Protocol for the use of OCTAPLEX - Transfusion Guidelines
[Pages:1]Protocol for the use of OCTAPLEX
This is a plasma derived, virally inactivated concentrate of clotting factors II, VII, IX and X. It also contains the naturally occurring anticoagulants Protein C and Protein S plus Heparin.
Indications Urgent reversal of Warfarin or another coumarin anticoagulant such as Nicoumalone or Phenindione e.g. major or life threatening bleed, emergency surgery Management of bleeding or surgery in patients with congenital Factor II or X deficiencies
Contraindications Allergic reactions to Octaplex or Heparin Previous Heparin induced Thrombocytopenia
Cautions Liver disease History of thromboembolic events Disseminated intravascular coagulation
Making up the Octaplex and infusion rates 500 iu of Octaplex is dissolved in 20 mls of sterile water. The solution will have a bluish tinge, this is normal. Start the infusion rate at 1 ml per minute for the first 5 minutes and if there is no allergic reaction the infusion rate can be increased by 1 ml per minute every 1 to 2 minutes up to a maximum rate of 8 mls per minute (480 mls/hr). Studies have shown that the latter faster rate is safe with Octaplex.
Dosing
This can be adjusted according to the INR as follows
INR
< 2.5
Dose (mls per kg body weight)
0.9 to 1.2
2.5 to 3.0 1.3 to 1.6
3.1 to 3.5 1.7 to 1.9
> 3.5 > 1.9
However many hospitals use a standard dose of 30 iu/ kg for all patients regardless of the INR. If the patients weight is not known and as long as the patient is not significantly obese a dose of 2000 iu (80 mls) for the majority of women and 2500 iu (100mls) for the majority of men would be appropriate.
Please note - The maximum dose would be 3000 iu (120mls) at any one time.
In cases of warfarin / coumarin anticoagulant reversal suggest combining Octaplex with up to 5 mg of IV Vitamin K for full and sustained correction.
Monitoring Check an INR immediately pre and 20 to 30 minutes post-treatment with Octaplex in order to assess the response. If the INR remained too high then additional doses of Octaplex can be given after discussion with the on call Haematology SpR or Consultant.
Dr J Mainwaring Consultant Haematologist December 2011
................
................
In order to avoid copyright disputes, this page is only a partial summary.
To fulfill the demand for quickly locating and searching documents.
It is intelligent file search solution for home and business.
Related download
- intravenous infusion calculations
- panzyga administration guide best blood
- safemedicate learner guide uk v2
- drug dosage iv rates calculations george brown college
- standardized adult 40 130 kg ivig infusion rate tables
- privigen infusion rates
- infusion rate calculator
- protocol for the use of octaplex transfusion guidelines
- guidelines standardised infusion rates for intravenous
Related searches
- the use of technology in education
- reasons for the fall of rome
- 10 reasons for the fall of rome
- for the purposes of definition
- twenty arguments for the existence of god
- word for the origin of words
- the use of myself
- formulas for the laws of motion
- through the use of synonym
- the use of the word the
- reason for the fall of rome
- reasons for the fall of roman empire