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ICD - O

International Classification of Diseases for Oncology

Third Edition

First Revision

ICD - O

International Classification of Diseases for Oncology

Third Edition

First Revision

Editors April Fritz Constance Percy Andrew Jack Kanagaratnam Shanmugaratnam Leslie Sobin D Max Parkin Sharon Whelan

WHO Library Cataloguing-in-Publication Data

International classification of diseases for oncology (ICD-O) ? 3rd edition, 1st revision.

1.Neoplams - classification. I.World Health Organization. II.ICD-O.

ISBN 978 92 4 154849 6 ISBN 978 92 4 069212 1 (PDF)

(NLM classification: QZ 15)

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Printed in Malta

Contents

Dedication

v

Acknowledgements

vii

1. Introduction

1

1.1 Historical background

1

2. Differences between ICD-O and ICD-10

4

2.1 ICD-10 categories not used in ICD-O, third edition

5

2.2 Special codes in ICD-O for topography of lymph nodes (C77) and

hematopoietic and reticuloendothelial systems (C42)

6

2.3 Hydatidiform mole and neurofibromatosis (Von Recklinghausen disease except bone) 6

2.4 HIV disease and AIDS

6

2.5 Functions of neoplasms

6

3. Structure and format of ICD-O, third edition

7

3.1 Abbreviations

7

3.2 American and British spelling

7

3.3 Topography ? numerical list

7

3.4 Morphology ? numerical list

7

3.5 Format of ICD-O terms in numerical list

8

3.6 Alphabetic index

8

3.7 Format and use of alphabetic index

9

3.8 Tumor-like lesions and conditions

9

3.9 Lymphoma and leukemia listings

9

3.10 Meaning of "NOS" (not otherwise specified) and how it is used

10

3.11 Meaning of [OBS] (obsolete) and how it is used

10

3.12 The hematologic malignancies

10

3.13 Using the lymphoma and leukemia sections of ICD-O

14

4. Coding guidelines for topography and morphology

14

4.1 Summary of principal rules for using ICD-O, third edition

14

4.2 Topography

16

4.3 Morphology

19

4.4 Multiple primary neoplasms

24

4.5 Basis of diagnosis

27

4.6 WHO grading system for central nervous system tumors and the ICD-O grade code 27

References

29

iii

Numerical lists

31

Topography

33

5th digit behavior code for neoplasms

52

6th digit code for histological grading and differentiation

52

6th digit code for immunophenotype designation for lymphomas and leukemias

52

Morphology

53

Alphabetic index

95

Appendixes

217

1: New codes in ICD-O, third edition

217

2: New morphology terms and synonyms in ICD-O, third edition

222

3: Terms that changed morphology code in ICD-O, third edition

227

4: Terms that changed from tumor-like lesions to neoplasms in ICD-O, third edition 230

5: Terms in ICD-O, second edition, which were deleted for ICD-O, third edition

230

6: ICD-O, second edition, terms that changed behaviour code for ICD-O, third edition 231

7: New codes, preferred terms, related terms, and synonyms in this ICD-O,

third edition, first revision

233

iv

Dedication

Calum Muir

1930?1995

This third edition of the International Classification of Diseases for Oncology (ICD-O) is dedicated to the memory of Dr Calum Muir.

Calum Muir was an editor of the second edition of ICD-O. As a pathologist, he did much to assemble the new morphologic terms and the latest classifications for lymphomas, leukemias and brain tumors. His contacts with cancer registries throughout the world helped to implement ICD-O worldwide.

After his retirement from the International Agency for Research on Cancer, initially as Chief of the Unit of Epidemiology and later as its Deputy Director, Calum Muir became the Director of Cancer Registration for Scotland. He was instrumental in founding the International Association of Cancer Registries (IARC) in 1966, serving as Deputy Secretary from 1972 to 1990 and as President from 1992 until his death.

Calum Muir's spirit and devotion to accurate and complete classification of neoplasms lives on in this edition.

iv

Acknowledgements

We are grateful to the following individuals and their institutions for their contributions to this edition of ICD-O.

Dr Timothy Cot?, National Cancer Institute, Bethesda, MD, USA Mme Catherine Exbrayat, Registre des Cancers de l'Is?re, Is?re, France Professor Ekkehard Grundmann, Gerhard Domagk Institut f?r Pathologie, M?nster

Universit?t, M?nster, Germany Professor Paul Hermanek, Chirurgische Klinik mit Poliklinik der Universit?t Erlangen-

N?rnberg, Erlangen, Germany Dr Elaine Jaffe, National Cancer Institute, Bethesda, MD, USA Dr Paul Kleihues, International Agency for Research on Cancer, Lyon, France Dr Franco Rilke, Societ? Italiana di Cancerologia, Milan, Italy Dr James Vardiman, University of Chicago, Chicago, IL, USA Mrs Annette Hurlbut, Fulton, NY, USA

We greatly appreciate the input of the expert groups that provided valuable background material for the development of this third edition and gave the editors the benefit of their advice on the field-trial edition:

European Network of Cancer Registries (ENCR) Working Group on the coding of haematological malignancies and lymphomas

Dr Ren?e Otter, Comprehensive Cancer Centre North, Groningen, The Netherlands Dr Aurora Astudillo, Hospital General de Asturias, Oviedo, Spain Professor Paule Marie Carli, Registre des H?mopathies Malignes en C?te d'Or, Dijon,

France Dr Andrew Jack, Leukaemia Research Fund, University of Leeds, Leeds, England Dr Han Van Krieken, The Academic Hospital, Leiden, The Netherlands International Society of Pediatric Oncology (SIOP) Working Group Professor Jillian M. Birch, CRC Paediatric and Familial Cancer Research Group,

Manchester, England Dr James Ironside, National Creutzfeldt-Jakob Disease Surveillance Unit, Western

General Hospital, Edinburgh, Scotland Dr Anna M. Kelsey, Royal Manchester Children's Hospital, Manchester, England Professor Dietmar Schmidt, Institut f?r Pathologie, Mannheim, Germany

We would like to thank the cancer registries and the pathologists and data collectors

associated with these registries who put an immense amount of careful work into the field

testing of ICD-O, third edition.

Australia, New South Wales

Australia, South

Canada, Manitoba

Australia, Victoria

Canada, Ontario

Belarus

Canada, Ontario, Princess Margaret

Belgium

Hospital

Brazil, Campinas

Canada, Nova Scotia

Brazil, Porto Alegre

China, Beijing

Canada, British Columbia

China, Qidong

vii

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