encoding human acid sphingomyelinase with a new mutation that renders the enzyme inactive. J Biochem. 114:15-20, 1993.

66. Chen H, Chan WY, Chen C-L, Mansfield, BC, Chou JY. The carboxyl-terminal domain of the human pregnancy specific glycoprotein specifies intracellular retention and stability. J Biol Chem. 268(29):22066-22075, 1993.

67. Pan C-J, Chamberlin ME, Wu SM, Chan WY, Chou JY. Pregnancy-specific (1-glycoprotein genes expression and their induction by 5-bromo-2'-deoxy-uridine. Biochemistry. 33(23):7260-7266, 1994.

68. Garnica AD, Chan WY, Rennert OM. Copper-histidine treatment of Menkes' disease. J Pediat. 125(2):336-338, 1994.

69. Rennert OM, Chan WY, Garnica AD. Menkes kinky hair disease - A glimpse from the past into the future. Menkes disease: The study of copper metabolism. Internat Pediat. 9(Supp. 2):69-73, 1994.

70. Laue L, Chan WY, Hsueh AJW, Kudo M, Hsu SY, Wu SM, Blomberg LA, Cutler GB Jr. Genetic heterogeneity of constitutively activating mutations of the luteinizing hormone receptor in familial male- limited precocious puberty. Proc Natl Acad Sci, USA. 92(6):1906-1910, 1995.

71. Laue L, Wu SM, Kudo M., Hsueh AJW, Griffin JE, Wilson JD, Grant DB, Brain C, Berry EC, Cutler GB Jr, Chan WY. A nonsense mutation of the human luteinizing hormone receptor gene in Leydig cell hypoplasia. Hum Mol Genet. 4(8):1429-1433, 1995.

72. Garnica AD, Chan WY. The role of the placenta in fetal nutrition and growth. J Am Coll Nutr. 15(3):206 -222, 1996.

73. Bano M, Prasad S, Dickson RB, Chan WY. Detection of pregnancy-specific (1-glycoprotein in human milk. Breast. 5:61-66, 1996.

74. Laue LL, Wu SM, Kudo M, Bourdony CJ, Cutler GB Jr, Hsueh AJW, Chan WY. Compound heterozygous mutations of the luteinizing hormone receptor gene in Leydig Cell Hypoplasia. Mol Endocrinol. 10(8): 987-997, 1996.

75. Laue L, Wu SM, Kudo M, Hsueh AJW, Cutler GB Jr, Jelly DH, Diamond FB, Chan WY. Heterogeneity of activating mutations of the human luteinizing hormone receptor in male-limited precocious puberty. Biochem Mol Med. 58:192-198, 1996.

76. Wu SM, Blomberg LA, Chan WY. Recovery of PCR products from polyacrylamide gel for sequencing. BioTechniques. 21(3):358-362, 1996.

77. Garnica AD, Chan WY. Placenta and growth factors in fetal growth and nutrition. Nutrition 13(4):384-385, 1997.

78. Stratakis CA, Lin J-P, Pras E, Rennert OM, Bourdony CJ, Chan WY. Allgrove (Triple-A) syndrome in Puerto Rican kindreds maps to chromosome 12 (12q13). Proc Assoc Am Physicians. 109(5):478-482,1997.

79. Wu SM, Jose M, Hallermeier K, Rennert OM, Chan WY. Polymorphisms in the coding exons of the human luteinizing hormone receptor. Hum Mut. 11(4):333-334 and Mutation in Brief #124, On-line,1997.

80. Blomberg LA, Wu SM, Dirami G, Dym M, Chou JY, Chan WY. Characterization and cellular localization of pregnancy-specific (1-glycoproteins in rat testis. Mol Cell Biochem. 177:229-237, 1997.

81. Chan WY, Cutler GB Jr. Molecular aspects of precocious puberty. Adv Mol Cell Endocrinol 2:121-141, 1998.

82. Blomberg LL, Cohn MJ, Cahill RA, Chan WY. Effect of human pregnancy-specific (1 glycoprotein on blood cell regeneration after bone marrow transplant. Proc Soc Expt Biol Med. 217:212-218, 1998.

83. Chan WY, Cutler GB Jr. Mutations of gonadotrophin receptors leading to loss or gain of function. Top Endocrinol. 8:9-12, 1998.

84. Chan WY. Molecular genetic, biochemical, and clinical implications of gonadotropin receptor mutations. Mol Genet Metab. 63(2):75-84, 1998.

85. Martin MM, Wu SM, Martin ALA, Rennert OM, Chan WY. Testicular seminoma in a patient with a constitutively activating mutation of the luteinizing hormone/chorionic gonadotropin receptor. Euro J Endocrinol. 139:101-106, 1998.

86. Wu SM, Stratakis CA, Chan CHY, Hallermeier K, Bourdony CJ, Chan WY. Genetic heterogeneity of ACTH resistance syndromes: A novel mutation of the ACTH receptor gene in hereditary glucocorticoid deficiency. Mol Gen Metab. 64:256-265, 1998.

87. Wu SM, Hallermeier MK, Laue L, Brain C, Berry EC, Grant DB, Griffin JE, Wilson JD, Cutler GB Jr, Chan WY. Inactivation of the luteinizing hormone/chorionic gonadotropin receptor by insertional mutation in Leydig cell hypoplasia. Mol Endocrinol. 12(11):1651-1660, 1998.

88. Wu SM, Arnold LL, Rone J, Trivedi M, Chan WY. Effect of pregnancy-specific (1-glycoprotein on the preimplantation embryo. Proc Soc Expt Biol Med. 220:169-177,1999.

89. Wu SM, Leschek EW, Brain C, Chan WY. A novel mutation of the luteinizing hormone receptor in a patient with familial male-limited precocious puberty – effect of the size of a critical amino acid on receptor activity. Mol Genet Metab. 66:68-73 1999.

90. Arnold LL, Doherty TM, Flor WA, Simon JA, Chou JY, Chan WY, Mansfield BC. Pregnancy-specific glycoprotein gene expression in recurrent aborters: A potential correlation to interleukin-10 expression. Amer J Reprod Immunol. 41:174-182, 1999.

91. Wu SM, Chan WY. Male pseudohermaphroditism due to inactivating luteinizing hormone receptor mutations. Arch Med Res. 30(6):495-500, 1999.

92. Wu SM, Leschek EW, Rennert OM, Chan WY. Luteinizing hormone receptor mutations in disorders of sexual development and cancer. Frontiers Biosci. 5:D342-352, 2000.

93. Wu SM, Leschek EW, Rennert OM, Chan WY. Luteinizing hormone receptor mutations in sexual development and cancer. J Pediat Path Mol Med. 19(1):21-40, 2000.

94. Massaro GD, Massaro D, Chan WY, Clerch LB, Ghyselinck N, Chambon P, Chandraratna RAS. Signalling via retinoic acid receptor ( mediates endogenous inhibition of the perinatal formation of pulmonary alveoli. Physiol Genomics. 4(1):51-57, 2000.

95. Leschek EW, Chan WY, Diamond D, Laefer M, Jones J, Barnes KM, Cutler GB Jr. Nodular Leydig cell hyperplasia in a boy with Familial male-limited precocious puberty (FMPP). J Pediatr. 138(6):949-951, 2001.

96. Sandrini F, Farmakidis C, Kirschner LS, Wu SM, Tullio-Pelet A, Lyonnet S, Metzger DL, Bourdony CJ, Hochberg Z, Chan WY, Stratakis CA. Spectrum of mutations of the AAAS gene and genotype-phenotype correlation in patients with isolated resistance to corticotropin or Allgrove syndrome. J Clin Endocrinol Metab. 86: 5433-5437, 2001.

97. Chan WY, Rennert OM. Molecular aspects of sexual differentiation. Curr Mol Med. 2:25-37, 2002.

98. Bastain TM, Lewczyk CM, Sharp WS, James RS, Long RT, Eagen PB, Ebens CL, Meck JM, Chan WY, Sidransky ER, Rapoport JL, Castellanos FX. Cytogenetic abnormalities in Attention- Deficit / Hyperactivity Disorder. J Am Acad Child Adolesc Psychiatry. 41(7):1-5, 2002.

99. Blomberg LA, Chan WY, Clerch L, Massaro G, Massaro D. Molecular cloning and characterization of two genes up-regulated early in lung development. Biochim Biophys Acta, 1574(3):391-398, 2002.

100. Pang ALY, Taylor HC, Johnson W, Alexander S, Chen Y, Su YA, Li X, Ravindranath N, Dym M, Rennert OM, Chan WY. Identification of differentially expressed genes in spermatogenesis in the mouse. J Androl. 2003 Apr;24(6):899-911.

101. Dogulu CF, Kansu T, Leung MYK, Baxendale V, Wu SM, Ozguc M, Chan WY, Rennert OM. Evidence for genetic susceptibility to thrombosis in Pseudotumor Cerebri. Thromb Res, 111(6):389-395, 2003.

102. Leung MLY, Al-Muslim O, Wu SM, Azizs A, Inam S, Awadh M, Rennert OM, Chan WY. A novel missense homozygous inactivating mutation in the fourth transmembrane helix of the luteinizing hormonereceptor in Leydig Cell Hypoplasia. Amer J Med Genet, 130A:146-153, 2004.

103. Ohta S, Lai EW, Pang ALY, Brouwers FM, Chan WY, Eisenhofer G, de Krijger R, Ksinantova L, Blazicek P, Breza J, Kvetnansky R, Wesley RA, Pacak K. (2004) Down-regulation of metastasis suppressor gene in malignant pheochromocytoma. Internat J Cancer. 114(1):139-43.

104. Wu SM, Baxendale V, Chen Y, Li X, ALY Pang, Stitely T, Munson PJ, Leung MYK, Ravindranath N, Dym M, Rennert OM, Chan WY. (2004). Analysis of mouse germ cell transcriptome at different stages of spermatogenesis: Biological significance. Genomics. 84(6):971-981.

105. Nalbandian A, Pang ALY, Rennert OM, Chan WY, Ravindranath N, Djakiew D. (2005). A novel function of differentiation revealed by cDNA microarray profiling of p75NTR-regulated gene expression. Differentiation. 73:385-396.

106. Nwosu BU, Raygada M, Tsilou ET, Rennert OM, Stratakis CA. (2005). Rieger's anomaly and other ocular abnormalities in association with osteogenesis imperfecta and a COL1A1 mutation. Ophthalmic Genet. 26(3):135-8.

107. Raygada, M. & Rennert, OM (2005). Congenital Generalized Lipodystrophy: Profile of the disease and gender differences. Clin Genetics. 67(1): 98-101.

108. Liu Y, Yao ZX, Bendavid C, Borgmeyer C, Han Z, Cavalli LR, Chan WY, Folmer J, Zirkin, BR, Haddad BR, Gallicano I, Papadopoulos V. (2005). Haploinsufficiency of cytochrome P450 17a-hydroxylase/17,20 lyase (CYP17) causes infertility in male mice. Mol Endocrinol. 19(9):2380-2389.

109. Ifon ET, Pang ALY, Johnson W, Cashman K, Zimmerman S, Muralidhar S, Chan WY, Casey J, Rosenthal LJ. U94 alters FN1 and ANGPTL4 gene expression and inhibits tumorigenesis of prostate cancer cell line PC3. Cancer Cell Int. 2005 Jun 22;5:19.

110. Salameh W, Choucair M, Guo TB, Zahed L, Wu SM, Leung MY, Rennert OM, Chan WY. Leydig cell hypoplasia due to inactivation of luteinizing hormone receptor by a novel homozygous nonsense truncation mutation in the seventh transmembrane domain. Mol Cell Endocrinol. 2005 Jan 14;229(1-2):57-64.

111. Oram SW, Liu XX, Lee TL, Chan WY, Lau YFC. (2006). TSPY potentiates cell proliferation and tumorigenesis by accelerating cell cycle progression in HeLa and NIH3T3 cells. BMC Cancer. 6:154.

112. Leung MYK, Steinbach P, Bear D, Baxendale V, PY Fechner, Rennert OM, Chan WY. (2006) Biological effect of a novel mutation in the third leucine-rich repeat of human luteinizing hormone receptor. Mol Endocrinol. 20(10): 2493-2503.

113. Jeha GS, Lowenthal ED, Chan WY, Wu SM, Karaviti LP. (2006). Variable presentation of precocious puberty associated with the D564G mutation of the LHCGR gene in children with testotoxicosis. J Pediatr. 149(2): 271-274.

114. Chan WY, Wu SM, Ruszczyk L, Law E, Lee TL, Baxendale V, Rennert OM. (2006). The complexity of antisense transcription revealed by the study of developing male germ cells. Genomics. 87:681-692.

115. Lee TL, Alba D, Wu SM, Baxendale V, Rennert OM, Chan WY. (2006). Application of transcriptional network analyses in mouse germ-cell transcriptomes. (Journal Cover) Genomics. 88:18-33.

116. Chan WY, Lee TL, Wu SM, Ruszczyk L, Alba D, Baxendale V, Rennert OM. ( 2006). Transcriptome analyses of male germ cells with serial analysis of gene expression (SAGE). Mol Cell Endocrinol. 250:8-19.

117. He Z, Chan WY, Dym M. (2006). Microarray technology offers a novel tool for the diagnosis of and identification of therapeutic targets for male infertility. Reproduction. 132:11-19.

118. Vong QP, Li YM. Lau CYF, Dym M, Rennert OM, Chan WY. (2006). Structural characterization and expression studies of Dby and its homologs in the mouse. J Androl. 27(5):653-661.

119. Pang ALY, Johnson W, Ravindranath N, Dym M, Rennert OM, Chan WY. (2006). Expression profiling of purified male germ cells: stage specific expression patterns related to meiosis and post-meiotic development. Physiol Genomics. 24:75-85.

120. Xingli Meng, Owen M Rennert, Waiyee Chan. Human Chorionic Gonadotropin Induces Neuronal Differentiation of PC12 Cells through Activation of Stably Expressed Lutropin / Choriogonadotropin Receptor. Endocrinology. 2007;148 (12): 5865-5873.

121. Ohta S, Lai EW, Morris JC, Pang AL, Watanabe M, Yazawa H, Zhang R, Green JE, Chan WY, Sirajuddin P, Taniguchi S, Powers JF, Tischler AS, Pacak K. Metastasis-associated gene expression profile of liver and subcutaneous lesions derived from mouse pheochromocytoma cells. Mol Carcinog. 2008 Apr;47(4):245-51.

Manuscript Submitted:

1. Lowenthal ED, Chan WY, Wu SM, Karaviti LP. A Case of Familial Testotoxicosis: Unexpected tall stature attained by untreated boys with Familial Testotoxicosis. Clinical Genetics. 2003.

2. Liu Y, Yao ZX, Bendavid C, Borgmeyer C, Han Z, Cavalli LR, Gallicano I, Chan WY, Folmer J, Zirkin BR, Haddad BR, and Papadopoulos V. Cytochrome P450 17a-hydroxylase/17,20 lyase (CYP17) gene deletion causes infertility in mice. Molecular Endocrinology, 2004.

3. Pang ALY, Johnson W, Dym M, Rennert OM, Chan WY. Expression profiling of purified male germ cells: stage specific expression patterns related to meiosis and post-meiotic development. Physiological Genomics, 2004.

4. Pang ALY, Johnson W, Dym M, Rennert OM, Chan WY. A survey of house-keeping gene expression during male germ cell development. Biology of Reproduction, 2004.

5. Vong QP, Lau CYF, Dym M, Rennert OM, Chan WY. Differential expression of Ddx3y, PL10 and Ddx3 in germ cell and gonad development in mouse. Biology of Reproduction, 2004.

6. Leung MYK, Bellan D, Steinback P, Baxendale V, Wu SM, Rennert OM, Chan WY. Mutation of the conserved hydrophobic amino acid residues of the leucine-rich repeats of human luteinizing hormone receptor deformed the LRR coils and reduced the availability of beta-strand to ligand-receptor interaction. Journal of Biological Chemistry, 2004.

Manuscript In Preparation:

1. Chan WY, Wu SM, Ruszcyzk L, Stitely T, Law E, Baxendale V, Pang ALY, Rennert OM. Spermatogenesis: Model for antisense transcription? Nature Genetics, 2004.

Published Abstracts:

1. Rennert OM, Garnica AD, Chan WY. Hyperornithinemia and hyperammonemia: A rare disorder of ammonia metabolism. Proc 2nd Internat Gstaad Symp. 1975. (podium)

2. Garnica AD, Rennert OM, Chan WY. Ornithine ketoacid transaminase deficiency associated with hyperammonemia and ornithinemia. Pediat Res. 10(4):365, 1976.

3. Chan WY, Garnica AD, Rennert OM. Defective metallothionein in Kinky Hair Syndrome fibroblasts. Pediat Res. 11(4):453, 1977.

4. Chan WY, Garnica AD, Rennert OM. Studies of 64Cu and 109Cd efflux and uptake in Menkes' Kinky Hair (MKHS) fibroblasts. Pediat Res. 11(4):453, 1977.

5. Chan WY, Garnica AD, Rennert OM. Defective metallothionein and copper accumulation in Menkes' Kinky Hair Syndrome (MKHS) fibroblasts. Am J Hum Genet. 29(6):29A, 1977. (podium)

6. Rennert OM, Seale TW, Chan WY, Flux M. No differences detected spectrophotometrically between blood peptides of Cystic Fibrosis and normal individuals fractionated by column chromatography. Pediat Res. 12(4): 511, 1978.

7. Chan WY, Seale TW, Shukla JB, Blackett P, Rennert OM. Characterization of a polyamine-conjugated l low molecular weight polypeptide in human third trimester amniotic fluid. Pediat Res. 12(4):392, 1978.

8. Seale TW, Chan WY, Shukla JB, Rennert OM. Human plasma polyamine-conjugated peptide, putrescinin. Pediat Res. 12(4):512, 1978.

9. Chan WY, Seale TW, Shukla JB, Rennert OM. Polyamines in human amniotic fluid. Clin Res. 26:812A, 1978.

10. Garnica AD, Chan WY, Rennert OM. Accumulation of infused protein bound copper in the Kinky Hair Syndrome. Clin Res. 26:820A, 1978.

11. Chan WY, Garnica AD, Rennert OM. Abnormal accumulation of copper in cultured fibroblasts as in vitro genetic marker for Wilson's Disease. Pediat Res. 13(4):418, 1979.

12. Chan WY, Perlman M, Kling OR, Seale TW, Rennert OM. Variation of trace element contents of human amniotic fluid with gestation. Pediat Res. 13(4):356, 1979.

13. Seale TW, Smith DJ, Chan WY, Rennert OM. Detection and properties of a sodium reabsorption inhibitor in serum from Cystic Fibrosis patients. Genetics 91:s113, 1979.

14. Chan WY, Garnica AD, Rennert OM. Abnormal copper metabolism in cultured fibroblasts - A genetic marker for Wilson's Disease. Am J Hum Genet. 31(6):41A, 1979.

15. Perlman M, Ramadan T, Chan WY, Rennert OM. Serial copper and ceruloplasmin values in serum of preterm infants. Clin Res. 27(5):799A, 1979.

16. Seale TW, Chan WY, Martinez R, Rennert OM. Detection and properties of sodium inhibition in serum from Cystic Fibrosis patients. Proc Joint Meet Genet Soc Canada Am Soc Nat. 1979.

17. Chan WY, Cushing W, Coffman MA, Rennert OM. Genetic expression of Wilson's Disease in culture. Pediat Res. 14(4):520, 1980.

18. Perlman M, Chan WY, Ramadan T, Griesmann G, Rennert OM. Urinary polyamines in preterm infants. Pediat Res. 14(4):578, 1980.

19. Chan WY, Ramadan TZ, Perlman M, McCaffree MA, Rennert OM. Manganese and copper metabolism in the mother and the neonate. Proc Am Coll Nutr. #29, 1980.

20. Chan WY, Ramadan TW, McCaffree MA, Perlman M, Rennert OM. Manganese and copper in full-term and preterm newborns. Clin Res. 28(5):853A, 1980.

21. Pineda JL, Rennert OM, Chan WY. Zinc metallopeptide in human milk. Clin Res. 28(5):867A, 1980.

22. Chan WY, Chung KW, Bates J, Blomberg LA, Rennert OM. Hormonal-metal ion interaction in testicular feminization. Pediat Res. 15(4):505, 1981

23. Chan WY, Coffman MA, Rennert OM. Wilson's Disease fibroblasts-mutants of intracellular copper transport. Pediat Res. 15(4):560, 1981.

24. McCaffree MA, Chan WY, Costiloe P, Rennert OM. Levels of copper and ceruloplasmin in infants fed two different formulas. Pediat Res. 15(4):540, 1981.

25. McCaffree MA, Chan WY, Ramadan TZ, Perlman M, Rennert OM. Copper and manganese levels in infants following exchange transfusion. Pediat Res. 15(4):540, 1981.

26. Blackett P, Donaldson D, Lee D, Chan WY, Holcombe JH, Rennert OM. Hyperlipidemia and glucose intolerance with hypocuprinemia in Menkes' Disease. Pediat Res. 15(4):626, 1981.

27. Chan WY, Bates J, Pineda J, Rennert OM. Manganese binding proteins in human breast milk. J Am Coll Nutr. 1(1):113, 1982. (podium)

28. Chan WY, Bates JM Jr, Rennert OM. Manganese binding ligands in human milk and its substitutes. Fed Proc. 41(3):360, 1982. (podium)

29. Fan MZ, Chan WY, Griesmann GE, Rennert OM. Polyamine conjugated protein in medium of McCoy cultures. Fed Proc. 41(3):519, 1982.

30. Griesmann GE, Fan MZ, Chan WY., and Rennert, O.M. Metabolic fate of exogenous putrescine in McCoy cultures. Fed Proc. 41(3):877, 1982.

31. Rennert OM, Fan MZ, Chan WY. Cellular origin of excreted polyamine conjugated protein in McCoy culture. Fed Proc. 41(4):1431, 1982.

32. Chan WY, Tease,LA, Rennert OM. Kinetic studies of copper metabolism in Wilson's Disease fibroblast culture. Pediat Res. 16(4):256A, 1982.

33. Chan WY, Bates JM Jr, Rennert OM. Molecular localization of manganese in human breast milk, bovine milk and infant formula. Pediat Res. 16(4):158A, 1982.

34. Liu HC, Chan WY, Rennert OM. Diseases of copper metabolism: Histochemical studies of Wilson's and Menkes' Disease fibroblasts. Pediat Res. 16(4):193A, 1982.

35. Chan WY, Tease LA, Bates JM Jr, Rennert OM. Zinc metabolism in Testicular Feminization Syndrome cultured fibroblasts. Pediat Res. 16(4):136A, 1982.

36. Germer M, Griesmann G, Garison R, Chan WY, Rennert OM. Chemical diagnosis of Reye's Syndrome- determination of (-aminobutyric acid and lysine. Pediat Res. 16(4):257A, 1982.

37. Chung KW, Chan WY, Dressler JB, Allison JE, Rennert OM. Androgen receptors in the brain of neonatal normal male and androgen insensitive rat. Endocrinology. 110(Suppl):200, 1982.

38. Bates JM Jr, Chan WY, Mahmood A, Rennert OM. Human milk, bovine milk and infant formula ligand- bound manganese transport in rat. Fed Proc. 42(4):817, 1983.

39. Rixon MW, Que BG, Chan WY, Chung DW, Davie EW. Isolation and characterization of cDNAs coding for the (, ( and ( chains of human fibrinogen. Fed Proc. 42(7):1761, 1983.

40. Chung DW, Rixon MW, Que BG, Chan WY, Davie EW. Isolation and characterization of cDNAs for the ( and ( chains of human fibrinogen. Proc. IX Internat Congr Thromb Haem. 1983. (podium)

41. Bates JM Jr, Chan WY, Rennert OM. Characterization of manganese binding ligand in Human breast milk. Fed Proc. 43(3):489, 1984.

42. Raghib HM, Chan WY, Rennert OM. Comparative bioavailability of manganese in human milk, cow's milk and infant formula. Fed Proc. 43(3):489, 1984.

43. Raghib HM, Chan WY, Rennert OM. Effect of age on absorption of manganese from human milk, cow's milk and infant formula. Pediat Res. 18(4):209A, 1984.

44. Chan WY, Rennert OM. Immunological screening for the cDNA of the oncodevelopmental protein (SP1 from a human placental expression library. Fed Proc. 44(5):1461, 1985.

45. Bates JM Jr, Chan WY, Chung KW, Rennert OM. Abnormal zinc metabolism in heritable maldescended testes of a mutant rat strain. Fed Proc. 44(4):933, 1985.

46. Raghib HM, Chan WY, Rennert OM. Changes associated with advancing age of suckling rats. Fed. Proc. 44(6):1850, 1985.

47. Chan WY, Rennert OM. Cloning of the cDNA of human pregnancy-specific (1-glycoprotein. Pediat Res. 19(4):152A, 1985.

48. Bates JM Jr, Chan WY, Chung KW, Rennert OM. Aberrant zinc binding in testes of Testicular Feminization rats. Pediat Res. 19(4):149A, 1985.

49. Chung KW, Chan WY, Rennert OM. Influence of zinc deficiency upon androgen receptor binding in the rat prostate gland. Proc 67th Ann Meet Endocr Soc. p.666, 1985.

50. Tease LA, Kim, SY, Garnica AD, Chan WY, Rennert OM. Molecular cloning of human apoferritin light chain cDNA. Am J Hum Genet. 37(4):178A, 1985.

51. Raghib HM, Chan WY, Rennert OM. Selenium bioavailability of infant milk diets. Fed Proc. 45(3):589, 1986.

52. Chan WY, Raghib, H.M., and Rennert, O.M. Factors affecting selenium absorption from infant milk diets. Pediat Res. 20(4):237A, 1986.

53. Garnica AD, Chan WY, Rennert OM. Ceruloplasmin infusion in Menke's Syndrome. Pediat Res. 20(4): 264A, 1986.

54. Chan WY, Chan PK, Rennert OM, Busch H. Identification and characterization of cloned cDNAs coding for the nucleolar phosphoprotein B23. Fed Proc. 45(6):1589, 1986.

55. Tease LA, Chan WY, Rennert OM. Characterization of the cDNA clones of human pregnancy-specific (1- glycoprotein. Fed Proc. 45(6):1512, 1986. (podium)

56. Chung KW, Kim SY, Giger NM, Chan WY, Rennert OM. Ultra-structure of Sertoli cells and concentration of androgen binding protein in testes and epididymids of zinc deficient rats. Anat Rec. 214(3):22A, 1986.

57. Chan WY, Raghib HM, Rennert OM. Absorption studies of manganese from milk diets in suckling rats. Abs 192nd Am Chem Soc Div Agri Food Chem. #13, 1986.

58. Tease LA, Chan PK, Cook RG, Rennert OM, Srinivasan B, Chan WY. Nucleotide sequence of cDNA coding for the N-terminal portion for human pregnancy-specific (1-glycoprotein. Fed Proc. 46(6):1949, 1987.

59. Qiu W, Tease LA, Chan WY. Cloning of human pregnancy-specific (1-glycoprotein gene. Fed Proc. 46(6): 1986, 1987.

60. Chan WY, Qiu WR, Rennert OM, Tease LA. Human pregnancy-specific (1 glycoprotein is coded by a multigene family. Am J Hum Genet. 41(3):A149, 1987.

61. Chan WY, Bates JM Jr, Tease LA. Presence of pregnancy-specific (1- glycoprotein mRNA in placental as well as non-placental tissues of rat. J Cell Biol. 105(4):258a, 1987.

62. Chan WY, Borjigin J, Shupert WL. Cloning and characterization of Schwangerschaftsprotein 1 cDNAs of human testis and HeLa cells. FASEB J. 2(6):A1686, 1988. (podium)

63. Tease LA, Bates JM. Jr, Borjigin J, Shupert WL, Chan WY. Presence of a protein homologous to human Schwangerschaftsprotein 1 in rat testis. FASEB J. 2(6):A1686, 1988. (podium)

64. Venkataraman PS, Chan WY, Fugate R. Cellular calcium responses to calcitonin in mouse hepatocytes: comparison of neonatal vs adult mice. Pediat Res. 23(4):254A, 1988.

65. Chan WY, Sung S-S L. Differential expression of human pregnancy-specific (1-glycoprotein in erythroid and myeloid cell lines. FASEB J. 3(3):A323, 1989.

66. Tease LA, Fazleabas AT, Chan WY. Animal model for the studies of human pregnancy-specific (1 glycoprotein. Pediat Res. 25(4):61A, 1989.

67. Ogilvie S, Larkin LH, Romrell LJ, Shiverick KT, Shupert WL, Chan WY. Localization of proteins immunochemically related to human pregnancy-specific (1-glycoprotein in the testes of rats. Proc Endocr Soc 71st Ann Meet. P.155, 1989.

68. Zheng QX, Borjigin J, Shupert WL, Tease LA, Sung JSS, Chan WY. Differential expression of multiple forms of SP1 in human tissues. Proc XVIIth Meet Internat Soc Oncodevelop Biol Med. P.12, 1989. (podium)

69. Tease LA, Shupert WL, Fazleabas AT, Zavy MT, Chan WY. Presence of pregnancy-specific (1-glycoprotein in different species of animal. Proc XVIIth Meet Internat Soc Oncodevelop Biol Med. P.62, 1989. (podium)

70. Ho WKK, Liu SC, Chan WY. Cloning of the anti-HIV plant protein (-momorcharin cDNA. FASEB J. 4(3):A491, 1990.

71. Richardson LL, Chan WY, Dym M. Expression of the "pregnancy-specific" (1-glycoprotien (SP1) in the male reproductive tract of the rat. J Androl. 11:32-P, 1990.

72. Shupert WL, Chan WY. Expression of pregnancy-specific (1-glycoproteins in human intestine. Proc CEA Workshop. p.7, 1990.

73. Wu SM, Bazar LS, Cohn ML, Burstein SA, Cahill R, Tease LA, Chan WY. Pregnancy-specific (1-glycoprotein in blood cells - expression and potential functions. Proc 2nd Internat PSG/CEA Workshop. p. 9, 1991. (podium)

74. Tease LA, Wu SM, Chan WY. Stable expression of human pregnancy-specific (1-glycoprotein in CHO cells. Proc 2nd Internat PSG/CEA Workshop. p. 11, 1991.

75. Wu M, Tease LA, Chan WY. In vitro expression of human pregnancy-specific (1-glycoprotein (PSG) in CHO cells. FASEB J. 6(1):A231, 1992.

76. Chan WY, Wu SM, Silavin S. Expression of the pregnancy-specific (1-glycoprotein gene family in cultured trophoblasts. FASEB J. 6(1):A450, 1992.

77. Chan WY, Wu SM, Pan CJ, Chou JY. Transformed trophoblasts as in vitro models for studying PSG expression. Proc 3rd Internat CEA/PSG Workshop. p. 8, 1992.

78. Wu SM, Thompson E, Hartmann D-P, Chan WY. Pregnancy-specific (1-glycoprotein in human breast tumor. Proc 4th Internat CEA/PSG Workshop. p. 22, 1993. (podium)

79. Laue L, Hsueh AJW, Cutler GB Jr, Chan WY. Multiple constitutively activating mutations of the human luteinizing hormone receptor (hLHR) in Familial Male Precocious Puberty (FMPP). FASEB J. 8(7):A1320, 1994.

80. Chan WY, Blomberg LA, Vornberger W, Suarez-Quian C. Distribution of pregnancy specific glycoprotein in the normal and azoospermic testis. Biol Reprod. 50(Supp 1):91, 1994. (podium)

81. Blomberg LA, Chen H-W, Dirami G, Chou JY, Dym M, Chan WY. Cloning and identification of specific cellular location of pregnancy-specific (1-glycoprotein (PSG) transcripts in rat testis. Biol Reprod. 50(Suppl 1): 120, 1994.

82. Arnold LL, Wu SM, Simon JA, Chan WY. Expression of pregnancy-specific (1-glycoprotein mRNA in human endometrial tissue. Biol Reprod. 50(Suppl 1):177, 1994.

83. Laue L, Chan WY, Hsueh AJW, Kudo M, Hsu SY, Wu SM, Blomberg LA, Cutler GB Jr. Genetic heterogeneity of activating mutations of the luteinizing hormone receptor gene in familial male-limited precocious puberty. Am J Hum Genet. 55:A228, 1994.

84. Wu SM, Chan WY. The expression of pregnancy-specific (1-glycoprotein genes in Meckel-Gruber syndrome fibroblasts. Am J Hum Genet. 55:A290, 1994.

85. Gursel DG, Blomberg, LA, Flor A, Garnica AD, Chan WY, Rennert OM. Characterization of a cDNA clone from human kidney sharing high homology with the cDNA sequence of placental sphingomyelinase. Am J Hum Genet. 55:A326, 1994.

86. Laue L, Wu SM, Hsueh AJW, Griffin J, Grant DB, Barry C, Cutler GB Jr, Chan WY. An inactivation mutation of the human luteinizing hormone receptor (hLHR) gene in Leydig Cell Hypoplasia (LCH). Mol Biol Cell. 5 (Suppl):68A, 1994.

87. Wu SM, Arnold LL, Rone J, Blomberg LA, Trivedi J, Chan WY. The novel effects of recombinant pregnancy -specific (1-glycoprotein on the preimplantation embryo. Mol Biol Cell. 5(Suppl):352A, 1994.

88. Arnold LL, Wu SM, Flor AW, Simons JA, Chan WY. Pattern of pregnancy-specific (1-glycoprotein gene expression in women with recurrent spontaneous abortion. J Soc Gynecol Invest. 2(2):P293, 1995.

89. Laue L, Wu SM, Jelly DH, Cutler GB Jr, Chan WY. A novel constitutively activating mutation of the human luteinizing hormone receptor (hLHR) gene in an African American patient with "sporadic" male-limited precocious puberty. Proc 77th Ann Meet Endocr Soc. p. 477, 1995.

90. Laue L, Wu SM, Kudo M, Hsueh AJW, Bourdony CJ, Cutler GB Jr, Chan WY. Heterogeneity of human luteinizing hormone receptor (hLHR) gene mutations in Leydig Cell Hypoplasia. Proc 77th Ann. Meet. Endocr. Soc. p. 478, 1995.

91. Arnold LL, Wu SM, Rone J, Simons JA, Chan WY. A prospective randomized comparison of mouse embryo development during Chinese Hamster Ovary (CHO) cell co-culture: Impact of pregnancy specific (1 glycoprotein. Proc 51st Ann Meet Am Soc Reprod Med. 1995.

92. Laue L, Wu SM, Kudo M, Hsueh AJW, Cutler GB Jr, Chan WY. Missense mutations in exons 10 and 11 of the human luteinizing hormone receptor gene cause Leydig Cell Hypoplasia. Am J Hum Genet. 57(4):A217, 1995.

93. Laue L, Wu SM, Kudo M, Hsueh AJW, Cutler GB Jr, Bourdony CJ, Chan WY. Heterozygous mutations of the luteinizing hormone receptor gene in a patient with Leydig cell hypoplasia. Prog Abst Internat Congr Endocrinol 96. p.747, 1996. (podium)

94. Blomberg LA, Rone J, Rennert OM, Chan WY. Molecular cloning and characterization of novel embryonic genes. Pediat Res. 41(4):41A, 1997.

95. Hallermeier K, Wu SM, Laue LL, Griffin JE, Wilson JD, Brain C, Berry AC, Grant DB, Cutler GB Jr, Chan WY. Compound heterozygous mutations of the luteinizing hormone/chorionic gonadotropin receptor gene in a family with two children affected by Leydig cell hypoplasia (LCH). Pediat Res. 41(4):67A, 1997. (podium)

96. Martin MM, Wu SM, Martin ALA, Rennert OM, Chan WY. Constitutive activation of the hLH receptor: A proposed etiology for seminoma. Pediat Res. 41(4):70A, 1997.

97. Flor WA, Chan WY, Rennert OM. Delayed motor and mental development in a male with an intermediate allele in the FMR-1 gene. Pediat Res. 41(4):102A, 1997.

98. Stratakis CA, Lin J-P, Pras E, Wu SM, Bourdony CJ, Rennert OM, Chan WY. Allgrove (Triple-A) syndrome in Puerto Rican kindreds maps to chromosome 12 (12q13). Pediat Res. 41(4):107A, 1997.

99. Wu SM, Jose M, Hallermeier K, Rennert OM, Chan WY. Polymorphisms in the coding exons of the human luteinizing hormone/chorionic gonadotropin receptor gene. Pediat Res. 41(4):109A, 1997.

100. Jose M, Wu SM, Rennert OM, Chan WY. Expression of the LH receptor in cultured human skin fibroblasts. Prog Abst 79th Ann Meet Endocr Soc. p. 553, 1997.

101. Wu SM, Jose M, Hallermeier K, Rennert OM, Chan WY. Polymorphisms of the coding exons of the hLH receptor. Prog Abst 79th Ann Meet Endocr Soc. p. 553, 1997.

102. Stratakis CA, Wu SM, Bourdony CJ, Cohen D, Rennert OM, Chan WY. Hereditary isolated glucocorticoid deficiency: Description of a kindred with adrenocorticotropin (ACTH) unresponsiveness and identification of a novel mutation (P237H) of the ACTH-receptor (MC2R); absence of MC2R defects in 4 kindreds with Allgrove syndrome. Prog Abst 79th Ann Meet Endocr Soc. p. 557, 1997.

103. Wu SM, Hallermeier K, Laue L, Griffin JE, Wilson JD, Grant DB, Brain C, Berry EC, Cutler GB Jr, Chan WY. Insertional mutation in exon 1 inactivates the LH/hCG receptor in a patient with Leydig Cell Hypoplasia. Prog Abst 79th Ann Meet Endocr Soc. p. 553, 1997.

104. Martin MM, Wu SM, Martin ALA, Rennert OM, Chan WY. Malignant seminoma in a patient with a constitutive activating mutation of the hLH receptor gene. Horm Res. 48(Suppl 2):118, 1997.

105. Wu SM, Stratakis CA, Bourdony CJ, Rennert OM, Chan WY. Molecular genetics of syndromes of Adrenocorticotropin (ACTH) resistance: Novel mutations of the ACTH receptor gene in hereditary glucocorticoid resistance patient and refinement of the Allgrove syndrome locus. Amer J Hum Genet. 61(4): A351, 1997.

106. Chan WY, Blomberg LA, Massaro GD, Massaro D. Identification of retinoic acid (RA)-induced genes in emphysematous rat lung. Amer J Resp Crit Care Med. 157(3):A433, 1998.

107. Chan WY, Blomberg LA, Massaro GD, Massaro D. Identification of differentially expressed genes involved in lung development in the rat. Amer J Resp Crit Care Med. 157(3):A547, 1998.

108. Zimmerman TN, Chan WY, Wu SM, Stratakis CA. Hereditary isolated glucocorticoid deficiency associated with Reye’s syndrome. Pediat Res. 43(4):89A, 1998. (podium).

109. Chan WY. Molecular abnormalities of LH action. . Prog Abs 80th Ann Meet Endo Soc. p. 27, 1998. (podium)

110. Wu SM, Brain C, Leschek E, Chan WY. A new mutation of the luteinizing hormone receptor in a patient with familial male-limited precocious puberty. Prog Abs 80th Ann Meet Endocr Soc. p. 283, 1998.

111. Prakasam G, Castro-Magana M, Arguello R, Angulo M, Canas A, Kam R, Vitollo P, and Chan WY. Hormonal profile during treatment in familial male-limited precocious puberty due to a novel heterozygous activating mutation of the LH receptor. Prog Abs 80th Ann Meet Endocr Soc. p. 283, 1998.

112. Chan WY, Blomberg LA, Massaro GD, Massaro D. Molecular cloning and characterization of two differentially expressed genes in rat lung. Amer J Resp Crit Care Med. 159(3):A665, 1999.

113. Massaro GD, Massaro D, Chan WY, Clerch LB, Ghyselinck N, Chambon P. Retinoids and the regulation of alveolus formation. FASEB J. 13(4):A353, 1999.

114. Colon AR, Chan WY. The Pediatric Ishimpo. Pediat Res. 47(4):182A, 2000.

115. Chan WY, Blomberg LA, Eckart M, Massaro D. Identification of retinoic-acid-modulated genes in emphysematous rat lungs by subtraction hybridization. FASEB J, 15(4)A156, 2001. (podium

116. Blomberg LA, Chan WY, Clerch L, Massaro D. Cloning and characterization of two genes differentially expressed during postnatal rat lung alveolus formation. FASEB J, 15(4)A164, 2001.

117. Blomberg LA, Massaro D, Clerch L, Chan WY. Identification of a gene up-regulated in emphysematous rat lung during retinoic acid-induced alveolus regeneration and during spontaneous postnatal alveolus formation. FASEB J, 15(4)A165, 2001.

118. Leschek EW, Jones J, Chan WY, Barnes KM, Jones JC, Cutler GB Jr. Effect of spironolactone, testolactone, and deslorelin treatment on the final height of boys with familial male-limited precocious puberty (FMPP). Lawson-Wilkens – Euro Pediat Endocr Soc Meet, 2001.

119. Wu SM, Leschek EW, Chan WY. A novel constitutive activating mutation of the luteinizing hormone receptor in a patient with familial male-limited precocious puberty (FMPP). Prog Abst, Endocr Soc 83rd Ann Meet, p. 567, 2001.

120. Sandrini F, Farmakidis C, Kirschner LS, Tullio-Pelet A, Lyonnet S, Bourdony CJ, Chan WY, Stratakis CA. Spectrum of mutations of the AAAS gene and genotype-phenotype correlation in a patients with isolated resistance to corticotropin or Allgrove Syndrome. Prog Abst, Endocr Soc 83rd Ann Meet, p. 568, 2001.

121. Abbasi V, Chan WY, Wu SM, Dowse J, Ali S. Clinical, biochemical, radiological, and genetic studies in a unique case of 46 XY gonadal dysgenesis. Pediat Res. 51(4)119A, 2002.

122. Wu SM, Al-Muslim O, Aziz A, Inam S, Awadh M, Rennert OM, Chan WY. A novel mutation in TM IV of the luteinizing hormone/chorionic gonadotropin receptor in a patient with the severe form of Leydig Cell Hypoplasia. Prog Abst, Endocr Soc 84th Annu Meet, p.316, 2002.

123. Chan WY, Chen Y, Pang LY, Li X, Su Y, Dym M, Rennert OM. Changes in germ cell gene expression during spermatogenesis in the mouse. Prog Abst, Endocr Soc 84th Annu Meet, p. 539, 2002.

124. Wu SM, Chen Y, Baxendale V, Dym M, Rennert OM, Chan WY. Elucidation of the transcriptome of mouse pachytene spermatocyte by Serial Analysis of Gene Expression (SAGE) analysis. Prog Abst, Endocr Soc 84th Annu Meet, p. 539, 2002.

125. Leschek EW, Chan WY, Jones J, Jones JC, Barnes KM, Cutler GB Jr. Gonadotropin-independent precocious puberty in a girl with an activating mutation of the Luteinizing Hormone Receptor (LHR). Prog Abst, Endocr Soc 84th Annu Meet, p. 483, 2002.

126. Li X, Ravindranath N, Chan WY, Manickam P, Dym M. Microarray analysis of spermatogonial responsiveness to stem cell factor. Prog Abst, Soc Study Reprod 35th Ann Meet, p. 141, 2002.

127. Dogulu CF, Kansu T, Baxendale V, Wu SM, Ozguc M, Chan WY, Rennert OM. Evidence for genetic susceptibility for Pseudotumor cerebri in Turkish population. Amer J Human Genet. 71(4)369, 2002.

128. Wu SM, Baxendale V, Chen Y, Leung MYK, Ravindranath N, Dym M, Rennert OM, and Chan WY. Identification of genes differentially expressed at different stages of spermatogenesis in mice using SAGE. Prog Abst 3rd International Symposium on Differential Gene Expression, p. 33, 2002.

129. Pang ALY, Chen Y, Su Y, Ravindranath N, Dym M, Rennert OM, and Chan WY. Identification of genes differentially expressed at different stages of spermatogenesis in mice using cDNA microarray hybridization. Prog Abst 3rd International Symposium on Differential Gene Expression, p. 25, 2002 (podium)

130. Chan WY, Wu SM, Baxendale V, Chen Y, Li X, Leung MYK, Ravindranath N, Dym M, and Rennert OM. Functional genomics of spermatogenesis: Profile of the transcriptome of mouse germ cells. North America Testis Workshop, Society of Andrology, March 26-29, 2003, Phenoix, AZ.

131. Ray R, Wu SM, Sellers EAC, Dean H, Taback S, Chan WY, Chudley AE. A multi-generation French Canadian kindred with familial male-limited precocious puberty caused by a C1118T mutation in the luteinizing hormone/choriogonadotropin receptor (LHCGR) gene. Annual Clinical Genetics Meeting, American College of Medical Genetics, San Diego, CA, March 13-15, 2003.

132. Leung MYK, Baxendale V, Leschek E, Wu SM, Fichman K, Chan WY, Rennert OM. A novel polymorphic site at the mutation hot-spot (TM VI) of the luteinizing hormone receptor in a patient with familial male-limited precocious puberty. Amer J Human Genet., 73(5):294, 2003.

133. Vong QP, Wu SM, Dym M, Rennert OM, and Chan WY. Dby expression and germ cell development. Amer J Human Genet. 73(5):328, 2003.

134. Tayebi N, Feng LX, Baxendale V, Wu SM, Pang ALY, Dym M, Chan WY, Rennert OM. Using SAGE to confirm a telomerase immortalized spermatogonial cell line as an experimental model. Amer J Human Genet. 73(5):329, 2003.

135. Pang ALY, Johnson W, Ravindranath N, Dym M, Rennert OM, Chan WY. A survey of housekeeping gene expression during germ cell development. Amer J Human Genet. 73(5):429, 2003.

136. Ravindranath N, Nalbandian A, Pang ALY, Djakiew DD, Chan WY. Identification of p75NTR-responsive genes in the human prostate cancer cells by cDNA microarray. American Association of Cancer Research, 2004.

137. Pang ALY, Johnson W, Rennert OM, and Chan WY. Characterization of a potential sense-antisense transcript pair that is differentially expressed in male germ cells. European Testis Workshop, Edingburgh, Scotland, 2004

138. Chan WY. Functional Genomics – an efficient approach to identify gene targets in cancer and development. 4th TWGHs - CUHK Eddie Wang Symposium. (podium)

139. Chan WY, Wu SM, and Rennert OM. Molecular genetics of human diseases caused by mutation of the LH receptor. Beijing 2004 International Conference on Medical Genetics. Abstract book, p. 37, 2004. (podium)

140. Chan WY, Wu SM, Baxendale V, Yali Chen, Li X, Pang ALY, Leung MYK, Ravindranath N, Dym M, Rennert OM. A global view on male fertility: gene expression profile in spermatogenesis. Society of Chinese Bioscientists in America Annual Meeting, Beijing, China, July 18-23, 2004. (podium).

141. Chan WY, Biological implications of functional genomic studies of germ cell development. Wuhan SCBA Satellite Workshop Abstract book, p. 13, 2004 (podium).

142. WY Chan, SM Wu, L Ruszczyk,V Baxendale, E Law, M Dym, and OM Rennert. Anti-Sense Transcription Plays An Important Role in Gene Regulation During Spermatogenesis. Amer J Human Genet. 54th Annual Meeting Abstract Book, p. 209, 2004.

143. ALY Pang, MM Martin, D Bellan, ALA Martin, OM Rennert and WY Chan. Alterations of Gene Expression Pattern in Testicular Biopsy from A Patient with DAX-1 Mutation. Amer J Human Genet 54th Annual Meeting Abst Bk, p. 298, 2004.

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